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Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Pediatrics |
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Assistant Professor |
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NISHIMURA Toyoki
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Papers 【 display / non-display 】
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A survey on food allergy countermeasures in nursery school in Miyazaki Prefecture
Yamamoto Ayako, Nishimura Toyoki, Kodama Takashi, Tsumagari Shuntaro, Yamamoto Hiroki, Sato Sakura
Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 40 ( 1 ) 1 - 8 2026.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY
Background : This study aimed to clarify the current status of food allergies (FA) in children attending nursery schools in Miyazaki Prefecture.Methods : In September 2023, a questionnaire on managing children with FA was distributed to all nursery schools in Miyazaki Prefecture. Responses were obtained via an online survey form or fax.Results : Responses were received from 194 of the 542 facilities (36％). Of 15,459 enrolled children, 531 (3％) had FA. All facilities accommodated children with FA, and 188 (97％) provided school meals. The 13 facilities (7％) that were unable to accept children with a history of anaphylaxis (An) responded that the main reason for not accepting them was a fear of inability to respond and provide timely emergency treatment. Of the 110 facilities that accepted children who were prescribed adrenaline autoinjectors, only 36 (33％) can administer the drug based solely on the judgment of facility staff in the event of an anaphylactic incident. Eight facilities reported incidents of accidental ingestion of the allergy-causing food, resulting in FA symptoms.Conclusion : This study revealed problems in managing FA in nursery schools in Miyazaki Prefecture, including accepting children with a history of An and providing emergency treatment. As a medical hospital for allergic diseases in Miyazaki Prefecture, efforts must be made to solve these problems.
DOI： 10.3388/jspaci.40.1
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CFAP43 variant in persistent respiratory symptoms after hematopoietic cell transplantation Reviewed
Nagasawa S., Nishimura T., Yamada A., Kamimura S., Ishimura M., Moritake H.
Human Genome Variation 11 ( 1 ) 41 2024.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Human Genome Variation
We describe a case of RAS-associated autoimmune leukoproliferative disease with primary ciliary dyskinesia (PCD)-like symptoms, such as recurrent pneumonia, sinusitis, and otitis media, that occurred 7 years after hematopoietic cell transplantation. Whole-exome sequencing revealed a heterozygous CFAP43 nonsense variant. Environmental factors related to hematopoietic cell transplantation may have led to PCD symptoms in this patient with this variant. Genetic screening can help avoid subsequent complications during patient management.
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An autopsy case of an adult woman with Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine Tumors (ROHHAD(NET)) syndrome developing nonalcoholic steatohepatitis and hepatocellular carcinoma: A case report. Reviewed
Hasuike S, Ozono Y, Uchida K, Ogawa S, Tamura H, Uchiyama N, Hatada H, Komaki Y, Nakamura K, Iwakiri H, Sueta M, Nagata K, Nishimura T, Matsuyama M, Sawada H, Oguri T, Sato Y, Kawakami H
Medicine 103 ( 22 ) e38383 2024.5
Language：English Publishing type：Research paper (scientific journal)
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Local Administration of H2O2 Reduced Aspergilloma in a Patient with Chronic Granulomatous Disease: A Case Report Reviewed
Toyoki Nishimura
journal of biotechnology and biomedicine 7 186 - 191 2024.4
Authorship：Lead author Language：English Publishing type：Case report
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B-cell deficiency identified by newborn screening Reviewed
Matsumoto Takayuki, Nishimura Toyoki, Yamamoto Ayako, Sawada Hirotake, Moritake Hiroshi
JSIAD Journal 3 ( 1 ) 16 - 20 2024.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Immunodeficiency and Autoinflammatory Diseases
Newborn screening（NBS）is carried out at public expense for approximately 20 diseases in Japan; however, each prefecture independently conducts additional NBS including several more diseases. Miyazaki Prefecture has optionally included inborn errors of immunity（IEIs）and lysosomal storage diseases since April 2020. We herein report a baby who suffered from B-cell deficiency（BCD）that was identified by NBS conducted in Miyazaki Prefecture. The baby had low levels of kappa-deleting recombination excision circles（KRECs）and was referred to our hospital. Several measurements of CD19-positive B cells in the peripheral blood consistently showed values <2%, leading to the diagnosis of BCD. Periodic immunoglobulin replacement successfully led to a healthy outcome without serious infection developing over a period of more than 17 months. This is the first case of BCD identified by NBS and that underwent prophylactic gamma globulin replacement in Japan. Severe combined immunodeficiency disease and BCD are IEIs known to cause severe sequelae, and patients sometimes die without a correct diagnosis being made; therefore, their early diagnosis and early treatment are extremely important. The inclusion of IEIs in NBS has proven to be cost-effective all over the world. In the future, it is expected that IEIs will be covered by NBS public funds in Japan as well.