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Affiliation |
Faculty of Agriculture Region of Applied Biochemistry and Biotechnology |
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Title |
Associate Professor |
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Related SDGs |
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OGAWA Kenjiro
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Papers 【 display / non-display 】
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Broccoli-derived nanovesicles inhibited LPS-induced inflammatory response in mouse macrophage RAW264 cells Reviewed
Sayaka Morita , Kako Machida , Yumi Yamasaki , Miku Sato , Himeno Oshikawa , Tatsuya Oshima , Kenjirou Ogawa , Kazuo Nishiyama , Hirofumi Tachibana , Masao Yamasaki
Bioscience, Biotechnology, and Biochemistry 90 ( 4 ) 561 - 570 2026.1
Language：English Publishing type：Research paper (scientific journal)
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Matsusaki T., Takakura C., Ichitani K., Tsend-Ayush C., Kataoka H., Fukushima T., Kurogi J., Nishiyama K., Ogawa K., Shinyama T., Nakano T., Yamasaki M.
Nutrients 17 ( 24 ) 2025.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Nutrients
Background/Objectives: The increase in the global prevalence of obesity has created a need for safe and effective preventive strategies. Probiotics have gained attention for their potential to modulate the gut microbiota and improve metabolic health. In this study, we examined the anti-obesity effects of Lactiplantibacillus plantarum strain 06CC2 (LP06CC2) in a mouse model of mild diet-induced obesity that mimics early-stage metabolic imbalance without significant body weight gain. Methods: Mice were fed a high-fat diet for 8 weeks, with or without LP06CC2 supplementation. Biochemical assays were used to determine the metabolic effects of LP06CC2, and 16S rRNA sequencing was performed to analyze the gut microbiota. Results: LP06CC2 attenuated epididymal fat accumulation and adipocyte hypertrophy, improved the gene expression profiles related to lipid metabolism and inflammation in adipose tissue, and reduced early hepatic steatosis. 16S rRNA sequencing revealed that LP06CC2 modulated the diversity and composition of the gut microbiota, notably suppressing HFD-induced increases in Mucispirillum schaedleri and other taxa associated with inflammation. LP06CC2-treated mice exhibited higher alpha diversity and partial restoration of their microbial profiles toward those of the normal diet-fed animals. LP06CC2 also downregulated pro-inflammatory cytokines and genes related to lipid uptake while modulating markers of thermogenesis and lipolysis. Conclusions: These findings indicate that LP06CC2 can prevent fat accumulation and gut dysbiosis in the pre-obese state, supporting its potential as a functional food ingredient for early intervention in obesity. Further human trials and studies using advanced obesity models are warranted to confirm its efficacy and elucidate its underlying mechanisms of action.
DOI： 10.3390/nu17243855
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Lactiplantibacillus plantarum 06CC2 Enhanced the Expression of Intestinal Uric Acid Excretion Transporter in Mice. Reviewed
Nei S, Matsusaki T, Kawakubo H, Ogawa K, Nishiyama K, Tsend-Ayush C, Nakano T, Takeshita M, Shinyama T, Yamasaki M
Nutrients 16 ( 17 ) 2024.9
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Koji Mold-derived Lipids Disrupt the Intracellular Redox State by Decreasing the GPx4 and Intracellular Glutathione Levels, Promoting Membrane Lipid Peroxidation, and Inducing Ferroptosis in HL-60 Cells. Reviewed
Takeguchi T, Kai H, Takeshita M, Miura M, Ogawa K, Nishiyama K, Yamasaki M
Journal of oleo science 73 ( 7 ) 991 - 999 2024.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.5650/jos.ess24043
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Effects of the Polyphenols Delphinidin and Rosmarinic Acid on the Inducible Intra-cellular Aggregation of Alpha-Synuclein in Model Neuron Cells.
Yamamoto H, Matsumura R, Nakashima M, Adachi M, Ogawa K, Hongo K, Mizobata T, Kawata Y
Applied biochemistry and biotechnology 195 ( 7 ) 4134 - 4147 2023.7
Language：English Publishing type：Research paper (scientific journal)
MISC 【 display / non-display 】
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ブルーベリー葉・茎エキスの涙液分泌改善作用および光刺激に対する網膜保護作用 Invited
小川健二郎、後藤陽
FOOD Style 21, 食品科学新聞社出版，8月号，特集1 アイケア 39 - 44 2023.8
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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現代人の目の健康問題とビルベリーの機能性 Invited
小川健二郎
Medical Herb, 日本メディカルハーブ協会出版 3月号 40 - 43 2020.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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現代人の目の健康問題とビルベリー由来アントシアニンの視機能改善作用． Invited
小川健二郎、荘厳哲哉
運動機能・認知機能改善食品の開発（㈱シーエムシー出版） 323 - 333 2020.2
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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The involvement of anthocyanin-rich foods in retinal damage. Invited
Ogawa K., Hara H.
Recent Advances in Polyphenol Research 193 - 205 2017
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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ビルベリー由来アントシアニンが目に与える機能性―ヒト臨床試験と機能性表示食品― Invited
小川健二郎，原英彰
岐阜薬科大学紀要 65 20 - 27 2016
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：岐阜薬科大学
Presentations 【 display / non-display 】
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Blueberry stem extract prevents lacrimal hyposecretion in Sjögren's Syndrome-like model of non-obese diabetic mice International conference
Kenjirou Ogawa, Karin Urata, Akane Tagashira, Yuta Ohno, Keitaro Satoh, Hisato Kunitake, Kazuo Nishiyama, Yo Goto, Takayuki Nakayama, Masao Yamasaki
22nd IUNS-ICN International Congress of Nutrition in Tokyo, Japan 2022.12
Event date： 2022.12.6 - 2022.12.11
Language：English Presentation type：Poster presentation
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Blueberry stem extract prevents endoplasmic reticulum stress on blue light-induced retinal photoreceptor cell damage in vitro International conference
Takara Karitani, Karin Urata, Masao Yamasaki, Hisato Kunitake, Kazuo Nishiyama, Yo Goto, Takayuki Nakayama, Kenjirou Ogawa
22nd IUNS-ICN International Congress of Nutrition in Tokyo, Japan 2022.12
Event date： 2022.12.6 - 2022.12.11
Language：English Presentation type：Poster presentation
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シェーグレン症候群様マウスの涙液分泌機能に及ぼすブルーベリー茎の影響
小川健二郎、浦田果林、田頭明音、大野雄太、佐藤慶太郎、後藤陽、中山貴之、國武久登、西山和夫、山﨑正夫
日本農芸化学会 2022 年度西日本支部大会 2022.9.23
Event date： 2022.9.23
Language：Japanese Presentation type：Oral presentation (general)
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自己免疫疾患シェーグレン症候群の涙液分泌機能低下に及ぼすブルーベリー葉エキスの作用
浦田果林、前田咲、小川健二郎、大野雄太、佐藤慶太郎、山﨑正夫、西山和夫、後藤陽、中山貴之
日本農芸化学会2021年度仙台大会 2021.3
Event date： 2021.3.18 - 2021.3.21
Language：Japanese Presentation type：Oral presentation (general)
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ブルーベリー素材が自己免疫疾患シェーグレン症候群モデル動物の唾液分泌量に及ぼす影響
小川健二郎、浦田果林、前田咲、佐藤慶太郎、大野雄太、山﨑正夫、西山和夫
日本農芸化学会2021年度仙台大会 2021.3
Event date： 2021.3.18 - 2021.3.21
Language：Japanese Presentation type：Oral presentation (general)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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涙液分泌機能におけるポリフェノール・パラドックスを脳腸軸から紐解く
Grant number：22K14844 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 若手研究
Authorship：Principal investigator