杉山 崇史 (スギヤマ タカシ)

SUGIYAMA Takashi

写真a

所属

医学部 附属病院 神経内科

職名

助教

外部リンク

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  • ライフサイエンス / 神経内科学

 

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  • Detailed analysis of neurological symptoms and sensory disturbances due to chronic arsenic exposure in toroku, japan 査読あり

    Sugiyama T., Ishii N., Ebihara Y., Shiomi K., Mochizuki H.

    International Journal of Environmental Research and Public Health   18 ( 20 )   10749 - 10749   2021年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Environmental Research and Public Health  

    As a result of population growth and the development of tube wells, humans’ exposure to arsenic has increased over the past few decades. The natural course of organ damage secondary to arsenic exposure is not yet well understood. In Toroku, Japan, an arsenic mine was intermittently operated from 1920 to 1962, and residents were exposed to high concentrations of arsenic. In this paper, we analyzed 190 consecutive residents for whom detailed records of neurological symptoms and findings were obtained from 1974 to 2005. All participants were interviewed regarding the presence of general, skin, hearing, respiratory, and neurological symptoms. Neurological symptoms were classified into extremity numbness or pain, constipation, dyshidrosis, sensory loss, and muscle atrophy. Superficial and vibratory sensation was also evaluated. More than 80% of participants experienced extremity numbness, and numbness was the most common neurological symptom. Numbness was associated with superficial sensory disturbance, and was correlated with the subsequent development of other neurological symptoms, including autonomic and motor symptoms. No previous studies have investigated the natural course of chronic arsenic intoxication; thus, these data serve as a guide for detecting early symptoms due to arsenic exposure.

    DOI: 10.3390/ijerph182010749

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  • ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function 査読あり

    Sugiyama T., Murao N., Kadowaki H., Takao K., Miyakawa T., Matsushita Y., Katagiri T., Futatsugi A., Shinmyo Y., Kawasaki H., Sakai J., Shiomi K., Nakazato M., Takeda K., Mikoshiba K., Ploegh H.L., Ichijo H., Nishitoh H.

    iScience   24 ( 7 )   102758 - 102758   2021年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:iScience  

    Derlin family members (Derlins) are primarily known as components of the endoplasmic reticulum-associated degradation pathway that eliminates misfolded proteins. Here we report a function of Derlins in the brain development. Deletion of Derlin-1 or Derlin-2 in the central nervous system of mice impaired postnatal brain development, particularly of the cerebellum and striatum, and induced motor control deficits. Derlin-1 or Derlin-2 deficiency reduced neurite outgrowth in vitro and in vivo and surprisingly also inhibited sterol regulatory element binding protein 2 (SREBP-2)-mediated brain cholesterol biosynthesis. In addition, reduced neurite outgrowth due to Derlin-1 deficiency was rescued by SREBP-2 pathway activation. Overall, our findings demonstrate that Derlins sustain brain cholesterol biosynthesis, which is essential for appropriate postnatal brain development and function.

    DOI: 10.1016/j.isci.2021.102758

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  • ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. 国際誌

    Kato H, Okabe K, Miyake M, Hattori K, Fukaya T, Tanimoto K, Beini S, Mizuguchi M, Torii S, Arakawa S, Ono M, Saito Y, Sugiyama T, Funatsu T, Sato K, Shimizu S, Oyadomari S, Ichijo H, Kadowaki H, Nishitoh H

    Life science alliance   3 ( 3 )   2020年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Life Science Alliance  

    Mitochondria play a central role in the function of brown adipocytes (BAs). Although mitochondrial biogenesis, which is indispensable for thermogenesis, is regulated by coordination between nuclear DNA transcription and mitochondrial DNA transcription, the molecular mechanisms of mitochondrial development during BA differentiation are largely unknown. Here, we show the importance of the ER-resident sensor PKR-like ER kinase (PERK) in the mitochondrial thermogenesis of brown adipose tissue. During BA differentiation, PERK is physiologically phosphorylated independently of the ER stress. This PERK phosphorylation induces transcriptional activation by GA-binding protein transcription factor α subunit (GABPα), which is required for mitochondrial inner membrane protein biogenesis, and this novel role of PERK is involved in maintaining the body temperatures of mice during cold exposure. Our findings demonstrate that mitochondrial development regulated by the PERK-GABPα axis is indispensable for thermogenesis in brown adipose tissue.

    DOI: 10.26508/lsa.201900576

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  • Disinhibited blink reflex recovery is related to lateral trunk flexion in Parkinson disease

    Sugiyama T., Mochizuki H., Hara Y., Miyamoto M., Nakazato Y., Taniguchi A., Ishii N., Shiomi K., Nakazato M.

    Journal of Clinical Neurophysiology   35 ( 4 )   346 - 350   2018年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Clinical Neurophysiology  

    Copyright © 2018 by the American Clinical Neurophysiology Society Purpose: Lateral trunk flexion is often observed in patients with Parkinson disease (PD) and causes poor quality of life. Asymmetrical function of the basal ganglia is believed to be the main cause of lateral trunk flexion, and dysfunction of the basal ganglia facilitates the blink reflex by disinhibiting the spinal trigeminal nucleus. Our aim was to investigate whether a disinhibited blink reflex recovery curve (BRrc) was associated with lateral trunk flexion in PD patients. Methods: We enrolled 21 PD patients, including 11 with marked lateral trunk flexion (F-PD) and 10 with normal posture (N-PD), and 10 normal controls. Blink reflex recovery curves at interstimulus intervals of 200, 300, and 500 ms were compared between F-PD N-PD and normal controls. Results: The BRrc in F-PD patients was more disinhibited than in N-PD patients and controls, and this disinhibition was asymmetrical. Conclusions: The asymmetrically disinhibited BRrc in F-PD patients was associated with lateral trunk flexion. This is the first neurophysiological study of patients with PD with abnormal posture. Examination of the BRrc may permit early detection of asymmetrical basal ganglia dysfunction that can eventually cause lateral trunk flexion.

    DOI: 10.1097/WNP.0000000000000457

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  • Increased body mass index associated with autonomic dysfunction in Parkinson's disease

    Mochizuki H., Taniguchi A., Nakazato Y., Ishii N., Ebihara Y., Sugiyama T., Shiomi K., Nakazato M.

    Parkinsonism and Related Disorders   24   129 - 131   2016年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Parkinsonism and Related Disorders  

    © 2016 Elsevier Ltd. Background: The association between Parkinson's disease (PD) and body mass index (BMI) has not been established. In this study, we investigated the correlation between BMI and autonomic dysfunction in patients with PD. Methods: Clinical features, BMI, cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy and the coefficient of variation of the electrocardiographic R-R interval (CVRR) were analyzed in 124 patients with PD who were naïve to anti-parkinsonian drugs. Results: BMI was negatively correlated with early heart-to-mediastinum ratio and CVRR in patients with PD, regardless of disease duration and severity. Conclusions: Autonomic dysfunction and BMI increase were associated with each other. Physicians should consider the possibility of autonomic dysfunction in PD patients with high BMI.

    DOI: 10.1016/j.parkreldis.2016.01.007

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  • Derlin familyの欠損による脳の発達障害は脳内コレステロール合成低下に起因する

    杉山崇史, 村尾直哉, 西頭英起

    第94回日本生化学会大会 

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    開催年月日: 2021年11月3日 - 2021年11月5日

    会議種別:ポスター発表  

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  • 慢性砒素中毒に起因する神経障害の自然経過

    杉山崇史, 望月仁志, 金丸和樹, 中里祐毅, 酒井克也, 中里雅光, 塩見一剛

    第62回日本神経学会学術大会  2021年5月21日 

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    開催年月日: 2021年5月19日 - 2021年5月22日

    会議種別:口頭発表(一般)  

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  • 大脳島皮質および頭頂葉皮質の脳梗塞により対側舞踏運動を生じたと考えられた1例.

    鈴木あい、杉山崇史、望月仁志、金丸和樹、中里祐毅、中里雅光、塩見一剛.

    第231回日本神経学会九州地方会.  (Web開催) 

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    開催年月日: 2021年3月20日

    記述言語:日本語   会議種別:口頭発表(一般)  

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  • ギラン・バレー症候群治療中に判明したツツガムシ病の1例.

    武田紘昌、杉山崇史、宮本美由貴、金丸和樹、酒井克也、中里祐毅、望月仁志、中里雅光、塩見一剛.

    第230回日本神経学会九州地方会.  (Web開催) 

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    開催年月日: 2020年12月12日

    記述言語:日本語   会議種別:口頭発表(一般)  

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  • 若年発症の破傷風例.

    小永田綾香、中里祐毅、酒井克也、杉山崇史、望月仁志、塩見一剛、中里雅光.

    第331回日本内科学会九州地方会.  (Web開催) 

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    開催年月日: 2020年11月29日

    記述言語:日本語   会議種別:口頭発表(一般)  

    開催地:Web開催  

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