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Faculty of Medicine School of Medicine Department of Surgery, Gastrointestinal, Endocrine and Pediatric Surgery |
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Assistant Professor |
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Related SDGs |
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ICHIHARA Akiko
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Papers 【 display / non-display 】
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Delorme Procedure for Mucosal Prolapse after Laparoscopic Intersphincteric Resection: A Case Report Reviewed
Ichihara Akiko, Takeno Shinsuke
Nihon Daicho Komonbyo Gakkai Zasshi 78 ( 6 ) 257 - 261 2025.6
Authorship：Lead author Language：Japanese Publishing type：Case report Publisher：The Japan Society of Coloproctology
A 45-year-old man underwent laparoscopic-assisted partial ISR for additional resection of rectal neuroendocrine tumor after endoscopic submucosal dissection. The patient recognized mucosal prolapse following stoma closure at four months postoperatively and underwent DP for prolonged dyschezia with frequent bowel movements and incontinence. Mucosal detachment was performed transanally at the oral side of the anastomosis to form the 8-cm mucosal tube. The muscle layer was sutured circumferentially from the dentate line side, and the mucosal tube was resected and anastomosed. Surgery was completed after confirming the reduction of the intestinal tract and anal skin inversion. The patient experienced no perioperative complications, improved dyschezia, and had no recurrence of mucosal prolapse or neuroendocrine tumor at one year and four months after DP. DP can be performed safely in patients with mucosal prolapse after ISR and is an effective treatment option. We studied the mechanism of postoperative mucosal prolapse and its prevention, including innovative techniques for ISR.
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臨床研究 術前治療後に骨盤内臓全摘術を施行した局所進行直腸癌の治療成績 Reviewed
市原明子，市来伸彦，千代反田顕，濵田聖暁，武野慎祐，七島篤志，賀本敏行，細川 歩，陣内 崇，池田拓人
宮崎医師会医学会誌 48 ( 2 ) 129 - 136 2024.9
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Hiyoshi M., Imamura N., Hamada T., Tsuchimochi Y., Shimizu I., Ochiai T., Ichihara A., Hamada K., Ichiki N., Kai K., Higuchi K.
Translational Cancer Research 14 ( 1 ) 461 - 472 2025.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Translational Cancer Research
Background: Progression of chronic liver dysfunction influenced by long-term chemotherapy or repeated hepatectomy might be related to patient overall survival as well as tumor factors in colorectal liver metastasis (CLM) patients. Our aim of this study was to clarify the relationship between fibrotic liver damage and malignant behaviors of CLM malignancy or its long-term survivals by the retrospective cohort study. Methods: We examined the relationship between tumor-related factors or six liver fibrosis-associated parameters, including platelet count, hyaluronic acid (HA), mac-2 binding protein glycosylation isomer (M2BPGi), type IV collagen 7S (T4C7), aspartate aminotransferase-to-platelet ratio index (APRI), The fibrosis-4 (Fib-4) index, and clinicopathological parameters, surgical records, and postoperative patient survival in the 45 consecutive patients with CLM who underwent radical hepatectomy. Results: Fibrotic parameters were platelet count of 23.0±8.5 ×10<sup>4</sup>/μL, HA level of 68.9±82.3 ng/mL, M2BPGi of 0.87±0.48 ng/mL, and type IV collagen level of 5.74±3.76 ng/mL. Platelet count was significantly correlated with HA level (P<0.05) and tended to be correlated with M2BPGi levels (P=0.056). HA level was significantly associated with albumin level (P<0.05). Overall survival in this series showed five-year overall survivors after hepatectomy in 44 patients (98%), but cancer-related deaths were observed in only one patient. Patients with higher grades and increased bilirubin levels demonstrated significantly lower cancer-free survival (P<0.05), but fibrotic parameters were not associated with prognostic factors. Conclusions: Fibrotic markers indicating chemotherapy or repeated surgical liver injury were not significant predictive factors reflecting cancer malignant behaviors or patient overall survival, contrary to our hypothesis. The current overall survival status using various modalities for cancer recurrence is satisfactory under our present perioperative management.
DOI： 10.21037/tcr-24-1138
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A case of mixed neuroendocrine-non-neuroendocrine neoplasm （MiNEN）with squamoid morule of the colon Reviewed
Tsuzuki Ryo, Umekita Yoshiko, Fukushima Tsuyoshi, Kiwaki Takumi, Chiyotanda Teru, Yamada Kazunosuke, Ichihara Akiko, Sato Yuichiro
Japanese Journal of Diagnostic Pathology 42 ( 2 ) 150 - 155 2025
Language：Japanese Publishing type：Case report Publisher：The Japanese Society of Pathology
We report a case of mixed neuroendocrine-non-neuroendocrine neoplasm （MiNEN） with squamoid morule. A 44-year-old man presented with fresh blood hemorrhage in his stool. Endoscopic examination revealed a colon tumor and the patient subsequently underwent right hemicolectomy. Histologically, the tumor contained both adenocarcinoma and neuroendocrine tumor （NET G3） components with each component occupying more than 30% of the tumor. Both components exhibited squamoid morule. The patient was diagnosed with MiNEN with squamoid morule, which are rare.
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SHIMIZU Ikko, UCHISE Yukako, ICHIKI Nobuhiko, HAMADA Kiyoaki, ICHIHARA Akiko, NANASHIMA Atushi, NAKAMURA Eriko, TSUZUKI Ryou
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 85 ( 11 ) 1551 - 1555 2024.11
Language：Japanese Publishing type：Case report Publisher：Japan Surgical Association
The patient was an 82-year-old woman. Blood tests showed progression of anemia, and CT was performed, which was suspicious for small bowel tumor. Small bowel series showed an elevated lesion in the ileum. Transanal small bowel balloon endoscopy revealed an elevated lesion with an irregular surface in the ileum, which was biopsied and diagnosed as malignant melanoma. There was no history of undergoing excision of skin tumors, and no primary lesions other than small bowel lesions were found on dermatological examination of the body surface and PET-CT. The patient was referred to our department with a diagnosis of primary malignant melanoma of the small intestine and underwent surgery. A tumor was found 190 cm proximal to the end of the ileum, invading the preperitoneum of the bladder. Partial resection of the small intestine, combined peritoneal resection, and regional lymph node dissection were performed. The patient's postoperative course was uneventful, and he was discharged on the 11th postoperative day. The patient has been followed up without recurrence after surgery.
DOI： 10.3919/jjsa.85.1551
Presentations 【 display / non-display 】
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手術適応に苦慮した腸管気腫性嚢胞症の1例．
千代反田顕，河野文彰，田代耕盛，西田卓弘，宮崎康幸，宗像 駿，落合貴祐，清水一晃，長友謙三，濱田朗子，鈴東昌也,市原明子，池田拓人，武野慎祐，七島篤志
第54回日本腹部救急医学会総会 (東京) 日本腹部救急医学会
Event date： 2018.3.8 - 2018.3.9
Language：Japanese Presentation type：Oral presentation (general)
Venue：東京
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パネルディスカッション 外傷医療におけるInter-Professional Work (多職種連携:IPW)：外傷外科手術と多職種連携の重要性．
田代耕盛，河野文彰，岩崎あや香，長友謙三，宗像 駿，宮崎康幸，和田 敬，池ノ上実，濵田朗子，西田卓弘，鈴東昌也，市原明子，池田拓人，武野慎祐，七島篤志，中村都英
第51回宮崎救急医学会 (宮崎) 宮崎救急医学会
Event date： 2018.2.18
Language：Japanese Presentation type：Symposium, workshop panel (public)
Venue：宮崎
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腹腔鏡下直腸・S状結腸切除後の縫合不全に対する腹腔鏡下人工肛門造設術の検討.
宮﨑康幸，池田拓人，市原明子，田上幸憲，濵田朗子，西田卓弘，土持有貴，田代耕盛，河野文彰，武野慎祐，七島篤志
第30回日本内視鏡外科学会総会 (京都) 日本内視鏡外科学会
Event date： 2017.12.7 - 2017.12.9
Language：Japanese Presentation type：Poster presentation
Venue：京都
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クローン病難治性直腸肛門病変に対し腹腔鏡下腹会陰式直腸切断術を施行した一例.
市原明子，池田拓人，宮﨑康幸，濵田朗子，西田卓弘，土持有貴，田代耕盛，河野文彰，武野慎祐，七島篤志
第30回日本内視鏡外科学会総会 (京都) 日本内視鏡外科学会
Event date： 2017.12.7 - 2017.12.9
Language：Japanese Presentation type：Poster presentation
Venue：京都
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膀胱浸潤を伴う局所進行大腸癌に対する腹腔鏡補助下手術の検討.
池田拓人，市原明子，宮﨑康幸，濵田朗子，西田卓弘，河野文彰，田代耕盛，土持有貴，田上幸憲，武野慎祐，七島篤志
第30回日本内視鏡外科学会総会 (京都) 日本内視鏡外科学会
Event date： 2017.12.7 - 2017.12.9
Language：Japanese Presentation type：Oral presentation (general)
Venue：京都