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Affiliation |
Frontier Science Research Center Living thing of experiment support section resource field |
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Title |
Assistant Professor |
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External Link |
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Goro A. Nagura-Kato
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Degree 【 display / non-display 】
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Doctor(Philosophy in Medicine) ( 2018.5 University of Miyazaki )
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Master(Agriculture) ( 2013.3 University of Miyazaki )
Research Areas 【 display / non-display 】
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Life Science / Evolutionary biology
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Life Science / Animal physiological chemistry, physiology and behavioral biology
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Life Science / Biodiversity and systematics
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Life Science / Laboratory animal science
Papers 【 display / non-display 】
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Ukyo R., Shinohara A., Koshimoto C., Nagura-Kato G.A., Ieiri S., Tsuzuki Y., Sakamoto S.H.
Scientific Reports 13 ( 1 ) 9518 2023.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports
Social separation is thought to induce a strong stress response in social juvenile mammals, but little is known about how this response might vary throughout the development. The present study examines the long-term effects of early-life stress (ELS) induced by social separation on individual behaviors later in life using the social and precocious species Octodon degus. Four experimental groups were established a positive control group of mothers and siblings from six litters comprised the socially housed (SH) group, while pups from seven litters were randomly assigned to three treatments: pups experiencing no separation (NS) treatment while their siblings did; repeated bouts of consecutive separation (CS); intermittent separation (IS). We analyzed the effects of separation treatment on the frequency and duration of freezing, rearing and grooming behaviors. ELS was correlated with higher hyperactivity, and hyperactivity increased with more frequent separation. However, the behavioral trend of the NS group changed to hyperactive in long-term observation. The findings suggest that the NS group was indirectly affected by ELS. In addition, suggesting ELS acts to converge an individual’s behavioral tendencies in a certain direction.
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Abe Y., Toyama K., Shinohara A., Nagura-Kato G.A., Ikai Y., Koshimoto C., Spin J.M., Hato N.
Anatomical Science International 98 ( 3 ) 426 - 433 2023.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Anatomical Science International
The Mongolian gerbil has historically been useful for brain ischemia experiments, owing to the gerbil’s uniquely underdeveloped circle of Willis (CoW). This led to a gerbil model of cochlear ischemia being generated in our unit. However, we have found that the usual severe hearing loss seen in this model was not being induced consistently in recent experiments using the MON/Jms/GbsSlc gerbil (the sole commercially available gerbil in Japan). We set out to evaluate the posterior communicating artery (PcomA) in MON/Jms/GbsSlc, to re-establish whether this strain is appropriate for ischemia models. Having found that this unique feature is often lost, we then attempted to breed for the characteristic absent PcomA. India-ink perfusion revealed that the percentage of intact bilateral PcomA (“communicating type”) in the MON/Jms/GbsSlc gerbil was 57%; unilateral only (“unilateral communicating type”) was 39%; and completely absent PcomA (“non-communicating type”) was 4%. We were able to obtain few examples of the indigenous old aged Japanese UNG/Mz gerbil strain (at University of Miyazaki). Unfortunately, the pure UNG/Mz female was too elderly for mating. Therefore, selective breeding crosses between MON/Jms/GbsSlc and male UNG/Mz were carried out. After five generations of selective breeding, the percentage of non-communicating type gerbils was significantly higher in the newly generated strain, MON/Jms/SlcMz (F6 generation; 63%) than in the MON/Jms/GbsSlc gerbil. Bilateral common carotid artery occlusion surgery demonstrated that the cerebral blood flow was significantly reduced in MON/Jms/SlcMz compared with MON/Jms/GbsSlc (p < 0.0001) and induced more hippocampal injuries in MON/Jms/SlcMz than in MON/Jms/GbsSlc (p < 0.01). In conclusion, the commercially available MON/Jms/GbsSlc gerbil can easily regain PcomA, and we established a new gerbil strain (MON/Jms/SlcMz) displaying non-PcomA.
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脳波測定を活用したデグー（Octodon degus）のセボフルラン及びイソフルラン吸入麻酔特性の検討. Invited
伊海結貴，七條宏樹，名倉悟郎，篠原明男，越本知大.
九州実験動物雑誌 36 53 - 55 2021.10
Language：Japanese Publishing type：Research paper (scientific journal)
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47 ( 1 ) 2021.7
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3106/ms2020-0102
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Evaluation index of epilepsy-like seizures observed in common degu (<i>Octodon degus</i>)
Ikai Yuki, Shinohara Akio, Nagura-Kato Goro A., Shichijo Hiroki, Koshimoto Chihiro
Honyurui Kagaku (Mammalian Science) 61 ( 1 ) 3 - 11 2021
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Mammal Society of Japan
The common degu (<i>Octodon degus</i>), originally native to South America, is now widely used as an experimental animal owing to several unique characteristics: common degus are highly social and use vocal sounds as communication tools. Importantly, their brain function is more complex than other laboratory rodents, making them a good model in the field of neuroscience. We established a colony of laboratory common degus and observed epilepsy-like seizures. We subsequently analyzed the process, strength, and duration of seizures by video recording. We examined 35 video images from 16 individuals (7 females and 9 males). The seizures began as abnormalities in the body parts (step 1), and then systemic tonic-clonic seizure (step 2) was observed. Following step 2, a short period of stillness (step 3) usually occurred, and then systemic tonic seizure occurred again (step 4). Ultimately, stillness (step 5) continued until recovery. We found sex-based differences in the strength and duration of seizures and observed large individual differences as well. Our results suggest that common degus have the potential to be used as a disease model for epilepsy.
Books 【 display / non-display 】
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動物／疾患モデルの 作製技術・病態解析・評価手法
加藤悟郎, 枝村 仁美, 越本知大（ Role： Contributor , 新たな神経・筋疾患モデルとしてのヨーロッパモリネズミの可能性.）
技術情報協会出版 2017
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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マウスの兄妹関係がもたらす影響とは？個体差に隠された謎を考える. Invited
名倉悟郎
実験動物ニュース 69 117 - 119 2020
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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マウスの休眠にみられる個体差の要因. Invited
名倉悟郎
九州実験動物雑誌 35 17 - 22 2019
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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希少固有種アマミトゲネズミの実験動物化に向けた飼育ストレス評価の試み. Invited
緒方穂波，前山賢太，林扶充子，仮屋博敬，川辺敏晃，名倉悟郎，城ヶ原貴通，篠原明男，越本知大.
九州実験動物雑誌 34 52 - 56 2018
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Presentations 【 display / non-display 】
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ヨーロッパモリネズミ(Apodemus sylvaticus）の誘起排卵卵子及び卵胞卵子の蛍光免疫染色による形態的解析．
竹口加那子，Narantsog Choijookhuu，名倉悟郎，篠原明男，菱川善隆，越本知大．
第39回九州実験動物研究会総会 2021.11.6
Event date： 2021.11.6 - 2021.11.7
Language：Japanese Presentation type：Oral presentation (general)
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トゲマウス属齧歯類の子宮内膜症モデル化に向けた基礎研究．
天野桃子，柴彩夏，名倉悟郎，篠原明男，中家雅隆，越本知大．
第39回九州実験動物研究会総会 2021.11.6
Event date： 2021.11.6 - 2021.11.7
Language：Japanese Presentation type：Oral presentation (general)
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ヨーロッパモリネズミ(Apodemus sylvaticus)の生殖工学技術の改善に向けた検討．
横上由惟，名倉悟郎，篠原明男，中家雅隆，越本知大．
第39回九州実験動物研究会総会 2021.11.6
Event date： 2021.11.6 - 2021.11.7
Language：Japanese Presentation type：Oral presentation (general)
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マウスの休眠から動物実験の個体差を考える．
名倉悟郎．
第82回宮崎大学イブニングセミナー「動物にも役立つ動物実験-保全，健康，福祉-」． 2021.8.5
Event date： 2021.8.5
Language：Japanese Presentation type：Oral presentation (general)
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脳波測定を活用したデグー（Octodon degus）のセボフルラン及びイソフルラン吸入麻酔特性の検討
伊海結貴，七條宏樹，名倉悟郎，篠原明男，越本知大．
2020年度九州実験動物研究会および実技協九州支部 臨時研究発表会（WEB発表） 2020.11.14
Event date： 2020.11.14 - 2020.11.15
Language：Japanese Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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山内・半田賞（若手奨励賞）
2021.11 九州実験動物研究会 ヨーロッパモリネズミ(Apodemus sylvaticus）の誘起排卵卵子及び卵胞卵子の蛍光免疫染色による形態的解析．
竹口加那子，Narantsog Choijookhuu，名倉悟郎，篠原明男，菱川善隆，越本知大．
Award type：Award from Japanese society, conference, symposium, etc.
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山内・半田賞（若手奨励賞）
2020.11 九州実験動物研究会 脳波測定を活用したデグー（Octodon degus）のセボフルラン及びイソフルラン吸入麻酔特性の検討.
伊海結貴，七條宏樹，名倉悟郎，篠原明男，越本知大.
Award type：Award from Japanese society, conference, symposium, etc.
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山内・半田賞（一般演題部門）
2018.11 九州実験動物研究会 稀少固有種アマミトゲネズミの実験動物化に向けた飼育ストレス評価の試み
緒方穂波, 前山賢太, 林扶充子, 仮屋博敬, 川辺敏晃, 名倉悟郎, 城ヶ原貴通, 篠原明男, 越本知大
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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日本哺乳類学会 2017年度大会 優秀ポスター賞
2017.9 日本哺乳類学会
篠原明男, 井上比加里, 稲留健人, 樫村敦, 江藤毅, 加藤悟郎, 坂本信介, 越本知大
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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山内・半田賞（若手奨励賞）
2014.11 九州実験動物研究会 BALB/c系統マウスの休眠発現は成長初期の栄養獲得量により調節される.
加藤悟郎
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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マウスにおける新たな休眠誘導メカニズムの解明
Grant number：23K14118 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 若手研究
Authorship：Principal investigator
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兄妹関係から解き明かす哺乳類の意思決定と適応進化
Grant number：19K16202 2019.04 - 2023.03
独立行政法人日本学術振興会 科学研究費補助金 若手研究
Authorship：Principal investigator
生息環境の変化に直面した動物は、自身がもつ適応形質から現況に適したものを判断し発現しなければ生残できない。しかしその判断は往々にして一様でなく、同種でも個体・集団のレベルでばらつきが見られる。こうした動物の意思決定の違いが何に起因するのかは殆ど分かっていない。これまでに申請者は、小型哺乳類の適応形質のひとつ「休眠」に着目し、その発現頻度が成熟したひと腹の兄妹内で異なること、更にその個体差が離乳以前に生じる「兄妹内の競争」に起因することを示唆してきた。本研究では胎仔期及び乳仔期の兄妹関係の詳細を明らかにし、これらが動物の意思決定と適応形質の進化に対し、どのように関係してきたのかについて考察する。