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Faculty of Medicine College Hospital Otorhinolaryngology |
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NAKAMURA Takeshi
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Research Areas 【 display / non-display 】
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Life Science / Otorhinolaryngology
Papers 【 display / non-display 】
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Nakamura T, Ganaha A, Tono T, Yamada Y, Okuda T, Shimoara S, Matsuda Y
Auris, nasus, larynx 49 ( 6 ) 1072 - 1077 2021.5
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Auris Nasus Larynx
There are few reports of the treatment for severe hearing loss due to otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV) achieved by cochlear implantation (CI). Here, we have reported the case of a patient with severe bilateral sensorineural hearing loss with low-frequency residual hearing by OMAAV. CI was performed in her right ear based on the results of contrast-enhanced magnetic resonance imaging (CE-MRI) and promontory stimulation test (PST). The residual hearing in her right ear was preserved after CI and utilized for combined electric acoustic stimulation (EAS). The combined EAS was used for 3 years until the residual hearing became stabilized. However, the usable hearing in low frequency worsened gradually, and the fitting strategy of cochlear implant was changed from combined EAS to CI alone 4 years after CI. Even when the speech discrimination score with CI no longer exceeds 50 %, the patient continued using CI because of its advantages in maintaining the quality of life of the patient. The combined EAS was found to be a feasible option even in an OMAAV patient with residual hearing. CE-MRI and PST may thus be helpful in deciding the side of CI surgery in a patient with OMAAV.
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The Clinical Details of MYH9-Related Disease and DFNA17 in a Large Japanese Hearing Loss Cohort. Reviewed
Goto S, Sasaki A, Nishio SY, Shinkawa C, Oda K, Wada T, Ishikawa K, Ikezono T, Oka SI, Nishiyama N, Ito T, Kobayshi M, Kumakawa K, Sakuma N, Nakanishi H, Morimoto C, Uehara N, Okazaki T, Sugahara K, Nakamura T, Usami SI
Genes 17 ( 2 ) 2026.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Genes
Background/Objectives: MYH9 gene variants cause MYH9-related disease (MYH9-RD), which is also known as Epstein syndrome, Fechtner syndrome, May–Hegglin anomaly, and Sebastian syndrome. MYH9-RD is characterized by sensorineural hearing loss, macrothrombocytopenia, thrombocytopenia, hematuria/proteinuria, glomerulonephritis, cataracts purpura, and mucosal bleeding. In addition, the MYH9 gene is also known to be causative of autosomal dominant non-syndromic hearing loss (DFNA17). MYH9-RD is a relatively rare disorder, and the detailed clinical features and mutational spectra remain unclear. Methods: In this study, we performed next-generation sequencing analysis for 15,684 hearing loss patients and identified MYH9-associated hearing loss patients. Detailed clinical information was collected for these patients and summarized. Results: In this study, we identified 24 patients from 18 families with MYH9-associated hearing loss. We clarified the details of hearing deterioration observed in patients based on collected serial audiogram data. Some cases showed rapid hearing deterioration that worsened by about 50 dB within 5 years. Hearing loss is more likely to progress in patients with myosin head domain variants than in patients with myosin tail domain variants, but hearing loss in each set of patients finally deteriorates to bilateral profound hearing loss. Conclusions: In this study, we were able to clarify the detailed characteristics of MYH9-RD- and DFNA17-related hearing loss in a relatively large number of patients, particularly in some cases that showed rapid and asymmetrical hearing deterioration progressing to bilateral profound hearing loss. Our data will be useful for providing more appropriate treatment and follow-up for MYH9-associated hearing loss.
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A Rare Case of Cutaneous Leiomyosarcoma Arising From the External Auditory Canal. Reviewed
Yamashita J, Ide S, Kajihara K, Nakamura T, Takahashi K
Cureus 18 ( 1 ) e102558 2026.1
Language：English Publishing type：Research paper (scientific journal)
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清水 謙祐, 中村 雄, 髙橋 邦行
ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ 68 ( 5 ) 384 2025.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本聴覚医学会
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Takahashi K, Takahashi O, Nakamura T, Ide S, Goto T, Okuda T, Morita Y, Ogi M, Kitazawa M, Yagi C, Yamagishi T, Ohshima S, Izumi S, Horii A
Auris, nasus, larynx 52 ( 4 ) 456 - 462 2025.8
Language：English Publishing type：Research paper (scientific journal) Publisher：Auris Nasus Larynx
Objective: Skull base osteomyelitis (SBO) is a rare but life-threatening inflammatory disease often misdiagnosed as a malignancy, such as nasopharyngeal carcinoma (NPC) and external auditory canal cancer (EACC), due to extensive bone destruction. This study aimed to identify the radiological features of SBO using high-resolution CT, which could help in the differential diagnosis of malignancies. Methods: High-resolution CT findings of 14 patients with SBO, 25 with NPC, and 19 with EACC were retrospectively reviewed. Abnormal findings at seven sites: 1) external auditory canal, 2) mastoid portion, 3) petrous portion of the temporal bone, 4) clivus, 5) jugular foramen, 6) nasopharyngeal soft tissue thickness, and 7) torus tubarius shape were compared among the patient groups on axial slice of HRCT. Results: When comparing SBO and NPC, there were significant differences in sites 1) (p = 0.0001), 3) (p = 0.0064), 5), and 7) (p < 0.0001); among them, the most specific finding was the site 7). When comparing SBO and EACC, there were significant differences in sites 1) (p = 0.0084), 3) (p < 0.0001), 4) (p = 0.0013), 5) (p = 0.0015), and 6) (p < 0.0001); among them, the most specific finding was cortical bone destruction in site 3). Conclusion: Our findings indicated that the bilateral preservation of “μ-shape sign” in the torus tubarius and bone destruction in the petrous portion on HRCT were the most specific signs differentiating SBO from NPC and EACC, respectively. Knowledge of these features can contribute to prompt diagnosis and treatment of SBO.
Presentations 【 display / non-display 】
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VSB implantation in a NF1 patient with multiple bony defects in the temporal bones and the skull. International conference
Akira Ganaha, Keiji Matsuda, Kei Kajihara, Takeshi Goto, Takeshi Nakamura, Noriaki Miyanaga, Tetsuya Tono
12th Asia Pacific Symposium on Cochlear Implants and Related Sciences
Event date： 2019.11.27 - 2019.11.30
Language：English Presentation type：Poster presentation
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Benefit of hearing preservation during cochlear implantation in patients with OMAAV. International conference
Nakamura Takeshi, Tetsuya Tono, Shouken Shimoara, Yuusuke Matsuda, Takahiro Nakashima
12th Asia Pacific Symposium on Cochlear Implants and Related Sciences
Event date： 2019.11.27 - 2019.11.30
Language：Japanese Presentation type：Poster presentation
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めまい主訴の側頭葉てんかん・巨赤芽球性貧血症例．
湯地俊子，清水謙祐，中村 雄，鳥原康治，東野哲也
第78回日本めまい平衡医学会総会・学術講演会
Event date： 2019.10.23 - 2019.10.25
Language：Japanese Presentation type：Poster presentation
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アブミ骨手術における顔面神経の解剖学的要因の影響．
中島崇博，梶原 啓，中村 雄，後藤隆史，我那覇章，松田圭二，東野哲也
第29回日本耳科学会総会・学術講演会
Event date： 2019.10.10 - 2019.10.12
Language：Japanese Presentation type：Oral presentation (general)
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新生児聴覚スクリーニングにより早期診断に至った先天性伝音難聴に対して手術治療を行った3例の検討．
中村 雄，池ノ上あゆみ，我那覇章，中島崇博，後藤隆史，山田悠祐，猿渡英美，東野哲也
第29回日本耳科学会総会・学術講演会
Event date： 2019.10.10 - 2019.10.12
Language：Japanese Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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音源定位をサポートするハプティックデバイスの開発/一側聲の包括的治療を目指して
Grant number：22K16914 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 若手研究
Authorship：Principal investigator
Other research activities 【 display / non-display 】
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音源定位をサポートするハプティックデバイスの開発/一側聾の包括的治療を目指して