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Frontier Science Research Center Department of Promotion of advanced Research Division of Young & Excellent Researcher Development |
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Associate Professor |
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SAITO Akatsuki
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Research Interests 【 display / non-display 】
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霊長類
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応用獣医学
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宿主因子
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動物モデル
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フラビウイルス
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エイズ
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ウイルス
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獣医微生物学
Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
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Life Science / Laboratory animal science
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Life Science / Molecular biology
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Life Science / Immunology
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Life Science / Virology
Education 【 display / non-display 】
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The University of Tokyo
- 2011.3
Country：Japan
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University of Miyazaki Faculty of Agriculture
- 2008.3
Country：Japan
Professional Memberships 【 display / non-display 】
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日本エイズ学会
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日本獣医学会
Papers 【 display / non-display 】
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Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation Reviewed
Akatsuki Saito, Takashi Irie, Rigel Suzuki, Tadashi Maemura, Hesham Nasser, Keiya Uriu, Yusuke Kosugi, Kotaro Shirakawa, Kenji Sadamasu, Izumi Kimura, Jumpei Ito, Jiaqi Wu, Kiyoko Iwatsuki-Horimoto, Mutsumi Ito, Seiya Yamayoshi, Samantha Loeber, Masumi Tsuda, Lei Wang, Seiya Ozono, Erika P. Butlertanaka, Yuri L. Tanaka, Ryo Shimizu, Kenta Shimizu, Kumiko Yoshimatsu, Ryoko Kawabata, Takemasa Sakaguchi, Kenzo Tokunaga, Isao Yoshida, Hiroyuki Asakura, Mami Nagashima, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Kazuhisa Yoshimura, Akifumi Takaori-Kondo, Masaki Imai, Mika Chiba, Hirotake Furihata, Haruyo Hasebe, Kazuko Kitazato, Haruko Kubo, Naoko Misawa, Nanami Morizako, Kohei Noda, Akiko Oide, Mai Suganami, Miyoko Takahashi, Kana Tsushima, Miyabishara Yokoyama, Yue Yuan, Shinya Tanaka, So Nakagawa, Terumasa Ikeda, Takasuke Fukuhara, Yoshihiro Kawaoka, Kei Sato
Nature 602 ( 7896 ) 300 - 306 2021.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/s41586-021-04266-9
Other Link： https://www.nature.com/articles/s41586-021-04266-9
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Kato NX, Dosaka H, Adachi Y, Kaneko Y, Hirai T, Sekiguchi S, Fuke N, Saito A
The Journal of veterinary medical science 2026.4
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Veterinary Science
DOI： 10.1292/jvms.26-0138
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Hinata ABE, Nanami X KATO, Mika TANABE, Taichi SHIMABUKURO, Saki HASHIMOTO, Takuya HIRAI, Naoyuki FUKE, Akatsuki SAITO
Journal of Veterinary Medical Science 2026.3
Authorship：Last author, Corresponding author Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Veterinary Science
DOI： 10.1292/jvms.25-0517
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Fukushima YV, Saito N, Mekata H, Saito A
Scientific reports 16 ( 1 ) 4101 2026.2
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC
Abstract
The development of non-invasive diagnostic methods for zoonotic viral infections is important for animal welfare and public health. Sebum-based diagnostic methods using commercial oil-blotting films have been used for SARS-CoV-2 detection in humans, but similar strategies for veterinary use remain unexplored. Severe fever with thrombocytopenia syndrome (SFTS), caused by the SFTS virus (SFTSV), presents a major health threat in Asia—especially in Japan, where multiple cases of cat-to-veterinarian transmission have been reported. To address this need for safer diagnostics, we sought to establish a sebum-based RNA virus detection method for cats. We designed primers that efficiently detected RNA from feline sebum while distinguishing it from human and feline DNA/RNA. Using this platform, we deemed the ear to be the optimal sebum collection site and confirmed that feline immunodeficiency virus RNA can be reliably identified from ear sebum with sensitivity comparable to conventional blood-based testing. Additionally, we detected SFTSV RNA from sebum samples of infected cat. Our findings introduce a minimally invasive, safe diagnostic platform for feline viral infections, reducing animal distress while safeguarding veterinarians and pet owners from zoonotic risks. This strategy is an important step toward realizing the One Health framework by advancing the well-being of animals and humans.DOI： 10.1038/s41598-026-37655-z
Other Link： https://www.nature.com/articles/s41598-026-37655-z
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Ryosuke Matsuura, Akatsuki Saito, Fumihiro Nagata, Noriko Fukushi, Yasunobu Matsumoto, Takashi Fukushima, Kazuhiro Fujimoto, Masato Kozaki, Junichi Somei, Yoko Aida
Catalysts 16 ( 2 ) 168 - 168 2026.2
Publishing type：Research paper (scientific journal) Publisher：MDPI AG
The highly pathogenic avian influenza virus (HPAIV) is widely distributed worldwide and causes significant economic losses. Transmission of HPAIV occurs through direct contact between infected and susceptible birds or indirectly via contaminated materials. In recent years, airborne transmission of HPAIV has also been reported, underscoring the need for novel approaches to effectively inactivate airborne HPAIV. Photocatalysts have attracted significant attention as potential antiviral agents. In this study, we demonstrated that a TiO2-mediated photocatalytic reaction inactivated HPAIV and H1N1 seasonal influenza viruses in liquid, reducing their infectivity by 90.7% and 94.4%, respectively, after 60 min. Mechanistic analyses revealed decreased virion size and surface structure disruption, as determined by transmission electron microscopy. Additional evidence of viral protein and genome damage was obtained using Western blotting and RT-qPCR, respectively. Given the broad antiviral activity of photocatalysts, these findings suggest that they can inactivate influenza viruses regardless of strain or subtype. Notably, photocatalysts inactivated 80% of aerosolized H1N1 seasonal influenza viruses within 5 min. These results provide strong evidence that photocatalysts are capable of inactivating airborne influenza viruses. This study represents the first demonstration that photocatalysts can inactivate HPAIV and aerosolized influenza viruses. These findings provide strong evidence that photocatalysts represent a promising countermeasure against HPAIV, with potential applicability across different strains and subtypes.
Books 【 display / non-display 】
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実験医学
齊藤暁、入江崇.（ Role： Joint author , SARS-CoV-2デルタ株の高病原性メカニズムの解明）
羊土社 2022.5
Language：Japanese Book type：General book, introductory book for general audience
MISC 【 display / non-display 】
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I型インターフェロンで処理した骨髄性白血病細胞株THP-1において,APOBEC3タンパク質は感染性ウイルス産生のためのHIV-1 Vifの主要な標的である
清水凌, JONATHAN Michael, JONATHAN Michael, 齊藤暁, 池田輝政
日本エイズ学会誌 26 ( 4 ) 2024
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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カニクイザルAPOBEC3遺伝子の遺伝的多様性と抗ウイルス活性の解析
麦田友佳, 浦野恵美子, 齊藤暁, 大出裕高, 岩谷靖雅, 保富康宏, 池田輝政
日本エイズ学会誌 26 ( 4 ) 2024
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Genetic and functional diversity of APOBEC3 genes in Cynomolgus monkey (Macaca fascicularis)
麦田友佳, 浦野恵美子, 齊藤暁, 大出裕高, 岩谷靖雅, 保富康宏, 池田輝政
日本ウイルス学会学術集会プログラム・予稿集(Web) 71st 2024
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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APOBEC3 proteins are the primary target of HIV-1 Vif for infectious virus production in THP-1, even with type I interferon treatment
清水凌, 清水凌, JONATHAN Michael, JONATHAN Michael, 齊藤暁, 池田輝政
日本ウイルス学会学術集会プログラム・予稿集(Web) 71st 2024
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Immune resistance of newly emerging SARS-CoV-2 Omicron variants
瓜生慧也, 伊東潤平, SHOFA Maya, 清水凌, BEGUM MST Monira, 山岨大智, PLIANCHAISUK Arnon, 藤田滋, 小杉優介, 齊藤暁, 池田輝政, 佐藤佳
日本ウイルス学会学術集会プログラム・予稿集(Web) 70th 2023
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Presentations 【 display / non-display 】
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Species tropism of Orthohepadnavirus Invited International conference
Akatsuki Saito
The 3rd France-Japan symposium on HIV/AIDS and infectious disease basic research
Event date： 2024.10.28 - 2024.10.30
Presentation type：Symposium, workshop panel (nominated)
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霊長類感染病態モデルを用いたウイルス学研究
齊藤暁
第167回日本獣医学会学術集会
Event date： 2024.9.10 - 2024.9.13
Presentation type：Symposium, workshop panel (nominated)
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抗レトロウイルス宿主因子である哺乳類TRIM5の遺伝的、機能的多様性 International conference
齊藤暁
日本遺伝学会第96回高知大会
Event date： 2024.9.4 - 2024.9.6
Presentation type：Symposium, workshop panel (nominated)
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Species tropism of Orthohepadnavirus Invited International conference
Akatsuki Saito
Japan-UK International Research project
Event date： 2024.7.29
Presentation type：Symposium, workshop panel (nominated)
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Host ZCCHC3 blocks HIV-1 infection and production by a dual mechanism International conference
Akatsuki Saito
United States - Japan Cooperative Medical Sciences Program, 22nd International Conference on Emerging Infectious Diseases in the Pacific Rim, AIDS Panel
Event date： 2024.3.8 - 2024.3.9
Presentation type：Symposium, workshop panel (nominated)
Industrial property rights 【 display / non-display 】
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ブタ由来培養細胞、及びそれを用いたウイルス増殖方法及びウイルス分離方法
齊藤 暁、田中友理
Applicant：宮崎大学
Application no：2024-178528 Date applied：2024.10.11
Announcement no：2025-067879 Date announced：2025.4.24
Country of applicant：Domestic
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臨床検体からのウイルスの分離方法
齊籐 暁、Maya Shofa
Applicant：宮崎大学
Application no：2023-051037 Date applied：2023.3.28
Announcement no：2024-140050 Date announced：2024.10.10
Country of applicant：Domestic
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ＳＡＲＳ－ＣｏＶ－２を含む広範なウイルス感染症に対する治療薬
齊藤 暁, 岡本 徹, 宮本 洋一, 岡 正啓
Applicant：国立大学法人 宮崎大学, 国立大学法人 大阪大学, 国立研究開発法人医薬基盤・健康・栄養研究所
Application no：2023-511333 Date applied：2022.3.29
Announcement no：WO2022/210644 Date announced：2023.9.28
Country of applicant：Domestic , International (PCT) application
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ＳＡＲＳ－ＣｏＶ－２を含む広範なウイルス感染症に対する治療薬
齊藤 暁、岡本 徹、宮本 洋一、岡 正啓
Applicant：宮崎大学、大阪大学、医薬基盤・健康・栄養研究所
Application no：PCT/JP2022/015292 Date applied：2022.3.29
Announcement no：WO2022/210644 A1 Date announced：2022.10.6
Awards 【 display / non-display 】
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ECC山口メモリアルエイズ研究奨励賞
2025.12 日本エイズ学会
齊藤暁
Award type：International academic award (Japan or overseas)
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最優秀発表賞＜症例報告部門＞
2025.11 JSFM第12回猫の集会 保護猫施設内でアウトブレイクが認められた猫ヘパドナウイルスの ウイルス学的、病理学的解析
加藤七海, 銅坂悠, 足立行庸, 金子泰之, 平井卓哉, 福家直幸, 齊藤暁
Award type：International academic award (Japan or overseas)
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最優秀発表賞＜キャットフレンドリー部門＞
2025.11 JSFM第12回猫の集会 皮脂を用いたネコ RNA ウイルス感染症診断方法の確立
福嶋優莉, 齊藤波子, 目堅博久, 齊藤暁
Award type：International academic award (Japan or overseas)
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CADIC最優秀論文賞
2024.7 宮崎大学産業動物防疫リサーチセンター（CADIC）
齊藤暁
Award type：International academic award (Japan or overseas)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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マダニが保有するＭ分節欠損フェヌイウイルスの生物学的意義の解明
Grant number：25K22364 2025.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 挑戦的研究（萌芽）
Authorship：Coinvestigator(s)
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Elucidation of species specificity of Jembrana disease virus
Grant number：24K09227 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Principal investigator
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動物フォーミーウイルスベクターの基盤構築と牛伝染性リンパ腫ワクチンの開発
Grant number：23K23765 2024.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship：Coinvestigator(s)
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ゲノムワイドスクリーニングに基づくSFTS発症小動物モデルの樹立と治療開発展開
Grant number：23K21273 2024.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship：Coinvestigator(s)
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Promotion of comprehensive interdisciplinary virology for the post-COVID era
Grant number：23K20041 2023.04 - 2030.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (International Leading Research )
Authorship：Coinvestigator(s)