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Affiliation |
Engineering educational research section Department of Applied Chemistry Program |
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Title |
Assistant Professor |
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External Link |
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INADA Asuka
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Degree 【 display / non-display 】
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博士（工学） ( 2016.9 宮崎大学 )
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修士（工学） ( 2014.3 宮崎大学 )
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学士（工学） ( 2012.3 宮崎大学 )
Research Areas 【 display / non-display 】
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Others / Others / Applied biofunctional and bioprocess engineering
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Others / Others / Transfer phenomena and unit operations
Papers 【 display / non-display 】
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Inada A, Motomura A, Oshima T
Chemistry - A European Journal 30 ( 11 ) e202303160 2023.11
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Chemistry - A European Journal
Designing supramolecular hydrogels using short peptides is challenging. To control self-assembly, a certain amount of organic solvent is typically added to the system, or the short peptide is modified with a functional group that is hydrophobic, hydrophilic, or highly coordinative. We discovered that l-His-l-Ile-l-Thr (HIT), a very short unmodified “native” tripeptide, selectively responds to Cu2+ ions in pure water to form a transparent supramolecular metallohydrogel. Circular dichroism analysis revealed that Cu2+ ions, but no other metal species, caused HIT to change from a random-coil-like to a β-sheet-like structure. Other spectroscopic methods were used to characterize the properties of the supramolecular metallohydrogel. These results are expected to facilitate the development of native short peptides as advanced functional biomaterials.
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Separation of gallium(III) using 2-nonanone based on ion solvation in acidic chloride media Reviewed
Hashizume M., Oshima T., Inada A.
Separation and Purification Technology 335 2024.5
Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Separation and Purification Technology
Gallium (Ga) is an indispensable electronic material for devices such as light-emitting diodes, and the demand for Ga is expected to increase. In this study, a comparative analysis was carried out on Ga(III) extraction by neutral ketones and ethers in the presence of highly concentrated hydrochloric acid (HCl). Generally, Ga(III) extractability was high using aliphatic and aromatic ketones. By comparison, Ga(III) extractability was lower using monoether compounds. High Ga(III) extractability was obtained using aromatic 1,2-diethers. Suitable solvents for Ga extraction were screened based on Hansen solubility parameters. 2-Nonanone (2-NON), an aliphatic ketone, was found to have a high extraction capacity (more than 95 mM) competitive with dibutyl carbitol. The physical properties of 2-NON a low water solubility (0.5 g dm−3), low viscosity (1.3 mPa·s), and a sufficiently high flash point (76 °C) are suitable for industrial processes. Ga(III) and Fe(III) were selectively extracted using 2-NON and other solvents. Ga(III) extracted using 2-NON was quantitatively stripped by contact with aqueous solutions with low HCl concentrations. 2-NON was used to separate Ga(III) from a mixed solution of metal ions to investigate recycling copper indium gallium diselenide solar cells. Ga(III) was selectively extracted from the mixture with over 90 % stripping. The concentrations of the metal ions in the stripping solutions were 1.0 mM for Cu(II), 9.9 mM for In(III), 56.7 mM for Ga(III), and 0.02 mM for Se(IV), suggesting that 2-NON can be used for Ga(III) separation.
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消化ペプチドとの複合化によるβ-クリプトキサンチンの水分散性およびCaco-2細胞膜透過性の改善 Reviewed
稲田飛鳥，野崎唯那，澤尾綾音，大島達也
化学工学論文集 2023.8
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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Oshima T., Iwakiri Y., Inada A.
Hydrometallurgy 220 2023.6
Authorship：Last author Publishing type：Research paper (scientific journal) Publisher：Hydrometallurgy
Ion solvation extraction using ethers and ketones is industrially applied for the extraction and separation of Au(III) from acidic chloride media. Although these have been in practical use since the 1970s, requirements for valid extractants (solvents) have not been systematically clarified. In this study, the relationship between Au(III) extractability using various organic solvents and their Hansen solubility parameters (HSPs) was investigated. The extractability of the solvents increases with the increase of the polar forces (δP) of the solvents, however, solvents with much higher δP values are water-miscible and unsuitable for solvent extraction. Hence a HSP sphere with center coordinates at δD = 17.73, δP = 7.82, δH = 2.48, where D, P and H represent dispersive, polar and hydrogen-bonding forces, was obtained from the results of extraction tests using 26 solvents, with the exclusion of HSPs for 25 water-miscible solvents. Twenty-four of the 26 solvents tested were properly classified as valid or invalid for the extraction of Au(III) using the Hansen sphere. The results suggest partial utility of the prediction of the extractability using HSPs. Dicyclohexylketone, which has HSPs within the sphere, was selected as a potential extractant: it showed sufficient extractability and selectivity for the extraction of Au(III).
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Extraction of Au(III) Using Aromatic Ketones in Acidic Chloride Media Reviewed
OSHIMA Tatsuya, MIYAKE Kota, HASHIZUME Mai, INADA Asuka
Solvent Extraction Research and Development, Japan 30 ( 2 ) 129 - 136 2023
Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Association of Solvent Extraction
Recently, the extraction of Au(III) using the series of aliphatic ketones in hydrochloric acid media has been investigated in detail. The present study describes the extraction behaviors of Au(III) using a series of aromatic ketones, which has never been reported. Aromatic ketones with shorter alkyl side chains showed higher extractability. The rapid extraction and the extraction capacity using aromatic ketones were comparable to the industrial extractant dibutyl carbitol (DBC). Aromatic ketones, except acetophenone, are less soluble in water than DBC. The flash points of aromatic ketones are satisfactorily high for industrial operation, but their specific gravities comparable to that of water are unwelcome. Butyrophenone selectively extracted Au(III) from many other metals, except for high extraction of Fe(III) and Ga(III) at high concentrations. Au(III) extracted using butyrophenone recovered quantitatively as metallic gold by reduction using oxalic acid.
Books 【 display / non-display 】
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分離プロセスの最適化とスケールアップの進め方, 5章8節 正浸透膜法（FO）における基礎物性の測定と条件検討
高橋智輝, 稲田飛鳥, 松山秀人（312-324）
技術情報協会 2019.11
Language：Japanese
MISC 【 display / non-display 】
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ペプチドで「溶かす」：薬・栄養を体に届ける Invited
大島達也，稲田飛鳥
化学工学 88 ( 2 ) 69 - 72 2024.2
Authorship：Last author Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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正浸透膜法に用いる熱応答性駆動溶液の研究動向
稲田 飛鳥
化学工学 84 ( 5 ) 256 - 256 2020.5
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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難水溶性薬物・生理活性物質のキャリアあるいは分散剤となるペプチドの設計
大島 達也, 稲田 飛鳥
ケミカルエンジニヤリング 65 25 - 31 2020.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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MEMBRANE 44 ( 6 ) 276 - 288 2019
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：THE MEMBRANE SOCIETY OF JAPAN
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Fabrication of Innovative Separation Membranes in Kobe University
KEIZO NAKAGAWA, ASUKA INADA, EIJI KAMIO, TOMOHISA YOSHIOKA, HIDETO MATSUYAMA
Sen'i Gakkaishi 74 ( 5 ) P - 186 2018.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Society of Fiber Science and Technology Japan
Presentations 【 display / non-display 】
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Enhanced bioaccessibility of curcumin by incorporation in a nanoparticle formulation using cocoa butter International conference
A. Taniguchi, A. Inada, T. Oshima
The 34th International Symposium on Chemical Engineering (ISChE 2023)
Event date： 2023.12.1 - 2023.12.3
Language：English Presentation type：Oral presentation (general)
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Factors for extraction selectivity for organic amines using a calix[6]arene acetic acid derivative International conference
K. Kawano, K. Ohe, A. Inada, T. Oshima
The 34th International Symposium on Chemical Engineering (ISChE 2023)
Event date： 2023.12.1 - 2023.12.3
Language：English Presentation type：Oral presentation (general)
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Development of nanoparticles formed between metal ions and peptides and application to DDS carriers International conference
N. Hoshihara, T. Oshima, A. Inada
The 34th International Symposium on Chemical Engineering (ISChE 2023)
Event date： 2023.12.1 - 2023.12.3
Language：English Presentation type：Oral presentation (general)
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Development of Short Peptide Metallohydrogels Self-Assembled by Copper Ions International conference
A. Motomura, T. Oshima, A. Inada
The 34th International Symposium on Chemical Engineering (ISChE 2023)
Event date： 2023.12.1 - 2023.12.3
Language：English Presentation type：Oral presentation (general)
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Development of amphiphilic tetrapeptides as dispersants for paclitaxel International conference
M. Shinoda, A. Sawao, A. Inada, T. Oshima
The 34th International Symposium on Chemical Engineering (ISChE 2023)
Event date： 2023.12.1 - 2023.12.3
Language：English Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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萌芽賞
2022.4 一般財団法人 田中貴金属記念財団 ペプチドと貴金属からなる革新的金属有機構造体の開発と水素吸蔵媒体への応用
稲田 飛鳥
Award type：International academic award (Japan or overseas)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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希少金属への優れた分離回収能力と低環境負荷性を両立した新規抽出溶媒の機械学習探索
Grant number：23H01756 2023.04 - 2027.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究（B）
大島 達也
Authorship：Coinvestigator(s)
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腫瘍組織特有環境に応答して薬剤放出する金属ペプチド構造体キャリアの開発
Grant number：21K14473 2021.04 - 2024.03
日本学術振興会 科学研究費助成事業 若手研究 若手研究
稲田 飛鳥
Authorship：Principal investigator
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Development of a thermoresponsive draw solute with zero leakage for forward osmosis process
Grant number：19K15339 2019.04 - 2021.03
Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Authorship：Principal investigator
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チャネル型正浸透膜の創製と究極的ゼロエネルギー水処理プロセスの構築
Grant number：18H03854 2018.04 - 2022.03
日本学術振興会 科学研究費補助金 基盤研究(A)
松山 秀人、稲田 飛鳥
Authorship：Coinvestigator(s)
1. 新規水チャネル型FO膜の創製
1-1．環状ペプチド分子集合体チャネル膜の創製（松山、吉岡、佐伯）：環状ペプチド分子集合体を導入した平面脂質二分子膜について、FO膜としての性能を確認するとともに、環状ペプチド内の官能基が水分子の拡散性や透過性に影響を及ぼすことを明らかにした。1-2．高分子液晶垂直配向チャネル膜の創製（彌田、稲田）：液晶性ブロックコポリマー（BCP）をFO膜として使うための複合膜化を検討した。新規購入の超音波ホモジナイザーで乳化したアルギン酸ナトリウム層（犠牲層）をガラス基板上に作製し、その上にBCP薄膜を製膜し、水中でBCP薄膜を犠牲層から剥離させ支持膜に重ねることで複合膜を作製する手法を開発した。1-3．革新的ロバスト無機ゼオライトFO膜の創製（松方）：ZSM-5膜を用いて、無機FO膜の正浸透膜特性を説明する透過モデルの検討を進めた。また、高い透過性と塩阻止率を両立する無機FO膜の設計指針を得る検討を継続した。1-4．計算機科学による高機能FO膜開発支援 (吉岡)：MD計算によりチャネル内表面特性が水および塩の拡散性に及ぼす影響を評価した。親水的なチャネル入り口が高透水性に寄与するが、疎水化されたチャネル内では塩の拡散性が大きくなることが明らかとなった。
2. 新規刺激応答性駆動溶液（DS）の創製（小野、高橋）
熱応答性イオン液体の温度依存的浸透圧発現機構の解析を基に、相図、粘度、浸透圧、相分離性をより最適化したイオン液体DSを設計した。また、イオン液体を利用した膜の調製と膜骨格にイオン液体構造を導入する技術についても開発した。
３．FO膜透過とDS再生を含む連続システムによるFS評価とFO膜システムの実証（松山、神尾、中川）
FO膜分離、DS連続再生、RO膜によるDS回収を一体化した小型連続FOシステムを構築し、海水淡水化を想定した連続運転条件検討を行った。 -
バイオファウリングを抑制するクォーラムセンシング阻害剤徐放型逆浸透膜の新規開発
Grant number：17H06861 2017.04 - 2019.03
科学研究費補助金 研究活動スタート支援
稲田 飛鳥
Authorship：Principal investigator