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Faculty of Medicine School of Medicine Department of Pathology, Pathophysiology |
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Assistant Professor |
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Related SDGs |
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AMAN Murasaki
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Papers 【 display / non-display 】
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Yamashita A., Oda T., Aman M., Wakasa T., Gi T., Ide R., Todo Y., Tamura N., Sato Y., Itoh H., Asada Y.
BJOG: An International Journal of Obstetrics and Gynaecology 130 ( 13 ) 1685 - 1696 2023.12
Language：English Publishing type：Research paper (scientific journal) Publisher：BJOG: An International Journal of Obstetrics and Gynaecology
Objective: To identify pulmonary/uterine thrombus formation in amniotic fluid embolism (AFE). Design: Retrospective, observational. Setting: Nationwide. Population: Eleven autopsy cases of AFE and control cases. Methods: We assessed pulmonary and uterine thrombus formation and thrombus area in AFE and pulmonary thromboembolism (PTE) as a control. The area of platelet glycoprotein IIb/IIIa, fibrin, neutrophil elastase, citrullinated histone H3 (a neutrophil extracellular trap marker) and mast cell chymase immunopositivity was measured in 90 pulmonary emboli, 15 uterine thrombi and 14 PTE. Main outcome measures: Pathological evidence of thrombus formation and its components in AFE. Results: Amniotic fluid embolism lung showed massive thrombus formation, with or without amniotic emboli in small pulmonary arteries and capillaries. The median pulmonary thrombus size in AFE (median, 0.012 mm2; P < 0.0001) was significantly smaller than that of uterine thrombus in AFE (0.61 mm2) or PTE (29 mm2). The median area of glycoprotein IIb/IIIa immunopositivity in pulmonary thrombi in AFE (39%; P < 0.01) was significantly larger than that of uterine thrombi in AFE (23%) and PTE (15%). The median area of fibrin (0%; P < 0.001) and citrullinated histone H3 (0%; P < 0.01) immunopositivity in pulmonary thrombi in AFE was significantly smaller than in uterine thrombi (fibrin: 26%; citrullinated histone H3: 1.1%) and PTE (fibrin: 42%; citrullinated histone H3: 0.4%). No mast cells were identified in pulmonary thrombi. Conclusions: Amniotic fluid may induce distinct thrombus formation in the uterus and lung. Pulmonary and uterine thrombi formation may contribute to cardiorespiratory collapse and/or consumptive coagulopathy in AFE.
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Novel SKIC3 variants in tricho-hepato-enteric syndrome with hemochromatosis Reviewed
Ochiai K., Aoki Y., Yamada N., Aman M., Yamashita A., Yamaguchi M., Nakato D., Takenouchi T., Kosaki K., Kodama Y., Moritake H.
Human Genome Variation 12 ( 1 ) 2025.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Human Genome Variation
Tricho-hepato-enteric syndrome (THES), a rare autosomal recessive disorder caused by variants in the SKIC3 or SKIC2 gene, is characterized by intractable diarrhea, woolly hair, growth restriction and liver disease. Here we report a neonatal case of THES with neonatal hemochromatosis, in which the novel compound heterozygous SKIC3 variants NM_014639.4:c.815_816del p.(Gly272AlafsTer9) and NM_014639.4:c.2284G>A p.(Gly762Arg) were identified. Further research is needed to elucidate the mechanisms underlying iron metabolism dysregulation in THES.
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Japan Maternal Death Exploratory Committee
Journal of Obstetrics and Gynaecology Research 51 ( 3 ) 2025.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
The maternal mortality rate remains approximately 4 per 100 000 deliveries. Between January 2010 and July 2024, 629 maternal deaths were reported, of which 590 were reviewed. The Maternal Safety Proposal summarizes these cases. Deaths from obstetric hemorrhage decreased from 28% in 2010 to 7% in 2019 but rose to approximately 20% in 2022 and dropped to 10% in 2023. In the past 4 years, suicide has surpassed obstetric hemorrhage as a leading cause of death. In 2023, intracranial hemorrhage/infarction became the leading cause, with six cases reported. Cardiopulmonary collapse from amniotic fluid embolism, along with cardiovascular, infectious, and pulmonary diseases, has remained stable at 6%-10%. Initial symptoms leading to death occurred during the antepartum (38%), intrapartum (41%), or postpartum periods (21%), with cases distributed across general hospitals, small maternity delivery facilities, and non-medical settings, including homes. The following are the year's maternal safety proposals: For pregnant women experiencing anxiety, a comprehensive evaluation addressing biological, psychological, and social factors should be conducted to identify key problem areas. Epidural analgesia during labor carries the risk of serious complications. Obstetricians and anesthesiologists must be aware of these risks to ensure the proper management of anesthesia and delivery. Pregnant and postpartum women are at a high risk of invasive group A streptococcal infections, and early screening and timely intervention should be prioritized. Pathological autopsy remains the most effective method for determining the cause of death and should be recommended to bereaved families in all cases of maternal death.
DOI： 10.1111/jog.16244
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Expression of fibroblast activation protein-α in human deep vein thrombosis. Reviewed
Oguri N, Gi T, Nakamura E, Furukoji E, Goto H, Maekawa K, Tsuji AB, Nishii R, Aman M, Moriguchi-Goto S, Sakae T, Azuma M, Yamashita A
Thrombosis Reserch 2024.6
Publishing type：Research paper (scientific journal)
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Association between fetal vascular malperfusion and gestational diabetes Reviewed
Goto T., Sato Y., Kodama Y., Tomimori K., Sameshima H., Aman M., Maekawa K., Yamashita A., Asada Y.
Journal of Obstetrics and Gynaecology Research 48 ( 1 ) 80 - 86 2022.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
Aim: Diabetes mellitus (DM) is a major complication in pregnancy. Placental lesions with DM remain unclear and controversial. Recently, the terms of placental pathological findings, such as maternal and fetal vascular malperfusions (MVM and FVM, respectively) were introduced by the Amsterdam Placental Workshop Group Consensus Statement (APWGCS). FVM cases were classified as the partial obstruction type (global FVM) and the complete obstruction type (segmental FVM). The aim of this study was to clarify the pathological characteristics of the placenta with pregestational DM/gestational DM; GDM according to APWGCS. Methods: We studied the placentas of 182 DM women (27 pregestational DM and 155 GDM) and control placentas of 460 women without DM during 2011–2018. We excluded cases of intrauterine fetal death or multiple pregnancies. We reviewed microscopical findings including, MVM, FVM, chorioamnionitis with the slides according to the APWGCS. Results: Microscopically, the incidence of FVM was significantly higher in GDM patients than control (17% vs. 10%, p = 0.0138), but not significant in pregestational DM (11%, p = 0.7410). Segmental FVM (complete obstruction) was significantly more observed in GDM than control group (5% vs. 0.4%, p = 0.0013). Segmental FVM in GDM showed high incidence of light-for-dates infant (three of seven cases, 43%, p = 0.0288). In addition, several segmental FVM findings (villous stromal-vascular karyorrhexis and stem vessel occlusion) were frequently noted in 2 or 3 points positive of 75 g oral glucose tolerance test than 1 point positive GDM. Conclusion: Our placental findings suggest disorder of carbohydrate metabolism might affect the fetal vascular damage, especially complete fetal vascular obstruction.
DOI： 10.1111/jog.15046
MISC 【 display / non-display 】
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羊水塞栓症の病理 Reviewed
若狭 朋子, 阿萬 紫
病理と臨床 42 883 - 891 2024.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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病理診断クイックリファレンス、第11章：女性生殖器
阿萬 紫
病理と臨床 2023.4
Authorship：Lead author Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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死因究明のための病理解剖の重要性
阿萬 紫, 若狹朋子
周産期医学 53 ( 3 ) 301 - 305 2023.3
Authorship：Lead author Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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W-1.子宮平滑筋におけるプロテイナーゼ活性化型受容体の性ホルモンによる発現調節(産婦人科領域における最近の平滑筋研究,ワークショップ,第48回 日本平滑筋学会総会)
平野 勝也, 阿萬 紫, 金出 英夫
日本平滑筋学会雑誌 10 ( 1 ) "J - 19" 2006.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：日本平滑筋学会
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GnRHアナログ,ダナゾール使用症例における骨密度の検討 (第13回婦人科骨粗鬆症研究会) -- (Session 2 骨量に影響する因子)
阿萬 紫, 江上 りか, 小金丸 泰子
オステオポローシスジャパン 11 ( 3 ) 493 - 496 2003
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：ライフサイエンス出版
Presentations 【 display / non-display 】
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多数の熊蜂刺傷による皮膚壊死・横紋筋融解症・びまん性肺胞傷害を来した1剖検例
阿萬 紫, 黒木麻由, 盛口淸香, 都築 諒, 猪瀬将之, 佐藤勇一郎, 落合秀信, 山下 篤
第114回日本病理学会総会 2025.4.17
Event date： 2025.4.17 - 2025.4.19
Language：Japanese Presentation type：Oral presentation (general)
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Mature cystic teratomaにependymomaを合併したと考えられる一例
佐藤愛結、今村紘子、藤玄一郎、田中大貴、細川義彦、高村一紘、谷口秀一、阿萬 紫、嶋本富博
第66回日本婦人科腫瘍学会学術講演会 2024.7.20
Event date： 2024.7.18 - 2024.7.20
Language：Japanese Presentation type：Oral presentation (general)
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The expression of PAR-1 and its activators in placenta accreta spectrum International conference
Aman M, Sato Y, Asada Y, Yamashita A
32th Congress of International Society on Thrombosis and Haemostasis 2024.6.24
Event date： 2024.6.22 - 2024.6.26
Presentation type：Oral presentation (general)
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癒着胎盤におけるPAR-1発現およびその活性化因子に関する検討.
阿萬 紫、佐藤勇一郎、浅田祐士郎、山下 篤
第113回日本病理学会総会 2024.3.29
Event date： 2024.3.28 - 2024.3.30
Language：Japanese Presentation type：Oral presentation (general)
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診断に苦慮した右卵管病変の一例
阿萬 紫, 丸塚浩助、中原一成
第55回日本婦人科病理学会学術集会 2022.12.3
Event date： 2022.12.3
Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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子宮頸部胃型腺癌の発癌機序の解明と早期発見に資するバイオマーカーの同定
Grant number：25K12713 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Coinvestigator(s)
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妊産婦死亡の主因である羊水塞栓症における血栓性病態の解明
Grant number：22K06961 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究基金 基盤研究(C)
Authorship：Principal investigator
Committee Memberships 【 display / non-display 】
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日本産婦人科医会 妊産婦死亡症例検討評価委員会
2019.8
Committee type：学協会