SUGIYAMA Takashi

写真a

Affiliation

Faculty of Medicine College Hospital Department of Neurological Medicine

Title

Assistant Professor

External Link

Research Areas 【 display / non-display

  • Life Science / Neurology

 

Papers 【 display / non-display

  • Detailed Analysis of Neurological Symptoms and Sensory Disturbances Due to Chronic Arsenic Exposure in Toroku, Japan Reviewed

    Takashi Sugiyama, Nobuyuki Ishii, Yuka Ebihara, Kazutaka Shiomi, Hitoshi Mochizuki

    International Journal of Environmental Research and Public Health   18 ( 20 )   10749 - 10749   2021.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:{MDPI} {AG}  

    DOI: 10.3390/ijerph182010749

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  • ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function Reviewed

    Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Keizo Takao, Tsuyoshi Miyakawa, Yosuke Matsushita, Toyomasa Katagiri, Akira Futatsugi, Yohei Shinmyo, Hiroshi Kawasaki, Juro Sakai, Kazutaka Shiomi, Masamitsu Nakazato, Kohsuke Takeda, Katsuhiko Mikoshiba, Hidde L. Ploegh, Hidenori Ichijo, Hideki Nishitoh

    iScience   24 ( 7 )   102758 - 102758   2021.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.isci.2021.102758

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  • ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. International journal

    Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh

    Life science alliance   3 ( 3 )   2020.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Mitochondria play a central role in the function of brown adipocytes (BAs). Although mitochondrial biogenesis, which is indispensable for thermogenesis, is regulated by coordination between nuclear DNA transcription and mitochondrial DNA transcription, the molecular mechanisms of mitochondrial development during BA differentiation are largely unknown. Here, we show the importance of the ER-resident sensor PKR-like ER kinase (PERK) in the mitochondrial thermogenesis of brown adipose tissue. During BA differentiation, PERK is physiologically phosphorylated independently of the ER stress. This PERK phosphorylation induces transcriptional activation by GA-binding protein transcription factor α subunit (GABPα), which is required for mitochondrial inner membrane protein biogenesis, and this novel role of PERK is involved in maintaining the body temperatures of mice during cold exposure. Our findings demonstrate that mitochondrial development regulated by the PERK-GABPα axis is indispensable for thermogenesis in brown adipose tissue.

    DOI: 10.26508/lsa.201900576

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  • Disinhibited blink reflex recovery is related to lateral trunk flexion in Parkinson disease

    Sugiyama T., Mochizuki H., Hara Y., Miyamoto M., Nakazato Y., Taniguchi A., Ishii N., Shiomi K., Nakazato M.

    Journal of Clinical Neurophysiology   35 ( 4 )   346 - 350   2018

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Clinical Neurophysiology  

    Copyright © 2018 by the American Clinical Neurophysiology Society Purpose: Lateral trunk flexion is often observed in patients with Parkinson disease (PD) and causes poor quality of life. Asymmetrical function of the basal ganglia is believed to be the main cause of lateral trunk flexion, and dysfunction of the basal ganglia facilitates the blink reflex by disinhibiting the spinal trigeminal nucleus. Our aim was to investigate whether a disinhibited blink reflex recovery curve (BRrc) was associated with lateral trunk flexion in PD patients. Methods: We enrolled 21 PD patients, including 11 with marked lateral trunk flexion (F-PD) and 10 with normal posture (N-PD), and 10 normal controls. Blink reflex recovery curves at interstimulus intervals of 200, 300, and 500 ms were compared between F-PD N-PD and normal controls. Results: The BRrc in F-PD patients was more disinhibited than in N-PD patients and controls, and this disinhibition was asymmetrical. Conclusions: The asymmetrically disinhibited BRrc in F-PD patients was associated with lateral trunk flexion. This is the first neurophysiological study of patients with PD with abnormal posture. Examination of the BRrc may permit early detection of asymmetrical basal ganglia dysfunction that can eventually cause lateral trunk flexion.

    DOI: 10.1097/WNP.0000000000000457

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  • Increased body mass index associated with autonomic dysfunction in Parkinson's disease

    Mochizuki H., Taniguchi A., Nakazato Y., Ishii N., Ebihara Y., Sugiyama T., Shiomi K., Nakazato M.

    Parkinsonism and Related Disorders   24   129 - 131   2016.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Parkinsonism and Related Disorders  

    © 2016 Elsevier Ltd. Background: The association between Parkinson's disease (PD) and body mass index (BMI) has not been established. In this study, we investigated the correlation between BMI and autonomic dysfunction in patients with PD. Methods: Clinical features, BMI, cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy and the coefficient of variation of the electrocardiographic R-R interval (CVRR) were analyzed in 124 patients with PD who were naïve to anti-parkinsonian drugs. Results: BMI was negatively correlated with early heart-to-mediastinum ratio and CVRR in patients with PD, regardless of disease duration and severity. Conclusions: Autonomic dysfunction and BMI increase were associated with each other. Physicians should consider the possibility of autonomic dysfunction in PD patients with high BMI.

    DOI: 10.1016/j.parkreldis.2016.01.007

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Presentations 【 display / non-display

  • Derlin familyの欠損による脳の発達障害は脳内コレステロール合成低下に起因する

    杉山崇史, 村尾直哉, 西頭英起

    第94回日本生化学会大会 

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    Event date: 2021.11.3 - 2021.11.5

    Presentation type:Poster presentation  

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  • 慢性砒素中毒に起因する神経障害の自然経過

    杉山崇史, 望月仁志, 金丸和樹, 中里祐毅, 酒井克也, 中里雅光, 塩見一剛

    第62回日本神経学会学術大会  2021.5.21 

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    Event date: 2021.5.19 - 2021.5.22

    Presentation type:Oral presentation (general)  

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  • 大脳島皮質および頭頂葉皮質の脳梗塞により対側舞踏運動を生じたと考えられた1例.

    鈴木あい、杉山崇史、望月仁志、金丸和樹、中里祐毅、中里雅光、塩見一剛.

    第231回日本神経学会九州地方会.  (Web開催) 

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    Event date: 2021.3.20

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web開催  

  • ギラン・バレー症候群治療中に判明したツツガムシ病の1例.

    武田紘昌、杉山崇史、宮本美由貴、金丸和樹、酒井克也、中里祐毅、望月仁志、中里雅光、塩見一剛.

    第230回日本神経学会九州地方会.  (Web開催) 

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    Event date: 2020.12.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web開催  

  • 若年発症の破傷風例.

    小永田綾香、中里祐毅、酒井克也、杉山崇史、望月仁志、塩見一剛、中里雅光.

    第331回日本内科学会九州地方会.  (Web開催) 

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    Event date: 2020.11.29

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web開催  

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