|
Affiliation |
Faculty of Medicine College Hospital Department of Neurological Medicine |
|
Title |
Assistant Professor |
|
External Link |
|
|
Related SDGs |
|
SUGIYAMA Takashi
|
|
|
Papers 【 display / non-display 】
-
ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. Reviewed International coauthorship
Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H.
iScience 24 ( 7 ) 102758 2021.1
Authorship：Lead author Language：English Publishing type：Doctoral thesis
Citation: Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021 Jun 19;24(7):102758. doi: 10.1016/j.isci.2021.102758. PMID: 34355142; PMCID: PMC8324814.
-
Chemical chaperones ameliorate neurodegenerative disorders in Derlin-1-deficient mice via improvement of cholesterol biosynthesis. Reviewed International journal
Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Hideki Nishitoh
Scientific reports 12 ( 1 ) 21840 - 21840 2022.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Neurodegenerative diseases associated with the disruption of proteostasis and their therapeutic strategies using chemical chaperones Invited Reviewed
Sugiyama T., Nishitoh H.
Journal of Biochemistry 176 ( 3 ) 179 - 186 2024.9
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Biochemistry
Aberrant proteostasis is thought to be involved in the pathogenesis of neurodegenerative diseases. Some proteostasis abnormalities are ameliorated by chaperones. Chaperones are divided into three groups: molecular, pharmacological and chemical. Chemical chaperones intended to alleviate stress in organelles, such as the endoplasmic reticulum (ER), are now being administered clinically. Of the chemical chaperones, 4-phenylbutyrate (4-PBA) has been used as a research reagent, and its mechanism of action includes chaperone effects and the inhibition of histone deacetylase. Moreover, it also binds to the B-site of SEC24 and regulates COPII-mediated transport from the ER. Although its therapeutic effect may not be strong, elucidating the mechanism of action of 4-PBA may contribute to the identification of novel therapeutic targets for neurodegenerative diseases.
DOI： 10.1093/jb/mvae048
-
Detailed Analysis of Neurological Symptoms and Sensory Disturbances Due to Chronic Arsenic Exposure in Toroku, Japan Reviewed International journal
Takashi Sugiyama, Nobuyuki Ishii, Yuka Ebihara, Kazutaka Shiomi, Hitoshi Mochizuki
International Journal of Environmental Research and Public Health 18 ( 20 ) 10749 - 10749 2021.10
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：{MDPI} {AG}
-
Disinhibited blink reflex recovery is related to lateral trunk flexion in Parkinson disease Reviewed
Sugiyama T., Mochizuki H., Hara Y., Miyamoto M., Nakazato Y., Taniguchi A., Ishii N., Shiomi K., Nakazato M.
Journal of Clinical Neurophysiology 35 ( 4 ) 346 - 350 2018
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Neurophysiology
Copyright © 2018 by the American Clinical Neurophysiology Society Purpose: Lateral trunk flexion is often observed in patients with Parkinson disease (PD) and causes poor quality of life. Asymmetrical function of the basal ganglia is believed to be the main cause of lateral trunk flexion, and dysfunction of the basal ganglia facilitates the blink reflex by disinhibiting the spinal trigeminal nucleus. Our aim was to investigate whether a disinhibited blink reflex recovery curve (BRrc) was associated with lateral trunk flexion in PD patients. Methods: We enrolled 21 PD patients, including 11 with marked lateral trunk flexion (F-PD) and 10 with normal posture (N-PD), and 10 normal controls. Blink reflex recovery curves at interstimulus intervals of 200, 300, and 500 ms were compared between F-PD N-PD and normal controls. Results: The BRrc in F-PD patients was more disinhibited than in N-PD patients and controls, and this disinhibition was asymmetrical. Conclusions: The asymmetrically disinhibited BRrc in F-PD patients was associated with lateral trunk flexion. This is the first neurophysiological study of patients with PD with abnormal posture. Examination of the BRrc may permit early detection of asymmetrical basal ganglia dysfunction that can eventually cause lateral trunk flexion.
MISC 【 display / non-display 】
-
コロナワクチン後に生じたと考えられる脳脊髄液減少症により体位性頻脈発作を認めた一例
長友優菜, 金丸和樹, 杉山崇史, 宮本美由貴, 酒井克也, 中里祐毅, 望月仁志, 塩見一剛
臨床神経学(Web) 61 ( 12 ) 2021
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Presentations 【 display / non-display 】
-
抗横紋筋抗体陽性の筋炎・心筋炎合併重症筋無力症（MG）に対するエフガルチギモド治療経験
田中啓文、大窪隆一、末原雅人、神田佳樹、平方翔太、杉山崇史、塩見一剛
第243回日本神経学会九州地方会 2024.3.2
Event date： 2024.3.2
Language：Japanese Presentation type：Oral presentation (general)
-
神経症状発症前に神経伝導検査で異常を検出し得た CANVAS の1 例
宮本美由貴、酒井克也、中里祐毅、杉山崇史、輿水江里子、宮武聡子、松本直通、塩見一剛
第243回日本神経学会九州地方会 2024.3.2
Event date： 2024.3.2
Language：Japanese Presentation type：Oral presentation (general)
-
水頭症を合併したが積極的な髄液排出により日常生活に復帰することができたリステリア髄膜炎の2例
武田紘昌、酒井克也、金丸和樹、杉山崇史、中里祐毅、塩見一剛
第27回日本神経感染症学会総会 2023.10.13
Event date： 2023.10.13 - 2023.10.14
Language：Japanese Presentation type：Oral presentation (general)
-
早期に眼瞼下垂を呈した悪性高熱症合併セントラルコア病の一例
宮本美由貴、武田紘昌、川上隆太郎、金丸和樹、酒井克也、中里祐毅、杉山崇史、西野一三、塩見一剛
第241回日本神経学会九州地方会 2023.9.23
Event date： 2023.9.23
Language：Japanese Presentation type：Oral presentation (general)
-
コレステロール合成に着目した神経変性に対するケミカルシャペロンの作用メカニズム
杉山崇史、村尾直哉、西頭英起
第66回日本神経化学会大会 2023.7.8
Event date： 2023.7.6 - 2023.7.8
Language：Japanese Presentation type：Poster presentation
Awards 【 display / non-display 】
-
ポスター賞
2018.11 第13回小胞体ストレス研究会
杉山崇史
Award type：Award from Japanese society, conference, symposium, etc.
-
若手研究奨励賞
2018.10 第13回日本臨床ストレス応答学会大会
杉山崇史
Award type：Award from Japanese society, conference, symposium, etc.
-
ポスター賞
2017.10 第12回小胞体ストレス研究会
杉山崇史
Award type：Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
ALS新規治療標的開発に向けたコレステロール合成経路の役割の解明
Grant number：24K18623 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 病態神経科学関連
Authorship：Principal investigator