KUROKI Daisuke

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Internal Medicine, Hematology, Gastroenterology and Hepatology

Title

Assistant Professor

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  • Metachronous Esophageal Ulcers after Immune-mediated Colitis Due to Immune Checkpoint Inhibitor Therapy: A Case Report and Literature Review

    Ogawa Soichiro, Kawakami Hiroshi, Suzuki Sho, Kuroki Daisuke, Uchiyama Naomi, Hatada Hiroshi, Gi Toshihiro, Sato Yuichiro

    Internal Medicine   60 ( 17 )   2783 - 2791   2021.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Internal Medicine  

    Although cases of gastrointestinal toxicity of pembrolizumab have been reported, cases of acute immune-mediated colitis accompanied with metachronous esophageal disorders (esophagitis and ulcer) are rare. We herein report a case of acute colitis and metachronous esophageal ulcers due to an immune-related adverse event following concomitant pembrolizumab chemotherapy for lung adenocarcinoma. To our knowledge, there have so far been no reports of cases in which both acute immune-mediated colitis and metachronous esophageal ulcers developed. We therefore report the details of this case along with a review of the pertinent literature.

    DOI： 10.2169/internalmedicine.6606-20

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  • SUCCESSFUL ENDOSCOPIC SUBMUCOSAL DISSECTION USING DEXMEDETOMIDINE FOR SEDATION IN A PATIENT WITH MYASTHENIA GRAVIS: A CASE REPORT

    KUROKI Daisuke, KAWAKAMI Hiroshi, NAKASHIMA Kouji, SUZUKI Sho, MIIKE Tadashi, ASHIZUKA Shinya, ABE Hiroo, YAMAMOTO Shojiro, INATSU Haruhiko, HOSOKAWA Ayumu

    GASTROENTEROLOGICAL ENDOSCOPY   63 ( 2 )   188 - 194   2021

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Gastroenterological Endoscopy Society  

    A 37-year-old man underwent thymectomy for myasthenia gravis and subsequently received oral medication. Screening upper gastrointestinal endoscopy revealed a 20mm fading concave lesion on the posterior wall of the greater curvature of the stomach. He was diagnosed with signet-ring cell carcinoma based on histopathological examination of a biopsy specimen and was referred to our hospital for further management. Preoperative evaluation led to a diagnosis of early gastric cancer and he was scheduled for endoscopic submucosal dissection (ESD). Benzodiazepines are contraindicated for sedation in patients with myasthenia gravis, and a drug that does not cause muscle relaxation should be administered. Therefore, in this patient, we performed successful ESD using a combination of dexmedetomidine, pentazocine, and hydroxyzine for sedation. Dexmedetomidine is useful for limited sedation that is required during endoscopic procedures in patients with myasthenia gravis.

    DOI： 10.11280/gee.63.188

    Scopus

    CiNii Research

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