|
所属 |
医学部 附属病院 脳神経内科 |
|
職名 |
助教 |
論文 【 表示 ／ 非表示 】
-
Validation and Discussion of Severity Evaluation and Disease Classification Using Tremor Video
Hayashida T., Sugiyama T., Sakai K., Ishii N., Mochizuki H., Zin T.T.
Electronics (Switzerland) 12 ( 7 ) 2023年4月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Electronics (Switzerland)
A tremor is a significant symptom of Parkinson’s disease, but it can also be a characteristic of essential tremor, thereby hampering even specialists’ ability to differentiate between the two. This study proposes a system that leverages a single RGB camera to evaluate tremor severity and support the differential diagnosis of Parkinson’s disease and essential tremor. The system captures motor symptoms, performs time–frequency analysis using wavelet transforms, and classifies severity and disease using linear classification models. The results showed an accuracy rate of 0.56 for disease classification and 0.50 for severity classification (with an acceptable accuracy rate of 0.96). The analysis indicated that there was a low level of correlation between disease and each feature and a moderate correlation (about 0.6) between severity and each feature. Based on these results, this study recommends classifying severity with a linear model and disease with a nonlinear model to obtain improved accuracy.
-
Oda Y., Tsubouchi H., Ishii N., Kitamura A., Moriyama E., Mitsutome E., Sakai K., Shiomi K., Yanagi S., Miyazaki T.
Respiratory Medicine Case Reports 46 101930 2023年1月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Respiratory Medicine Case Reports
Small cell lung carcinoma (SCLC) is a neuroendocrine carcinoma with a poor prognosis and is a common cause of paraneoplastic syndromes. Paraneoplastic syndromes are characterized by neurological and endocrinological problems in patients with malignancy and are often associated with difficulty in induction of chemotherapy. Here we report the case of a patient with SCLC concomitant with two paraneoplastic syndromes, syndrome of inappropriate antidiuretic hormone secretion (SIADH) and Lambert–Eaton myasthenic syndrome (LEMS), who was treated with a platinum-doublet chemotherapy regimen. A 66-year-old male patient presented with a 1-month history of progressive proximal muscle weakness, ataxia gait and 5 kg of body weight loss. The laboratory tests revealed hyponatremia due to SIADH and the existence of antibodies against P/Q-type voltage-gated calcium channels. The nerve conduction study showed a low amplitude of compound muscle action potential (0.38 mv), a 34% decrement on 3-Hz stimulation, and a 1939% increment after maximum voluntary contraction in 10 seconds (7.75 mv). The endobronchial ultrasound transbronchial needle aspiration biopsy revealed the pathological findings of SCLC. A 2-cycle chemotherapy regimen of irinotecan plus cisplatin resulted in temporary tumor shrinkage that lasted 2 months, but the improvement of proximal muscle weakness and hyponatremia were maintained over the tumor re-progression period after chemotherapy. Although paraneoplastic syndromes accelerate the decrease in performance status, chemotherapy for SCLC may improve symptoms related to paraneoplastic syndromes and could be considered in similar cases.
-
Md Nurul Islam, Weidong Zhang, Katsuya Sakai, Yuki Nakazato, Ryota Tanida, Hideyuki Sakoda, Toshiki Takei, Toshifumi Takao, Masamitsu Nakazato
Peptides 151 170763 - 170763 2022年5月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Peptides
Ghrelin is a gastric-derived peptide that stimulates feeding, blood glucose elevation, body temperature reduction, and growth hormone (GH) secretion. Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist of the ghrelin receptor, also called growth hormone secretagogue receptor (GHSR). We studied the effects of LEAP2 administration on feeding, body weight, glycemia, body temperature, and inflammation-related genes in the liver in C57BL/6 J mice and Ghsr-knockout (Ghsr-KO) mice. We found that a single administration of LEAP2 did not abolish fasting-induced food intake in 24-h fasted C57BL/6 J mice or Ghsr-KO mice. Moreover, continuous LEAP2 administration to mice fed ad libitum for 6 days did not affect feeding, body temperature, plasma ghrelin, or blood glucose. By contrast, continuous LEAP2 administration to calorie-restricted C57BL/6 J mice and Ghsr-KO mice induced body weight loss, hypoglycemia, body temperature reduction, and upregulation of Il-6 and Il-1β mRNAs in the liver. Our findings suggest that LEAP2 functions independently of GHSR, implying that LEAP2 affects physiology beyond the ghrelin-GHSR system.
-
RGB カメラによって観測された運動症状を用いたパーキンソン病、本態性振戦の鑑別可能性に関する研究
林田 高典, 杉山 崇史, 酒井 克也, 石井 信之, 望月 仁志
バイオメディカル・ファジィ・システム学会大会講演論文集 35 ( 0 ) C-1 2022年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：バイオメディカル・ファジィ・システム学会
Movements that appear unconsciously are called involuntary movements. Especially, rhythmic involuntary movements are called tremors. Tremor interferes with daily life and is one of the characteristic symptoms of neurological disorders such as Parkinson's disease (PD) and essential tremor (ET). Symptoms and progression of PD patients are assessed by a neurologist through neurological examination and interview according to the revised Unified Parkinson's Disease Rating Scale (UPDRS) sponsored by the Movement Disorders Society (MDS). PD is associated with other symptoms such as bradykinesia, whereas ET is characterized by tremor alone. However, in the early onset of PD, other symptoms may not be noticeable, and even neurologists may find it difficult to differentiate it from ET. In this paper, to solve this issue of getting lost in this judgment, consider whether it is possible to distinguish between PD and ET two types of neurological disorders from two approaches, time domain and frequency domain which from observed tremor movement by using an RGB camera.
-
Katsuya Sakai, Kazutaka Shiomi, Hitoshi Mochizuki, Md Nurul Islam, Hiroki Nabekura, Ryota Tanida, Hideyuki Sakoda, Masamitsu Nakazato
Brain and behavior 11 ( 5 ) e02111 2021年5月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Brain and Behavior
OBJECTIVE: To study the presence of liver-expressed antimicrobial peptide 2 (LEAP2) in human cerebrospinal fluid (CSF) and to measure its concentrations in neurological disorders. MATERIALS & METHODS: We identified the presence of LEAP2 in human CSF by chromatographic analysis and a LEAP2-specific enzyme immunoassay. We measured LEAP2 concentrations in the CSF of 35 patients with neurological disorders. RESULTS: CSF LEAP2 concentrations in the bacterial meningitis group (mean ± SD, 9.32 ± 3.76 ng/ml) were significantly higher (p < .05) than those in the other four groups (psychosomatic disorder, 0.56 ± 0.15 ng/ml; peripheral autoimmune disease, 1.00 ± 0.60 ng/ml; multiple sclerosis, 0.62 ± 0.30 ng/ml; aseptic meningitis, 1.59 ± 0.69 ng/ml). CONCLUSIONS: This is the first study to identify the presence of human LEAP2 in the CSF. Levels of LEAP2 were increased in the CSF of patients with bacterial meningitis. LEAP2 may have potential as a biomarker for bacterial meningitis.
DOI： 10.1002/brb3.2111
MISC 【 表示 ／ 非表示 】
-
スマートフォンを用いた振戦の定量評価
酒井 克也、石井 信之、望月 仁志
Clinical Neuroscience 40 ( 9 ) 1176 - 1177 2022年9月
記述言語：日本語 掲載種別：記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
-
グレリンとLEAP2
酒井 克也, 中里 雅光
BIO Clinica 37 ( 4 ) 16 (326) - 20 (330) 2022年3月
掲載種別：速報，短報，研究ノート等（学術雑誌）
-
本年の動向 振戦の定量解析
酒井 克也, 石井 信之, 望月 仁志
Annual Review神経 2021 109 - 115 2021年6月
記述言語：日本語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：(株)中外医学社
-
ギラン・バレー症候群治療中に判明したツツガムシ病の1例
武田 紘昌, 杉山 崇史, 宮本 美由貴, 金丸 和樹, 酒井 克也, 中里 祐毅, 望月 仁志, 中里 雅光, 塩見 一剛
臨床神経学 61 ( 6 ) 430 - 430 2021年6月
記述言語：日本語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：(一社)日本神経学会
-
細菌性髄膜炎における髄液中Liver-expressed microbial peptide 2 (LEAP2)の上昇
酒井克也, 望月仁志, 塩見一剛, 中里雅光
第62回日本神経学会学術大会 62nd 2021年5月
掲載種別：速報，短報，研究ノート等（学術雑誌）
講演・口頭発表等 【 表示 ／ 非表示 】
-
細菌性髄膜炎における髄液中Liver-expressed antimicrobial peptide 2 (LEAP2)の上昇.
酒井克也，望月仁志，塩見一剛，中里雅光.
第62回日本神経学会学術大会 (ハイブリッド開催)
開催年月日： 2021年5月19日 - 2021年5月21日
会議種別：口頭発表（一般）
開催地：ハイブリッド開催
-
筋萎縮性側索硬化症におけるMRIを用いた中枢神経画像と臨床症状、予後の関連の検討．
酒井克也，望月仁志，谷口晶俊，塩見一剛，中里雅光.
第61回日本神経学会学術大会 (ハイブリッド開催)
開催年月日： 2020年8月31日 - 2022年9月2日
会議種別：口頭発表（一般）
開催地：ハイブリッド開催
-
眼症状に限局し，外眼筋萎縮を呈した抗 LRP4 抗体陽性の double seronegative MG 2 例の検討
酒井克也，金丸和樹，石井信之，杉山崇史，小川 剛，望月仁志，塩見一剛，中里雅光，樋口 理
第226回日本神経学会九州地方会 (長崎)
開催年月日： 2019年6月29日
会議種別：口頭発表（一般）
開催地：長崎
-
パーキンソン病の神経放射線所見と飲酒・喫煙を含めた環境因子との関連についての検討
酒井克也、望月仁志、塩見一剛、中里雅光
第60回日本神経学会学術大会 (大阪)
開催年月日： 2019年5月22日
会議種別：口頭発表（一般）
開催地：大阪
-
一側性の外眼筋麻痺をきたした再発性多発軟骨炎の一例．
酒井克也，外山晶子，中里祐毅，石井信之，望月仁志，塩見一剛，中里雅光.
第207回日本神経学会九州地方会 (大分)
開催年月日： 2014年9月20日
会議種別：口頭発表（一般）
開催地：大分