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Affiliation |
Faculty of Agriculture Department of Biochemistry and Applied Biosciences |
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Title |
Associate Professor |
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External Link |
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OGAWA Kenjiro
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Papers 【 display / non-display 】
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Effects of the Polyphenols Delphinidin and Rosmarinic Acid on the Inducible Intra-cellular Aggregation of Alpha-Synuclein in Model Neuron Cells.
Yamamoto H, Matsumura R, Nakashima M, Adachi M, Ogawa K, Hongo K, Mizobata T, Kawata Y
Applied biochemistry and biotechnology 195 ( 7 ) 4134 - 4147 2023.7
Language：English Publishing type：Research paper (scientific journal)
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Blueberry Stem Extract Prevents Lacrimal Hyposecretion in Non-obese Diabetic Mice via Activation of AMPK.
Ogawa K, Ohno Y, Tagashira A, Urata K, Satoh K, Fujimoto N, Sonoda H, Ikeda M, Matsuzaki T, Nishiyama K, Kunitake H, Goto YO, Yamasaki M
In vivo (Athens, Greece) 37 ( 3 ) 1003 - 1015 2023.5
Language：English Publishing type：Research paper (scientific journal)
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Blueberry stem extract and stem active components prevent blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro.
Ogawa K, Urata K, Suzuki Y, Sugamoto K, Goto Y, Nakayama T, Nishiyama K, Kunitake H, Yamasaki M
Bioscience, biotechnology, and biochemistry 87 ( 4 ) 378 - 388 2023.3
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1093/bbb/zbad001
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Blueberry Leaf Extract Prevents Lacrimal Hyposecretion in Sjögren's Syndrome-like Model of Non-obese Diabetic Mice.
Ogawa K, Urata K, Maeda S, Ohno Y, Satoh K, Yamada Y, Suzuki Y, Koga Y, Sugamoto K, Kawaguchi M, Kunitake H, Nishiyama K, Goto YO, Nakayama T, Yamasaki M
In vivo (Athens, Greece) 37 ( 1 ) 149 - 162 2023.1
Language：English Publishing type：Research paper (scientific journal)
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Blueberry Stem Extract Suppresses Blue Light-Emitting Diode Light-Induced Endoplasmic Reticulum Stress on Retinal Photoreceptor Cells Reviewed
Ogawa Kenjirou, Karitani Takara, Otsu Wataru, Nishiyama Kazuo, Kunitake Hisato, Goto Yo, Nomiyama Shota, Hara Hideaki, Yamasaki Masao
BPB Reports 6 ( 3 ) 87 - 97 2023
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：公益社団法人 日本薬学会
<i>Background</i>: Blue light causes retinal photoreceptor damage via oxidative and endoplasmic reticulum (ER) stress. A previous study showed that blueberry stem extract (BStEx) and its active components have cytoprotective effects against blue-light-induced photoreceptor cell damage by suppressing oxidative stress. This study demonstrated the inhibitory effect of BStEx against blue light-induced ER stress in photoreceptor cells. <i>Methods</i>: The photoreceptor cells treated with BStEx or the antioxidant <i>N</i>-Acetyl-L-cysteine (NAC) as a positive control were used and then exposed to blue light. The cytoprotective effects of BStEx and NAC were evaluated using CCK-8. The ER stress-related protein expression changes over time, and its levels were measured after each exposure time to blue light in photoreceptor cells treated with BStEx or NAC. <i>Results</i>: BStEx and NAC showed protective effects against blue-light-induced photoreceptor morphological abnormalities and cell damage. Although blue light triggered ER stress factors such as BiP, PERK, ATF6, eIF2α, ATF4, and CHOP, which in turn stimulated cell cycle arrest factors p53 and p21 and upregulation of apoptosis-inducing factors caspase-3. However, BStEx suppressed the increase in expression of BiP, ATF4, ATF6, CHOP, p53, p21, and caspase-3, but not mitochondrial apoptotic factors Bax and cytochrome c. Furthermore, the antioxidant NAC showed similar suppressive effects on BStEx. <i>Conclusion</i>: Our findings suggest that blue light-induced ER stress is primarily caused by oxidative stress, and BStEx might suppress ER stress via an antioxidant effect. The antioxidant NAC contributes to the cell proliferative capacity and suppression of apoptosis in photoreceptor cells.
MISC 【 display / non-display 】
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The involvement of anthocyanin-rich foods in retinal damage. Invited
Ogawa K., Hara H.
Recent Advances in Polyphenol Research 193 - 205 2017
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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ビルベリー由来アントシアニンが目に与える機能性―ヒト臨床試験と機能性表示食品― Invited
小川健二郎，原英彰
岐阜薬科大学紀要 65 20 - 27 2016
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：岐阜薬科大学
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網膜障害に対する食品色素成分の有効性（特集 色のもつ多彩な食機能） Invited
小川健二郎，原英彰
Foods & Food Ingredients Journal of Japan 219 ( 2 ) 114 - 125 2014
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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アントシアニン（特集 眼科で使えるサプリメント） Invited
小川健二郎，田中潤司，原英彰
眼科 54 ( 7 ) 873 - 886 2012
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：金原出版
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アレルギー疾患とキノコ
沼津工業高等専門学校研究報告
沼津工業高等専門学校研究報告 38 123 - 128 2004
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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涙液分泌機能におけるポリフェノール・パラドックスを脳腸軸から紐解く
Grant number：22K14844 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 若手研究
Authorship：Principal investigator