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Faculty of Medicine School of Medicine Department of Internal Medicine, Cardiovascular Medicine and Nephrology |
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Associate Professor |
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Related SDGs |
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MATSUURA Yunosuke
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Papers 【 display / non-display 】
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Reference Intervals and Clinical Determinants of Blood Thrombogenicity in Antithrombotic Drug-Naïve Adults Using an Advanced Microchip-Based Device. Reviewed International journal
Takeaki Kudo, Yunosuke Matsuura, Michikazu Nakai, Shohei Koyama, Hironao Iwakiri, Yoshisato Shibata, Koichi Kaikita
The journal of applied laboratory medicine 2026.4
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: The Total Thrombus-formation Analysis System 01 (T-TAS 01) is an advanced microchip-based device that enables quantitative assessment of blood thrombogenicity. However, broader clinical implementation remains limited by the lack of well-established reference intervals (RIs) in healthy, antithrombotic drug-naïve individuals. This study aimed to define RIs and identify clinical determinants of blood thrombogenicity in antithrombotic drug-naïve adults using T-TAS 01. METHODS: Blood thrombogenicity was measured using T-TAS 01 in 319 adults without antithrombotic therapy who underwent health checkups at the Miyakonojo Health Service Center. The T-TAS 01 parameters, PL18-AUC10 and AR10-AUC30, were calculated as the areas under the flow-pressure curves of the PL-chip (type I collagen-coated) and the AR-chip (type I collagen and tissue factor-coated), respectively. Their associations with clinical parameters were assessed using multivariate regression analysis. RESULTS: The median age was 46.0 years; 64.3% of participants were female, and 82.1% had no hypertension, dyslipidemia, or diabetes. The median platelet count was 247 × 109/L. The median PL18-AUC10 and AR10-AUC30 values were 392.3 and 1335.9, with RIs of 236.3 to 468.1 and 1010.0 to 1496.2, respectively. PL18-AUC10 was independently associated with white blood cell count (coefficient, 5.15; 95% CI, 0.88-9.41) and platelet count (0.36; 95% CI, 0.25-0.47), whereas AR10-AUC30 was independently associated with body mass index (4.06; 95% CI, 0.06-8.06), platelet count (0.79; 95% CI, 0.52-1.06), and γ-glutamyl transpeptidase (-0.54; 95% CI, -0.90 to -0.18). CONCLUSIONS: Our findings provide foundational reference data for the clinical application of T-TAS 01 and support its potential as a point-of-care tool for individualized assessment of thrombogenicity.
DOI： 10.1093/jalm/jfag042
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冠攣縮の診断アルゴリズムと冠攣縮誘発試験 Reviewed
松浦祐之介, 海北幸一
JCVA会誌 「心血管薬物療法」 第13巻 ( 1 ) 16 - 22 2026.3
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Toshihiro Tsuruda, Narukuni Kodama, Toshihiro Tanahashi, Yosuke Suiko, Kinuko Yamamoto, Soichi Komaki, Kohei Moribayashi, Chiharu Terakawa, Minayo Iwai, Katsuya Sakai, Kazutaka Shiomi, Tamasa Terada, Hiroshi Nakada, Miyuki Ogata, Miyo Tanaka, Atsushi Yamashita, Hiroyuki Iida, Yunosuke Matsuura, Koichi Kaikita
Internal medicine (Tokyo, Japan) 2026.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Internal Medicine
Transthyretin Val122Ile variant carriers are at risk of developing heart failure, with this variant being observed in individuals of Western African ancestry. We encountered three patients carrying this variant in a single kindred from southern Japan. The detection of amyloid in the carpal tunnel tissue prompted comprehensive clinical evaluation, confirming cardiac involvement. Speckle-tracking echocardiography and cardiac magnetic resonance imaging revealed age-related progression of myocardial involvement predominantly affecting the basal inferoseptum. The transthyretin Val122Ile variant is associated with poor clinical outcomes. Clinicians should be aware that this variant can also be sporadically present in elderly Japanese patients with cardiomyopathy or heart failure.
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Hiroki Tanaka, Yunosuke Matsuura, Kinuko Yamamoto, Soichi Komaki, Masashi Yamaguchi, Kohei Moribayashi, Takeshi Ideguchi, Michikazu Nakai, Toshihiro Tsuruda, Koichi Kaikita
Circulation Reports 8 ( 3 ) 453 - 460 2026.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Circulation Society
BACKGROUND: Although angiopoietin-like protein 3 (ANGPTL3) has emerged as a novel therapeutic target for lipid modulation, its prognostic significance in chronic coronary syndrome (CCS) remains unclear. This study aimed to evaluate the clinical determinants and prognostic value of circulating ANGPTL3 levels in patients with CCS. METHODS AND RESULTS: We prospectively enrolled 264 consecutive patients with CCS (median age 74 years; 73% male) undergoing cardiac catheterization. Serum ANGPTL3 levels were measured using an enzyme-linked immunosorbent assay. The primary endpoint was major adverse cardiovascular events (MACE). Female sex, elevated C-reactive protein and B-type natriuretic peptide, low high-density lipoprotein cholesterol levels, and absence of statin use were independently associated with higher ANGPTL3 levels. During follow up, 35 patients experienced MACE. In multivariable Cox regression models, ANGPTL3 remained an independent predictor of MACE. Receiver operating characteristic analysis identified 90.7 ng/mL as the optimal cut-off value for event discrimination. Kaplan-Meier curves demonstrated significantly higher event rates among patients with ANGPTL3 >90.7 ng/mL. In patients with CCS with low-density lipoprotein cholesterol (LDL-C) <70 mg/dL, elevated ANGPTL3 levels were also associated with increased MACE risk. CONCLUSIONS: Circulating ANGPTL3 levels independently predict adverse cardiovascular outcomes in CCS, including those in patients who achieve LDL-C targets, and may help identify residual cardiovascular risk not captured by traditional lipid parameters.
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Intravascular ultrasound-guided tip detection-antegrade dissection re-entry as a bailout technique for coronary artery dissection: a case report. Reviewed International journal
Shintaro Izumoto, Kazumasa Kurogi, Yunosuke Matsuura, Nobuyasu Yamamoto, Koichi Kaikita
European heart journal. Case reports 10 ( 3 ) ytag162 2026.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)
Abstract
Background
Coronary artery dissection during percutaneous coronary intervention (PCI) may lead to hemodynamic collapse. Intravascular ultrasound (IVUS)-guided tip detection–antegrade dissection re-entry (TD-ADR) may serve as a bailout strategy. We describe a unique case in which IVUS-guided TD-ADR successfully achieved true lumen re-entry after severe coronary dissection.
Case summary
A 64-year-old woman who had received long-term immunosuppressive therapy for rheumatoid arthritis was admitted for unstable angina. Subsequent evaluation revealed severe multivessel disease, and the patient underwent PCI of the left anterior descending artery (LAD). During the procedure, the patient experienced cardiac arrest, likely due to worsening global myocardial ischemia, and required venoarterial extracorporeal membrane oxygenation support. IVUS demonstrated subintimal wire tracking with true lumen collapse. IVUS-guided TD-ADR using a high-penetration chronic total occlusion wire supported by a microcatheter enabled precise re-entry into the true lumen and successful LAD revascularization. Severe left circumflex artery stenoses were also considered to perpetuate myocardial ischemia and hemodynamic instability, necessitating rescue PCI for hemodynamic stabilization. In addition, major bleeding complications due to guidewire-induced perforation of the right subclavian artery branch were managed using stenting and coil embolization. The patient recovered left ventricular function and was discharged in stable condition. During the 8-month follow-up after discharge, the patient was free of adverse events.
Discussion
This case highlights the feasibility of IVUS-guided TD-ADR as a bailout technique for coronary dissection during complex PCI. By enabling accurate true lumen re-entry, this approach facilitates timely revascularization and contributes to hemodynamic stabilization and recovery in a life-threatening setting.
Books 【 display / non-display 】
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最新 MINOCA/INOCA の診断と治療
松浦祐之介, 海北幸一（ Role： Contributor , 1. MINOCAの診断 (4. 冠攣縮の診断), 2. INOCAの診断(3. 冠攣縮性狭心症の診断)）
日本医事新報社 2025.10
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内科臨床誌 メディチーナ Vol.60 No.13 特集 : 一般医家のためのDOAC時代の心房細動診療
小牧聡一, 松浦祐之介, 海北幸一（ Role： Contributor , 18. PCI後の抗血栓療法をどうする？）
医学書院 2023.12
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特集/冠攣縮性狭心症と冠微小循環障害: 新たな知見 冠攣縮性狭心症の診断基準・冠攣縮薬物誘発試験: 循環器内科
松浦祐之介、水光洋輔、海北幸一（ Role： Joint author , 分担執筆 (7．冠攣縮性狭心症の診断基準・冠攣縮薬物誘発試験)）
科学評論社 2023.10
Language：Japanese Book type：Scholarly book
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臨床冠動脈疾患学-冠動脈疾患の最新治療戦略-
松浦祐之介、水光洋輔、海北幸一（ Role： Joint author , 分担執筆 (VI 冠動脈疾患の検査・診断 (3) アセチルコリン誘発試験)）
日本臨床 2023.8
Language：Japanese Book type：Textbook, survey, introduction
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臨床と研究 特集/心筋梗塞の診療と予防のエビデンス
松浦祐之介、海北幸一（ Role： Joint author , 分担執筆 (急性期評価と治療 薬物治療)）
大道学館 2023.5
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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Association between angiopoietin-like protein 3 and frailty in cardiovascular disease patients
H Tanaka, Y Matsuura, K Yamamoto, S Komaki, M Yamaguchi, K Moribayashi, T Ideguchi, T Tsuruda, K Kaikita
European Heart Journal, Volume 46, Issue Supplement_1, November 2025, ehaf784.4076, 2025.11
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Unique amino acid profile and prognostic significance of the Fischer ratio in end-stage kidney disease patients with cardiovascular disease
K Moribayashi, Y Matsuura, K Yamamoto, H Tanaka, S Komaki, M Yamaguchi, T Ideguchi, T Tsuruda, K Kaikita
European Heart Journal, Volume 46, Issue Supplement_1, November 2025, ehaf784.4188, 2025.11
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Renal blood flow response after transcatheter aortic valve replacement for severe aortic stenosis: a longitudinal renal artery doppler ultrasound study
N Kodama, Y Matsuura, K Yamamoto, H Tanaka, S Komaki, M Yamaguchi, K Moribayashi, T Ideguchi, T Tsuruda, K Kaikita
European Heart Journal, Volume 46, Issue Supplement_1, November 2025, ehaf784.2261 2025.11
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Prognostic predictive value of circulating angiopoietin-like protein 3 in patients with chronic coronary syndrome
H Tanaka, Y Matsuura, K Yamamoto, S Komaki, M Yamaguchi, K Moribayashi, T Ideguchi, T Tsuruda, K Kaikita
European Heart Journal, Volume 46, Issue Supplement_1, November 2025, ehaf784.1632, 2025.11
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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ATTR型心アミロイドーシスにおける右房ストレイン異常の臨床的意義
尾方 美幸, 松浦 祐之介, 伊藤 芽生, 田中 美与, 山口 昌志, 鶴田 敏博, 海北 幸一, 古川 貢之, 渡邉 望
超音波医学 52 ( Suppl. ) S494 - S494 2025.4
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(公社)日本超音波医学会
Grant-in-Aid for Scientific Research 【 display / non-display 】
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健康寿命延伸を見据えた抗血栓療法のための新規出血リスクスコアの開発
Grant number：24K11294 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
松浦 祐之介
Authorship：Principal investigator
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The monitoring of monocyte glucose metabolism for the prevention of atherosclerosis progression in diabetes
Grant number：20K17121 2020.04 - 2023.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists Grant-in-Aid for Early-Career Scientists
Authorship：Principal investigator
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動脈血栓症の発症前予測法の開発
Grant number：25560205 2013.04 - 2016.03
日本学術振興会 科学研究費助成事業 挑戦的萌芽研究
Authorship：Coinvestigator(s)