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Affiliation |
Faculty of Medicine College Hospital Orthopedics department |
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Title |
Assistant Professor |
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External Link |
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Related SDGs |
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OHTA Tomomi
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Papers 【 display / non-display 】
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Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway Reviewed
Nagai T., Sekimoto T., Kurogi S., Ohta T., Miyazaki S., Yamaguchi Y., Tajima T., Chosa E., Imasaka M., Yoshinobu K., Araki K., Araki M., Choijookhuu N., Sato K., Hishikawa Y., Funamoto T.
Scientific Reports 13 ( 1 ) 14639 2023.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports
Bone remodeling is an extraordinarily complex process involving a variety of factors, such as genetic, metabolic, and environmental components. Although genetic factors play a particularly important role, many have not been identified. In this study, we investigated the role of transmembrane 161a (Tmem161a) in bone structure and function using wild-type (WT) and Tmem161a-depleted (Tmem161aGT/GT) mice. Mice femurs were examined by histological, morphological, and bone strength analyses. Osteoblast differentiation and mineral deposition were examined in Tmem161a-overexpressed, -knockdown and -knockout MC3T3-e1 cells. In WT mice, Tmem161a was expressed in osteoblasts of femurs; however, it was depleted in Tmem161aGT/GT mice. Cortical bone mineral density, thickness, and bone strength were significantly increased in Tmem161aGT/GT mice femurs. In MC3T3-e1 cells, decreased expression of alkaline phosphatase (ALP) and Osterix were found in Tmem161a overexpression, and these findings were reversed in Tmem161a-knockdown or -knockout cells. Microarray and western blot analyses revealed upregulation of the P38 MAPK pathway in Tmem161a-knockout cells, which referred as stress-activated protein kinases. ALP and flow cytometry analyses revealed that Tmem161a-knockout cells were resistant to oxidative stress. In summary, Tmem161a is an important regulator of P38 MAPK signaling, and depletion of Tmem161a induces thicker and stronger bones in mice.
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Remnant-Preserved Single-Bundle Anterior Cruciate Ligament Augmentation in Multi-ligamentous Knee Reconstruction. Reviewed
Tajima T, Yamaguchi N, Morita Y, Yokoe T, Nagasawa M, Ota T, Kawagoe S, Nakamura Y, Chosa E.
J Knee Surg 36 ( 10 ) 1095 - 1101 2023.10
Language：English Publishing type：Research paper (scientific journal)
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第2趾DIP関節脱臼に対する観血的整復術後の早期スポーツ復帰の一例
川越 亮, 田島 卓也, 山口 奈美, 大田 智美, 長澤 誠, 森田 雄大, 横江 琢示, 帖佐 悦男
整形外科と災害外科 72 ( 3 ) 485 - 487 2023.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：西日本整形・災害外科学会
【はじめに】観血的整復術を必要とした第2趾のDIP関節脱臼の1例を経験した．【症例】16歳男性．空手中に受傷．第2趾DIP関節脱臼で徒手整復を行ったが整復不能であったため，観血的整復術を行った．整復阻害因子は長趾屈筋腱であり，蹠側板の嵌頓は認めなかった．術後早期の競技復帰希望があったため母趾とのbuddy tapingを指示し復帰とした．術後6か月が経過し特に問題なく競技継続している．【考察】DIP関節脱臼の整復阻害因子は蹠側板や長趾屈筋腱の報告があり，本症例では長趾屈筋腱であった．また，術後のスポーツ復帰について，競技によっては症状次第で早期復帰が見込めると考えられた．
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Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway Reviewed
Takuya Nagai,Tomohisa Sekimoto,Syuji Kurogi,Tomomi Ohta, Shihoko Miyazaki,Yoichiro Yamaguchi,Takuya Tajima, Etsuo Chosa,Mai Imasaka,Kumiko Yoshinobu,Yoshitaka Hishikawa,Taro Funamoto
Scientific reports ( 14639 ) 2023.9
Language：English Publishing type：Research paper (bulletin of university, research institution)
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Ureter position and risk of ureteral injury during lateral lumbar interbody fusion Reviewed
Makoto Nagasawa,MD,Takuya Tajima,MD,PhD,Shuichi Kawagoe, MD,Nami Yamaguchi,MD,PhD, Yudai Morita,MD,Takuji Yokoe, MD,Tomomi Ota,MD,Toshihiko Izumi, MD, PhD,Yasuyuki Ishida, MD,Etsuo Chosa,MD,PhD
Journal of Clinical Medicine 32 ( 8 ) 1673 - 1680 2023.5
Language：English Publishing type：Research paper (bulletin of university, research institution) Publisher：Elsevier
Presentations 【 display / non-display 】
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遠井上腕二頭筋腱断裂の2例
大野鉄平、大田智美、長澤誠、帖佐悦男
第36回日本肘関節学会学術集会 2024.3.1
Event date： 2024.3.1 - 2024.3.2
Presentation type：Oral presentation (general)
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徒手前方引き出しテストとストレス超音波検査による足関節回旋不安定性の関係
横江琢示、田島卓也、山口奈美、大田智美、長澤誠、森田雄大、帖佐悦男
第35回九州・山口スポーツ医・科学研究会 2023.12.9
Event date： 2023.12.9
Presentation type：Oral presentation (general)
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大腿骨膝蓋面に生じた骨軟骨病変に対して自家骨軟骨柱と吸収ピンが骨接合に必要であった1例
肥後聖、横江琢示、田島卓也、山口奈美、大田智美、長澤誠、森田雄大、帖佐悦男
第35回九州・山口スポーツ医・科学研究会 2023.12.9
Event date： 2023.12.9
Presentation type：Oral presentation (general)
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リファピシン使用によりステロイド作用が減弱し治療に難渋した手関節非定型抗酸菌症の1例
松永美穂、大田智美、田島卓也、山口奈美、長澤誠、森田雄大、横江様示、帖佐悦男
第146回西日本整形・災害外科学会学術集会 2023.11.3
Event date： 2023.11.3 - 2023.11.4
Presentation type：Oral presentation (general)
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野球検診の結果から見た、肩関節可動域と投球障害の関連
長澤誠、大田智美、泉俊彦、川越秀一、帖佐悦男
第50回日本肩関節学会学術集会 2023.10.14
Event date： 2023.10.13 - 2023.10.14
Presentation type：Poster presentation