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Affiliation |
Engineering educational research section Applied Chemistry Program |
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Title |
Associate Professor |
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External Link |
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Related SDGs |
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INADA Asuka
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Degree 【 display / non-display 】
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博士（工学） ( 2016.9 宮崎大学 )
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修士（工学） ( 2014.3 宮崎大学 )
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学士（工学） ( 2012.3 宮崎大学 )
Research Areas 【 display / non-display 】
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Others / Others / Applied biofunctional and bioprocess engineering
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Others / Others / Transfer phenomena and unit operations
Papers 【 display / non-display 】
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Water‐Based Synthesis of β‐Sheet‐Like Supramolecular Metallohydrogel Organized by Using a Native Ultrashort Peptide Sequence Reviewed International journal
Asuka Inada, Aki Motomura, Tatsuya Oshima
Chemistry – A European Journal 30 ( 11 ) e202303160 2024.2
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley
Designing supramolecular hydrogels using short peptides is challenging. To control self‐assembly, a certain amount of organic solvent is typically added to the system, or the short peptide is modified with a functional group that is hydrophobic, hydrophilic, or highly coordinative. We discovered that l‐His‐l‐Ile‐l‐Thr (HIT), a very short unmodified “native” tripeptide, selectively responds to Cu2+ ions in pure water to form a transparent supramolecular metallohydrogel. Circular dichroism analysis revealed that Cu2+ ions, but no other metal species, caused HIT to change from a random‐coil‐like to a β‐sheet‐like structure. Other spectroscopic methods were used to characterize the properties of the supramolecular metallohydrogel. These results are expected to facilitate the development of native short peptides as advanced functional biomaterials.
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Controlled release of nanoparticles in the tumor environment by tripeptide coordination-driven self-assembly Reviewed International journal
Inada A., Hoshihara N., Oshima T.
Colloids and Surfaces A Physicochemical and Engineering Aspects 723 2025.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Colloids and Surfaces A Physicochemical and Engineering Aspects
In this study, nanoparticles (NPs) were synthesized by the coordination-bond-driven self-assembly of two tripeptides, H-Trp-His-Phe-OH (WHF) and H-Trp-His-Tyr-OH (WHY), with zinc ions. In addition, a one-pot method was developed to synthesize NP complexes with the anticancer drug doxorubicin (DOX) for application as drug delivery carriers. DOX release from DOX@NP-Zn(WHF) and DOX@NP-Zn(WHY) was enhanced under pH conditions mimicking the tumor microenvironment compared to physiological conditions. Cell viability assays demonstrated that NP-Zn(WHF) and NP-Zn(WHY) carriers exhibited minimal toxicity, whereas DOX@NP-Zn(WHF) and DOX@NP-Zn(WHY) showed excellent anticancer activity against tumor cells in a DOX concentration-dependent manner. NP-Zn(WH-X) could be a promising new carrier for controlled drug delivery in cancer therapy.
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Machine Learning Prediction of Au(III) Extractability of Various Organic Solvents Based on Ion Solvation in Hydrochloric Acid Media Reviewed International journal
Oshima T., Iwakiri Y., Yokota H., Inada A.
ACS Sustainable Chemistry and Engineering 13 ( 24 ) 9110 - 9118 2025.6
Language：English Publishing type：Research paper (scientific journal) Publisher：ACS Sustainable Chemistry and Engineering
Selective recovery of gold from waste electrical and electronic equipment has attracted increasing attention. Au(III), which is present as tetrachloroauric acid (HAuCl<inf>4</inf>) in hydrochloric acid media, can be extracted by using various organic solvents, such as ketones and ethers. However, the decisive factors of the solvent for predicting Au(III) extractability have not been confirmed. In the present study, the relationship between the extraction percentage of Au(III) and the properties of the solvent was investigated for 79 types of solvents. Based on the relationships between the Hansen solubility parameters of the solvent and the extraction percentage of Au(III) in 5.0 M HCl with a threshold of 80%, the extractability was classified with 93.7% accuracy. To predict the Au(III) extractability, a machine learning model was constructed using the relationship between the molecular descriptors of the solvents obtained from RDKit as explanatory variables and the extraction percentage of Au(III) as the objective variable. By selection of the descriptors that showed a strong correlation with the Au(III) extraction percentage, the squared correlation coefficient (R<sup>2</sup>) of the test data for the nonlinear support vector regression model using 35 descriptors was 0.943. Machine learning was performed again with the addition of surface charge density descriptors obtained from the solvent structure using the conductor-like screening model for real solvents. The R<sup>2</sup> value of the test data for the nonlinear support vector regression model using 28 descriptors, including the hydrogen bond acceptor descriptor as an additional descriptor, was 0.899, which was slightly lower than that of the model with 35 descriptors. Experimental validation using six additional solvents confirmed the model’s accuracy, with predicted values closely matching the measured extraction percentages.
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Sequence optimization of lipid-modified amphiphilic tetrapeptides as anticancer drug carriers. Reviewed International journal
Inada A, Sawao A, Shinoda M, Oshima T
Journal of pharmaceutical sciences 114 ( 6 ) 103768 2025.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Pharmaceutical Sciences
In this study, 19 tetrapeptides, each consisting of four amino acid residues, were designed and modified with oleic acid to serve as amphiphilic dispersants for anticancer drug delivery. The lipid-modified peptides (Ole-pep) were evaluated for their ability to disperse paclitaxel (Ptx), a poorly water-soluble anticancer drug. The water dispersibility of Ptx was significantly increased when peptides with two or more positively or negatively charged functional groups were used as dispersants. One specific Ole-pep demonstrated a critical micelle concentration of 0.0682 × 10−3 mol/dm3, confirming its excellent amphiphilic properties and capacity to encapsulate Ptx. Cytotoxicity studies in HeLa cells, a cell line derived from human cervical cancer cells, confirmed that the complexes with Ptx were highly cytotoxic regardless of the peptide used. Additionally, the results suggested that certain peptides, particularly those with a high number of Lys residues, exhibited cytotoxicity on their own.
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Evaluation of Water Dispersibility and Cell Accumulation of β-Cryptoxanthin Formulations Prepared Using Membrane Emulsification Method Reviewed International journal
Taniguchi Arisa, Ochi Takahiro, Oshima Tatsuya, Inada Asuka, Akaki Takeshi, Yamamoto Kenji, Shimizu Masataka
KAGAKU KOGAKU RONBUNSHU 51 ( 1 ) 12 - 17 2025.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Society of Chemical Engineers, Japan
Various health functions have been reported for β-cryptoxanthin (BCX), which is abundantly contained in citrus fruits. As BCX is a poorly water-soluble and chemically unstable carotene, formulation techniques for increased dispersibility in digestive fluids and stability is desired to improve oral bioavailability. In this study, an O/W emulsion was prepared using an oil phase containing BCX extracted from tangerine juice residue and an aqueous phase containing sodium caseinate (CasNa) and sucrose fatty acid ester (L-1695). The emulsion was then subjected to membrane emulsification using a Shirasu porous glass (SPG) membrane with a uniform pore size. The resulting emulsion was of monodisperse particle size and was lyophilized to obtain a solid dispersion. For the solid dispersion, the water dispersibility and thermal stability of BCX were significantly improved, and the particle size was also monodisperse. In order to evaluate the oral bioavailability of BCX, cell membrane permeation and accumulation tests for the BCX formulation after pseudo-digestion were performed using Caco-2 cell monolayer membranes. Cell membrane permeation of BCX was not confirmed, however, the amount of BCX accumulated in Caco-2 cells was increased by the formulation.
Books 【 display / non-display 】
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分離プロセスの最適化とスケールアップの進め方, 5章8節 正浸透膜法（FO）における基礎物性の測定と条件検討
高橋智輝, 稲田飛鳥, 松山秀人（312-324）
技術情報協会 2019.11
Language：Japanese
MISC 【 display / non-display 】
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ペプチドで「溶かす」：薬・栄養を体に届ける Invited
大島達也，稲田飛鳥
化学工学 88 ( 2 ) 69 - 72 2024.2
Authorship：Last author Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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正浸透膜法に用いる熱応答性駆動溶液の研究動向
稲田 飛鳥
化学工学 84 ( 5 ) 256 - 256 2020.5
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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難水溶性薬物・生理活性物質のキャリアあるいは分散剤となるペプチドの設計
大島 達也, 稲田 飛鳥
ケミカルエンジニヤリング 65 25 - 31 2020.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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MEMBRANE 44 ( 6 ) 276 - 288 2019
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：THE MEMBRANE SOCIETY OF JAPAN
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Fabrication of Innovative Separation Membranes in Kobe University
KEIZO NAKAGAWA, ASUKA INADA, EIJI KAMIO, TOMOHISA YOSHIOKA, HIDETO MATSUYAMA
Sen'i Gakkaishi 74 ( 5 ) P - 186 2018.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Society of Fiber Science and Technology Japan
Presentations 【 display / non-display 】
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One-pot development of nanoparticles using zinc ions and peptides and application to DDS carriers International conference
Naoto Hoshihara, Asuka Inada, Tatsuya Oshima
The 35th International Symposium on Chemical Engineering (ISChE 2024)
Event date： 2024.11.29 - 2024.12.1
Presentation type：Oral presentation (general)
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Development of unmodified Short Peptide Metallohydrogels Self-Assembled by Copper Ions International conference
Aki Motomura, Asuka Inada, Tatsuya Oshima
The 35th International Symposium on Chemical Engineering (ISChE 2024)
Event date： 2024.11.29 - 2024.12.1
Presentation type：Oral presentation (general)
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Enhanced water-dispersibility of linolenic acid by complexation with peptides prepared from casein or soy proteins International conference
Shinohara Chihiro, Tatsuya Oshima,Asuka Inada
The 35th International Symposium on Chemical Engineering (ISChE 2024)
Event date： 2024.11.29 - 2024.12.1
Presentation type：Oral presentation (general)
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D2EHPAによる3価金属イオンの抽出における中性配位子共存の影響
門川雄大、大島達也、大榮薫、大渡啓介
連合年会2024（第43回溶媒抽出討論会・第37回日本イオン交換研究発表会）
Event date： 2024.10.31 - 2024.11.1
Presentation type：Poster presentation
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D2EHPAを用いた3価金属の分離に対する希釈剤の影響
長友鳳潤、大島達也、大榮薫、稲田飛鳥
連合年会2024（第43回溶媒抽出討論会・第37回日本イオン交換研究発表会）
Event date： 2024.10.31 - 2024.11.1
Presentation type：Poster presentation
Awards 【 display / non-display 】
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萌芽賞
2022.4 一般財団法人 田中貴金属記念財団 ペプチドと貴金属からなる革新的金属有機構造体の開発と水素吸蔵媒体への応用
稲田 飛鳥
Award type：International academic award (Japan or overseas)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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配位高分子型金属ペプチド錯体を基盤材料とした革新的DDSキャリアの開発
Grant number：25K08405 2025.04 - 2028.03
日本学術振興会 科学研究費助成事業 基盤研究(C)（一般） 基盤研究(C)（一般）
稲田 飛鳥
Authorship：Principal investigator
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希少金属への優れた分離回収能力と低環境負荷性を両立した新規抽出溶媒の機械学習探索
Grant number：23H01756 2023.04 - 2027.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
大島 達也
Authorship：Coinvestigator(s)
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腫瘍組織特有環境に応答して薬剤放出する金属ペプチド構造体キャリアの開発
Grant number：21K14473 2021.04 - 2024.03
日本学術振興会 科学研究費助成事業 若手研究 若手研究
稲田 飛鳥
Authorship：Principal investigator
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Development of a thermoresponsive draw solute with zero leakage for forward osmosis process
Grant number：19K15339 2019.04 - 2021.03
Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Authorship：Principal investigator
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チャネル型正浸透膜の創製と究極的ゼロエネルギー水処理プロセスの構築
Grant number：18H03854 2018.04 - 2022.03
日本学術振興会 科学研究費補助金 基盤研究(A)
松山 秀人、稲田 飛鳥
Authorship：Coinvestigator(s)
1. 新規水チャネル型FO膜の創製
1-1．環状ペプチド分子集合体チャネル膜の創製（松山、吉岡、佐伯）：環状ペプチド分子集合体を導入した平面脂質二分子膜について、FO膜としての性能を確認するとともに、環状ペプチド内の官能基が水分子の拡散性や透過性に影響を及ぼすことを明らかにした。1-2．高分子液晶垂直配向チャネル膜の創製（彌田、稲田）：液晶性ブロックコポリマー（BCP）をFO膜として使うための複合膜化を検討した。新規購入の超音波ホモジナイザーで乳化したアルギン酸ナトリウム層（犠牲層）をガラス基板上に作製し、その上にBCP薄膜を製膜し、水中でBCP薄膜を犠牲層から剥離させ支持膜に重ねることで複合膜を作製する手法を開発した。1-3．革新的ロバスト無機ゼオライトFO膜の創製（松方）：ZSM-5膜を用いて、無機FO膜の正浸透膜特性を説明する透過モデルの検討を進めた。また、高い透過性と塩阻止率を両立する無機FO膜の設計指針を得る検討を継続した。1-4．計算機科学による高機能FO膜開発支援 (吉岡)：MD計算によりチャネル内表面特性が水および塩の拡散性に及ぼす影響を評価した。親水的なチャネル入り口が高透水性に寄与するが、疎水化されたチャネル内では塩の拡散性が大きくなることが明らかとなった。
2. 新規刺激応答性駆動溶液（DS）の創製（小野、高橋）
熱応答性イオン液体の温度依存的浸透圧発現機構の解析を基に、相図、粘度、浸透圧、相分離性をより最適化したイオン液体DSを設計した。また、イオン液体を利用した膜の調製と膜骨格にイオン液体構造を導入する技術についても開発した。
３．FO膜透過とDS再生を含む連続システムによるFS評価とFO膜システムの実証（松山、神尾、中川）
FO膜分離、DS連続再生、RO膜によるDS回収を一体化した小型連続FOシステムを構築し、海水淡水化を想定した連続運転条件検討を行った。