NAKAMURA Takeshi

写真a

Affiliation

Faculty of Medicine College Hospital Otorhinolaryngology

Title

Assistant Professor

External Link

Research Areas 【 display / non-display

  • Life Science / Otorhinolaryngology

 

Papers 【 display / non-display

  • Active Middle Ear Implant in a Patient with Neurofibromatosis Type 1 and Multiple Calvarial Defects: A Case Report.

    Kajihara K, Ganaha A, Matsuda K, Nakamura T, Tono T

    The journal of international advanced otology   18 ( 2 )   183 - 187   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of International Advanced Otology  

    Bony abnormalities, including sphenoid dysplasia and calvarial defects, are well recognized in patients with neurofibromatosis type 1. However, having multiple calvarial defects is rare. We present a case of a 35-year-old Japanese male patient who was referred to our hospital because of hearing loss. He was diagnosed with neurofibromatosis type 1 during early childhood. Otoscopic examination revealed a protrusion from the anterior wall of the external auditory canal that obstructed the external auditory canal. Computed tomography findings revealed multiple defects and an uneven skull surface. Large bony defects of the anterior wall of the external auditory canal were also identified bilaterally. Conductive hearing loss was caused by temporomandibular joint herniation that was obstructing the external auditory canal in both ears. An active middle ear implant was implanted in the right ear. A floating mass transducer was placed into the round window niche using a round window coupler. The active middle ear implant improved postoperative audiometric thresholds to approximately 35 dB across all frequencies. No complications occurred for up to 30 months after the operation. An active middle ear implant is a feasible and valuable option for patients with neurofibromatosis type 1 and conductive hearing loss due to multiple skull defects that result in temporomandibular joint herniation.

    DOI: 10.5152/iao.2022.21279

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  • Comparison of speech perception lists used to evaluate Japanese single syllable hearing.

    Matsuda Y, Okuda T, Kamie A, Miyanaga N, Nakamura T, Shirane M, Shimoara S, Ganaha A, Tono T

    Auris, nasus, larynx   49 ( 3 )   383 - 388   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Auris Nasus Larynx  

    Objective: In Japan, the 57S and 67S single syllable lists have been used to test speech perception in cochlear implant (CI) users. However, due to advances in implants and processors, these lists have become too simple for CI users. In 2019, the Japan Otological Society created a new list, referred to as the iCI2004. The objective of this study was to compare the performance of these lists. Methods: The Japanese single syllable speech perception tests, iCI2004, 57S, and 67S, were administered to 70 patients with CI users. The effects of single syllable characteristics on the test scores were examined. The type and number of single syllables used in each list were different. Therefore, we compared the scores for normal lists, shared single syllables, and non-shared single syllables. Results: The average test results were 52% for iCI2004, 64% for 57S, and 77% for 67S; 67S performed the best, followed by 57S and iCI2004. The test results were significantly different. In a comparison of shared single syllables, the average scores were 58% for iCI2004 and 63% for 57S (45 pieces). A comparison of iCI2004 and 67S (17 pieces) showed that the average scores were 63% for iCI2004 and 75% for 67S. A comparison of 57S and 67S (20 pieces) showed that the average score for 57S was 70% and the average scored for 67S was 77%. No significant differences were detected under all conditions. Based on these results, the type of single syllable adopted affected the result. Conclusion: The data gives no clear indication that the selection of the word table or presentation of sound pressure affects listening to sound for CI users in Japan. Based on the type and number of single syllables used, iCI2004 seems appropriate for evaluation of hearing in patients using CI.

    DOI: 10.1016/j.anl.2021.09.007

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  • Combined Electric acoustic stimulation in a patient with otitis media with antineutrophil cytoplasmic antibody-associated vasculitis.

    Nakamura T, Ganaha A, Tono T, Yamada Y, Okuda T, Shimoara S, Matsuda Y

    Auris, nasus, larynx   49 ( 6 )   1072 - 1077   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Auris Nasus Larynx  

    There are few reports of the treatment for severe hearing loss due to otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV) achieved by cochlear implantation (CI). Here, we have reported the case of a patient with severe bilateral sensorineural hearing loss with low-frequency residual hearing by OMAAV. CI was performed in her right ear based on the results of contrast-enhanced magnetic resonance imaging (CE-MRI) and promontory stimulation test (PST). The residual hearing in her right ear was preserved after CI and utilized for combined electric acoustic stimulation (EAS). The combined EAS was used for 3 years until the residual hearing became stabilized. However, the usable hearing in low frequency worsened gradually, and the fitting strategy of cochlear implant was changed from combined EAS to CI alone 4 years after CI. Even when the speech discrimination score with CI no longer exceeds 50 %, the patient continued using CI because of its advantages in maintaining the quality of life of the patient. The combined EAS was found to be a feasible option even in an OMAAV patient with residual hearing. CE-MRI and PST may thus be helpful in deciding the side of CI surgery in a patient with OMAAV.

    DOI: 10.1016/j.anl.2021.04.009

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  • The Cytokine Expression in Patients with Cardiac Complication after Immune Checkpoint Inhibitor Therapy

    Tsuruda Toshihiro, Yoshikawa Naoki, Kai Motoaki, Yamaguchi Masashi, Toida Reiko, Kodama Tsuyoshi, Kajihara Kei, Kawabata Takayuki, Nakamura Takeshi, Sakata Koji, Hatakeyama Kinta, Gi Toshihiro, Asada Yujiro, Tono Tetsuya, Kitamura Kazuo, Ikeda Ryuji

    Internal Medicine   60 ( 3 )   423 - 429   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Internal Medicine  

    <p>We herein report the cytokine expression at different stages for three patients who developed cardiac complications after immune checkpoint inhibitor (ICI) therapy. Case 1 with biopsy-proven myocarditis showed increased levels of interleukin (IL)-8, monocyte chemotactic and activating factor, and granulocyte macrophage colony-stimulating factor (GM-CSF) when he developed Takotsubo cardiomyopathy. Case 2 with subclinical myocarditis showed predominant activation of IL-8 during the progressive clinical course. Case 3 with cytokine-releasing syndrome showed substantial activations of IL-6, IL-8, GM-CSF, and interferon-γ. Our data suggest the development of unique cytokine activation in individual patients with cardiac complications after ICI therapy. </p>

    DOI: 10.2169/internalmedicine.5317-20

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    CiNii Research

  • Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan Otological Society.

    Harabuchi Y, Kishibe K, Tateyama K, Morita Y, Yoshida N, Okada M, Kunimoto Y, Watanabe T, Inagaki A, Yoshida T, Imaizumi M, Nakamura T, Matsunobu T, Kobayashi S, Iino Y, Murakami S, Takahashi H, Tono T

    Auris, nasus, larynx   48 ( 1 )   2 - 14   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Auris Nasus Larynx  

    Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a form of necrotizing vasculitis with few or no immune deposits. It primarily affects small and medium blood vessels. AAV is classified into three categories, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangitis (EGPA), and two major ANCAs, proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA are involved in their pathogenesis. Intractable otitis media frequently occurs in patients with GPA, MPA or EGPA, although all patients show similar clinical features, regardless of the type of AAV. Furthermore, approximately 15% patients with otitis media caused by AAV do not show ANCA positivity, histopathological evidence, or any other AAV-related lesions at the initial visit; therefore, these patients do not fulfill the ordinary diagnostic criteria for systemic AAV. Thus, we first proposed that this condition could be categorized as “otitis media with AAV (OMAAV)”. Subsequently, the Japanese Otological Society (JOS) conducted a nationwide survey between December 2013 and February 2014 and identified 297 patients with OMAAV. The survey revealed that OMAAV is a disease that initially occurs in the middle ear and subsequently spreads to other organs such as the lungs and kidneys, with eventual involvement of all body organs. Severe sequelae such as facial palsy, hypertrophic pachymeningitis, complete deafness, and subarachnoid hemorrhage resulting in death can also occur. In this review, we introduce the clinical features, diagnostic criteria, and treatment strategies recommended by JOS for early diagnosis and treatment of OMAAV.

    DOI: 10.1016/j.anl.2020.07.004

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Presentations 【 display / non-display

  • VSB implantation in a NF1 patient with multiple bony defects in the temporal bones and the skull. International conference

    Akira Ganaha, Keiji Matsuda, Kei Kajihara, Takeshi Goto, Takeshi Nakamura, Noriaki Miyanaga, Tetsuya Tono

    12th Asia Pacific Symposium on Cochlear Implants and Related Sciences 

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    Event date: 2019.11.27 - 2019.11.30

    Language:English   Presentation type:Poster presentation  

  • Benefit of hearing preservation during cochlear implantation in patients with OMAAV. International conference

    Nakamura Takeshi, Tetsuya Tono, Shouken Shimoara, Yuusuke Matsuda, Takahiro Nakashima

    12th Asia Pacific Symposium on Cochlear Implants and Related Sciences 

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    Event date: 2019.11.27 - 2019.11.30

    Language:Japanese   Presentation type:Poster presentation  

  • めまい主訴の側頭葉てんかん・巨赤芽球性貧血症例.

    湯地俊子,清水謙祐,中村 雄,鳥原康治,東野哲也

    第78回日本めまい平衡医学会総会・学術講演会 

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    Event date: 2019.10.23 - 2019.10.25

    Language:Japanese   Presentation type:Poster presentation  

  • アブミ骨手術における顔面神経の解剖学的要因の影響.

    中島崇博,梶原 啓,中村 雄,後藤隆史,我那覇章,松田圭二,東野哲也

    第29回日本耳科学会総会・学術講演会 

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    Event date: 2019.10.10 - 2019.10.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 新生児聴覚スクリーニングにより早期診断に至った先天性伝音難聴に対して手術治療を行った3例の検討.

    中村 雄,池ノ上あゆみ,我那覇章,中島崇博,後藤隆史,山田悠祐,猿渡英美,東野哲也

    第29回日本耳科学会総会・学術講演会 

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    Event date: 2019.10.10 - 2019.10.12

    Language:Japanese   Presentation type:Oral presentation (general)  

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