Takao Irie

写真a

Affiliation

Faculty of Agriculture Department of Veterinary Science

Title

Associate Professor

External Link

Degree 【 display / non-display

  • 博士(獣医学) ( 2018.3   山口大学大学院連合獣医学研究科 )

Research Areas 【 display / non-display

  • Life Science / Parasitology

 

Papers 【 display / non-display

  • Anthelmintic Baiting of Foxes against Echinococcus multilocularis in Small Public Area, Japan. Reviewed International journal

    Kohji Uraguchi, Takao Irie, Hirokazu Kouguchi, Azusa Inamori, Mariko Sashika, Michito Shimozuru, Toshio Tsubota, Kinpei Yagi

    Emerging infectious diseases   28 ( 8 )   1677 - 1680   2022.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    We distributed anthelmintic baits on a university campus in Japan inhabited by foxes infected with Echinococcus multilocularis to design an effective baiting protocol for small public areas. High-density baiting can reduce the risk for human exposure to the parasite to near zero. However, monthly baiting is recommended to maintain this effect.

    DOI: 10.3201/eid2808.212016

    Scopus

    PubMed

    researchmap

  • Tongue worm (subclass: Pentastomida) infection and treatment in two domesticated reptiles - A case report. Reviewed

    Takaki Y, Irie T, Takami Y, Asakawa M, Yoshida A

    Parasitology international   91   102617   2022.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.parint.2022.102617

    PubMed

  • Diagnostic value of recombinant nanoluciferase fused <i>Toxoplasma gondii</i> antigens in Luciferase-linked Antibody Capture Assay (LACA) for <i>Toxoplasma</i> infection in pigs Reviewed

    DUONG Hieu Duc, TANIGUCHI Yuji, TAKASHIMA Yasuhiro, SEKIGUCHI Satoshi, AYE Khin Myo, AHMADI Parnian, BUI Linh Khanh, IRIE Takao, NAGAYASU Eiji, YOSHIDA Ayako

    Journal of Veterinary Medical Science   advpub ( 0 )   905 - 913   2022.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPANESE SOCIETY OF VETERINARY SCIENCE  

    DOI: 10.1292/jvms.22-0099

    PubMed

    CiNii Research

  • Sensitivity comparison between Mini-FLOTAC and conventional techniques for the detection of Echinococcus multilocularis eggs. Reviewed International journal

    Izumi Kida, Hirokazu Kouguchi, Takao Irie, Kinpei Yagi, Ryo Nakao, Nariaki Nonaka

    Parasitology international   87   102522 - 102522   2022.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Canines serve as the definitive host of Echinococcus multilocularis. This study evaluated the sensitivity of the Mini-FLOTAC technique (MF) for the detection of E. multilocularis eggs in definitive hosts. First, we investigated the effects of heat inactivation and preservative conditions on the detection rate of eggs obtained from experimentally infected dogs. The sensitivity of MF was compared with that of eight other techniques: the centrifugal flotation with sucrose or zinc sulfate, MGL, AMS III, and a combination of MF and flotation/sedimentation techniques. Finally, we compared the sensitivity of MF and the centrifugal flotation with sucrose for the feces of E. multilocularis-infected foxes. The detection rate reached a plateau level with a specific gravity (s.g.) 1.22 for fresh eggs, but the highest rates were obtained with s.g. greater than 1.32 for heat-inactivated eggs. There was no significant difference in the detection rate among the preservative conditions. MF showed significantly higher EPG than the other techniques. Moreover, it showed higher diagnostic sensitivity for the fox feces than the centrifugal flotation technique. These results suggest that heat inactivation may alter s.g. of E. multilocularis eggs and that MF with zinc sulfate (s.g. = 1.32) would be effective for detecting heat-inactivated E. multilocularis eggs.

    DOI: 10.1016/j.parint.2021.102522

    Scopus

    PubMed

    researchmap

  • Sporadic endemicity of zoonotic Paragonimus in raccoon dogs and Japanese badgers from Miyazaki Prefecture, Japan. Reviewed

    Mari Ishida, Chiho Kaneko, Takao Irie, Yoshino Maruyama, Asami Tokuda, Ayako Yoshida

    The Journal of veterinary medical science   84 ( 3 )   454 - 456   2022.2

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPANESE SOCIETY OF VETERINARY SCIENCE  

    Paragonimiasis is a zoonotic trematode infection caused by Paragonimus spp. To determine the recent status of Paragonimus infections in wild animals, this study investigated Paragonimus spp. in 39 raccoon dogs and 54 Japanese badgers from March 2019 to January 2021 in Miyazaki Prefecture, and examined metacercariae in freshwater crabs. Triploid P. westermani was found in one raccoon dog (2.6%), and metacercariae were recovered from Eriocheir japonica captured near the infected animal collected. One Japanese badger (1.9%) harbored P. skrjabini miyazakii; this prevalence was lower than the approximately 30% that was reported in the 1970s. Results indicated that zoonotic Paragonimus was sporadically prevalent in wild animals. Further investigation in various animals is awaited to elucidate current wildlife reservoirs for those Paragonimus.

    DOI: 10.1292/jvms.21-0573

    Scopus

    PubMed

    CiNii Research

    researchmap

display all >>

MISC 【 display / non-display

  • Some Observations on the Means to Inactivate Echinococcus multilocularis Eggs Reviewed

    Hirokazu KOUGUCHI, Takao IRIE

    Rep. Hokkaido Inst. Pub. Health   67   87 - 89   2017

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)  

    researchmap

  • ミルベマイシンオキシム・プラジカンテル併用による北海道とヨーロッパで分離された多包条虫に対する有効性の比較 Reviewed

    孝口裕一, 入江隆夫, 八木欣平

    北海道立衛生研究所報   66   91 - 93   2016

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:北海道立衛生研究所  

    北海道根室市で分離された根室株およびヨーロッパ株の多包条虫を用いて、プラジカンテル(PZ)にミルベマイシンオキシム(MB)を配合した合剤の有効性について検討した。PZおよびMBの混合比が製剤と同じ10:1となるよう作成し、培養液で10倍段階希釈し、PZ濃度(MB濃度)1.0(0.1)、0.1(0.01)、0.01(0.001)μg/mLとした。両株とも1.0(0.1)および0.1(0.01)μg/mL添加群において、幼弱成虫の急激な運動性喪失に加えて全体的に丸みを帯びる顕著な形態変化を認めた。一方、0.01(0.001)μg/mLではこのような変化は認められなかった。

    J-GLOBAL

    researchmap

  • 実験室内における多包条虫卵の不活化条件に関する諸検討 Reviewed

    入江隆夫, 孝口裕一

    北海道立衛生研究所報   64   63 - 65   2014

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)  

    J-GLOBAL

    researchmap

Presentations 【 display / non-display

  • 国内野生ニホンジカにおけるSarcocystis属の定量的疫学解析

    山﨑朗子、白藤由紀子、入江隆夫、松本七海、山田翔子、推野千紘、漆原優衣、桑原多佳子、寺島淳

    第43回日本食品微生物学会学術総会  2022.9.29 

     More details

    Event date: 2022.9.29 - 2022.9.30

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 野生鳥獣糞便からの黄色ブドウ球菌及びβラクタム系抗菌薬耐性腸内細菌目細菌の分離とゲノム解析

    鈴木康規、髙井伸二、久保田寛顕、長谷川乃映瑠、小林甲斐、壁谷英則、入江隆夫、佐々木由香子、角田勤

    第43回日本食品微生物学会学術総会  2022.9.29 

     More details

    Event date: 2022.9.29 - 2022.9.30

    Language:Japanese   Presentation type:Poster presentation  

  • コットンラットの系統差比較が解き明かすヒト下咽頭梨状窩瘻の由来

    中村鉄平、細谷実里奈、市居修、渡邉敬文、Yaser Hosny Ali Elewa、入江隆夫、篠原明男、昆泰寛

    第165回日本獣医学会学術集会  2022.9.8 

     More details

    Event date: 2022.9.6 - 2022.9.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 多包虫感染中間宿主の血中循環セルフリーDNAの網羅的同定と診断用配列の検討

    長野礼太郎、山野公明、伊東拓也、中尾亮、迫康仁、吉田彩子、入江隆夫

    第165回日本獣医学会学術集会  2022.9.7 

     More details

    Event date: 2022.9.6 - 2022.9.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  • エキノコックス症制御のための終宿主動物対策 -新規検査法の確立と疫学実践- Invited

    入江隆夫

    第165回日本獣医学会学術集会  2022.9.6 

     More details

    Event date: 2022.9.6 - 2022.9.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

display all >>

Awards 【 display / non-display

  • 第13回 日本獣医寄生虫学奨励賞

    2022.9   日本獣医寄生虫学会   エキノコックス症制御のための終宿主動物対策

    入江隆夫

     More details

    Award type:Award from Japanese society, conference, symposium, etc. 

Grant-in-Aid for Scientific Research 【 display / non-display

  • 寄生虫由来の宿主コミュニケーション因子 血中循環核酸の網羅的同定と診断利用

    Grant number:21K16325  2021.04 - 2025.03

    日本学術振興会  科学研究費補助金  若手研究

    入江 隆夫

      More details

    Authorship:Principal investigator 

    researchmap

  • 野生鳥獣由来食肉の食中毒発生防止と衛生管理ガイドラインの改良に資する研究

    Grant number:21KA0401  2021.04 - 2024.03

    厚生労働省  食品の安全確保推進研究事業  応用研究

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • エキノコックス中間ならびに終宿主に対する二方面からの感染圧抑制による疾病制御

    Grant number:17K08815  2017.04 - 2020.03

    日本学術振興会  科学研究費補助金  基盤研究(C)

    孝口 裕一、入江 隆夫, 大久保 和洋

      More details

    Authorship:Coinvestigator(s) 

    エキノコックスは主にキツネと野ネズミの間で生活環が維持されており、終宿主対策として駆虫薬入りベイト散布が北海道内の一部の地域で行われている。しかしながら本法では多包条虫の生活環を破壊することは困難とされ、新しい媒介動物対策が求められている。本研究では、現行の駆虫薬入りベイトに虫体抗原成分やアジュバントを配合することで、駆虫薬入りベイトにワクチン機能を付加できないかをイヌをモデルとした感染実験により検討している。一方、中間宿主である野ネズミに対する対策については、昨年度に引き続き、抗エキノコックス薬開発の成果を発展させ、共同研究者から提供される薬剤を用いて、マウス虫卵感染の予防および病巣の治療試験を実施し、中間宿主対策やヒトの予防・治療薬の開発を検討している。
    平成30年度、イヌをモデル動物として、ワクチン強化ベイトに配合するべき抗原を見出すため、多包条虫原頭節の凍結乾燥物(①群)、成虫培養上清および凍結させた虫卵(②群)、活性を示す虫卵(③群)を8週間連続的に継続経口投与した(n=2)。その後、50万原頭節を免疫イヌおよび未感作のイヌ(コントロール)に経口投与し、35日目の感染虫体数を計数した。未感作群(コントロール)に感染した虫体数は、216,150匹および316,200匹であった。①群の虫体数は、230,013匹および290,788匹、②群は46,000匹および179,375匹、③群は179,375匹および36,400匹であった。②および③群は感染期間中、予想通り未感作群には通常観察されない、激しい粘血便や下痢を呈したが、著しい虫体排除には至らなかった。 一方、昨年度見出した中間宿主に対する新しい薬剤に、感染予防効果があるかどうかを調べた。その結果、病巣の発育抑制効果は示したものの、予防効果は示さないことが明らかになった。

    researchmap

  • An epidemiological study on echinococcosis in Qinghai, China, and development of a chemotherapeutic drug for humans and domestic animals

    2014.04 - 2017.03

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

    Nonaka Nariaki, HORII Yoichiro, KOUGUCHI Hirokazu, IRIE Takao, LEE Wei, GUO ZhiHong, NI Ma, ENKAI Shigehiro, KAI Feng

      More details

    In order to contribute to the echinococcosis control in Qinghai province, China, an epidemiological survey and a deworming trial were conducted. Since the feces of foxes, one of the most important definitive hosts of Echinococcus multilocularis, were deposited away from the residence area of nomad people, the risk of E. multilocularis transmission from foxes to humans was assumed to be low. Although a deworming trial was conducted to evaluate the effect of education on deworiming conductivity, a national deworming trial of dogs was started in the last year at our study site, thus, the effect of education could not be elucidated. In parallel to this, a new chemotherapeutic drug for echinococcosis was developed against mitochondrial respiratory chain of the parasite and an effective compound that reduced the cyst development of E. multilocularis was discovered.