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Faculty of Medicine School of Medicine Department of Infectious Diseases, Microbiology |
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Assistant Professor |
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TAKATSUKI Hanae
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Degree 【 display / non-display 】
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博士（医学） ( 2015.9 長崎大学 )
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修士（薬学） ( 2010.3 長崎大学 )
Papers 【 display / non-display 】
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Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures. Reviewed
Takatsuki H, Imamura M, Mori T, Atarashi R
Sci Rep 12 ( 1 ) 7923 2022.5
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system. Reviewed
Imamura M, Tabeta N, Iwamaru Y, Takatsuki H, Mori T, Atarashi R
Biochem Biophys Res Commun 613 67 - 72 2022.5
Language：English Publishing type：Research paper (scientific journal)
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Ethanolamine is a new anti‐prion compound
Uchiyama K., Hara H., Chida J., Pasiana A.D., Imamura M., Mori T., Takatsuki H., Atarashi R., Sakaguchi S.
International Journal of Molecular Sciences 22 ( 21 ) 2021.11
Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Molecular Sciences
Prion diseases are a group of fatal neurodegenerative disorders caused by accumulation of proteinaceous infectious particles, or prions, which mainly consist of the abnormally folded, am-yloidogenic prion protein, designated PrPSc. PrPSc is produced through conformational conversion of the cellular isoform of prion protein, PrPC, in the brain. To date, no effective therapies for prion diseases have been developed. In this study, we incidentally noticed that mouse neuroblastoma N2a cells persistently infected with 22L scrapie prions, termed N2aC24L1‐3 cells, reduced PrPSc levels when cultured in advanced Dulbecco’s modified eagle medium (DMEM) but not in classic DMEM. PrPC levels remained unchanged in prion‐uninfected parent N2aC24 cells cultured in advanced DMEM. These results suggest that advanced DMEM may contain an anti‐prion compound(s). We then successfully identified ethanolamine in advanced DMEM has an anti‐prion activity. Ethanola-mine reduced PrPSc levels in N2aC24L1‐3 cells, but not PrPC levels in N2aC24 cells. Also, oral administration of ethanolamine through drinking water delayed prion disease in mice intracerebrally inoculated with RML scrapie prions. These results suggest that ethanolamine could be a new anti-prion compound.
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Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion. Reviewed
Ubagai K, Fukuda S, Mori T, Takatsuki H, Taguchi Y, Kageyama S, Nishida N, Atarashi R
Biochem Biophys Res Commun 526 ( 4 ) 1049 - 1053 2020.6
Language：English Publishing type：Research paper (scientific journal)
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Administration of FK506 from late stage of disease prolongs survival of human prion-inoculated mice. Reviewed
Nakagaki T*, Ishibashi D, Mori T, Miyazaki Y, Takatsuki H, Tange H, Taguchi Y, Satoh K, Atarashi R, Nishida N
Neurotherapeutics 2020.6
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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病原微生物学 基礎と臨床
西田教行、高月英恵（ Role： Joint author）
東京化学同人 2014.12
Total pages：312 Responsible for pages：205-208 Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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バキュロウイルス-昆虫細胞発現組換えPrP を用いた試験管内変換系の構築に基づくプリオン変換・生成機構の解明. Invited
今村守一，森剛志，高月英恵，岩丸祥史，新竜一郎
YAKUGAKU ZASSHI 139 ( 7 ) 989 - 992 2019.7
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：公益財団法人日本薬学会
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プリオン病の最新研究 Invited
高月英恵、西田教行
難病と在宅ケア 22 ( 3 ) 5 - 7 2016.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：（株）日本プランニングセンター
Presentations 【 display / non-display 】
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プリオン感染後期におけるトリプロリジン投与は感染マウスの生存期間を延長する
高月英恵
第71回日本ウイルス学会学術集会
Event date： 2024.11.4 - 2024.11.6
Presentation type：Poster presentation
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Genotype diversity of rotaviruses in Nepal in 2021-2023
Hanae Takatsuki
第70回日本ウイルス学会学術集会
Event date： 2023.9.26 - 2023.9.28
Presentation type：Poster presentation
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試験管内プリオン増幅法を用いた抗プリオン薬の再評価と薬剤耐性プリオンの分子機構の解明
高月英恵
第69回日本ウイルス学会学術集会
Event date： 2022.11.12 - 2022.11.15
Presentation type：Oral presentation (general)
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ペントサンポリサルフェートによるプリオン(Fukuoka-1株) 持続感染細胞における薬剤誘導性潜伏感染.
髙月英恵, 森剛志, 今村守一, 新竜一郎
第68回日本ウイルス学会学術集会 2021.11.16
Event date： 2021.11.16 - 2021.11.18
Language：Japanese Presentation type：Oral presentation (general)
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Pentosan polysulfate induces latent prion infection in cell cultures infected with Fukuoka-1 strain. International conference
Takatsuki Hanae
APPS2021 Online 2021.11.7
Event date： 2021.11.7
Language：English Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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薬剤耐性プリオンの出現予測法の開発と耐性化克服への展開
Grant number：24K10623 2024.04 - 2027.03
科学研究費基金 基盤研究(C)
Authorship：Principal investigator
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次世代ヒトプリオン増幅法の構築とヒトプリオン病創薬スクリーニングへの応用
Grant number：21K07277 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
次世代ヒトプリオン増幅法の構築とヒトプリオン病創薬スクリーニングへの応用
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ネパールにおけるロタウイルス種間伝播機序とウイルス循環における成人の役割の解明
Grant number：19KK0245 2019.10 - 2023.03
独立行政法人日本学術振興会 科学研究費補助金 国際共同研究加速基金(国際共同研究強化(B))
新 竜一郎、
Authorship：Coinvestigator(s)
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ヒトプリオン病に対する構造ベースに基づくコンビネーションセラピーの確率
Grant number：19K16920 2019.04 - 2021.03
科学研究費補助金 若手研究
Authorship：Principal investigator
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試験管内増幅法を用いた孤発性ヤコブ病のプリオン体内分布と増幅機構の解明
Grant number：16K18384 2016.04 - 2018.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator