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医学部 医学科 病理学講座構造機能病態学分野 |
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助教 |
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Yamashita A., Oda T., Aman M., Wakasa T., Gi T., Ide R., Todo Y., Tamura N., Sato Y., Itoh H., Asada Y.
BJOG: An International Journal of Obstetrics and Gynaecology 130 ( 13 ) 1685 - 1696 2023年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：BJOG: An International Journal of Obstetrics and Gynaecology
Objective: To identify pulmonary/uterine thrombus formation in amniotic fluid embolism (AFE). Design: Retrospective, observational. Setting: Nationwide. Population: Eleven autopsy cases of AFE and control cases. Methods: We assessed pulmonary and uterine thrombus formation and thrombus area in AFE and pulmonary thromboembolism (PTE) as a control. The area of platelet glycoprotein IIb/IIIa, fibrin, neutrophil elastase, citrullinated histone H3 (a neutrophil extracellular trap marker) and mast cell chymase immunopositivity was measured in 90 pulmonary emboli, 15 uterine thrombi and 14 PTE. Main outcome measures: Pathological evidence of thrombus formation and its components in AFE. Results: Amniotic fluid embolism lung showed massive thrombus formation, with or without amniotic emboli in small pulmonary arteries and capillaries. The median pulmonary thrombus size in AFE (median, 0.012 mm2; P < 0.0001) was significantly smaller than that of uterine thrombus in AFE (0.61 mm2) or PTE (29 mm2). The median area of glycoprotein IIb/IIIa immunopositivity in pulmonary thrombi in AFE (39%; P < 0.01) was significantly larger than that of uterine thrombi in AFE (23%) and PTE (15%). The median area of fibrin (0%; P < 0.001) and citrullinated histone H3 (0%; P < 0.01) immunopositivity in pulmonary thrombi in AFE was significantly smaller than in uterine thrombi (fibrin: 26%; citrullinated histone H3: 1.1%) and PTE (fibrin: 42%; citrullinated histone H3: 0.4%). No mast cells were identified in pulmonary thrombi. Conclusions: Amniotic fluid may induce distinct thrombus formation in the uterus and lung. Pulmonary and uterine thrombi formation may contribute to cardiorespiratory collapse and/or consumptive coagulopathy in AFE.
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Expression of fibroblast activation protein-α in human deep vein thrombosis. 査読あり
Oguri N, Gi T, Nakamura E, Furukoji E, Goto H, Maekawa K, Tsuji AB, Nishii R, Aman M, Moriguchi-Goto S, Sakae T, Azuma M, Yamashita A
Thrombosis Reserch 2024年6月
掲載種別：研究論文（学術雑誌）
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Association between fetal vascular malperfusion and gestational diabetes 査読あり
Goto T., Sato Y., Kodama Y., Tomimori K., Sameshima H., Aman M., Maekawa K., Yamashita A., Asada Y.
Journal of Obstetrics and Gynaecology Research 48 ( 1 ) 80 - 86 2022年1月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Obstetrics and Gynaecology Research
Aim: Diabetes mellitus (DM) is a major complication in pregnancy. Placental lesions with DM remain unclear and controversial. Recently, the terms of placental pathological findings, such as maternal and fetal vascular malperfusions (MVM and FVM, respectively) were introduced by the Amsterdam Placental Workshop Group Consensus Statement (APWGCS). FVM cases were classified as the partial obstruction type (global FVM) and the complete obstruction type (segmental FVM). The aim of this study was to clarify the pathological characteristics of the placenta with pregestational DM/gestational DM; GDM according to APWGCS. Methods: We studied the placentas of 182 DM women (27 pregestational DM and 155 GDM) and control placentas of 460 women without DM during 2011–2018. We excluded cases of intrauterine fetal death or multiple pregnancies. We reviewed microscopical findings including, MVM, FVM, chorioamnionitis with the slides according to the APWGCS. Results: Microscopically, the incidence of FVM was significantly higher in GDM patients than control (17% vs. 10%, p = 0.0138), but not significant in pregestational DM (11%, p = 0.7410). Segmental FVM (complete obstruction) was significantly more observed in GDM than control group (5% vs. 0.4%, p = 0.0013). Segmental FVM in GDM showed high incidence of light-for-dates infant (three of seven cases, 43%, p = 0.0288). In addition, several segmental FVM findings (villous stromal-vascular karyorrhexis and stem vessel occlusion) were frequently noted in 2 or 3 points positive of 75 g oral glucose tolerance test than 1 point positive GDM. Conclusion: Our placental findings suggest disorder of carbohydrate metabolism might affect the fetal vascular damage, especially complete fetal vascular obstruction.
DOI： 10.1111/jog.15046
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An Extragastrointestinal Tumor Diagnosed as a Vaginal Mass during Pregnancy 査読あり
Ando R., Taniguchi S., Arita S., Aman M., Marutsuka K., Shimamoto T.
Case Reports in Obstetrics and Gynecology 2022 2022年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Case Reports in Obstetrics and Gynecology
We report a case of an extragastrointestinal stromal tumor diagnosed as a vaginal mass during pregnancy. The mass was detected during routine examination at 24 weeks of gestation. At 26 weeks, the patient underwent transvaginal ultrasonography and magnetic resonance imaging, which revealed a blood flow-rich mass of approximately 50×30 mm in the rectovaginal septum. At 29 weeks of gestation, we resected the mass vaginally and the pathological diagnosis was a gastrointestinal stromal tumor. Chemotherapy was withheld until after full-term birth because the proliferation index of the tumor cells was low. The patient delivered a healthy infant. Imatinib was commenced at 1 month postpartum, with no recurrence or metastasis after 2.5 years. An extragastrointestinal stromal tumor as a vaginal mass in pregnancy has not been reported; however, our case suggests that the tumor should be considered a differential diagnosis of a vaginal mass in pregnancy.
DOI： 10.1155/2022/7879220
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High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus 査読あり
Gi T., Kuroiwa Y., Yamashita A., Mizutani Y., Asanuma T., Miyati T., Maekawa K., Aman M., Imamura T., Asada Y.
Thrombosis and Haemostasis 120 ( 10 ) 1463 - 1473 2020年10月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Thrombosis and Haemostasis
The effects of antithrombotic therapy on deep vein thrombosis (DVT) can be affected by thrombus age, which cannot be reliably determined by noninvasive imaging modalities. We investigated whether magnetic resonance (MR) diffusion-weighted imaging (DWI) can localize and determine the age of venous thrombus in patients with DVT, animal models, and human blood in vitro. Signal intensity (SI) on DWI and the apparent diffusion coefficient (ADC) of thrombi were assessed in eight patients with DVT using a 1.5-T MR imaging (MRI) system. We assessed the organizing processes as venous thrombus developed in the rabbit jugular vein using a 3.0-T MRI system over time. We also assessed MRI signals of human blood in vitro using the 1.5-T MRI system. Venous thrombi were detected by DWI as areas of high or mixed high and iso SI in all patients. The ADCs were lower in the proximal, than in the distal portion of the thrombi. The thrombi of rabbit jugular veins histologically organized in a time-dependent manner, with high SI on DWI at 4 hours, mixed high and iso SI at 1 and 2 weeks, and iso SI at 3 weeks. The ADC correlated negatively with erythrocyte content, and positively with smooth muscle cells, macrophages, hemosiderin, and collagen content. MRI signals of human blood in vitro showed that ADCs were affected by erythrocyte content, but not by blood clotting. MR-DWI can detect venous thrombus, and high SI on DWI accompanied by a low ADC might reflect erythrocyte-rich, acute-phase thrombi.
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羊水塞栓症の病理 査読あり
若狭 朋子, 阿萬 紫
病理と臨床 42 883 - 891 2024年9月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
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病理診断クイックリファレンス、第11章：女性生殖器
阿萬 紫
病理と臨床 2023年4月
担当区分：筆頭著者 掲載種別：記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
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死因究明のための病理解剖の重要性
阿萬 紫, 若狹朋子
周産期医学 53 ( 3 ) 301 - 305 2023年3月
担当区分：筆頭著者 掲載種別：記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
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W-1.子宮平滑筋におけるプロテイナーゼ活性化型受容体の性ホルモンによる発現調節(産婦人科領域における最近の平滑筋研究,ワークショップ,第48回 日本平滑筋学会総会)
平野 勝也, 阿萬 紫, 金出 英夫
日本平滑筋学会雑誌 10 ( 1 ) "J - 19" 2006年4月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（大学・研究所紀要） 出版者・発行元：日本平滑筋学会
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GnRHアナログ,ダナゾール使用症例における骨密度の検討 (第13回婦人科骨粗鬆症研究会) -- (Session 2 骨量に影響する因子)
阿萬 紫, 江上 りか, 小金丸 泰子
オステオポローシスジャパン 11 ( 3 ) 493 - 496 2003年
記述言語：日本語 掲載種別：記事・総説・解説・論説等（大学・研究所紀要） 出版者・発行元：ライフサイエンス出版
講演・口頭発表等 【 表示 ／ 非表示 】
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Mature cystic teratomaにependymomaを合併したと考えられる一例
佐藤愛結、今村紘子、藤玄一郎、田中大貴、細川義彦、高村一紘、谷口秀一、阿萬 紫、嶋本富博
第66回日本婦人科腫瘍学会学術講演会 2024年7月20日
開催年月日： 2024年7月18日 - 2024年7月20日
記述言語：日本語 会議種別：口頭発表（一般）
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The expression of PAR-1 and its activators in placenta accreta spectrum 国際会議
Aman M, Sato Y, Asada Y, Yamashita A
32th Congress of International Society on Thrombosis and Haemostasis 2024年6月24日
開催年月日： 2024年6月22日 - 2024年6月26日
会議種別：口頭発表（一般）
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癒着胎盤におけるPAR-1発現およびその活性化因子に関する検討.
阿萬 紫、佐藤勇一郎、浅田祐士郎、山下 篤
第113回日本病理学会総会 2024年3月29日
開催年月日： 2024年3月28日 - 2024年3月30日
記述言語：日本語 会議種別：口頭発表（一般）
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診断に苦慮した右卵管病変の一例
阿萬 紫, 丸塚浩助、中原一成
第55回日本婦人科病理学会学術集会 2022年12月3日
開催年月日： 2022年12月3日
会議種別：口頭発表（一般）
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皮膚生検で卵巣seromucinous carcinomaの転移が疑われた症例
佐藤勇一郎, 阿萬紫, 魏俊洸, 浅田祐士郎, 大西淳仁, 川越靖之, 鮫島浩, 古田賢.
第51回日本婦人科病理学会
開催年月日： 2020年1月25日 - 2020年1月26日
記述言語：日本語 会議種別：口頭発表（一般）
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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妊産婦死亡の主因である羊水塞栓症における血栓性病態の解明
研究課題/領域番号：22K06961 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究基金 基盤研究(C)
担当区分：研究代表者