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Faculty of Medicine School of Medicine Department of Medical Sciences, Vascular and cellular dynamics |
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Assistant Professor |
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OGO Honami
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Papers 【 display / non-display 】
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Biomechanical control of vascular morphogenesis by the surrounding stiffness Reviewed
花田 保之, 小河 穂波, 西山 功一
Nature Communications 16 6788 2025.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature
Sprouting angiogenesis is a form of morphogenesis which expands vascular networks from preexisting networks. However, the precise mechanism governing efficient branch elongation driven by directional movement of endothelial cells (ECs), while the lumen develops under the influence of blood inflow, remains unknown. Herein, we show perivascular stiffening to be a major factor that integrates branch elongation and lumen development. The lumen expansion seen during lumen development inhibits directional EC movement driving branch elongation. This process is counter-regulated by the presence of pericytes, which induces perivascular stiffening by promoting the deposition of EC-derived collagen-IV (Col-IV) on the vascular basement membrane (VBM), thereby preventing excessive lumen expansion. Furthermore, inhibition of forward directional movement of the tip EC during lumen development is associated with decreased localization of the F-BAR proteins and Arp2/3 complexes at the leading front. Our results demonstrate how ECs elongate branches, while the lumen develops, by properly building the surrounding physical environment in coordination with pericytes during angiogenesis.
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Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion Reviewed
Kurosawa K., Inoue Y., Kakugawa Y., Yamashita Y., Kanazawa K., Kishimoto K., Nomura M., Momoi Y., Sato I., Chiba N., Suzuki M., Ogoh H., Yamada H., Miura K., Watanabe T., Tanuma N., Tachi M., Shima H.
Cancer Science 2018.5
Language：English Publishing type：Research paper (scientific journal)
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Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development Reviewed
Ogoh H., Yamagata K., Nakao T., Sandell LL., Yamamoto A., Yamashita A., Tanga N., Suzuki M., Abe T., Kitabayashi I., Watanabe T., Sakai D
Scientific Reports 2017.9
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis Reviewed
Ogoh H., Tanuma N., Matsui Y., Hayakawa N., Inagaki A., Sumiyoshi M., Momoi Y., Kishimoto A., Suzuki M., Sasaki N., Ohuchi T., Nomura M., Teruya Y., Yasuda K., Watanabe T., Shima H
Mechanisms of Development 2016.2
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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The ADP-ribosylation factor 1 gene is indispensable for mouse embryonic development after implantation Reviewed
Hayakawa N., Ogoh H., Sumiyoshi M., Matsui Y., Nishikawa S., Miyamoto K., Maede Y., Kiyonari H., Suzuki M., Watanabe T
Biochem Biophys Res Commun 2014.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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My Role Model
小河穂波 他（ Role： Joint author）
奈良女子大学・御茶ノ水大学 2018.3
Language：Japanese
Presentations 【 display / non-display 】
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Haploinsufficiency of SNX13 contributes to leukemogenesis as a responsible gene for monosomy 7 in EVI1 high AML
Honami Ogoh
.第77回日本癌学会学術総会
Event date： 2018.9.27 - 2018.9.29
Language：English Presentation type：Oral presentation (general)
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Af10 regulates spatiotemporal cell proliferation of neural progenitor and neural crest cells in mid facial development via H3K79 methylation
Honami Ogoh
The 16th Stem Cell Research Symposium
Event date： 2018.6.1 - 2018.6.2
Language：English Presentation type：Poster presentation
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Af10 regulates spatiotemporal cell proliferation of neural progenitor and neural crest cells in mid facial development via H3K79 methylation
Honami Ogoh
第7回幹細胞若手の会（つくしの会)
Event date： 2018.6.1
Language：Japanese Presentation type：Oral presentation (general)
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Af10 regulates mid facial development via H3K79 methylation International conference
Honami Ogoh
Neural Crest & Cranial Placodes Gordon Research Seminar/ Conference
Event date： 2018.2.10 - 2018.2.16
Language：English Presentation type：Poster presentation
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顔面発生におけるH3K79メチル化の機能
Honami Ogoh
平成29年度 若手支援技術講習会（先端モデル動物支援プラットフォーム）
Event date： 2017.9.7 - 2017.9.9
Language：English Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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ベストトーク賞
2017.9 平成29年度【先端モデル動物支援プラットフォーム】若手支援技術講習会
小河穂波
Award type：Award from Japanese society, conference, symposium, etc.
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平成27年度 奈良女子大学人間文化研究科奨励賞
2016.4 奈良女子大学
小河穂波
Grant-in-Aid for Scientific Research 【 display / non-display 】
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頭部神経堤細胞の分化運命決定におけるAF10-Dot1LによるH3K79me機能解析
Grant number：16J02655 2016.03 - 2018.03
科学研究費補助金 特別研究員奨励費
Authorship：Principal investigator
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毛細血管網異常を起因とする間質環境変容を介した組織老化・加齢性病態形成機序の解明
Grant number：25K18730 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 若手研究
Authorship：Principal investigator
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微小血管網異常による組織機能の破綻を理解するマウスモデル解析系の開発
Grant number：22K20744 2022.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 研究活動スタート支援
Authorship：Principal investigator