Papers - INADA Asuka
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Preparation of a positively charged NF membrane by evaporation deposition and the reaction of PEI on the surface of the C-PES/PES blend UF membrane Reviewed International journal
Maryam Bagheri, Saeid Rajabzadeh, Mohamed R. Elmarghany, Rozita M. Moattari, Omid Bakhtiari, Asuka Inada, Hideto Matsuyama, Toraj Mohammadi
Progress in Organic Coatings 141 105570 2020.4
Language：English Publishing type：Research paper (scientific journal)
© 2020 Elsevier B.V. A positive surface thin-film composite membrane was prepared via evaporation deposition and the reaction of polyethyleneimine (PEI) with the carboxyl groups on the surface of a carboxylated polysulfone (C-PES)/PES UF blend membrane. UF blend membranes with different C-PES/PES ratios were prepared and PEI solution was deposited on them, with subsequent cross-linking using glutaraldehyde. The optimal C-PES/PES ratio was used on the supporting UF blend membrane, with optimal crosslinking time using glutaraldehyde to obtain a significant rejection of salt and organic molecules rejection, while retaining the water flux at a reasonable level. The preparation of a UF blend membrane with a negative surface charge based on the C-PES/PES ratio and its interaction with PEI solutions with different concentrations for deposition and reaction was the key point in obtaining a membrane with the appropriate rejection of divalent cation and organic solutes. The effects of the membrane surface charge on the rejection of different salts and organic solutes were evaluated at different pressures to understand the rejection mechanism of the prepared NF membranes.
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Inada A., Oue T., Yamashita S., Yamasaki M., Oshima T., Matsuyama H.
European Journal of Pharmaceutical Sciences 136 104936 2019.8
Language：English Publishing type：Research paper (scientific journal) Publisher：European Journal of Pharmaceutical Sciences
© 2019 Elsevier B.V. The water-solubility of coenzyme Q10 (CoQ10) is extremely low because of its hydrophobicity, which results in low bioavailability. In this study, peptide mixtures derived from different proteins (casein, albumin, gelatin, lysozyme, zein and hemoglobin) were prepared and used as dispersants ofCoQ10. Most peptide mixtures, except for that derived from lysozyme, enhanced the water-dispersibility of CoQ10 by forming complexes with CoQ10. In particular, the apparent solubility of CoQ10complexed with the casein hydrolysate (Pepcas) was the highest. Pepcas was fractionated by ammonium sulfate precipitation and ultrafiltration to find the most effective peptides for enhancing water-dispersibility of CoQ10. The peptide fraction that had a relatively hydrophobic nature and peptides of higher-than-average molecular weights (PepcasA) was found to be the most effective. Results from differential thermal analysis and powder X-ray diffraction revealed that the complex between CoQ10 and PepcasA in the solid state was amorphous. In solution, the complex is a hydrocolloid with particle sizes of 154–279 nm.
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Poly(amine-co-ester) nanoparticles for effective Nogo-B knockdown in the liver
Jiajia Cui, Alexandra S. Piotrowski-Daspit, Junwei Zhang, Mingjie Shao, Laura G. Bracaglia, Teruo Utsumi, Young-Eun Seo, Jenna DiRito, Eric Song, Christine Wu, Asuka Inada, Gregory T. Tietjen, Jordan S. Pober, Yasuko Iwakiri, W. Mark Saltzman
Journal of Controlled Release 304 ( 28 ) 259 - 267 2019.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Morpholine derivatives as thermoresponsive draw solutes for forward osmosis desalination Reviewed
Inada A., Takahashi T., Kumagai K., Matsuyama H.
Industrial and Engineering Chemistry Research 58 ( 27 ) 12253 - 12260 2019.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Industrial and Engineering Chemistry Research
© 2019 American Chemical Society. To develop a forward osmosis (FO) process, selection of draw solutes (DSs) is a critical factor in determining water permeability of the process. In this search for novel high-performance DSs, various morpholine derivatives were investigated for their thermoresponsive potential. 4-Butylmorpholine (BuMP) showed a preferable minimum lower critical solution temperature for the FO process (31.7 °C). The dilute phase of BuMP after phase separation at 70 °C showed a low concentration (3.3 wt %) and low osmotic pressure (3.16 bar). In the FO flux test, the water permeability and reverse solute flux of BuMP (55.0 wt %, 28 bar) against water were Jw 2.09 L m-2 h-1 and Js 14.0 g m-2 h-1, respectively. Using 0.6 M NaCl (model seawater) as feed solution, BuMP (94.6 wt %) could extract water from this model seawater (Jw 0.56 L m-2 h-1). These results indicate a high potential for MP derivatives as DSs and provide new guidance for their development for FO desalination.
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Inada A., Yumiya K., Takahashi T., Kumagai K., Hashizume Y., Matsuyama H.
Journal of Membrane Science 574 147 - 153 2019.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Membrane Science
© 2018 Elsevier B.V. Recently, forward osmosis (FO) is attracting research attention once again. In a FO process, it is important to develop a draw solution (DS) with a high osmotic pressure and low solute leakage. In this study, thermoresponsive star-shaped oligomers with a glycerol backbone were developed as new draw solutes for FO. A series of glycerol-oligo(ethylene oxide)-block-oligo(butylene oxide) (GEB) oligomers were systematically designed and synthesized. The average degrees of polymerization of ethylene oxide (EO; m) and butylene oxide (BO; n) units of GEmBn were varied to control the hydrophilic/hydrophobic balance of the molecule. Aqueous solutions of GEBs were evaluated in terms of their osmotic pressures, phase diagrams, and viscosities. Most of them showed a lower critical solution (LCST)-type phase separation at temperatures below 60 °C. The osmotic pressure of 68 wt% GE7B3 (concentration of the dense phase after phase separation at 60 °C) was 74 bar, about 2.6 times higher than that of seawater. Moreover, the leakage of GE7B3 was much lower than that of conventional draw solutes. The osmotic pressure of the dilute phase of a GE7B3 solution at 60 °C was less than 2 bar, implying reduced energy consumption during post-processing by low-pressure reverse osmosis to collect pure water.
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Inada A., Sakurai Y., Oshima T., Baba Y., Matsuyama H.
Colloids and Surfaces B: Biointerfaces 167 144 - 149 2018.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Colloids and Surfaces B: Biointerfaces
© 2018 Elsevier B.V. Recently, digestive peptides prepared as a casein hydrolysate have been found to be an effective dispersant for the poorly water-soluble drug paclitaxel (Ptx). A major hydrophobic peptide in the digested peptides was identified as YQEPVLGPVRGPFPIIV (PepY) by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry with the “LIFT” technique. In the present study, three peptides PepY, VVVPPFLQPEVMGVSKV (PepV), and KFQSEEQQQTEDELQDK (PepK) were chemically synthesized by Fmoc solid-phase synthesis to compare their function as dispersants for Ptx. PepV and PepK are the most hydrophobic and hydrophilic peptides, respectively, in the sequence of β-casein, which are the same length as PepY (PepY, PepV, and PepK are abbreviated as Peps). The complex between Ptx and Peps (Ptx-Peps) was prepared by mixing an ethanol solution of Ptx and an aqueous solution of Peps, followed by lyophilization. The complex with PepV, which is estimated to be the most hydrophobic of the peptides, had the greatest ability to improve the water dispersibility of Ptx. The water dispersibility of the complexes between Ptx and PepY and PepV increased as the amount of the peptides increased, whereas PepK was not effective in enhancing the dispersibility of Ptx. Furthermore, a peptide mixture obtained from a casein hydrolysate [Pep (fraction A)] was more effective for the enhancement of Ptx dispersibility than the single peptide PepY. These results suggests that a variety of peptides in the casein hydrolysate contribute toward complexation with Ptx.
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Inada A., Wang M., Oshima T., Baba Y.
Journal of Chemical Engineering of Japan 49 ( 6 ) 544 - 551 2016
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Chemical Engineering of Japan
© 2016 The Society of Chemical Engineers, Japan. Recently, a peptide mixture (Pep) obtained as a casein hydrolysate was found to be effective for enhancing the water solubility or water dispersibility for poorly water-soluble drugs. In the present study, complexation of Pep with ionic and nonionic drugs indomethacin (Indo), ibuprofen (Ibu), and prednisolone (Pre) was studied. The water solubility of complexes containing Indo and Ibu, both of which have a dissociable carboxylic group, increased with increasing pH. In contrast, the water solubility of a complex containing Pre, which does not contain dissociable groups, was almost independent of pH. As all three complexes were permeable through an ultrafiltration membrane with a molecular-weight cutoff 10,000 gmol-1, the complexes were present not as colloidal materials but relatively small species in aqueous media. Moreover, Indo, Ibu, and Pre were complexed with twelve peptide fractions, which were derived from Pep by combining ammonium sulfate precipitation with ultrafiltration. Water solubility of the drugs increased with all Pep-derived fractions, suggesting that various peptides interact with the drugs.
DOI： 10.1252/jcej.15we313
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Enhancing the water dispersibility of paclitaxel by complexation with hydrophobic peptides Reviewed
Inada A., Oshima T., Baba Y.
Colloids and Surfaces B: Biointerfaces 135 408 - 415 2015.11
Language：English Publishing type：Research paper (scientific journal) Publisher：Colloids and Surfaces B: Biointerfaces
© 2015 Elsevier B.V. The complex between paclitaxel (Ptx) and a peptide mixture (Pep) was prepared to enhance of the water-dispersibility of Ptx. Pep was prepared by enzymatic hydrolysis of casein, followed by fractionation using ammonium sulfate precipitation and ultrafiltration. The Ptx and Pep complex (Ptx-Pep) was prepared by mixing an ethanol solution of Ptx and an aqueous solution of Pep followed by lyophilization. The water dispersibility test of Ptx-Pep prepared using different fractions of Pep demonstrated that a fraction (Pep-A), containing relatively hydrophobic peptides with high molecular weights, was effective in enhancing the water dispersibility of Ptx. The sequences of the major peptides in Pep-A were identified by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry with "LIFT" technique. The water dispersibility of the complex between Ptx and Pep-A (Ptx-Pep-A) was independent of pH, even though it is positively or negatively charged under strongly acidic and neutral conditions. As the particle size of Ptx-Pep-A in aqueous media was 147-215 nm, Ptx-Pep-A was present as a hydrocolloidal material in aqueous media.
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Enhancement of water dispersibility of quercetin by complexation with casein Reviewed
Oshima T., Masuda Y., Haranomura T., Inada A., Baba Y.
Kagaku Kogaku Ronbunshu 40 ( 2 ) 125 - 130 2014
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kagaku Kogaku Ronbunshu
The flavonoid quercetin (Que) is believed to act as an antioxidant as well as a scavenger for free radicals. However, the oral bioavailability of Que is insufficient due to its low aqueous solubility. In the present study, a complex of Que and milk casein (Cas) was prepared to enhance the water dispersibility of Que. The complex (Que-Cas) was prepared by mixing an ethanol solution of Que and an aqueous solution of Cas, followed by evaporation of ethanol in vacuo and lyophilization. The water dispersibility of Que-Cas increased as the quantity of Cas in the complex increased. The zeta potential of Que-Cas suggests that Cas dominates the surface charge of Que-Cas. The particle size of Que-Cas in aqueous media was polydisperse and 90-120 nm or larger, suggesting that Que-Cas was present as a hydrocolloidal material. Characterization of Que-Cas using X-ray diffraction as well as fluorescence quenching of Que showed that Que was incorporated in the hydrocolloid in an amorphous state. © 2014 The Society of Chemical Engineers, Japan.
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Enhancement of water solubility of indomethacin by complexation with protein hydrolysate Reviewed
Inada A., Oshima T., Takahashi H., Baba Y.
International Journal of Pharmaceutics 453 ( 2 ) 587 - 593 2013
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：International Journal of Pharmaceutics
Complex formation between indomethacin (Indo) and casein hydrolysate was developed as a novel technique for enhancing the water solubility of Indo. The complex (Indo-Pep) was prepared by mixing an ethanol solution of Indo and an aqueous solution of peptide mixture, followed by lyophilization. The water solubility of Indo-Pep under weakly acidic and neutral conditions is much higher than that of Indo alone. The water solubility of Indo increased with increasing quantity of peptide. Characterization of Indo-Pep using scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction showed that Indo was incorporated in Indo-Pep in an amorphous state. The fluorescence quenching of Indo-Pep also suggested complexation between Indo and the peptides. An aqueous solution of Indo-Pep was fractioned by centrifugation followed by filtration using membrane filters and ultrafilters. Analysis of the fractions by dynamic light scattering and ultraviolet-visible spectroscopy showed that Indo-Pep consisted of small particles and was not a hydrocolloidal material. © 2013 Elsevier B.V. All rights reserved.
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Oshima T., Inada A., Baba Y.
Solvent Extraction Research and Development 20 ( 0 ) 71 - 77 2013
Language：English Publishing type：Research paper (scientific journal) Publisher：Solvent Extraction Research and Development
Complexation with casein hydrolysate (Pep) can be used for enhancing the water solubility of indomethacin. In the present study, the hydrophilic/ hydrophobic balance of the complex (Indo-Pep) was evaluated using a poly(ethylene glycol)/dextran (PEG/DEX) aqueous two-phase system (ATPS). As the distribution ratio of Indo-Pep decreases with increasing Pep concentration, indomethacin was found to be more hydrophilic by complexation with Pep. The distribution ratio of Indo-Pep reached a minimum value when the pH was 7-8, where the distribution ratio of Pep showed a maximum value. From the results of the distribution ratios of Indo-Pep prepared using different components of Pep, the hydrophilic/hydrophobic balance of Pep seemed to influence the hydrophilic/hydrophobic balance of Indo-Pep.
DOI： 10.15261/serdj.20.71