中村 雄 (ナカムラ タケシ)

NAKAMURA Takeshi

写真a

所属

医学部 附属病院 耳鼻いんこう・頭頸部外科

職名

助教

外部リンク

研究分野 【 表示 / 非表示

  • ライフサイエンス / 耳鼻咽喉科学

 

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  • Comparison of speech perception lists used to evaluate Japanese single syllable hearing.

    Matsuda Y, Okuda T, Kamie A, Miyanaga N, Nakamura T, Shirane M, Shimoara S, Ganaha A, Tono T

    Auris, nasus, larynx   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.anl.2021.09.007

    PubMed

  • Combined Electric acoustic stimulation in a patient with otitis media with antineutrophil cytoplasmic antibody-associated vasculitis.

    Nakamura T, Ganaha A, Tono T, Yamada Y, Okuda T, Shimoara S, Matsuda Y

    Auris, nasus, larynx   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Auris Nasus Larynx  

    There are few reports of the treatment for severe hearing loss due to otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV) achieved by cochlear implantation (CI). Here, we have reported the case of a patient with severe bilateral sensorineural hearing loss with low-frequency residual hearing by OMAAV. CI was performed in her right ear based on the results of contrast-enhanced magnetic resonance imaging (CE-MRI) and promontory stimulation test (PST). The residual hearing in her right ear was preserved after CI and utilized for combined electric acoustic stimulation (EAS). The combined EAS was used for 3 years until the residual hearing became stabilized. However, the usable hearing in low frequency worsened gradually, and the fitting strategy of cochlear implant was changed from combined EAS to CI alone 4 years after CI. Even when the speech discrimination score with CI no longer exceeds 50 %, the patient continued using CI because of its advantages in maintaining the quality of life of the patient. The combined EAS was found to be a feasible option even in an OMAAV patient with residual hearing. CE-MRI and PST may thus be helpful in deciding the side of CI surgery in a patient with OMAAV.

    DOI: 10.1016/j.anl.2021.04.009

    Scopus

    PubMed

  • The Cytokine Expression in Patients with Cardiac Complication after Immune Checkpoint Inhibitor Therapy.

    Tsuruda T, Yoshikawa N, Kai M, Yamaguchi M, Toida R, Kodama T, Kajihara K, Kawabata T, Nakamura T, Sakata K, Hatakeyama K, Gi T, Asada Y, Tono T, Kitamura K, Ikeda R

    Internal medicine (Tokyo, Japan)   60 ( 3 )   423 - 429   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Internal Medicine  

    We herein report the cytokine expression at different stages for three patients who developed cardiac complications after immune checkpoint inhibitor (ICI) therapy. Case 1 with biopsy-proven myocarditis showed increased levels of interleukin (IL)-8, monocyte chemotactic and activating factor, and granulocyte macrophage colony-stimulating factor (GM-CSF) when he developed Takotsubo cardiomyopathy. Case 2 with subclinical myocarditis showed predominant activation of IL-8 during the progressive clinical course. Case 3 with cytokine-releasing syndrome showed substantial activations of IL-6, IL-8, GM-CSF, and interferon-γ. Our data suggest the development of unique cytokine activation in individual patients with cardiac complications after ICI therapy.

    DOI: 10.2169/internalmedicine.5317-20

    Scopus

    PubMed

  • Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan Otological Society.

    Harabuchi Y, Kishibe K, Tateyama K, Morita Y, Yoshida N, Okada M, Kunimoto Y, Watanabe T, Inagaki A, Yoshida T, Imaizumi M, Nakamura T, Matsunobu T, Kobayashi S, Iino Y, Murakami S, Takahashi H, Tono T

    Auris, nasus, larynx   48 ( 1 )   2 - 14   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Auris Nasus Larynx  

    Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a form of necrotizing vasculitis with few or no immune deposits. It primarily affects small and medium blood vessels. AAV is classified into three categories, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangitis (EGPA), and two major ANCAs, proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA are involved in their pathogenesis. Intractable otitis media frequently occurs in patients with GPA, MPA or EGPA, although all patients show similar clinical features, regardless of the type of AAV. Furthermore, approximately 15% patients with otitis media caused by AAV do not show ANCA positivity, histopathological evidence, or any other AAV-related lesions at the initial visit; therefore, these patients do not fulfill the ordinary diagnostic criteria for systemic AAV. Thus, we first proposed that this condition could be categorized as “otitis media with AAV (OMAAV)”. Subsequently, the Japanese Otological Society (JOS) conducted a nationwide survey between December 2013 and February 2014 and identified 297 patients with OMAAV. The survey revealed that OMAAV is a disease that initially occurs in the middle ear and subsequently spreads to other organs such as the lungs and kidneys, with eventual involvement of all body organs. Severe sequelae such as facial palsy, hypertrophic pachymeningitis, complete deafness, and subarachnoid hemorrhage resulting in death can also occur. In this review, we introduce the clinical features, diagnostic criteria, and treatment strategies recommended by JOS for early diagnosis and treatment of OMAAV.

    DOI: 10.1016/j.anl.2020.07.004

    Scopus

    PubMed

  • Is the Conductive Hearing Loss in NOG-Related Symphalangism Spectrum Disorder Congenital?

    Nakashima T, Ganaha A, Tsumagari S, Nakamura T, Yamada Y, Nakamura E, Usami SI, Tono T

    ORL; journal for oto-rhino-laryngology and its related specialties   83 ( 3 )   196 - 202   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ORL  

    We describe a dominant Japanese patient with progressive conductive hearing loss who was diagnosed with NOG-related symphalangism spectrum disorder (NOG-SSD), a spectrum of congenital stapes fixation syndromes caused by NOG mutations. Based on the clinical features, including proximal symphalangism, conductive hearing loss, hyper-opia, and short, broad middle, and distal phalanges of the thumbs, his family was diagnosed with stapes ankylosis with broad thumbs and toes syndrome (SABTT). Genetic analysis revealed a heterozygous substitution in the NOG gene, c.645C>A, p.C215∗ in affected family individuals. He had normal hearing on auditory brainstem response (ABR) testing at ages 9 months and 1 and 2 years. He was followed up to evaluate the hearing level because of his family history of hearing loss caused by SABTT. Follow-up pure tone average testing revealed the development of progressive conductive hearing loss. Stapes surgery was performed, and his post-operative hearing threshold improved to normal in both ears. According to hearing test results, the stapes ankylosis in our SABTT patient seemed to be incomplete at birth and progressive in early childhood. The ABR results in our patient indicated the possibility that newborn hearing screening may not detect conductive hearing loss in patients with NOG-SSD. Hence, children with a family history and/or known congenital joint abnormality should undergo periodic hearing tests due to possible progressive hearing loss. Because of high success rates of stapes surgeries in cases of SABTT, early surgical interventions would help minimise the negative effect of hearing loss during school age. Identification of the nature of conductive hearing loss due to progressive stapes ankylosis allows for better genetic counselling and proper intervention in NOG-SSD patients.

    DOI: 10.1159/000512668

    Scopus

    PubMed

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  • VSB implantation in a NF1 patient with multiple bony defects in the temporal bones and the skull. 国際会議

    Akira Ganaha, Keiji Matsuda, Kei Kajihara, Takeshi Goto, Takeshi Nakamura, Noriaki Miyanaga, Tetsuya Tono

    12th Asia Pacific Symposium on Cochlear Implants and Related Sciences 

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    開催年月日: 2019年11月27日 - 2019年11月30日

    記述言語:英語   会議種別:ポスター発表  

  • Benefit of hearing preservation during cochlear implantation in patients with OMAAV. 国際会議

    Nakamura Takeshi, Tetsuya Tono, Shouken Shimoara, Yuusuke Matsuda, Takahiro Nakashima

    12th Asia Pacific Symposium on Cochlear Implants and Related Sciences 

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    開催年月日: 2019年11月27日 - 2019年11月30日

    記述言語:日本語   会議種別:ポスター発表  

  • めまい主訴の側頭葉てんかん・巨赤芽球性貧血症例.

    湯地俊子,清水謙祐,中村 雄,鳥原康治,東野哲也

    第78回日本めまい平衡医学会総会・学術講演会 

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    開催年月日: 2019年10月23日 - 2019年10月25日

    記述言語:日本語   会議種別:ポスター発表  

  • アブミ骨手術における顔面神経の解剖学的要因の影響.

    中島崇博,梶原 啓,中村 雄,後藤隆史,我那覇章,松田圭二,東野哲也

    第29回日本耳科学会総会・学術講演会 

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    開催年月日: 2019年10月10日 - 2019年10月12日

    記述言語:日本語   会議種別:口頭発表(一般)  

  • 新生児聴覚スクリーニングにより早期診断に至った先天性伝音難聴に対して手術治療を行った3例の検討.

    中村 雄,池ノ上あゆみ,我那覇章,中島崇博,後藤隆史,山田悠祐,猿渡英美,東野哲也

    第29回日本耳科学会総会・学術講演会 

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    開催年月日: 2019年10月10日 - 2019年10月12日

    記述言語:日本語   会議種別:口頭発表(一般)  

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授業 【 表示 / 非表示

  • 生命と病気

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    科目区分:共通教育科目