AMAN Murasaki



Faculty of Medicine School of Medicine Department of Pathology, Pathophysiology


Assistant Professor

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Degree 【 display / non-display

  • 博士(医学) ( 2006.3   九州大学 )

Research Areas 【 display / non-display

  • Life Science / Human pathology


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  • Massive platelet-rich thrombus formation in small pulmonary vessels in amniotic fluid embolism: An autopsy study Reviewed

    Yamashita A., Oda T., Aman M., Wakasa T., Gi T., Ide R., Todo Y., Tamura N., Sato Y., Itoh H., Asada Y.

    BJOG: An International Journal of Obstetrics and Gynaecology   130 ( 13 )   1685 - 1696   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BJOG: An International Journal of Obstetrics and Gynaecology  

    Objective: To identify pulmonary/uterine thrombus formation in amniotic fluid embolism (AFE). Design: Retrospective, observational. Setting: Nationwide. Population: Eleven autopsy cases of AFE and control cases. Methods: We assessed pulmonary and uterine thrombus formation and thrombus area in AFE and pulmonary thromboembolism (PTE) as a control. The area of platelet glycoprotein IIb/IIIa, fibrin, neutrophil elastase, citrullinated histone H3 (a neutrophil extracellular trap marker) and mast cell chymase immunopositivity was measured in 90 pulmonary emboli, 15 uterine thrombi and 14 PTE. Main outcome measures: Pathological evidence of thrombus formation and its components in AFE. Results: Amniotic fluid embolism lung showed massive thrombus formation, with or without amniotic emboli in small pulmonary arteries and capillaries. The median pulmonary thrombus size in AFE (median, 0.012 mm2; P < 0.0001) was significantly smaller than that of uterine thrombus in AFE (0.61 mm2) or PTE (29 mm2). The median area of glycoprotein IIb/IIIa immunopositivity in pulmonary thrombi in AFE (39%; P < 0.01) was significantly larger than that of uterine thrombi in AFE (23%) and PTE (15%). The median area of fibrin (0%; P < 0.001) and citrullinated histone H3 (0%; P < 0.01) immunopositivity in pulmonary thrombi in AFE was significantly smaller than in uterine thrombi (fibrin: 26%; citrullinated histone H3: 1.1%) and PTE (fibrin: 42%; citrullinated histone H3: 0.4%). No mast cells were identified in pulmonary thrombi. Conclusions: Amniotic fluid may induce distinct thrombus formation in the uterus and lung. Pulmonary and uterine thrombi formation may contribute to cardiorespiratory collapse and/or consumptive coagulopathy in AFE.

    DOI: 10.1111/1471-0528.17532


  • Association between fetal vascular malperfusion and gestational diabetes Reviewed

    Goto T., Sato Y., Kodama Y., Tomimori K., Sameshima H., Aman M., Maekawa K., Yamashita A., Asada Y.

    Journal of Obstetrics and Gynaecology Research   48 ( 1 )   80 - 86   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Obstetrics and Gynaecology Research  

    Aim: Diabetes mellitus (DM) is a major complication in pregnancy. Placental lesions with DM remain unclear and controversial. Recently, the terms of placental pathological findings, such as maternal and fetal vascular malperfusions (MVM and FVM, respectively) were introduced by the Amsterdam Placental Workshop Group Consensus Statement (APWGCS). FVM cases were classified as the partial obstruction type (global FVM) and the complete obstruction type (segmental FVM). The aim of this study was to clarify the pathological characteristics of the placenta with pregestational DM/gestational DM; GDM according to APWGCS. Methods: We studied the placentas of 182 DM women (27 pregestational DM and 155 GDM) and control placentas of 460 women without DM during 2011–2018. We excluded cases of intrauterine fetal death or multiple pregnancies. We reviewed microscopical findings including, MVM, FVM, chorioamnionitis with the slides according to the APWGCS. Results: Microscopically, the incidence of FVM was significantly higher in GDM patients than control (17% vs. 10%, p = 0.0138), but not significant in pregestational DM (11%, p = 0.7410). Segmental FVM (complete obstruction) was significantly more observed in GDM than control group (5% vs. 0.4%, p = 0.0013). Segmental FVM in GDM showed high incidence of light-for-dates infant (three of seven cases, 43%, p = 0.0288). In addition, several segmental FVM findings (villous stromal-vascular karyorrhexis and stem vessel occlusion) were frequently noted in 2 or 3 points positive of 75 g oral glucose tolerance test than 1 point positive GDM. Conclusion: Our placental findings suggest disorder of carbohydrate metabolism might affect the fetal vascular damage, especially complete fetal vascular obstruction.

    DOI: 10.1111/jog.15046


    CiNii Research

  • An Extragastrointestinal Tumor Diagnosed as a Vaginal Mass during Pregnancy Reviewed

    Ando R., Taniguchi S., Arita S., Aman M., Marutsuka K., Shimamoto T.

    Case Reports in Obstetrics and Gynecology   2022   2022

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Case Reports in Obstetrics and Gynecology  

    We report a case of an extragastrointestinal stromal tumor diagnosed as a vaginal mass during pregnancy. The mass was detected during routine examination at 24 weeks of gestation. At 26 weeks, the patient underwent transvaginal ultrasonography and magnetic resonance imaging, which revealed a blood flow-rich mass of approximately 50×30 mm in the rectovaginal septum. At 29 weeks of gestation, we resected the mass vaginally and the pathological diagnosis was a gastrointestinal stromal tumor. Chemotherapy was withheld until after full-term birth because the proliferation index of the tumor cells was low. The patient delivered a healthy infant. Imatinib was commenced at 1 month postpartum, with no recurrence or metastasis after 2.5 years. An extragastrointestinal stromal tumor as a vaginal mass in pregnancy has not been reported; however, our case suggests that the tumor should be considered a differential diagnosis of a vaginal mass in pregnancy.

    DOI: 10.1155/2022/7879220


  • High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus Reviewed

    Gi T., Kuroiwa Y., Yamashita A., Mizutani Y., Asanuma T., Miyati T., Maekawa K., Aman M., Imamura T., Asada Y.

    Thrombosis and Haemostasis   120 ( 10 )   1463 - 1473   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Thrombosis and Haemostasis  

    The effects of antithrombotic therapy on deep vein thrombosis (DVT) can be affected by thrombus age, which cannot be reliably determined by noninvasive imaging modalities. We investigated whether magnetic resonance (MR) diffusion-weighted imaging (DWI) can localize and determine the age of venous thrombus in patients with DVT, animal models, and human blood in vitro. Signal intensity (SI) on DWI and the apparent diffusion coefficient (ADC) of thrombi were assessed in eight patients with DVT using a 1.5-T MR imaging (MRI) system. We assessed the organizing processes as venous thrombus developed in the rabbit jugular vein using a 3.0-T MRI system over time. We also assessed MRI signals of human blood in vitro using the 1.5-T MRI system. Venous thrombi were detected by DWI as areas of high or mixed high and iso SI in all patients. The ADCs were lower in the proximal, than in the distal portion of the thrombi. The thrombi of rabbit jugular veins histologically organized in a time-dependent manner, with high SI on DWI at 4 hours, mixed high and iso SI at 1 and 2 weeks, and iso SI at 3 weeks. The ADC correlated negatively with erythrocyte content, and positively with smooth muscle cells, macrophages, hemosiderin, and collagen content. MRI signals of human blood in vitro showed that ADCs were affected by erythrocyte content, but not by blood clotting. MR-DWI can detect venous thrombus, and high SI on DWI accompanied by a low ADC might reflect erythrocyte-rich, acute-phase thrombi.

    DOI: 10.1055/s-0040-1714280


    CiNii Research

  • Pathologically diagnosed superficial form of placenta accreta: a comparative analysis with invasive form and asymptomatic muscular adhesion. Reviewed

    Sato Y, Aman M, Maekawa K, Yamashita A, Kodama Y, Doi K, Sameshima H, Asada Y

    Virchows Archive   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

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Presentations 【 display / non-display

  • 皮膚生検で卵巣seromucinous carcinomaの転移が疑われた症例

    佐藤勇一郎, 阿萬紫, 魏俊洸, 浅田祐士郎, 大西淳仁, 川越靖之, 鮫島浩, 古田賢.


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    Event date: 2020.1.25 - 2020.1.26

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 術中細胞診の血管像からgliomaを推定しえた脳腫瘍の1例.

    佐藤勇一郎、徳満貴子, 野口裕史, 大野招伸, 森田勝代, 峰松映子, 黒木栄輝, 阿萬紫, 前川和也、佐藤信也


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    Event date: 2019.6.7 - 2019.6.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 心膜欠損への心嵌頓による急性心筋梗塞の一例

    大栗伸行 他


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    Event date: 2019.5.9 - 2019.5.11

    Language:Japanese   Presentation type:Poster presentation  

  • Hybrid chromophobe RCC/Oncocytomaの一例



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    Event date: 2019.2.23

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 閉塞性気管支炎により慢性肺移植片機能不全をきたした一剖検症例

    魏峻洸 他


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    Event date: 2018.11.22 - 2018.11.23

    Language:Japanese   Presentation type:Poster presentation  

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Grant-in-Aid for Scientific Research 【 display / non-display

  • 妊産婦死亡の主因である羊水塞栓症における血栓性病態の解明

    Grant number:22K06961  2022.04 - 2025.03

    独立行政法人日本学術振興会  科学研究基金  基盤研究(C)

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    Authorship:Principal investigator