Papers - NISHIYAMA Koichi
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Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Reviewed International journal
Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita, Ryuji Yokokawa, Takashi Miura, Toshiki Itoh, Kenichi Tsujita, Naoki Mochizuki, Shigetomo Fukuhara
Nature communications 13 ( 1 ) 2594 - 2594 2022.12
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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A new perfusion culture method with a self-organized capillary network Reviewed
Kei Sugihara, Yoshimi Yamaguchi, Shiori Usui, Yuji Nashimoto, Sanshiro Hanada, Etsuko Kiyokawa, Akiyoshi Uemura, Ryuji Yokokawa, Koichi Nishiyama, Takashi Miura
PLOS ONE 15 ( 10 October ) e0240552 - e0240552 2020.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Public Library of Science (PLoS)
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RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells Reviewed
Yoko Fukushima, Koichi Nishiyama, Hiroshi Kataoka, Marcus Fruttiger, Shigetomo Fukuhara, Kohji Nishida, Naoki Mochizuki, Hiroki Kurihara, Shin‐Ichi Nishikawa, Akiyoshi Uemura
The EMBO Journal 39 ( 12 ) e102930 2020.6
Language：English Publishing type：Research paper (scientific journal)
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Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid Reviewed
Yuji Nashimoto, Ryu Okada, Sanshiro Hanada, Yuichiro Arima, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa
Biomaterials 229 119547 2020.1
Language：English Publishing type：Research paper (scientific journal)
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Sex differences in the functional morphology of coronary arteries in embryonic mice. Reviewed International journal
Shion Nagasawa, Masami Kodama, Ryu Hagiwara, Kazuho Sakamoto, Koichi Nishiyama, Yuichiro Arima, Hiroki Kurihara, Junko Kurokawa
American journal of physiology. Heart and circulatory physiology 327 ( 6 ) H1390 - H1399 2024.12
Language：English Publishing type：Research paper (scientific journal)
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Watanabe-Takano H., Kato K., Oguri-Nakamura E., Ishii T., Kobayashi K., Murata T., Tsujikawa K., Miyata T., Kubota Y., Hanada Y., Nishiyama K., Watabe T., Fässler R., Ishii H., Mochizuki N., Fukuhara S.
Nature Communications 15 ( 1 ) 1622 2024.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Communications
Alveologenesis is a spatially coordinated morphogenetic event, during which alveolar myofibroblasts surround the terminal sacs constructed by epithelial cells and endothelial cells (ECs), then contract to form secondary septa to generate alveoli in the lungs. Recent studies have demonstrated the important role of alveolar ECs in this morphogenetic event. However, the mechanisms underlying EC-mediated alveologenesis remain unknown. Herein, we show that ECs regulate alveologenesis by constructing basement membranes (BMs) acting as a scaffold for myofibroblasts to induce septa formation through activating mechanical signaling. Rap1, a small GTPase of the Ras superfamily, is known to stimulate integrin-mediated cell adhesions. EC-specific Rap1-deficient (Rap1iECKO) mice exhibit impaired septa formation and hypo-alveolarization due to the decreased mechanical signaling in myofibroblasts. In Rap1iECKO mice, ECs fail to stimulate integrin β1 to recruit Collagen type IV (Col-4) into BMs required for myofibroblast-mediated septa formation. Consistently, EC-specific integrin β1-deficient mice show hypo-alveolarization, defective mechanical signaling in myofibroblasts, and disorganized BMs. These data demonstrate that alveolar ECs promote integrin β1-mediated Col-4 recruitment in a Rap1-dependent manner, thereby constructing BMs acting as a scaffold for myofibroblasts to induce mechanical signal-mediated alveologenesis. Thus, this study unveils a mechanism of organ morphogenesis mediated by ECs through intrinsic functions.
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第1土曜特集 "かたちづくり" を制御する分子メカニズム 形態形成と多細胞動態 血管新生における血流による物理的力の役割
花田 保之, 西山 功一
医学のあゆみ 290 ( 1 ) 42 - 46 2024.7
Publishing type：Research paper (scientific journal) Publisher：医歯薬出版
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第5土曜特集 血管･リンパ管研究の最前線と治療への展開 血管研究のフロンティア 再構成解析系を駆使した血流による血管新生の生体力学機序の解明
西山 功一
医学のあゆみ 289 ( 13 ) 1093 - 1098 2024.6
Publishing type：Research paper (scientific journal) Publisher：医歯薬出版
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血管をとりまく力学環境による血管新生の制御
西山 功一
生体医工学 Annual62 ( Abstract ) 95_2 - 95_2 2024
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Part of collection (book) Publisher：公益社団法人 日本生体医工学会
血管新生は、既存の血管から新たな血管が増生する反応である。個体発生期だけでなく成体においても、損傷した血管の修復や虚血状態の解除などの生理的な反応として生じる。逆にがんや炎症では、異常な血管を増生し、病態形成やその進展に関与する。我々はこれまで、血管新生で血管が効率よく増生するためには、血管新生因子VEGFなどの化学シグナルに刺激された血管内皮細胞が、集団として効率よく移動することが重要であることを明らかにした（Development, 2011; Cell Rep, 2015; EMBO J, 2020）。一方、新生した血管にはすぐに管腔構造が形成され血流が流れこむため、血流による力学刺激に常に晒されている。しかし、この血流刺激が、化学シグナルと相まってどのように血管新生制御に関与しているのか、ほとんどわかっていない。この点において我々は、血流によって生じる血管壁の伸展が、血管内皮細胞の移動を抑制することで血管新生による血管の伸長を負に制御する、新たな力学シグナルであることを報告した（Nat Commun, 2022）。 本セッションでは、最近さらに見出した血管新生の新たな生体力学的制御機構を紹介する。そこでは、血管内皮細胞の周囲に存在するもう一つの血管細胞ペリサイトが、血管周囲基質を硬くすることで血管内腔の拡張性を調節し、血流による血管新生抑制作用をさらに制御することで血管の増生を促進していた。
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Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. Reviewed International journal
Kiyotake Yamamoto, Haruko Watanabe-Takano, Eri Oguri-Nakamura, Hitomi Matsuno, Daiki Horikami, Tomohiro Ishii, Ryuji Ohashi, Yoshiaki Kubota, Koichi Nishiyama, Takahisa Murata, Naoki Mochizuki, Shigetomo Fukuhara
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37 ( 12 ) e23310 2023.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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VEGF-NFAT-ダウン症因子-1シグナル軸を介した血管内皮分化や血管分岐制御機構の解明
亀井 竣輔, 福嶋 葉子, 植村 明嘉, 有馬 勇一郎, 西山 功一, 南 敬
脈管学 63 ( 1 ) 14 - 14 2023.2
Language：Japanese Publishing type：Part of collection (book) Publisher：(一社)日本脈管学会
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特集 新組織学シリーズⅢ:血管とリンパ管 Ⅰ.血管･リンパ管研究の多様なアプローチ In vitro再構成モデルを用いた血管新生における血流力学作用の解析
西山 功一
生体の科学 73 ( 6 ) 517 - 522 2022.12
Publishing type：Research paper (scientific journal) Publisher：株式会社医学書院
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Pericytes and shear stress each alter the shape of a self-assembled vascular network
Kazuya Fujimoto, Scott Erickson, Masamune Nakayama, Hroki Ihara, Kei Sugihara, Yuji Nashimoto, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa
Lab on a Chip 23 ( 2 ) 306 - 317 2022.12
Language：English Publishing type：Research paper (other academic)
DOI： 10.1039/d2lc00605g
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VEGF-NFAT-ダウン症因子-1シグナル軸を介した血管分岐制御機構の解明
亀井 竣輔, 福嶋 葉子, 植村 明嘉, 有馬 勇一郎, 西山 功一, 南 敬
日本生化学会大会プログラム・講演要旨集 95回 3T12a - 06 2022.11
Language：Japanese Publishing type：Part of collection (book) Publisher：(公社)日本生化学会
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ペリサイトによる血管周囲基質の力学的性質変化を介した血管新生促進機構
春田 望智, 花田 保之, 市川 朝永, 尾関 有香, 宮崎 紬, 徐 宇卿, 有馬 勇一郎, 植村 明嘉, 白木 幸彦, 西山 功一
日本生化学会大会プログラム・講演要旨集 95回 2T10a - 09 2022.11
Authorship：Lead author, Last author, Corresponding author Language：Japanese Publishing type：Research paper (other academic) Publisher：(公社)日本生化学会
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Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer. Reviewed International journal
Luke Bu, Atsuko Yonemura, N Yasuda-Yoshihara, Tomoyuki Uchihara, Galym Ismagulov, Sanae Takasugi, Tadahito Yasuda, Yuya Okamoto, Fumimasa Kitamura, Takahiko Akiyama, Kota Arima, Rumi Itoyama, Jun Zhang, Lingfeng Fu, Xichen Hu, Feng Wei, Yuichiro Arima, Toshiro Moroishi, Koichi Nishiyama, Guojun Sheng, Toshifumi Mukunoki, Jun Otani, Hideo Baba, Takatsugu Ishimoto
Cancer science 113 ( 10 ) 3579 - 3592 2022.10
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1111/cas.15495
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NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator Reviewed
Masashi Muramatsu, Takeshi Ito, Hokuto Shimoji, Miko Komiya, Yuri Miyamura, Koichi Nishiyama, Takashi Suzuki, Takashi Minami
Biochemical and Biophysical Research Communications 571 201 - 209 2021.9
Language：English Publishing type：Research paper (scientific journal)
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心駆出率が保持されている肥満関連心不全患者において内因性のケトン体は心保護作用を発揮する(Endogenous ketone bodies have cardioprotective effects in obesity related heart failure with preserved ejection fraction)
山田 敏寛, 石田 俊史, 徐 宇卿, 高潮 征爾, 花谷 信介, 荒木 智, 中村 太志, 山本 英一郎, 松下 健一, 西山 功一, 有馬 勇一郎, 辻田 賢一
日本心臓病学会学術集会抄録 69回 YIA1 - 4 2021.9
Language：Japanese Publishing type：Research paper (other academic) Publisher：(一社)日本心臓病学会
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Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma Reviewed International coauthorship
Yoshida N., Yamamoto S., Hamashima T., Okuno N., Okita N., Horikawa S., Hayashi M., Dang T.C., Nguyen Q.L., Nishiyama K., Makinod T., Ishii Y., Tomihara K., Shimizu T., Shibuya M., Noguchi M., Sasahara M.
Proceedings of the National Academy of Sciences of the United States of America 118 ( 19 ) 2021.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Proceedings of the National Academy of Sciences of the United States of America
Along with blood vessels, lymphatic vessels play an important role in the circulation of body fluid and recruitment of immune cells. Postnatal lymphangiogenesis commonly occurs from preexisting lymphatic vessels by sprouting, which is induced by lymphangiogenic factors such as vascular endothelial growth factor C (VEGF-C). However, the key signals and cell types that stimulate pathological lymphangiogenesis, such as human cystic lymphangioma, are less well known. Here, we found that mouse dermal fibroblasts that infiltrate to sponges subcutaneously implanted express VEGF-D and sushi, Von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) in response to PDGFRβ signal. In vitro, Pdgfrb knockout (β-KO) fibroblasts had reduced expression of VEGF-D and SVEP1 and overproduced Amphiregulin. Dysregulation of these three factors was involved in the cyst-like and uneven distribution of lymphatic vessels observed in the β-KO mice. Similarly, in human cystic lymphangioma, which is one of the intractable diseases and mostly occurs in childhood, fibroblasts surrounding cystic lymphatics highly expressed Amphiregulin. Moreover, fibroblastderived Amphiregulin could induce the expression of Amphiregulin in lymphatic endothelial cells. The dual source of Amphiregulin activated EGFR expressed on the lymphatic endothelial cells. This exacerbation cascade induced proliferation of lymphatic endothelial cells to form cystic lymphangioma. Ultimately, excessive Amphiregulin produced by fibroblasts surrounding lymphatics and by lymphatic endothelial cells per se results in pathogenesis of cystic lymphangioma and will be a fascinating therapeutic target of cystic lymphangioma.
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Yuichiro Arima, Yoshiko Nakagawa, Toru Takeo, Toshifumi Ishida, Toshihiro Yamada, Shinjiro Hino, Mitsuyoshi Nakao, Sanshiro Hanada, Terumasa Umemoto, Toshio Suda, Tetsushi Sakuma, Takashi Yamamoto, Takehisa Watanabe, Katsuya Nagaoka, Yasuhito Tanaka, Yumiko K. Kawamura, Kazuo Tonami, Hiroki Kurihara, Yoshifumi Sato, Kazuya Yamagata, Taishi Nakamura, Satoshi Araki, Eiichiro Yamamoto, Yasuhiro Izumiya, Kenji Sakamoto, Koichi Kaikita, Kenichi Matsushita, Koichi Nishiyama, Naomi Nakagata, Kenichi Tsujita
Nature Metabolism 3 ( 2 ) 196 - 210 2021.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC
DOI： 10.1038/s42255-021-00342-6
Other Link： http://www.nature.com/articles/s42255-021-00342-6
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[Role of the liaison officer in disaster countermeasures implemented by the Japanese Society of Neurology: Hope for the best and prepare for the worst].
Nakane S, Mizoguchi K, Abe K, Atsuta N, Iguchi Y, Ikeda Y, Kaji R, Kamei S, Kitagawa K, Kimura K, Suzuki M, Takashima H, Terayama Y, Nishiyama K, Furuya H, Matsubara E, Muramatsu SI, Yamamura O, Takeda A, Ito H, Committee for Measures Against Disaster, Japanese Society of Neurology
Rinsho shinkeigaku = Clinical neurology 60 ( 10 ) 643 - 652 2020.10
Language：Japanese Publishing type：Research paper (scientific journal)
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脈管のメカノバイオロジー 創傷治癒過程の血管新生における内腔圧の新たな役割の解明
福原 茂朋, 弓削 進弥, 有馬 勇一郎, 花田 保之, 花田 三四郎, 石井 智裕, 若山 勇紀, 横川 隆司, 三浦 岳, 望月 直樹, 西山 功一
脈管学 60 ( Suppl. ) S113 - S114 2020.10
Language：Japanese Publishing type：Research paper (other academic) Publisher：(一社)日本脈管学会
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血流依存的な転移がん血管内浸潤メカニズム解明に資する新規オンチップモデル
西山 功一, 花田 三四郎
日本癌学会総会記事 79回 OE10 - 7 2020.10
Language：Japanese Publishing type：Research paper (other academic) Publisher：(一社)日本癌学会
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An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling
Erickson S., Ihara H., Hanada S., Nishiyama K., Miura T., Yokokawa R.
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) 2020-January 444 - 447 2020.1
Language：Japanese Publishing type：Research paper (international conference proceedings) Publisher：Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pericytes are critical support cells for vasculature. They aid in sprout formation, promote the expression of junction proteins between endothelial cells, and help regulate blood flow. But to perform these roles, they must first be recruited by endothelial cells. Here, we use a microchannel device to create self-assembling vasculature and study the effect of inhibiting pericyte-endothelial cell communication. We explore the effect of pericytes on vascular morphology and track pericyte coverage with and without the inhibitory drug, Imatinib. We find that pericyte migration and vessel morphology are changed with inhibition of platelet-derived growth factor (PDGF) receptor. In this way, we show the value of this system for both drug development and basic biological studies.
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Oxygen metabolism analysis of a vascularized spheroid using a scanning electrochemical microscopy
Nashimoto Y., Mukomoto R., Terai T., Ino K., Nishiyama K., Yokokawa R., Miura T., Shiku H.
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 520 - 521 2020
Language：English Publishing type：Research paper (international conference proceedings) Publisher：MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
We investigated the effect of vascularization on oxygen metabolism in a fibroblast spheroid. By the scanning of a microelectrode, the oxygen reduction current was monitored, which allowed us to analyze the oxygen metabolism quantitatively. The oxygen metabolism of the spheroids were determined by the spheroid radius (volume) and did not depend on whether the spheroid was vascularized or not, implying the identical activity of oxygen metabolism of the fibroblast and endothelial cells. Our system is useful for the metabolic evaluation of a three-dimensional culture model.
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Angiogenesis derived from shear stress optimised by a microfruidic device
Teraoka Y., Nakayama M., Nashimoto Y., Nakamasu A., Hanada S., Arima Y., Torisawa Y.S., Kotera H., Nishiyama K., Miura T., Yokokawa R.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 1072 - 1073 2020
Language：Japanese Publishing type：Research paper (conference, symposium, etc.) Publisher：21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Previously, we created a 3D vascular network in a microfluidic device and demonstrated that the luminal flow significantly enhanced the formation of angiogenic sprouts as compared to static conditions [1]. These results could not be explained based on either biochemical factors (oxygen and nutrient transport) or mechanical factors (pressure and shear stress) derived angiogenesis. In this study, we investigated the effect of flow rate and shear stress on angiogenesis induced by luminal flow. We calculated the shear stress exposed on the endothelium where new sprouting initiated. Our results showed that angiogenesis was induced in the specific range of shear stress.
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Perfusion culture through a vasculature constructed in a tumor spheroid
Nashimoto Y., Teraoka Y., Nakamasu A., Hanada S., Arima Y., Torisawa Y.S., Kotera H., Nishiyama K., Miura T., Yokokawa R.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 1029 - 1030 2020
Language：English Publishing type：Research paper (other academic) Publisher：21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
We developed a microfluidic system for a perfusion culture of tumor spheroids utilizing engineered vasculatures. By the definition of the cellular interaction between fibroblast cells in a tumor spheroid and endothelial cells in microchannels, we successfully induced angiogenic sprouts from the microchannels, which anastomosed with the spheroid and formed perfusable vasculatures. We continuously supplied medium to the tumor spheroid through the vasculature and evaluated the effect of perfusion on the growth of the tumor spheroid. Our perfusion system greatly improved the cellular proliferation activity, mimicking the nutrition supply and evacuation of waste product through vasculatures surrounding tumors in vivo.
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Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells.
Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y, Nakagawa O
Angiogenesis 21 ( 2 ) 415 - 423 2018.5
Language：English Publishing type：Research paper (scientific journal)
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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device.
Nashimoto Y, Teraoka Y, Banan Sadeghian R, Nakamasu A, Arima Y, Hanada S, Kotera H, Nishiyama K, Miura T, Yokokawa R
Journal of visualized experiments : JoVE ( 134 ) 2018.4
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Evaluation of Collateral Source Characteristics With 3-Dimensional Analysis Using Micro-X-Ray Computed Tomography.
Arima Y, Hokimoto S, Tabata N, Nakagawa O, Oshima A, Matsumoto Y, Sato T, Mukunoki T, Otani J, Ishii M, Uchikawa M, Yamamoto E, Izumiya Y, Kaikita K, Ogawa H, Nishiyama K, Tsujita K
Journal of the American Heart Association 7 ( 6 ) 2018.3
Language：English Publishing type：Research paper (scientific journal)
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Study on the tumor-induced angiogenesis using mathematical models.
Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ
Cancer science 109 ( 1 ) 15 - 23 2018.1
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Fetal Origins of Hypertension.
Arima Y, Nishiyama K, Izumiya Y, Kaikita K, Hokimoto S, Tsujita K
Advances in experimental medicine and biology 1012 41 - 48 2018
Language：English Publishing type：Research paper (scientific journal)
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Autonomy and Non-autonomy of Angiogenic Cell Movements Revealed by Experiment-Driven Mathematical Modeling.
Sugihara K, Nishiyama K, Fukuhara S, Uemura A, Arima S, Kobayashi R, Köhn-Luque A, Mochizuki N, Suda T, Ogawa H, Kurihara H
Cell reports 13 ( 9 ) 1814 - 27 2015.12
Language：English Publishing type：Research paper (scientific journal)
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Association of estimated central blood pressure measured non-invasively with pulse wave velocity in patients with coronary artery disease.
Sueta D, Yamamoto E, Tanaka T, Hirata Y, Sakamoto K, Tsujita K, Kojima S, Nishiyama K, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H
International journal of cardiology. Heart & vasculature 8 52 - 54 2015.9
Language：English Publishing type：Research paper (scientific journal)
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The accuracy of central blood pressure waveform by novel mathematical transformation of non-invasive measurement.
Sueta D, Yamamoto E, Tanaka T, Hirata Y, Sakamoto K, Tsujita K, Kojima S, Nishiyama K, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H
International journal of cardiology 189 244 - 6 2015
Language：English Publishing type：Research paper (scientific journal)
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Id1 gene transfer confers angiogenic property on fully differentiated endothelial cells and contributes to therapeutic angiogenesis.
Nishiyama K, Takaji K, Kataoka K, Kurihara Y, Yoshimura M, Kato A, Ogawa H, Kurihara H
Circulation 112 ( 18 ) 2840 - 50 2005.11
Language：English Publishing type：Research paper (scientific journal)
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Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men.
Nishiyama K, Yasue H, Moriyama Y, Tsunoda R, Ogawa H, Yoshimura M, Kugiyama K
American heart journal 141 ( 5 ) E9 2001.5
Language：English Publishing type：Research paper (scientific journal)
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The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity.
Moriyama Y, Yasue H, Yoshimura M, Mizuno Y, Nishiyama K, Tsunoda R, Kawano H, Kugiyama K, Ogawa H, Saito Y, Nakao K
The Journal of clinical endocrinology and metabolism 85 ( 5 ) 1834 - 40 2000.5
Language：English Publishing type：Research paper (scientific journal)
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Elevated levels of soluble intercellular adhesion molecule-1 in the coronary circulation of patients with coronary organic stenosis and spasm.
Ogawa H, Sakamoto T, Nishiyama K, Soejima H, Kaikita K, Takazoe K, Miyamoto S, Kugiyama K, Yoshimura M, Yasue H
Japanese circulation journal 64 ( 3 ) 170 - 6 2000.3
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Increased blood vascular endothelial growth factor levels in patients with acute myocardial infarction.
Ogawa H, Suefuji H, Soejima H, Nishiyama K, Misumi K, Takazoe K, Miyamoto S, Kajiwara I, Sumida H, Sakamoto T, Yoshimura M, Kugiyama K, Yasue H, Matsuo K
Cardiology 93 ( 1-2 ) 93 - 9 2000
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Angiotensin-converting enzyme inhibition reduces monocyte chemoattractant protein-1 and tissue factor levels in patients with myocardial infarction.
Soejima H, Ogawa H, Yasue H, Kaikita K, Takazoe K, Nishiyama K, Misumi K, Miyamoto S, Yoshimura M, Kugiyama K, Nakamura S, Tsuji I
Journal of the American College of Cardiology 34 ( 4 ) 983 - 8 1999.10
Language：English Publishing type：Research paper (scientific journal)
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Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis in patients with unstable angina.
Soejima H, Ogawa H, Yasue H, Kaikita K, Nishiyama K, Misumi K, Takazoe K, Miyao Y, Yoshimura M, Kugiyama K, Nakamura S, Tsuji I, Kumeda K
Circulation 99 ( 22 ) 2908 - 13 1999.6
Language：English Publishing type：Research paper (scientific journal)
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Plasma soluble intercellular adhesion molecule-1 levels in coronary circulation in patients with unstable angina.
Ogawa H, Yasue H, Miyao Y, Sakamoto T, Soejima H, Nishiyama K, Kaikita K, Suefuji H, Misumi K, Takazoe K, Kugiyama K, Yoshimura M
The American journal of cardiology 83 ( 1 ) 38 - 42 1999.1
Language：English Publishing type：Research paper (scientific journal)
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Plasma tissue factor pathway inhibitor and tissue factor antigen levels after administration of heparin in patients with angina pectoris.
Soejima H, Ogawa H, Yasue H, Nishiyama K, Kaikita K, Misumi K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K, Nakamura S
Thrombosis research 93 ( 1 ) 17 - 25 1999.1
Language：English Publishing type：Research paper (scientific journal)
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Simultaneous elevation of the levels of circulating monocyte chemoattractant protein-1 and tissue factor in acute coronary syndromes.
Nishiyama K, Ogawa H, Yasue H, Soejima H, Misumi K, Takazoe K, Yoshimura M, Kugiyama K, Tsuji I, Kumeda K
Japanese circulation journal 62 ( 9 ) 710 - 2 1998.9
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Circadian variation in plasma levels of free-form tissue factor pathway inhibitor antigen in patients with coronary spastic angina.
Misumi K, Ogawa H, Yasue H, Soejima H, Suefuji H, Nishiyama K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K
Japanese circulation journal 62 ( 6 ) 419 - 24 1998.6
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Heparin-releasable endothelial cell-associated tissue factor pathway inhibitor (TFPI) is increased in the coronary circulation after coronary spasm in patients with coronary spastic angina.
Nishiyama K, Ogawa H, Yasue H, Soejima H, Misumi K, Kugiyama K, Tsuji I, Kumeda K
Thrombosis research 89 ( 3 ) 137 - 46 1998.2
Language：English Publishing type：Research paper (scientific journal)
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Comparison of plasma tissue factor levels in unstable and stable angina pectoris.
Misumi K, Ogawa H, Yasue H, Soejima H, Suefuji H, Nishiyama K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K, Nakamura S
The American journal of cardiology 81 ( 1 ) 22 - 6 1998.1
Language：English Publishing type：Research paper (scientific journal)
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Relationship between serum angiotensin-converting enzyme activity and plasma plasminogen activator inhibitor activity in patients with recent myocardial infarction.
Moriyama Y, Ogawa H, Oshima S, Arai H, Takazoe K, Shimomura H, Hirai N, Suefuji H, Soejima H, Nishiyama K, Misumi K, Yasue H
Coronary artery disease 9 ( 10 ) 691 - 6 1998
Language：English Publishing type：Research paper (scientific journal)
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Effects of imidapril therapy on endogenous fibrinolysis in patients with recent myocardial infarction.
Soejima H, Ogawa H, Yasue H, Suefuji H, Kaikita K, Nishiyama K
Clinical cardiology 20 ( 5 ) 441 - 5 1997.5
Language：English Publishing type：Research paper (scientific journal)
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Effect of niceritrol on fibrinolysis and lipoprotein (a) levels in patients with coronary artery disease.
Suefuji H, Ogawa H, Yasue H, Imoto N, Sakamoto T, Miyao Y, Kaikita K, Soejima H, Nishiyama K
Coronary artery disease 7 ( 2 ) 167 - 72 1996.2
Language：English Publishing type：Research paper (scientific journal)