|
Affiliation |
Faculty of Medicine School of Medicine Department of community Pediatrics and Support Raising Next-Generation |
|
Related SDGs |
|
KODAMA Yoshihiko
|
|
|
Research Areas 【 display / non-display 】
-
Life Science / Embryonic medicine and pediatrics
-
Life Science / Cardiology
Papers 【 display / non-display 】
-
Yokoyama R., Kodama Y., Takamura K., Takahashi M., Tanaka M., Watanabe N., Moritake H.
Journal of Cardiology Cases 31 ( 6 ) 155 - 157 2025.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Cardiology Cases
Exercise stress echocardiography (ESE) is a feasible and valuable tool for evaluating subclinical pulmonary hypertension (PH). However, its utility in patients with unilateral pulmonary branch stenosis remains unclear. We present a case involving a 17-year-old patient with left pulmonary branch stenosis who exhibited exercise-induced PH in the contralateral pulmonary artery as detected by ESE. Standard echocardiography was unable to visualize the left pulmonary artery clearly; therefore, computed tomography was performed, revealing a left pulmonary branch stenosis with a minimum diameter of 4.2 mm. Resting echocardiography showed a pressure gradient of 17 mmHg, calculated using the tricuspid regurgitant velocity. During ESE with a prone ergometer, the slope of the mean pulmonary arterial pressure to systemic cardiac output was 3.1 mmHg/L/min, meeting the diagnostic criteria for exercise-induced PH. The patient underwent stent implantation to treat the left pulmonary branch stenosis. Follow-up ESE demonstrated improvement, with the slope of the mean pulmonary arterial pressure to systemic cardiac output decreasing to 1.5 mmHg/L/min. These findings underscore that ESE is both feasible and effective for assessing subclinical unilateral pulmonary branch stenosis. Learning objective: Patients with congenital unilateral peripheral branch pulmonary artery stenosis usually do not have pulmonary hypertension at rest, and identifying patients who require treatment is challenging. Exercise stress echocardiography can detect latent pulmonary hypertension of the contralateral pulmonary artery in some patients, providing valuable insights for determining treatment indications and evaluating the efficacy of catheter interventions for the stenotic lesion.
-
Clinical Course and Operative Indication of Hiatal Hernia in Patient with Heterotaxy Syndrome and Single Ventricle Reviewed
Suzuki Sayo, Ishikawa Yuichi, Tao Katsuo, Kuraoka Ayako, Yamamura Kenichiro, Kodama Yoshihiko, Hayashida Makoto, Nakano Toshihide, Sagawa Koichi
Pediatric Cardiology and Cardiac Surgery 41 ( 1 ) 42 - 50 2025.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Pediatric Cardiology and Cardiac Surgery
<b>Background:</b> Hiatal hernia (HH) in patients with heterotaxy syndrome can potentially affect the circulation of a single ventricle. The indications for HH repair have not been clearly established in this cohort.<b>Methods:</b> We conducted a comprehensive review of the clinical course, encompassing HH complications and repairs, of 109 patients diagnosed with heterotaxy syndrome and a single ventricle. Neonates treated at our hospital from January 2008 to December 2018 were enrolled in the present study.<b>Results:</b> Among the cohort, 13 patients (12％) had HH, with 6 patients undergoing subsequent HH repair. Four patients exhibited pulmonary venous compression by a herniated stomach, all of whom presented with a herniation positioned between the atrium and vertebrae, impacting the pulmonary veins from behind. Three patients underwent surgery with postoperative duodenal stenosis, and one patient died in the perioperative period of HH surgery. Among the 7 patients who did not undergo HH surgery, 4 patients successfully completed the Fontan procedure and remained asymptomatic during follow-up (median, 104.5 months; range, 100–112 months).<b>Conclusion:</b> The surgical indications for HH repair in patients with a single ventricle should be determined according to their characteristic symptoms and postoperative course.
DOI： 10.9794/jspccs.41.42
-
Lymphatic dysplasia evaluated by indocyanine green lymphography in congenital myotonic dystrophy Reviewed
Tate M., Aoki Y., Ochiai K., Kodama Y., Nakame K., Kodama Y., Moritake H.
Pediatrics International 67 ( 1 ) e70170 2025.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Pediatrics International
DOI： 10.1111/ped.70170
-
Isolated Blind-Ended Major Aortic Pulmonary Collateral Artery With an Aneurysm in an Infant With Trisomy 21. Reviewed
Yonaga R, Kodama Y, Takamura K, Harada M, Moritake H.
Cureus 16 ( 10 ) e72078 2024.10
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
-
Shusei Ebihara，Yoshihiko Kodama，Kazunari Takamura，Masako Harada，Hiroshi Moritake
Journal of Pediatric Cardiology and Cardiac Surgery 8 ( 2 ) 82 - 86 2024.7
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児循環器学会
Symptoms of coronavirus infectious disease 2019 (COVID-19) are usually mild in young patients. Some children, however, present with a significant degree of complications which may be associated with an excessive reaction by the immune system. Herein, we report an analysis of cytokine and chemokine in an 11-year-old girl diagnosed with left ventricular dysfunction and cardiac tamponade complicated with COVID-19. She recovered without complications after intravenous immunoglobulin, dexamethasone, remdesivir, and surgical pericardial drainage. Cytokine concentrations had markedly increased in the pericardial fluid specimen; especially for interleukin-6 being disproportionate to its serum concentration. Cytokine storm originating from the pericardial cavity was considered an underlying mechanism of her condition.
MISC 【 display / non-display 】
-
特集 おさえておきたい! 胎児･新生児の超音波検査 新生児の超音波検査:心臓･胸部 非チアノーゼ性心疾患 Invited
兒玉 祥彦
周産期医学 55 ( 10 ) 1270 - 1273 2025.10
Authorship：Lead author, Corresponding author Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
-
特集 急増する患者を誰が診る? 成人先天性心疾患 [Chapter 3] 成人先天性心疾患各論 Ebstein病 Reviewed
兒玉 祥彦
内科 136 ( 2 ) 245 - 247 2025.8
Authorship：Lead author, Corresponding author Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：南江堂
-
【成人移行支援の二面性】成人医療との連携の場 小児科と成人診療科との連携 異なる病院間での連携． Invited
兒玉 祥彦
小児内科 2021.8
Authorship：Lead author Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
-
【小児の症候群】循環器 Bland-White-Garland症候群(左冠動脈肺動脈起始症) Invited
兒玉 祥彦, 石川 司朗
小児科診療 2016.10
Authorship：Lead author Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Awards 【 display / non-display 】
-
第56回日本小児循環器学会 会長賞
2020.10 日本小児循環器学会
兒玉 祥彦
Award type：Award from Japanese society, conference, symposium, etc.
-
第53回欧州小児循環器学会 YIA賞
2019.5 欧州小児循環器学会（AEPC）
兒玉 祥彦
Award type：International academic award (Japan or overseas)
-
第21回日本心不全学会 YIA最優秀賞
2017.10 日本心不全学会
兒玉 祥彦
Award type：Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
深層学習を用いた複雑心奇形患者の心室機能推定プログラムの開発
Grant number：23K07480 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
-
先天性骨系統疾患の医療水準と患者QOLの向上を目的とした研究
Grant number：22FC1012 2022.04 - 2025.03
厚生労働省 厚生科研 厚生労働科学研究費補助金 難治性疾患政策研究事業
Authorship：Coinvestigator(s)
-
フォンタン術後青年期患者の予後改善を目的とした安全で新しい運動管理プランの開発
Grant number：20K08417 2020.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Principal investigator