Papers - ODA Yasuharu
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Oda Y., Tsubouchi H., Ishii N., Kitamura A., Moriyama E., Mitsutome E., Sakai K., Shiomi K., Yanagi S., Miyazaki T.
Respiratory Medicine Case Reports 46 101930 2023.10
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Respiratory Medicine Case Reports
Small cell lung carcinoma (SCLC) is a neuroendocrine carcinoma with a poor prognosis and is a common cause of paraneoplastic syndromes. Paraneoplastic syndromes are characterized by neurological and endocrinological problems in patients with malignancy and are often associated with difficulty in induction of chemotherapy. Here we report the case of a patient with SCLC concomitant with two paraneoplastic syndromes, syndrome of inappropriate antidiuretic hormone secretion (SIADH) and Lambert–Eaton myasthenic syndrome (LEMS), who was treated with a platinum-doublet chemotherapy regimen. A 66-year-old male patient presented with a 1-month history of progressive proximal muscle weakness, ataxia gait and 5 kg of body weight loss. The laboratory tests revealed hyponatremia due to SIADH and the existence of antibodies against P/Q-type voltage-gated calcium channels. The nerve conduction study showed a low amplitude of compound muscle action potential (0.38 mv), a 34% decrement on 3-Hz stimulation, and a 1939% increment after maximum voluntary contraction in 10 seconds (7.75 mv). The endobronchial ultrasound transbronchial needle aspiration biopsy revealed the pathological findings of SCLC. A 2-cycle chemotherapy regimen of irinotecan plus cisplatin resulted in temporary tumor shrinkage that lasted 2 months, but the improvement of proximal muscle weakness and hyponatremia were maintained over the tumor re-progression period after chemotherapy. Although paraneoplastic syndromes accelerate the decrease in performance status, chemotherapy for SCLC may improve symptoms related to paraneoplastic syndromes and could be considered in similar cases.
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悪性胸水に対するTalcとOK-432による胸膜癒着術の検討． Reviewed
小田康晴、松元信弘、瀬戸口健介、宇都加寿子、重草貴文、松尾彩子、坪内拡伸、坂元昭裕、今津善史、有村保次、柳 重久、飯干宏俊、中里雅光
宮崎県医師会医学会誌 42 17 - 21 2018
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Mitsutome E., Yanagi S., Uchida T., Horiguchi T., Tsubouchi H., Sumiyoshi M., Kitamura A., Oda Y., Ueno H., Yamaguchi H., Miyazaki T.
Journal of Infection and Chemotherapy 31 ( 1 ) 102482 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Most cases of nontuberculous mycobacterial pulmonary disease (NTM-PD) have a progressive clinical course, and initiation of treatment is recommended rather than watchful waiting. The NTM-PD medications are frequently associated with adverse reactions, occasionally serious. Optimization of the methods for monitoring and managing adverse events in NTM-PD treatment is thus an important medical issue. Here we report a first case of postprandial hypoglycemia caused by the combination of clarithromycin (CAM) and rifampicin (RFP) in a patient with NTM-PD. A 73-year-old Japanese woman with NTM-PD was hospitalized for treatment with a combination of oral CAM, RFP, and ethambutol. She took the first doses of antibiotics before breakfast, and 3 h later went into a hypoglycemic state. Postprandial hypoglycemia occurred with high reproducibility and was accompanied by relative insulin excess. Continuous glucose monitoring with or without food and in combination with various patterns of medication revealed that the combination of CAM and RFP specifically induced postprandial hypoglycemia. Shifting the timing of administration of the CAM and RFP combination from morning to before sleep corrected the hypoglycemia and enabled continuation of the antimicrobial treatment. In conclusion, our report suggests the importance of introducing NTM-PD medication under inpatient management in order to closely monitor and early detect postprandial hypoglycemia and other serious adverse events.
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Kitamura A., Yanagi S., Shide K., Sato Y., Kamiunten A., Yamanari Y., Kitamura A., Sumiyoshi M., Oda Y., Tsubouchi H., Shimoda K., Miyazaki T.
American Journal of Case Reports 25 e945804 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Case Reports
Patient: Male, 32-year-old Final Diagnosis: B-acute lymphoblastic leukemia Symptoms: Dyspnea • face swelling Clinical Procedure: — Specialty: Oncology Objective: Unknown etiology Background: Fibrosing mediastinitis (FM) is a rare, fibroproliferative disorder within the mediastinum. It is extremely rare for hematologic malignancies to develop as FM. Case Report: A 32-year-old Japanese man with a 1-month history of headache and 2-week history of facial swelling underwent chest computed tomography (CT); a diffuse mass-like lesion was revealed in the anterior mediastinum with severe stenosis of vital mediastinal organs. After a surgical biopsy, an initial diagnosis of idiopathic FM was made. The FM lesions responded mildly to corticosteroids but recurred repeatedly. Sixteen months after the treatment initiation, blasts appeared in the peripheral blood (PB), and the patient was diagnosed with B-acute lymphoblastic leukemia/lymphoblastic lymphoma (B-ALL/LBL). Chemotherapy led to complete remission of the B-ALL/LBL and almost complete disappearance of FM-like lesions. Immunohistochemistry of the mediastinal biopsy specimen taken before the blasts’ appearance in PB demonstrated a CD34/CD7/terminal deoxynucleotidyl transferase-positive population, an identical pattern of expression common to the blasts in the patient’s PB and bone marrow. Conclusions: This is the first case report of B-ALL/LBL presenting as FM. This case underscores the importance of considering the possibility of latent hematologic malignancy even in the absence of new symptoms other than those caused by FM lesions for a long period of time. This is the first demonstration that leukemia cells may be present in the FM lesions from the initial stage of disease onset. Even if a diagnosis of idiopathic FM is confirmed, continued suspicion of the presence of hematologic malignancy is vital for improving patient outcomes.
DOI： 10.12659/AJCR.945804
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Comparison of evaluation by residents between simulation-based training and video-assisted lectures in induction training Reviewed
11 77 - 83 2023.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Clinico-radiologic Characteristics of Pulmonary Visceral Larva Migrans Caused by Ascaris suum. Reviewed
Nobuhiro Matsumoto, Hironobu Tsubouchi, Kensuke Setoguchi, Takanori Horiguchi, Takafumi Shigekusa, Shinpei Tsuchida, Ayako Matsuo, Yasuharu Oda, Shigehisa Yanagi, Haruhiko Maruyama, Masamitsu Nakazato
Internal medicine (Tokyo, Japan) 60 ( 18 ) 2899 - 2903 2021
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine
Objective Visceral larva migrans (VLM) caused by Ascaris suum is a major health problem in pig farming regions. The clinical characteristics of pulmonary VLM caused by A. suum, however, are unclear. We assessed the clinico-radiologic features of this disease. Methods Medical records, including the results of chest radiography and high-resolution computed tomography (HRCT), were retrospectively reviewed from January 2000 through June 2019, at the University of Miyazaki Hospital and Kyoritsuiin Hospital in Miyazaki Prefecture, Japan. Results Seven patients with VLM caused by A. suum were identified. All seven patients had a unique habit of consuming raw foods, such as organic vegetables, chicken, turkey, wild boar, and venison. All but one patient, who had eosinophilic pneumonia with a fever and severe fatigue, had only mild or no respiratory symptoms. All 7 patients had remarkable eosinophilia (median, 1960/μL) and high serum IgE levels (median, 1346 IU/mL). Chest HRCT revealed multiple nodules and multiple nodular ground-glass opacities in 57% and 29% of the patients, respectively. The pulmonary lesions were located predominantly in subpleural areas. All seven patients were treated with albendazole, which led to improvement within two to three months. Neither eggs nor parasites were detected in the feces or sputum of any patient. Conclusion Consumption of raw organic vegetables or raw meat is a possible route of A. suum infection. Infected patients exhibit mild respiratory symptoms, and multiple nodules with a halo in the subpleural area are a common finding on chest HRCT. Treatment with albendazole was effective in these cases.
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Yoshikawa N, Tazaki T, Hatanaka M, Oda Y, Matsumoto N, Sonoda J, Ikeda R
Journal of Clinical Pharmacy and Therapeutics 44 ( 1 ) 119 - 121 2019.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Pharmacy and Therapeutics
© 2018 John Wiley & Sons Ltd What is known and objective: Multi-drug combinations often make chemotherapy difficult owing to drug-drug interactions (DDIs). We report a rare and difficult-to-treat case due to DDIs between drugs for Mycobacterium avium complex (MAC) infection and antiepileptic drugs. Case description: A 70-year-old Japanese woman was diagnosed as having pulmonary MAC disease. She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital. Serum phenytoin concentrations increased upon the initiation of MAC infection treatment. What is new and Conclusion: We evaluated DDIs and adjusted the dosage of drugs by monitoring the serum drug level.
DOI： 10.1111/jcpt.12764
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上皮成長因子受容体(EGFR)遺伝子変異陽性進行非小細胞肺癌患者における治療耐性化後再生検結果の検討 Reviewed
瀬戸口 健介, 松尾 彩子, 松元 信弘, 宇都 加寿子, 重草 貴文, 小田 康晴, 坪内 拡伸, 坂元 昭裕, 有村 保次, 柳 重久, 飯干 宏俊, 中里 雅光
宮崎県医師会医学会誌 42 ( 2 ) 126 - 131 2018.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Arimura Yasuji, Tokojima Masatoshi, Matsumoto Nobuhiro, Kitamura Akiko, Tsuchida Shinpei, Matsuo Ayako, Oda Yasuharu, Tsubouchi Hironobu, Sakamoto Akihiro, Imazu Yoshifumi, Iiboshi Hirotoshi
The Journal of the Japan Society for Respiratory Endoscopy 38 ( 4 ) 285 - 290 2016.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society for Respiratory Endoscopy
<b><i>Background.</i></b> The diagnostic rate of pulmonary actinomycosis by bronchoscopy is reportedly low. <b><i>Case.</i></b> A 62-year-old woman complained of bloody sputum, which had started three weeks before admission to a neighborhood hospital. Chest computed tomography (CT) indicated a mass in the right upper lobe, and the patient was referred to another hospital. Bronchoscopy was performed but was not contributory in making a diagnosis. The bloody sputum persisted and the mass on CT enlarged. She was then referred to our hospital. She had untreated dental caries and diabetes. CT revealed a mass with central low attenuation areas, raising the possibility of pulmonary actinomycosis in the differential diagnosis. To collect a specimen from the central part of the mass, bronchoscopy using endobronchial ultrasonography with a guide-sheath (EBUS-GS) method was performed. Brushing cytology revealed sulfur granules characteristic of actinomycosis. <b><i>Conclusions.</i></b> The suspicion of pulmonary actinomycosis necessitated collection of a specimen from the deep part of the lesion. Bronchoscopy by the EBUS-GS method was useful for making the diagnosis.