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Affiliation |
Faculty of Medicine School of Medicine Department of Surgery, Gastrointestinal, Endocrine and Pediatric Surgery |
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Title |
Assistant Professor |
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External Link |
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ICHIHARA Akiko
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Papers 【 display / non-display 】
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Kai K., Hamada T., Sato Y., Hiyoshi M., Imamura N., Yano K., Ikeda T., Ichihara A., Ogata S., Choijookhuu N., Hishikawa Y., Hosokawa A., Nanashima A.
Journal of Oncology 2023 1440257 2023
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Oncology
Background. Oxaliplatin (OX)-based chemotherapy induces sinusoidal obstruction syndrome (SOS) in the nontumorous liver parenchyma, which can increase the risk of liver resection due to colorectal liver metastasis (CRLM). The extracellular volume (ECV) calculated from contrast-enhanced computed tomography (CT) has been reported to reflect the morphological change of hepatic fibrosis. The present retrospective study aimed to evaluate the ECV fraction as a predictive factor for OX-induced SOS. Methods. Our study included 26 patients who underwent liver resection for CRLM after OX-based chemotherapy with a preoperative dynamic CT of appropriate quality. We investigated the relationship between the pathological SOS grade and the ECV fraction. Results. Overall, 26 specimens from the patients were graded with the SOS classification of Rubbia-Brandt et al. as follows: grade 0, n = 17 (65.4%); grade 1, n = 4 (15.4%); and grade 2, n = 5 (19.2%). No specimens showed grade 3 SOS. In a univariate analysis, the ECV fraction in grade 0 SOS was significantly lower than that in grade 1 + 2 SOS (26.3 ± 3.4% vs. 30.6 ± 7.0%; P = 0.025). The cutoff value and AUC value of the ECV fraction to distinguish between grades 0 and 1 + 2 were 27.5% and 0.771, respectively. Conclusions. Measurement of the ECV fraction was found to be a potential noninvasive diagnostic method for determining early-stage histopathological sinusoidal injury induced by OX-based chemotherapy.
DOI： 10.1155/2023/1440257
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A Case of Minute Carcinoma in Situ in the Ascending Colon with Sign of Leser-Trélat
Hara Daisuke, Kai Kengo, Ikeda Takuto, Ichihara Akiko, Inomata Mayu, Kanemaru Shiho, Kiwaki Takumi, Kataoka Hiroaki, Nanashima Atsushi
The Japanese Journal of Gastroenterological Surgery 55 ( 11 ) 701 - 708 2022
Language：Japanese Publishing type：Case report Publisher：The Japanese Society of Gastroenterological Surgery
A 74-year-old man presented to the dermatology department of our hospital with multiple eruptions with itching. Leser-Trélat was suspected due to a rapid increase in seborrheic keratosis. Colonoscopy revealed a 35-mm multinodular polypoid lesion with a laterally spreading tumor that was partially non-granular. The tumor was diagnosed as carcinoma in adenoma with submucosal invasion. Because of the difficulty of endoscopic en bloc resection, laparoscopic ileocecal resection was performed in our department. A pathologic examination revealed that the resected cancer was a minute carcinoma in situ, of only 500 μm in size. We confirmed that the skin lesions were related to the Leser-Trélat sign, based on improvement of the skin after resection of colon cancer and high expression of epidermal growth factor receptor in the skin lesions. The Leser-Trélat sign, a skin symptom of paraneoplastic dermadromes, is frequently associated with gastrointestinal cancers, such as gastric and colorectal cancer, and is reported to be associated with advanced stage disease. In contrast, reports of the sign in association with early colorectal cancer are rare. Our search of the Japanese literature yielded only 3 cases in which the sign was described in submucosal invasive cancer and none involving intramucosal cancer. We present this case of minute carcinoma in situ in the ascending colon with a Leser-Trélat sign and review the relevant literature to investigate the clinical differences between cases of early and advanced cancer with a Leser-Trélat sign.
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ICHIKI Nobuhiko, IKEDA Takuto, ICHIHARA Akiko, HAMADA Roko, OTA Yusuke, NANASHIMA Atsushi
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 83 ( 3 ) 542 - 549 2022
Language：Japanese Publishing type：Case report Publisher：Japan Surgical Association
Two cases of mixed neuroendocrine carcinoma and non-neuroendocrine neoplasm (MiNEN) are presented. A 50-year-old woman noticed an abdominal mass. Transverse colon cancer [cT3N2bM0 cStage IIIc] was diagnosed by computed tomography and colonoscopy. Right hemi-colectomy and lymphadenectomy were performed. Pathological examination showed combined features of adenocarcinoma and neuroendocrine carcinoma. The pathological diagnosis was MiNEN, pT3N0M0 pStage IIa. The patient received 8 courses of adjuvant CapeOX chemotherapy. At 12-month follow-up, the patient was well with no evidence of recurrence. A 72-year-old man was found to be positive for fecal occult blood. Colonoscopy showed a sigmoid colon polyp. The patient underwent endoscopic mucosal resection (EMR) of the polyp. The pathological diagnosis was MiNEN with deep submucosal (SM) invasion. Based on these findings, additional resection (laparoscopic sigmoidectomy and D3 lymph node dissection) was performed. The pathological diagnosis was MiNEN, pT1bN1M0 pStage IIIa. However, the patient did not wish to receive chemotherapy. At 60-month follow-up, the patient was well, with no evidence of recurrence. Although the prognosis of MiNEN is quite poor, multidisciplinary treatment resulted in a relatively good course. These cases are reported with a review of the literature.
DOI： 10.3919/jjsa.83.542
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An adult case of a retroperitoneal isolated enteric duplication cyst with the imaging changes over time. Reviewed
Inomata M, Kai K, Ikeda T, Ichihara A, Masuda R, Kiwaki T, Tanaka H, Kataoka H, Nanashima A
Surgical case reports 7 ( 1 ) 258 2021.12
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A Case of Acute Gastric Volvulus Resulting in Panperitonitis Due to Gastric Perforation
Masuya Ryuta, Nakame Kazuhiko, Tate Mayumi, Kurogi Jun, Kawano Fumiaki, Ichihara Akiko, Ikeda Takuto, Takeno Shinsuke, Nanashima Atsushi, Ieiri Satoshi
Journal of the Japanese Society of Pediatric Surgeons 57 ( 6 ) 1002 - 1007 2021.10
Language：Japanese Publishing type：Case report Publisher：The Japanese Society of Pediatric Surgeons
The patient was a two-year-old girl who had been treated for recurrent vomiting for three days. She was brought to our hospital after her previous doctor suspected gastrointestinal perforation due to sudden abdominal distension. When she arrived at our hospital, her face was pale, her vitality was poor, and she had a peripheral cold sensation. Her pulse rate was 200/min, her blood pressure was 60/42 mmHg, her respiratory rate was 43/min, and she was in shock. Contrast-enhanced computed tomography (CT) of the abdomen showed a large amount of free air and ascites along with findings of gastric volvulus. Emergency laparoscopic surgery was performed. The gastric volvulus was corrected laparoscopically. Because the site of perforation was challenging to identify, we changed the procedure to open laparotomy. A pinhole perforation was found at the upper gastric corpus due to detachment of the omentum. Wedge-shaped resection was performed around the perforation, and the stomach was fixed to the abdominal wall. No migrating spleen was observed. The postoperative recovery from disseminated intravascular coagulation and improvement of gastric peristalsis took a few days, but she gradually improved. She was discharged on the 19th postoperative day. Since her discharge from the hospital, there has been no recurrence of volvulus. There have been several reports on gastric perforation associated with acute gastric volvulus. Since there have been some reports of death due to the rapid and severe onset of symptoms, a prompt diagnosis and treatment are required.
Presentations 【 display / non-display 】
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手術適応に苦慮した腸管気腫性嚢胞症の1例．
千代反田顕，河野文彰，田代耕盛，西田卓弘，宮崎康幸，宗像 駿，落合貴祐，清水一晃，長友謙三，濱田朗子，鈴東昌也,市原明子，池田拓人，武野慎祐，七島篤志
第54回日本腹部救急医学会総会 (東京) 日本腹部救急医学会
Event date： 2018.3.8 - 2018.3.9
Language：Japanese Presentation type：Oral presentation (general)
Venue：東京
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パネルディスカッション 外傷医療におけるInter-Professional Work (多職種連携:IPW)：外傷外科手術と多職種連携の重要性．
田代耕盛，河野文彰，岩崎あや香，長友謙三，宗像 駿，宮崎康幸，和田 敬，池ノ上実，濵田朗子，西田卓弘，鈴東昌也，市原明子，池田拓人，武野慎祐，七島篤志，中村都英
第51回宮崎救急医学会 (宮崎) 宮崎救急医学会
Event date： 2018.2.18
Language：Japanese Presentation type：Symposium, workshop panel (public)
Venue：宮崎
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腹腔鏡下直腸・S状結腸切除後の縫合不全に対する腹腔鏡下人工肛門造設術の検討.
宮﨑康幸，池田拓人，市原明子，田上幸憲，濵田朗子，西田卓弘，土持有貴，田代耕盛，河野文彰，武野慎祐，七島篤志
第30回日本内視鏡外科学会総会 (京都) 日本内視鏡外科学会
Event date： 2017.12.7 - 2017.12.9
Language：Japanese Presentation type：Poster presentation
Venue：京都
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クローン病難治性直腸肛門病変に対し腹腔鏡下腹会陰式直腸切断術を施行した一例.
市原明子，池田拓人，宮﨑康幸，濵田朗子，西田卓弘，土持有貴，田代耕盛，河野文彰，武野慎祐，七島篤志
第30回日本内視鏡外科学会総会 (京都) 日本内視鏡外科学会
Event date： 2017.12.7 - 2017.12.9
Language：Japanese Presentation type：Poster presentation
Venue：京都
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膀胱浸潤を伴う局所進行大腸癌に対する腹腔鏡補助下手術の検討.
池田拓人，市原明子，宮﨑康幸，濵田朗子，西田卓弘，河野文彰，田代耕盛，土持有貴，田上幸憲，武野慎祐，七島篤志
第30回日本内視鏡外科学会総会 (京都) 日本内視鏡外科学会
Event date： 2017.12.7 - 2017.12.9
Language：Japanese Presentation type：Oral presentation (general)
Venue：京都