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Faculty of Medicine School of Medicine Department of Pathology, Pathophysiology |
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Assistant Professor |
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AMAN Murasaki
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Papers 【 display / non-display 】
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Massive platelet-rich thrombus formation in small pulmonary vessels in amniotic fluid embolism: An autopsy study Reviewed International journal
Yamashita A., Oda T., Aman M., Wakasa T., Gi T., Ide R., Todo Y., Tamura N., Sato Y., Itoh H., Asada Y.
BJOG: An International Journal of Obstetrics and Gynaecology 130 ( 13 ) 1685 - 1696 2023.12
Language：English Publishing type：Research paper (scientific journal) Publisher：BJOG: An International Journal of Obstetrics and Gynaecology
Objective: To identify pulmonary/uterine thrombus formation in amniotic fluid embolism (AFE). Design: Retrospective, observational. Setting: Nationwide. Population: Eleven autopsy cases of AFE and control cases. Methods: We assessed pulmonary and uterine thrombus formation and thrombus area in AFE and pulmonary thromboembolism (PTE) as a control. The area of platelet glycoprotein IIb/IIIa, fibrin, neutrophil elastase, citrullinated histone H3 (a neutrophil extracellular trap marker) and mast cell chymase immunopositivity was measured in 90 pulmonary emboli, 15 uterine thrombi and 14 PTE. Main outcome measures: Pathological evidence of thrombus formation and its components in AFE. Results: Amniotic fluid embolism lung showed massive thrombus formation, with or without amniotic emboli in small pulmonary arteries and capillaries. The median pulmonary thrombus size in AFE (median, 0.012 mm2; P < 0.0001) was significantly smaller than that of uterine thrombus in AFE (0.61 mm2) or PTE (29 mm2). The median area of glycoprotein IIb/IIIa immunopositivity in pulmonary thrombi in AFE (39%; P < 0.01) was significantly larger than that of uterine thrombi in AFE (23%) and PTE (15%). The median area of fibrin (0%; P < 0.001) and citrullinated histone H3 (0%; P < 0.01) immunopositivity in pulmonary thrombi in AFE was significantly smaller than in uterine thrombi (fibrin: 26%; citrullinated histone H3: 1.1%) and PTE (fibrin: 42%; citrullinated histone H3: 0.4%). No mast cells were identified in pulmonary thrombi. Conclusions: Amniotic fluid may induce distinct thrombus formation in the uterus and lung. Pulmonary and uterine thrombi formation may contribute to cardiorespiratory collapse and/or consumptive coagulopathy in AFE.
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Helicobacter felis-Associated Acute Gastric Mucosal Lesion: Ultrastructure by Low-Vacuum Scanning Electron Microscopy. Reviewed International journal
Murasaki Aman, Toshihiro Gi, Kazunari Maekawa, Tomoaki Kimura, Akira Sawaguchi, Atsushi Yamashita
Pathology international 76 ( 4 ) e70109 2026.4
Language：English Publishing type：Research paper (scientific journal)
This report describes a rare case of acute gastric mucosal lesion associated with H. felis infection. Numerous bacilli were identified within the mucopurulent exudate. The microorganisms were larger, longer, and more tightly coiled than H. pylori. Low vacuum-SEM reveals the spiral microorganisms with characteristic two or three periplasmic fibrils on the surface. RT-PCR detected the presence of H. felis urease B gene.
DOI： 10.1111/pin.70109
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Cathepsin G is associated with cerebral vascular injury in myeloid leukemia: a pathologic insight into intracranial hemorrhage. Reviewed International journal
Toshihiro Gi, Kaiyou Kai, Kotaro Shide, Eriko Nakamura, Nobuyuki Oguri, Murasaki Aman, Kazunari Maekawa, Sayaka Moriguchi-Goto, Michikazu Nakai, Kazuya Shimoda, Yohei Hisada, Atsushi Yamashita
Research and practice in thrombosis and haemostasis 10 ( 3 ) 103433 - 103433 2026.3
Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: Intracranial hemorrhage (ICH) is a fatal complication of leukemia; however, mechanisms underlying its development, particularly central nervous system (CNS) involvement and vascular injury, remain unclear. OBJECTIVES: We aimed to investigate the histopathologic features of cerebral vessels in leukemia and the expression of hemostasis-related factors in leukemia cells. METHODS: We conducted an autopsy-based study including 37 leukemia cases and 20 matched controls. Histopathologic analysis of CNS tissues was performed to evaluate ICH, leukemia cell localization, and vascular injury. Immunohistochemistry was performed to assess expression of vascular endothelial growth factor (VEGF), cathepsin G, tissue-type plasminogen activator, urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor, and tissue factor in leukemia cells. Vascular integrity was evaluated using stains for smooth muscle actin, collagen, fibrin, and von Willebrand factor. RESULTS: ICH was identified in 68% of leukemia cases and was associated with fatal brain herniation in 40%. CNS involvement was observed in 54% of cases, often without a clinical diagnosis. The leukemia cell infiltration of meninges and vascular walls was frequently associated with changes in smooth muscle cells and adventitial collagen. CNS vascular injury was frequently associated with ICH in the presence of leukemia cell infiltration. VEGF and urokinase-type plasminogen activator were highly expressed in leukemia cells. VEGF was associated with meningeal invasion, while cathepsin G was predominantly expressed in myeloid leukemia and linked to vascular damage. CONCLUSION: VEGF and cathepsin G may serve as markers of meningeal invasion and cerebral vascular damage in leukemia, respectively.
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Epithelioid Trophoblastic Tumor Presenting as a Large Cystic Mass: Diagnostic Clue From Foreign DNA Sequences Detected by Comprehensive Genomic Profiling. Reviewed International journal
Yui Kojima, Akiko Tonooka, Tomohiro Chiba, Sanshiro Okamoto, Shogo Nishino, Akiko Abe, Satomi Kitai, Murasaki Aman, Yuichiro Sato, Naomi Hayashi, Ippei Fukada, Shunji Takahashi, Kengo Takeuchi
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2026.1
Language：English Publishing type：Research paper (scientific journal)
Epithelioid trophoblastic tumor (ETT) is an extremely rare gestational trophoblastic neoplasm typically presenting as solid nodular lesions. We report an unusual case of ETT in a postmenopausal woman in her 50s that occurred 20 years after her last pregnancy. The tumor presented as a 19-cm multilocular cystic mass protruding from the cervix and was suspected to be infected. Initial histopathological examination revealed a solid proliferation of epithelioid to spindle cells expressing cytokeratins and p40, leading to a provisional diagnosis of sarcomatoid carcinoma. Comprehensive genomic profiling (CGP) was performed because of uncertainty regarding the primary site. Unexpectedly, CGP revealed DNA sequences of foreign origin, which prompted consideration of gestational trophoblastic disease rather than contamination. Additional immunohistochemical staining demonstrated positivity for HSD3B1, a specific marker of trophoblastic differentiation, confirming a diagnosis of ETT. Complete surgical resection was achieved, with no recurrence during 18 months of follow-up. This case has 2 important teaching points. First, ETT can present as a large cystic lesion rather than as a classical solid mass, likely as a result of extensive necrosis and superimposed infection. Second, detection of foreign DNA sequences during genomic profiling of a uterine tumor should alert pathologists to the possibility of gestational trophoblastic disease, given that these tumors are of fetal origin with a distinct genetic profile differing from that of maternal tissue. Recognition of these features is crucial for accurate diagnosis and appropriate management of this rare neoplasm.
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Novel SKIC3 variants in tricho-hepato-enteric syndrome with hemochromatosis Reviewed International journal
Ochiai K., Aoki Y., Yamada N., Aman M., Yamashita A., Yamaguchi M., Nakato D., Takenouchi T., Kosaki K., Kodama Y., Moritake H.
Human Genome Variation 12 ( 1 ) 14 - 14 2025.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Human Genome Variation
Tricho-hepato-enteric syndrome (THES), a rare autosomal recessive disorder caused by variants in the SKIC3 or SKIC2 gene, is characterized by intractable diarrhea, woolly hair, growth restriction and liver disease. Here we report a neonatal case of THES with neonatal hemochromatosis, in which the novel compound heterozygous SKIC3 variants NM_014639.4:c.815_816del p.(Gly272AlafsTer9) and NM_014639.4:c.2284G>A p.(Gly762Arg) were identified. Further research is needed to elucidate the mechanisms underlying iron metabolism dysregulation in THES.
Books 【 display / non-display 】
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The forest of differentials : journeying through the expert pathologist's mind
（ Role： Contributor）
2026.4 （ ISBN:9784830607028 ）
Total pages：ix, 500p Language：Japanese
MISC 【 display / non-display 】
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内膜生検でp53異常の腺癌を疑った癌肉腫の1例
佐藤 勇一郎, 阿萬 紫, 盛口 清香, 平田 徹, 後藤 裕磨, 桂木 真司
日本婦人科病理学会誌 15 ( 2 ) 71 - 76 2024.12
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本婦人科病理学会
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僧帽弁形成術に関連した左心室 mesothelial/monocytic incidental cardiac excrescenceの1例
黒木 麻由, 大栗 伸行, 中村 恵理子, 阪口 修平, 魏 峻洸, 阿萬 紫, 盛口 清香, 古川 貢之, 佐藤 勇一郎, 山下 篤
診断病理 41 ( 4 ) 343 - 348 2024.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本病理学会
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羊水塞栓症の病理 Reviewed
若狭 朋子, 阿萬 紫
病理と臨床 42 883 - 891 2024.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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若狹 朋子, 阿萬 紫
病理と臨床 42 ( 9 ) 0892 - 0898 2024.9
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(株)文光堂
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【日常診療に潜むリンパ腫・リンパ増殖性疾患-リンパ腫との鑑別が問題になる関連疾患-】IgA免疫組織化学的染色が診断に有用であった多中心性Castleman病の1例
森 愛菜, 西元 順子, 後田 優香, 持田 耕介, 阿萬 紫, 盛口 清香, 天野 正宏
皮膚科の臨床 65 ( 12 ) 1810 - 1814 2023.11
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：金原出版(株)
Presentations 【 display / non-display 】
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多数の熊蜂刺傷による皮膚壊死・横紋筋融解症・びまん性肺胞傷害を来した1剖検例
阿萬 紫, 黒木麻由, 盛口淸香, 都築 諒, 猪瀬将之, 佐藤勇一郎, 落合秀信, 山下 篤
第114回日本病理学会総会 2025.4.17
Event date： 2025.4.17 - 2025.4.19
Language：Japanese Presentation type：Oral presentation (general)
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Mature cystic teratomaにependymomaを合併したと考えられる一例
佐藤愛結、今村紘子、藤玄一郎、田中大貴、細川義彦、高村一紘、谷口秀一、阿萬 紫、嶋本富博
第66回日本婦人科腫瘍学会学術講演会 2024.7.20
Event date： 2024.7.18 - 2024.7.20
Language：Japanese Presentation type：Oral presentation (general)
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The expression of PAR-1 and its activators in placenta accreta spectrum International conference
Aman M, Sato Y, Asada Y, Yamashita A
32th Congress of International Society on Thrombosis and Haemostasis 2024.6.24
Event date： 2024.6.22 - 2024.6.26
Presentation type：Oral presentation (general)
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癒着胎盤におけるPAR-1発現およびその活性化因子に関する検討.
阿萬 紫、佐藤勇一郎、浅田祐士郎、山下 篤
第113回日本病理学会総会 2024.3.29
Event date： 2024.3.28 - 2024.3.30
Language：Japanese Presentation type：Oral presentation (general)
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診断に苦慮した右卵管病変の一例
阿萬 紫, 丸塚浩助、中原一成
第55回日本婦人科病理学会学術集会 2022.12.3
Event date： 2022.12.3
Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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子宮頸部胃型腺癌の発癌機序の解明と早期発見に資するバイオマーカーの同定
Grant number：25K12713 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
長峯 理子, 阿萬 紫, 田部 宏, 桑田 健
Authorship：Coinvestigator(s)
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妊産婦死亡の主因である羊水塞栓症における血栓性病態の解明
Grant number：22K06961 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究基金 基盤研究(C)
阿萬 紫, 小田 智昭, 魏 峻洸, 若狭 朋子, 山下 篤
Authorship：Principal investigator
Committee Memberships 【 display / non-display 】
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日本産婦人科医会 妊産婦死亡症例検討評価委員会
2019.8
Committee type：学協会
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日本病理学会 剖検・病理技術委員会
2026.4
Committee type：学協会
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妊産婦死亡症例検討評価委員会 妊産婦死亡症例検討評価委員会 小委員会委員
2019.7
Committee type：学協会