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Affiliation |
Engineering educational research section Applied Chemistry Program |
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Title |
Associate Professor |
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External Link |
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Related SDGs |
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INADA Asuka
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Degree 【 display / non-display 】
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博士（工学） ( 2016.9 宮崎大学 )
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修士（工学） ( 2014.3 宮崎大学 )
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学士（工学） ( 2012.3 宮崎大学 )
Research Areas 【 display / non-display 】
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Others / Others / Applied biofunctional and bioprocess engineering
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Others / Others / Transfer phenomena and unit operations
Papers 【 display / non-display 】
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Water‐Based Synthesis of β‐Sheet‐Like Supramolecular Metallohydrogel Organized by Using a Native Ultrashort Peptide Sequence Reviewed International journal
Asuka Inada, Aki Motomura, Tatsuya Oshima
Chemistry – A European Journal 30 ( 11 ) e202303160 2024.2
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley
Designing supramolecular hydrogels using short peptides is challenging. To control self‐assembly, a certain amount of organic solvent is typically added to the system, or the short peptide is modified with a functional group that is hydrophobic, hydrophilic, or highly coordinative. We discovered that l‐His‐l‐Ile‐l‐Thr (HIT), a very short unmodified “native” tripeptide, selectively responds to Cu2+ ions in pure water to form a transparent supramolecular metallohydrogel. Circular dichroism analysis revealed that Cu2+ ions, but no other metal species, caused HIT to change from a random‐coil‐like to a β‐sheet‐like structure. Other spectroscopic methods were used to characterize the properties of the supramolecular metallohydrogel. These results are expected to facilitate the development of native short peptides as advanced functional biomaterials.
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Dissolving Amyloid Fibrils with Natural Deep Eutectic Solvents: Citric Acid-Glycerol Achieves Superior Solubilization and Partial Protein Refolding. Reviewed International journal
Hirano S, Oshima T, Inada A, Tsuruda T
ACS applied bio materials 9 ( 7 ) 3564 - 3572 2026.3
Language：English Publishing type：Research paper (scientific journal) Publisher：ACS Applied Bio Materials
Amyloid protein aggregates pose a significant challenge due to their extreme insolubility and association with neurodegenerative diseases. To identify effective solvents for dissolving amyloid-forming proteins, a screening of deep eutectic solvents (DESs), including natural DESs (NADES), and related solvents was conducted. Aggregated lysozyme (LA) was reproducibly prepared under acidic and thermal conditions as a model of poorly soluble protein aggregates. Spectroscopic analyses using Thioflavin T fluorescence and circular dichroism (CD), along with morphological observations under polarized light and SEM, confirmed the formation of β-sheet-rich amyloid-like structures. The citric acid−glycerol DES showed the highest solubility for LA, outperforming other DESs and DMSO. Its performance was further enhanced by the addition of ∼5% water. This result also suggests a strong contribution of multivalent organic acids, such as citric and malic acid, to protein solubilization. CD analysis indicated that lysozyme recovered a native-like secondary structure, suggesting partial structural recovery after dissolution in this DES. These findings highlight the potential of DESs as effective media for dissolving protein aggregates and suggest their possible utility in protein refolding and related biotechnological applications, including potential future biomedical applications.
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Enhanced bioaccessibility of curcumin incorporated in microparticles prepared using cocoa butter which has a moderate melting point Reviewed International journal
Taniguchi A., Oshima T., Inada A.
Journal of Food Science and Technology 2026
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Food Science and Technology
A solid dispersion of curcumin in cocoa butter was prepared. The dispersion was prepared by emulsification followed by lyophilization. The apparent solubility of curcumin was increased by formulation with cocoa butter. The formulation was dispersed in an aqueous medium as a hydrocolloid. The formulation increased the accumulation of curcumin in Caco-2 cells.
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Controlled release of nanoparticles in the tumor environment by tripeptide coordination-driven self-assembly Reviewed International journal
Asuka Inada, Naoto Hoshihara, Tatsuya Oshima
Colloids and Surfaces A: Physicochemical and Engineering Aspects 723 137412 - 137412 2025.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV
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Cancer cell microenvironment-responsive bio-metal-organic frameworks for anticancer drug delivery Reviewed International journal
Asuka Inada, Hirona Yoshinaka, Misa Kikuchi, Tatsuya Oshima
JCIS Open 19 100149 - 100149 2025.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV
Books 【 display / non-display 】
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金属有機構造体(MOF)研究の動向と用途展開
稲田飛鳥（ Role： Joint author , 第2章 配位子にペプチドを用いた金属有機構造体の開発）
株式会社シーエムシー出版 2025.4 （ ISBN:9784781318646 ）
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分離プロセスの最適化とスケールアップの進め方, 5章8節 正浸透膜法（FO）における基礎物性の測定と条件検討
高橋智輝, 稲田飛鳥, 松山秀人（312-324）
技術情報協会 2019.11
Language：Japanese
MISC 【 display / non-display 】
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ペプチドで「溶かす」：薬・栄養を体に届ける Invited
大島達也，稲田飛鳥
化学工学 88 ( 2 ) 69 - 72 2024.2
Authorship：Last author Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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正浸透膜法に用いる熱応答性駆動溶液の研究動向
稲田 飛鳥
化学工学 84 ( 5 ) 256 - 256 2020.5
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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難水溶性薬物・生理活性物質のキャリアあるいは分散剤となるペプチドの設計
大島 達也, 稲田 飛鳥
ケミカルエンジニヤリング 65 25 - 31 2020.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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MEMBRANE 44 ( 6 ) 276 - 288 2019
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：THE MEMBRANE SOCIETY OF JAPAN
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Fabrication of Innovative Separation Membranes in Kobe University
KEIZO NAKAGAWA, ASUKA INADA, EIJI KAMIO, TOMOHISA YOSHIOKA, HIDETO MATSUYAMA
Sen'i Gakkaishi 74 ( 5 ) P - 186 2018.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Society of Fiber Science and Technology Japan
Presentations 【 display / non-display 】
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Screening of Natural Deep Eutectic Solvents for Dissolution of Poorly soluble Proteins International conference
S. Hirano, T. Oshima, A. Inada, T. Tsuruda
The 35th International Symposium on Chemical Engineering (ISChE 2025)
Event date： 2025.12
Presentation type：Oral presentation (general)
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Supramolecular Gelation Driven by Cu(II)-Binding Tetrapeptides International conference
K. Fukumoto, A. Inada, T. Oshima, K. Ohe
The 36th International Symposium on Chemical Engineering (ISChE 2025)
Event date： 2025.12
Presentation type：Oral presentation (general)
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Structure control of dipeptide-AuNP composites via peptide sequence variation and their application in catalysis International conference
N. Hiramatsu, A. Inada, T. Oshima, K. Ohe
The 36th International Symposium on Chemical Engineering (ISChE 2025)
Event date： 2025.12
Presentation type：Oral presentation (general)
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Application of Natural Deep Eutectic Solvents for Enhancing Solubility of Poorly Water-Soluble Drugs International conference
C. Shinohara, T. Oshima, A. Inada
The 36th International Symposium on Chemical Engineering (ISChE 2025)
Event date： 2025.12
Presentation type：Oral presentation (general)
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【特別講演】銅(II)イオンによる短鎖ペプチドの超分子化
稲田 飛鳥
令和７年度 高分子学会九州支部特別講演会
Event date： 2025.11
Presentation type：Oral presentation (invited, special)
Awards 【 display / non-display 】
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萌芽賞
2022.4 一般財団法人 田中貴金属記念財団 ペプチドと貴金属からなる革新的金属有機構造体の開発と水素吸蔵媒体への応用
稲田 飛鳥
Award type：International academic award (Japan or overseas)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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配位高分子型金属ペプチド錯体を基盤材料とした革新的DDSキャリアの開発
Grant number：25K08405 2025.04 - 2028.03
日本学術振興会 科学研究費基金 基盤研究(C)（一般）
稲田 飛鳥
Authorship：Principal investigator
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希少金属への優れた分離回収能力と低環境負荷性を両立した新規抽出溶媒の機械学習探索
Grant number：23H01756 2023.04 - 2027.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
大島 達也
Authorship：Coinvestigator(s)
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腫瘍組織特有環境に応答して薬剤放出する金属ペプチド構造体キャリアの開発
Grant number：21K14473 2021.04 - 2024.03
日本学術振興会 科学研究費助成事業 若手研究 若手研究
稲田 飛鳥
Authorship：Principal investigator
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Development of a thermoresponsive draw solute with zero leakage for forward osmosis process
Grant number：19K15339 2019.04 - 2021.03
Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Authorship：Principal investigator
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チャネル型正浸透膜の創製と究極的ゼロエネルギー水処理プロセスの構築
Grant number：18H03854 2018.04 - 2022.03
日本学術振興会 科学研究費補助金 基盤研究(A)
松山 秀人、稲田 飛鳥
Authorship：Coinvestigator(s)
1. 新規水チャネル型FO膜の創製
1-1．環状ペプチド分子集合体チャネル膜の創製（松山、吉岡、佐伯）：環状ペプチド分子集合体を導入した平面脂質二分子膜について、FO膜としての性能を確認するとともに、環状ペプチド内の官能基が水分子の拡散性や透過性に影響を及ぼすことを明らかにした。1-2．高分子液晶垂直配向チャネル膜の創製（彌田、稲田）：液晶性ブロックコポリマー（BCP）をFO膜として使うための複合膜化を検討した。新規購入の超音波ホモジナイザーで乳化したアルギン酸ナトリウム層（犠牲層）をガラス基板上に作製し、その上にBCP薄膜を製膜し、水中でBCP薄膜を犠牲層から剥離させ支持膜に重ねることで複合膜を作製する手法を開発した。1-3．革新的ロバスト無機ゼオライトFO膜の創製（松方）：ZSM-5膜を用いて、無機FO膜の正浸透膜特性を説明する透過モデルの検討を進めた。また、高い透過性と塩阻止率を両立する無機FO膜の設計指針を得る検討を継続した。1-4．計算機科学による高機能FO膜開発支援 (吉岡)：MD計算によりチャネル内表面特性が水および塩の拡散性に及ぼす影響を評価した。親水的なチャネル入り口が高透水性に寄与するが、疎水化されたチャネル内では塩の拡散性が大きくなることが明らかとなった。
2. 新規刺激応答性駆動溶液（DS）の創製（小野、高橋）
熱応答性イオン液体の温度依存的浸透圧発現機構の解析を基に、相図、粘度、浸透圧、相分離性をより最適化したイオン液体DSを設計した。また、イオン液体を利用した膜の調製と膜骨格にイオン液体構造を導入する技術についても開発した。
３．FO膜透過とDS再生を含む連続システムによるFS評価とFO膜システムの実証（松山、神尾、中川）
FO膜分離、DS連続再生、RO膜によるDS回収を一体化した小型連続FOシステムを構築し、海水淡水化を想定した連続運転条件検討を行った。