|
所属 |
医学部 医学科 感覚運動医学講座眼科学分野 |
|
外部リンク |
|
所属学協会 【 表示 ／ 非表示 】
-
日本網膜硝子体学会
2008年4月 - 現在
-
日本緑内障学会
2006年4月 - 現在
-
The Association for Research in Vision and Ophthalmology (ARVO)
2000年10月 - 現在
-
日本遺伝子細胞治療学会
1999年4月 - 現在
-
日本眼科学会
1995年5月 - 現在
論文 【 表示 ／ 非表示 】
-
Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice 査読あり
Igarashi T., Ohsawa I., Kobayashi M., Miyazaki K., Igarashi T., Kameya S., Shiozawa A.L., Ikeda Y., Miyagawa Y., Sakai M., Okada T., Sakane I., Takahashi H.
Scientific Reports 12 ( 1 ) 13610 2022年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Scientific Reports
Retinitis pigmentosa (RP) is a genetically heterogeneous group of inherited retinal disorders involving the progressive dysfunction of photoreceptors and the retinal pigment epithelium, for which there is currently no treatment. The rd6 mouse is a natural model of autosomal recessive retinal degeneration. Given the known contributions of oxidative stress caused by reactive oxygen species (ROS) and selective inhibition of potent ROS peroxynitrite and OH·by H2 gas we have previously demonstrated, we hypothesized that ingestion of H2 water may delay the progression of photoreceptor death in rd6 mice. H2 mice showed significantly higher retinal thickness as compared to controls on optical coherence tomography. Histopathological and morphometric analyses revealed higher thickness of the outer nuclear layer for H2 mice than controls, as well as higher counts of opsin red/green-positive cells. RNA sequencing (RNA-seq) analysis of differentially expressed genes in the H2 group versus control group revealed 1996 genes with significantly different expressions. Gene and pathway ontology analysis showed substantial upregulation of genes responsible for phototransduction in H2 mice. Our results show that drinking water high in H2 (1.2–1.6 ppm) had neuroprotective effects and inhibited photoreceptor death in mice, and suggest the potential of H2 for the treatment of RP.
-
Incidence of Leber hereditary optic neuropathy in 2019 in Japan: a second nationwide questionnaire survey. 査読あり
Takano F, Ueda K, Godefrooij DA, Yamagami A, Ishikawa H, Chuman H, Ishikawa H, Ikeda Y, Sakamoto T, Nakamura M
Orphanet journal of rare diseases 17 ( 1 ) 319 2022年8月
-
Sano Y, Koyanagi Y, Wong JH, Murakami Y, Fujiwara K, Endo M, Aoi T, Hashimoto K, Nakazawa T, Wada Y, Ueno S, Gao D, Murakami A, Hotta Y, Ikeda Y, Nishiguchi KM, Momozawa Y, Sonoda KH, Akiyama M, Fujimoto A
Journal of medical genetics 2022年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Medical Genetics
Despite the successful identification of causative genes and genetic variants of retinitis pigmentosa (RP), many patients have not been molecularly diagnosed. Our recent study using targeted short-read sequencing showed that the proportion of carriers of pathogenic variants in EYS, the cause of autosomal recessive RP, was unexpectedly high in Japanese patients with unsolved RP. This result suggested that causative genetic variants, which are difficult to detect by short-read sequencing, exist in such patients. Using long-read sequencing technology (Oxford Nanopore), we analysed the whole genomes of 15 patients with RP with one heterozygous pathogenic variant in EYS detected in our previous study along with structural variants (SVs) in EYS and another 88 RP-associated genes. Two large exon-overlapping deletions involving six exons were identified in EYS in two patients with unsolved RP. An analysis of an independent patient set (n=1189) suggested that these two deletions are not founder mutations. Our results suggest that searching for SVs by long-read sequencing in genetically unsolved cases benefits the molecular diagnosis of RP.
-
Kawano S., Imai T., Sakamoto T., Yamamoto S., Baba T., Sato E., Kitahashi M., Tatsumi T., Miura G., Niizawa T., Sakamoto T., Yamakiri K., Yamashita T., Otsuka H., Sameshima S., Yoshinaga N., Sonoda S., Hirakata A., Koto T., Inoue M., Hirota K., Itoh Y., Orihara T., Emoto Y., Sano M., Takahashi H., Tokizawa R., Yamashita H., Nishitsuka K., Kaneko Y., Nishi K., Yoshida A., Ono S., Hirokawa H., Sogawa K., Omae T., Ishibazawa A., Kishi S., Akiyama H., Matsumoto H., Mukai R., Morimoto M., Nakazawa M., Suzuki Y., Kudo T., Adachi K., Ishida S., Noda K., Kase S., Mori S., Ando R., Saito M., Suzuki T., Takahashi K., Nagai Y., Nakauchi T., Yamada H., Kusaka S., Tsujioka D., Tsujikawa A., Suzuma K., Ishibashi T., Sonoda K.H., Ikeda Y., Kohno R., Keijiro Ishikawa , Kondo M., Kozawa M., Kitaoka T., Tsuiki E., Ogura Y., Yoshida M., Morita H., Kato A., Hirano Y., Sugitani K., Terasaki H., Iwase T., Ito Y., Ueno S., Kaneko H., Nonobe N., Kominami T., Azuma N., Yokoi T., Shimada H., Nakashizuka H., Hattori T., Shinojima A., Kutagawa Y., Shiraga F., Morizane Y., Kimura S., Ikeda T., Kida T., Sato T., Fukumoto M., Emi K., Nakashima H., Ohji M.
Japanese Journal of Ophthalmology 66 ( 3 ) 271 - 277 2022年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Ophthalmology
Purpose: To investigate the characteristics of retinal detachment (RD) and compare the outcomes of surgical interventions, such as scleral buckling (SB), pars plana vitrectomy (PPV), or PPV combined with SB, conducted on holidays and on workdays to determine the optimal surgical timing for primary RD treatment in clinical practice. Study design: Retrospective cohort study. Methods: The cohort included 3178 patients with primary RD registered in the Japan Retinal Detachment Registry between February 2016 and March 2017. Surgery data were divided into holiday and workday groups. A descriptive analysis of primary RD characteristics was performed, and the outcomes for each surgical intervention were assessed. The primary outcome was anatomical failure at 6 months post-surgery classified as follows: level 1, inoperable state; level 2, anatomical recovery with silicone-oil use; and level 3, additional surgery required for RD repair. Results: The holiday group comprised 108 and the workday, 3070 cases of primary RD. Compared with those in the workday group, surgery in the holiday group took longer (PPV, P < 0.0001; SB, P = 0.047) and was performed by less experienced surgeons (P = 0.014). However, there were no statistically significant differences in surgical failure 6 months post-surgery between the workday and holiday groups. Conclusion: Although surgery conducted on holidays and workdays was not significantly different in terms of outcome, some surgery should be postponed with proper preoperative interim measures to limit RD progress until it can be conducted on workdays by a well-prepared team.
書籍等出版物 【 表示 ／ 非表示 】
-
眼科診療ビジュアルラーニング５ 「網膜, 硝子体」
池田 康博（ 担当： 分担執筆）
中山書店 2020年9月
記述言語：日本語
-
眼疾患アトラスシリーズ２ 「後眼部アトラス」
池田 康博（ 担当： 分担執筆）
総合医学社 2019年10月
記述言語：日本語
-
眼疾患アトラスシリーズ２ 「後眼部アトラス」
池田 康博（ 担当： 分担執筆）
総合医学社 2019年10月
記述言語：日本語
MISC 【 表示 ／ 非表示 】
-
【眼科領域の最新医療・プレシジョンメディシン】網膜色素変性の遺伝子治療
池田康博
Precision Medicine 2020年2月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
-
【眼科の先進的医療Up to Date】遺伝性網膜変性疾患の遺伝子治療
池田康博
あたらしい眼科 2019年11月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
-
機器・薬剤紹介 HOYA暗所視支援眼鏡MW-10 HiKARI
池田康博
眼科 2019年9月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
-
【知っておきたい稀な網膜・硝子体ジストロフィ】錐体杆体ジストロフィ
吉田倫子、池田康博
OCULISTA 2019年6月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
-
【眼科医の手引】 暗所視支援眼鏡
池田康博
日本の眼科 2019年3月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌）
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
-
短後毛様動脈虚血による正常眼圧緑内障モデルの作成とアドレノメジュリン効果の検討
研究課題/領域番号：22K09770 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
中馬 秀樹、
担当区分：研究分担者
-
網膜色素変性を自然発症するカニクイザルの繁殖と治療法開発への応用
研究課題/領域番号：22K09769 2022年04月 - 2025年03月
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
担当区分：研究代表者