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Affiliation |
Faculty of Medicine College Hospital Neurology |
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Title |
Assistant Professor |
SAKAI Katsuya
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Papers 【 display / non-display 】
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Validation and Discussion of Severity Evaluation and Disease Classification Using Tremor Video
Hayashida T., Sugiyama T., Sakai K., Ishii N., Mochizuki H., Zin T.T.
Electronics (Switzerland) 12 ( 7 ) 2023.4
Publishing type：Research paper (scientific journal) Publisher：Electronics (Switzerland)
A tremor is a significant symptom of Parkinson’s disease, but it can also be a characteristic of essential tremor, thereby hampering even specialists’ ability to differentiate between the two. This study proposes a system that leverages a single RGB camera to evaluate tremor severity and support the differential diagnosis of Parkinson’s disease and essential tremor. The system captures motor symptoms, performs time–frequency analysis using wavelet transforms, and classifies severity and disease using linear classification models. The results showed an accuracy rate of 0.56 for disease classification and 0.50 for severity classification (with an acceptable accuracy rate of 0.96). The analysis indicated that there was a low level of correlation between disease and each feature and a moderate correlation (about 0.6) between severity and each feature. Based on these results, this study recommends classifying severity with a linear model and disease with a nonlinear model to obtain improved accuracy.
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Oda Y., Tsubouchi H., Ishii N., Kitamura A., Moriyama E., Mitsutome E., Sakai K., Shiomi K., Yanagi S., Miyazaki T.
Respiratory Medicine Case Reports 46 101930 2023.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Respiratory Medicine Case Reports
Small cell lung carcinoma (SCLC) is a neuroendocrine carcinoma with a poor prognosis and is a common cause of paraneoplastic syndromes. Paraneoplastic syndromes are characterized by neurological and endocrinological problems in patients with malignancy and are often associated with difficulty in induction of chemotherapy. Here we report the case of a patient with SCLC concomitant with two paraneoplastic syndromes, syndrome of inappropriate antidiuretic hormone secretion (SIADH) and Lambert–Eaton myasthenic syndrome (LEMS), who was treated with a platinum-doublet chemotherapy regimen. A 66-year-old male patient presented with a 1-month history of progressive proximal muscle weakness, ataxia gait and 5 kg of body weight loss. The laboratory tests revealed hyponatremia due to SIADH and the existence of antibodies against P/Q-type voltage-gated calcium channels. The nerve conduction study showed a low amplitude of compound muscle action potential (0.38 mv), a 34% decrement on 3-Hz stimulation, and a 1939% increment after maximum voluntary contraction in 10 seconds (7.75 mv). The endobronchial ultrasound transbronchial needle aspiration biopsy revealed the pathological findings of SCLC. A 2-cycle chemotherapy regimen of irinotecan plus cisplatin resulted in temporary tumor shrinkage that lasted 2 months, but the improvement of proximal muscle weakness and hyponatremia were maintained over the tumor re-progression period after chemotherapy. Although paraneoplastic syndromes accelerate the decrease in performance status, chemotherapy for SCLC may improve symptoms related to paraneoplastic syndromes and could be considered in similar cases.
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Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice. Reviewed International journal
Md Nurul Islam, Weidong Zhang, Katsuya Sakai, Yuki Nakazato, Ryota Tanida, Hideyuki Sakoda, Toshiki Takei, Toshifumi Takao, Masamitsu Nakazato
Peptides 151 170763 - 170763 2022.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Peptides
Ghrelin is a gastric-derived peptide that stimulates feeding, blood glucose elevation, body temperature reduction, and growth hormone (GH) secretion. Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist of the ghrelin receptor, also called growth hormone secretagogue receptor (GHSR). We studied the effects of LEAP2 administration on feeding, body weight, glycemia, body temperature, and inflammation-related genes in the liver in C57BL/6 J mice and Ghsr-knockout (Ghsr-KO) mice. We found that a single administration of LEAP2 did not abolish fasting-induced food intake in 24-h fasted C57BL/6 J mice or Ghsr-KO mice. Moreover, continuous LEAP2 administration to mice fed ad libitum for 6 days did not affect feeding, body temperature, plasma ghrelin, or blood glucose. By contrast, continuous LEAP2 administration to calorie-restricted C57BL/6 J mice and Ghsr-KO mice induced body weight loss, hypoglycemia, body temperature reduction, and upregulation of Il-6 and Il-1β mRNAs in the liver. Our findings suggest that LEAP2 functions independently of GHSR, implying that LEAP2 affects physiology beyond the ghrelin-GHSR system.
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HAYASHIDA Takafumi, Thi Zin Thi, SUGIYAMA Takashi, SAKAI Katsuya, ISHII Nobuyuki, MOCHIZUKI Hitoshi
Proceedings of the Annual Conference of Biomedical Fuzzy Systems Association 35 ( 0 ) C-1 2022
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biomedical Fuzzy Systems Association
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Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis. Reviewed International journal
Katsuya Sakai, Kazutaka Shiomi, Hitoshi Mochizuki, Md Nurul Islam, Hiroki Nabekura, Ryota Tanida, Hideyuki Sakoda, Masamitsu Nakazato
Brain and behavior 11 ( 5 ) e02111 2021.5
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Brain and Behavior
OBJECTIVE: To study the presence of liver-expressed antimicrobial peptide 2 (LEAP2) in human cerebrospinal fluid (CSF) and to measure its concentrations in neurological disorders. MATERIALS & METHODS: We identified the presence of LEAP2 in human CSF by chromatographic analysis and a LEAP2-specific enzyme immunoassay. We measured LEAP2 concentrations in the CSF of 35 patients with neurological disorders. RESULTS: CSF LEAP2 concentrations in the bacterial meningitis group (mean ± SD, 9.32 ± 3.76 ng/ml) were significantly higher (p < .05) than those in the other four groups (psychosomatic disorder, 0.56 ± 0.15 ng/ml; peripheral autoimmune disease, 1.00 ± 0.60 ng/ml; multiple sclerosis, 0.62 ± 0.30 ng/ml; aseptic meningitis, 1.59 ± 0.69 ng/ml). CONCLUSIONS: This is the first study to identify the presence of human LEAP2 in the CSF. Levels of LEAP2 were increased in the CSF of patients with bacterial meningitis. LEAP2 may have potential as a biomarker for bacterial meningitis.
DOI： 10.1002/brb3.2111
MISC 【 display / non-display 】
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スマートフォンを用いた振戦の定量評価
酒井 克也、石井 信之、望月 仁志
Clinical Neuroscience 40 ( 9 ) 1176 - 1177 2022.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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Ghrelin and liver-expressed antimicrobial peptide 2 (LEAP 2)
酒井克也, 中里雅光
Bio Clinica 37 ( 4 ) 16 (326) - 20 (330) 2022.3
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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本年の動向 振戦の定量解析
酒井 克也, 石井 信之, 望月 仁志
Annual Review神経 2021 109 - 115 2021.6
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(株)中外医学社
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ギラン・バレー症候群治療中に判明したツツガムシ病の1例
武田 紘昌, 杉山 崇史, 宮本 美由貴, 金丸 和樹, 酒井 克也, 中里 祐毅, 望月 仁志, 中里 雅光, 塩見 一剛
臨床神経学 61 ( 6 ) 430 - 430 2021.6
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本神経学会
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細菌性髄膜炎における髄液中Liver-expressed microbial peptide 2 (LEAP2)の上昇
酒井克也, 望月仁志, 塩見一剛, 中里雅光
第62回日本神経学会学術大会 62nd 2021.5
Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Presentations 【 display / non-display 】
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細菌性髄膜炎における髄液中Liver-expressed antimicrobial peptide 2 (LEAP2)の上昇.
酒井克也，望月仁志，塩見一剛，中里雅光.
第62回日本神経学会学術大会 (ハイブリッド開催)
Event date： 2021.5.19 - 2021.5.21
Presentation type：Oral presentation (general)
Venue：ハイブリッド開催
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筋萎縮性側索硬化症におけるMRIを用いた中枢神経画像と臨床症状、予後の関連の検討．
酒井克也，望月仁志，谷口晶俊，塩見一剛，中里雅光.
第61回日本神経学会学術大会 (ハイブリッド開催)
Event date： 2020.8.31 - 2022.9.2
Presentation type：Oral presentation (general)
Venue：ハイブリッド開催
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眼症状に限局し，外眼筋萎縮を呈した抗 LRP4 抗体陽性の double seronegative MG 2 例の検討
酒井克也，金丸和樹，石井信之，杉山崇史，小川 剛，望月仁志，塩見一剛，中里雅光，樋口 理
第226回日本神経学会九州地方会 (長崎)
Event date： 2019.6.29
Presentation type：Oral presentation (general)
Venue：長崎
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パーキンソン病の神経放射線所見と飲酒・喫煙を含めた環境因子との関連についての検討
酒井克也、望月仁志、塩見一剛、中里雅光
第60回日本神経学会学術大会 (大阪)
Event date： 2019.5.22
Presentation type：Oral presentation (general)
Venue：大阪
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一側性の外眼筋麻痺をきたした再発性多発軟骨炎の一例．
酒井克也，外山晶子，中里祐毅，石井信之，望月仁志，塩見一剛，中里雅光.
第207回日本神経学会九州地方会 (大分)
Event date： 2014.9.20
Presentation type：Oral presentation (general)
Venue：大分