MIURA Ayako

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Medical Sciences, Pharmacology

Title

Assistant Professor

External Link

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Degree 【 display / non-display

  • 博士(医学) ( 2013.3   鹿児島大学 )

Research Areas 【 display / non-display

  • Life Science / Respiratory medicine

 

Papers 【 display / non-display

  • The NERP-4–SNAT2 axis regulates pancreatic β-cell maintenance and function Reviewed International coauthorship

    Weidong Zhang, Ayako Miura, Md Moin Abu Saleh, Koichiro Shimizu, Yuichiro Mita, Ryota Tanida, Satoshi Hirako, Seiji Shioda, ValeryGmyr, Julie Kerr-Conte, Francois Pattou,Chunhuan Jin, Yoshikatsu Kanai, Kazuki Sasaki, Naoto Minamino, Hideyuki Sakoda & Masamitsu Nakazato

    Nature Communications   14 ( 8158 )   2023.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1038/s41467-023-43976-8

  • Reversible neuropathic pain model created by long-term optogenetic nociceptor stimulation using light-responsive pain mice Reviewed

    丸田 豊明, 日髙 康太郎, 越田 智広, 黒木 未央, 鹿毛 陽子, 三浦 綾子, 中川 光, 柳田 俊彦, 武谷 立, 恒吉 勇男

    Plos One   20 ( 5 )   e0323628   2025.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    Neuropathic pain has a significant social impact, with high morbidity and reduced productivity, the underlying mechanisms of neuropathic pain remain poorly understood, and effective therapeutic strategies remain elusive. The development of animal models of neuropathic pain that stimulate only the nociceptors and not the other sensory receptors or motor nerves is desirable for elucidating the complex pathogenesis of neuropathic pain. We have previously reported the generation of NaV1.7−channelrhodopsin-2 (ChR2), NaV1.8−ChR2, and NaV1.9−ChR2 mice. Optogenetics was employed in these light-responsive pain mice for generating nociceptive pain by specifically exciting the spinal dorsal root ganglion neurons, in which the respective Na+ channels are expressed through exposure to blue light. This study aimed to compare the neuropathic pain produced by the prolonged exposure of light-responsive pain mice to blue light. A reversible neuropathic pain state was established persisting for a minimum of 24 hours when each light-responsive pain mouse was irradiated with light of an intensity that consistently elicited pain. Furthermore, the mice also showed pain sensitivity to light irradiation and mechanical stimulation. The expression of c-Fos, a marker for neuronal activity following noxious stimulation, was increased in the dorsal horn of the spinal cord on the light irradiated side. DS-1971a, a selective NaV1.7 inhibitor, was effective in attenuating neuropathic pain in all light-responsive pain mice. In conclusion, optogenetics helps elucidate the specific functions of sodium channel subtypes in pain signaling, thereby advancing our understanding and paving the way for the development of further effective treatments for pain disorders in the future.

    CiNii Research

  • Reversible neuropathic pain model created by long-term optogenetic nociceptor stimulation using light-responsive pain mice Reviewed

    Kouroki S., Maruta T., Hidaka K., Koshida T., Kurogi M., Kage Y., Miura A., Nakagawa H., Yanagita T., Takeya R., Tsuneyoshi I.

    Plos One   20 ( 5 May )   2025.5

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    Publishing type:Research paper (scientific journal)   Publisher:Plos One  

    Neuropathic pain has a significant social impact, with high morbidity and reduced productivity, the underlying mechanisms of neuropathic pain remain poorly understood, and effective therapeutic strategies remain elusive. The development of animal models of neuropathic pain that stimulate only the nociceptors and not the other sensory receptors or motor nerves is desirable for elucidating the complex pathogenesis of neuropathic pain. We have previously reported the generation of Na<inf>V</inf>1.7−channelrhodopsin-2 (ChR2), Na<inf>V</inf>1.8−ChR2, and Na<inf>V</inf>1.9−ChR2 mice. Optogenetics was employed in these light-responsive pain mice for generating nociceptive pain by specifically exciting the spinal dorsal root ganglion neurons, in which the respective Na<sup>+</sup> channels are expressed through exposure to blue light. This study aimed to compare the neuropathic pain produced by the prolonged exposure of light-responsive pain mice to blue light. A reversible neuropathic pain state was established persisting for a minimum of 24 hours when each light-responsive pain mouse was irradiated with light of an intensity that consistently elicited pain. Furthermore, the mice also showed pain sensitivity to light irradiation and mechanical stimulation. The expression of c-Fos, a marker for neuronal activity following noxious stimulation, was increased in the dorsal horn of the spinal cord on the light irradiated side. DS-1971a, a selective Na<inf>V</inf>1.7 inhibitor, was effective in attenuating neuropathic pain in all light-responsive pain mice. In conclusion, optogenetics helps elucidate the specific functions of sodium channel subtypes in pain signaling, thereby advancing our understanding and paving the way for the development of further effective treatments for pain disorders in the future.

    DOI: 10.1371/journal.pone.0323628

    Scopus

  • Reversible neuropathic pain model created by long-term optogenetic nociceptor stimulation using light-responsive pain mice Reviewed

    Satoshi Kouroki, Toyoaki Maruta, Kotaro Hidaka, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Ayako Miura, Hikaru Nakagawa, Toshihiko Yanagita, Ryu Takeya, Isao Tsuneyoshi

    PLOS ONE   2025.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • The expression of the formin Fhod3 in mouse tongue striated muscle Reviewed International coauthorship

    Nakagawa Hikaru, Kage Yohko, Miura Ayako, Wahyu Sulistomo Hikmawan, Matsuyama Sho, Yamashita Yoshihiro, Takeya Ryu

    Cell Structure and Function   advpub ( 0 )   111 - 122   2024.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Society for Cell Biology  

    The sarcomere is the contractile unit of striated muscle and is composed of actin and myosin filaments. There is increasing evidence to support that actin assembly mediated by Fhod3, a member of the formin family of proteins, is critical for sarcomere formation and maintenance in cardiac muscle. Fhod3, which is abundantly expressed in the heart, localizes to the center of sarcomeres and contributes to the regulation of the cardiac function, as evidenced by the fact that mutations in Fhod3 cause cardiomyopathy. However, the role of Fhod3 in skeletal muscle, another type of striated muscle, is unclear. We herein show that Fhod3 is expressed in the tongue at both mRNA and protein levels, although in smaller amounts than in the heart. To determine the physiological role of Fhod3 expressed in the tongue, we generated embryos lacking Fhod3 in the tongue. The tongue tissue of the Fhod3-depleted embryos did not show any significant structural defects, suggesting that Fhod3 is dispensable for normal development of the mouse tongue. Unexpectedly, the immunostaining analysis revealed the absence of specific sarcomeric signals for Fhod3 in the wild-type tongue when compared to the Fhod3-depleted tongue as a negative control, despite the use of antibodies that had previously been validated by immunostaining of heart tissues. Taken together, although Fhod3 protein is expressed at a significant level in the tongue, Fhod3 in the tongue does not appear to exhibit the same sarcomeric pattern as observed in the heart, suggesting a different role for Fhod3 in the tongue muscles.Key words: actin, formin, sarcomere, striated muscle

    DOI: 10.1247/csf.24044

    Scopus

    PubMed

    CiNii Research

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Books 【 display / non-display

  • PACAP・VIP受容体の構造と機能の多様性 -PACAPの中枢神経機能を中心として-

    宮田篤郎, 三浦綾子( Role: Joint author)

    医学のあゆみ. 医歯薬出版. 第五土曜特集. 2010;233(9),928-33.  2010 

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    Language:Japanese Book type:Scholarly book

Presentations 【 display / non-display

  • 新規ペプチドNERP-4はアミノ酸トランスポーターSNAT2を介して膵β細胞機能を改善する International coauthorship

    三浦 綾子、張 維東、迫田 秀之、南野 直人、中里 雅光

    第77回日本薬理学会西南部会  2024.11.16 

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    Event date: 2024.11.16

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Role of ERM proteins in the regulation of actin cytoskeleton in migrating alveolar macrophage

    Ayako Miura,Fumiyuki Sanematsu,Ryu Takeya

    2023.12 

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    Event date: 2023.12.14 - 2023.12.16

    Language:English   Presentation type:Poster presentation  

  • Regulation of directional cell motility in alveolar macrophages by a formin family protein Fhod1

    Ayako Miura,Fumiyuki Sanematsu,Ryu Takeya

    2022.11 

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    Event date: 2022.11.30 - 2022.12.3

    Language:English   Presentation type:Poster presentation  

  • ARDS線維化過程におけるfibroblast/myofibroblastの核内LOXL2阻害の意義

    松尾彩子、谷田亮太、柳 重久、坪内拡伸、三浦綾子、重草貴文、松元信弘、中里雅光、宮崎泰可

    第62回日本呼吸器学会学術講演会   2022.4 

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    Event date: 2022.4.22 - 2022.4.24

    Language:Japanese   Presentation type:Oral presentation (general)  

  • The actin-nucleating protein Fhod1 in alveolar macrophage

    Ayako Miura,Fumiyuki Sanamatsu,Ryu Takeya

    2022.3 

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    Event date: 2022.3.7 - 2022.3.9

    Language:English   Presentation type:Poster presentation  

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Awards 【 display / non-display

  • 松尾壽之賞

    2025.3   宮崎大学   ペプチド研究を基盤とした生体機能制御機構の解析

    三浦綾子

  • 肺がん検診への導入を目指した診断技術の開発に関する臨床疫学研究

    2018   2018年度がん研究財団シニアリサーチフェロー  

    三浦綾子

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • ERS Young Scientist Sponsorship

    2016.9   Europian Respiratory Society   The role of Pten in the cell-fate determination of epithelial cells in lung development.

    三浦綾子

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    Award type:Award from international society, conference, symposium, etc.  Country:United Kingdom

  • Kyushu Diabetes Research Conference 最優秀奨励賞

    2016.7   Kyusyu Diabetes Research Conference   糖代謝調節に機能する新規生理活性ペプチドの発見

    三浦綾子

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 児玉記念基礎医学助成基金 優秀研究論文顕彰

    2013.10   児玉記念基礎医学助成基金   Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation.

    三浦綾子

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • 異種細胞間の細胞接着装置の恒常性維持機構の解析

    Grant number:21K08183  2021.04 - 2024.03

    独立行政法人日本学術振興会  科学研究費補助金   基盤研究(C)

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    Authorship:Principal investigator 

  • サルコメアは回転トルクを生み出すか?

    Grant number:22K19407  2022.04 - 2024.03

    独立行政法人日本学術振興会  科学研究費補助金  挑戦的研究(萌芽)

    武谷 立、

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    Authorship:Coinvestigator(s) 

  • The Role of Epithelial Pten in Epithelial Cell Fate and Programmed Cellular Senescence during Lung Development

    Grant number:17K16051  2017.04 - 2021.03

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(B)

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    Authorship:Principal investigator 

  • 上皮間葉連関を焦点とした肺発生での上皮Ptenの機能解析

    Grant number:26860610  2014.04 - 2016.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

 

Social Activities 【 display / non-display

  • 令和5年度宮崎サイエンスキャンプ「“くすり”は何故効くの?」

    Role(s): Lecturer, Organizing member

    2023.8.7 - 2023.8.8

  • 日南学園高等学校田野看護専攻科「生物学」講義

    Role(s): Lecturer

    2020.6.11 - Now

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    Audience: High school students

    Type:Other