阿萬　紫 (アマン　ムラサキ)

AMAN Murasaki

写真a

所属

医学部 医学科 病理学講座構造機能病態学分野

職名

助教

外部リンク

関連SDGs


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学位 【 表示 ／ 非表示 】

  • 博士（医学） （ 2006年3月   九州大学 ）

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 人体病理学

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論文 【 表示 ／ 非表示 】

  • Massive platelet-rich thrombus formation in small pulmonary vessels in amniotic fluid embolism: An autopsy study 査読あり

    Yamashita A., Oda T., Aman M., Wakasa T., Gi T., Ide R., Todo Y., Tamura N., Sato Y., Itoh H., Asada Y.

    BJOG: An International Journal of Obstetrics and Gynaecology   130 ( 13 )   1685 - 1696   2023年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BJOG: An International Journal of Obstetrics and Gynaecology  

    Objective: To identify pulmonary/uterine thrombus formation in amniotic fluid embolism (AFE). Design: Retrospective, observational. Setting: Nationwide. Population: Eleven autopsy cases of AFE and control cases. Methods: We assessed pulmonary and uterine thrombus formation and thrombus area in AFE and pulmonary thromboembolism (PTE) as a control. The area of platelet glycoprotein IIb/IIIa, fibrin, neutrophil elastase, citrullinated histone H3 (a neutrophil extracellular trap marker) and mast cell chymase immunopositivity was measured in 90 pulmonary emboli, 15 uterine thrombi and 14 PTE. Main outcome measures: Pathological evidence of thrombus formation and its components in AFE. Results: Amniotic fluid embolism lung showed massive thrombus formation, with or without amniotic emboli in small pulmonary arteries and capillaries. The median pulmonary thrombus size in AFE (median, 0.012 mm2; P < 0.0001) was significantly smaller than that of uterine thrombus in AFE (0.61 mm2) or PTE (29 mm2). The median area of glycoprotein IIb/IIIa immunopositivity in pulmonary thrombi in AFE (39%; P < 0.01) was significantly larger than that of uterine thrombi in AFE (23%) and PTE (15%). The median area of fibrin (0%; P < 0.001) and citrullinated histone H3 (0%; P < 0.01) immunopositivity in pulmonary thrombi in AFE was significantly smaller than in uterine thrombi (fibrin: 26%; citrullinated histone H3: 1.1%) and PTE (fibrin: 42%; citrullinated histone H3: 0.4%). No mast cells were identified in pulmonary thrombi. Conclusions: Amniotic fluid may induce distinct thrombus formation in the uterus and lung. Pulmonary and uterine thrombi formation may contribute to cardiorespiratory collapse and/or consumptive coagulopathy in AFE.

    DOI： 10.1111/1471-0528.17532

    Scopus

  • Novel SKIC3 variants in tricho-hepato-enteric syndrome with hemochromatosis 査読あり

    Ochiai K., Aoki Y., Yamada N., Aman M., Yamashita A., Yamaguchi M., Nakato D., Takenouchi T., Kosaki K., Kodama Y., Moritake H.

    Human Genome Variation   12 ( 1 )   2025年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Human Genome Variation  

    Tricho-hepato-enteric syndrome (THES), a rare autosomal recessive disorder caused by variants in the SKIC3 or SKIC2 gene, is characterized by intractable diarrhea, woolly hair, growth restriction and liver disease. Here we report a neonatal case of THES with neonatal hemochromatosis, in which the novel compound heterozygous SKIC3 variants NM_014639.4:c.815_816del p.(Gly272AlafsTer9) and NM_014639.4:c.2284G>A p.(Gly762Arg) were identified. Further research is needed to elucidate the mechanisms underlying iron metabolism dysregulation in THES.

    DOI： 10.1038/s41439-025-00318-y

    Scopus

  • Proposals for improving maternal safety (2023 edition): Insights from the analysis of maternal deaths in Japan 査読あり

    Japan Maternal Death Exploratory Committee

    Journal of Obstetrics and Gynaecology Research   51 ( 3 )   2025年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Obstetrics and Gynaecology Research  

    The maternal mortality rate remains approximately 4 per 100 000 deliveries. Between January 2010 and July 2024, 629 maternal deaths were reported, of which 590 were reviewed. The Maternal Safety Proposal summarizes these cases. Deaths from obstetric hemorrhage decreased from 28% in 2010 to 7% in 2019 but rose to approximately 20% in 2022 and dropped to 10% in 2023. In the past 4 years, suicide has surpassed obstetric hemorrhage as a leading cause of death. In 2023, intracranial hemorrhage/infarction became the leading cause, with six cases reported. Cardiopulmonary collapse from amniotic fluid embolism, along with cardiovascular, infectious, and pulmonary diseases, has remained stable at 6%-10%. Initial symptoms leading to death occurred during the antepartum (38%), intrapartum (41%), or postpartum periods (21%), with cases distributed across general hospitals, small maternity delivery facilities, and non-medical settings, including homes. The following are the year's maternal safety proposals: For pregnant women experiencing anxiety, a comprehensive evaluation addressing biological, psychological, and social factors should be conducted to identify key problem areas. Epidural analgesia during labor carries the risk of serious complications. Obstetricians and anesthesiologists must be aware of these risks to ensure the proper management of anesthesia and delivery. Pregnant and postpartum women are at a high risk of invasive group A streptococcal infections, and early screening and timely intervention should be prioritized. Pathological autopsy remains the most effective method for determining the cause of death and should be recommended to bereaved families in all cases of maternal death.

    DOI： 10.1111/jog.16244

    Scopus

  • Expression of fibroblast activation protein-α in human deep vein thrombosis. 査読あり

    Oguri N, Gi T, Nakamura E, Furukoji E, Goto H, Maekawa K, Tsuji AB, Nishii R, Aman M, Moriguchi-Goto S, Sakae T, Azuma M, Yamashita A

    Thrombosis Reserch   2024年6月

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    掲載種別：研究論文（学術雑誌）  

  • Association between fetal vascular malperfusion and gestational diabetes 査読あり

    Goto T., Sato Y., Kodama Y., Tomimori K., Sameshima H., Aman M., Maekawa K., Yamashita A., Asada Y.

    Journal of Obstetrics and Gynaecology Research   48 ( 1 )   80 - 86   2022年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Obstetrics and Gynaecology Research  

    Aim: Diabetes mellitus (DM) is a major complication in pregnancy. Placental lesions with DM remain unclear and controversial. Recently, the terms of placental pathological findings, such as maternal and fetal vascular malperfusions (MVM and FVM, respectively) were introduced by the Amsterdam Placental Workshop Group Consensus Statement (APWGCS). FVM cases were classified as the partial obstruction type (global FVM) and the complete obstruction type (segmental FVM). The aim of this study was to clarify the pathological characteristics of the placenta with pregestational DM/gestational DM; GDM according to APWGCS. Methods: We studied the placentas of 182 DM women (27 pregestational DM and 155 GDM) and control placentas of 460 women without DM during 2011–2018. We excluded cases of intrauterine fetal death or multiple pregnancies. We reviewed microscopical findings including, MVM, FVM, chorioamnionitis with the slides according to the APWGCS. Results: Microscopically, the incidence of FVM was significantly higher in GDM patients than control (17% vs. 10%, p = 0.0138), but not significant in pregestational DM (11%, p = 0.7410). Segmental FVM (complete obstruction) was significantly more observed in GDM than control group (5% vs. 0.4%, p = 0.0013). Segmental FVM in GDM showed high incidence of light-for-dates infant (three of seven cases, 43%, p = 0.0288). In addition, several segmental FVM findings (villous stromal-vascular karyorrhexis and stem vessel occlusion) were frequently noted in 2 or 3 points positive of 75 g oral glucose tolerance test than 1 point positive GDM. Conclusion: Our placental findings suggest disorder of carbohydrate metabolism might affect the fetal vascular damage, especially complete fetal vascular obstruction.

    DOI： 10.1111/jog.15046

    Scopus

    CiNii Research

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  • 多数の熊蜂刺傷による皮膚壊死・横紋筋融解症・びまん性肺胞傷害を来した1剖検例

    阿萬　紫, 黒木麻由, 盛口淸香, 都築　諒, 猪瀬将之, 佐藤勇一郎, 落合秀信, 山下　篤

    第114回日本病理学会総会  2025年4月17日 

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    開催年月日： 2025年4月17日 - 2025年4月19日

    記述言語：日本語   会議種別：口頭発表（一般）  

  • Mature cystic teratomaにependymomaを合併したと考えられる一例

    佐藤愛結、今村紘子、藤玄一郎、田中大貴、細川義彦、高村一紘、谷口秀一、阿萬　紫、嶋本富博

    第66回日本婦人科腫瘍学会学術講演会  2024年7月20日 

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    開催年月日： 2024年7月18日 - 2024年7月20日

    記述言語：日本語   会議種別：口頭発表（一般）  

  • The expression of PAR-1 and its activators in placenta accreta spectrum 国際会議

    Aman M, Sato Y, Asada Y, Yamashita A

    32th Congress of International Society on Thrombosis and Haemostasis  2024年6月24日 

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    開催年月日： 2024年6月22日 - 2024年6月26日

    会議種別：口頭発表（一般）  

  • 癒着胎盤におけるPAR-1発現およびその活性化因子に関する検討.

    阿萬　紫、佐藤勇一郎、浅田祐士郎、山下　篤

    第113回日本病理学会総会  2024年3月29日 

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    開催年月日： 2024年3月28日 - 2024年3月30日

    記述言語：日本語   会議種別：口頭発表（一般）  

  • 診断に苦慮した右卵管病変の一例

    阿萬　紫, 丸塚浩助、中原一成

    第55回日本婦人科病理学会学術集会  2022年12月3日 

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    開催年月日： 2022年12月3日

    会議種別：口頭発表（一般）  

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  • 子宮頸部胃型腺癌の発癌機序の解明と早期発見に資するバイオマーカーの同定

    研究課題/領域番号：25K12713  2025年04月 - 2028年03月

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

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    担当区分：研究分担者 

  • 妊産婦死亡の主因である羊水塞栓症における血栓性病態の解明

    研究課題/領域番号：22K06961  2022年04月 - 2025年03月

    独立行政法人日本学術振興会  科学研究基金  基盤研究(C)

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    担当区分：研究代表者 

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委員歴 【 表示 ／ 非表示 】

  • 日本産婦人科医会   妊産婦死亡症例検討評価委員会  

    2019年8月 - 現在   

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    団体区分：学協会

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