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• Spindle epithelial tumor with thymus-like elements (SETTLE): a surgical case diagnosed preoperatively using fine-needle aspiration cytology 査読あり

  河野 文彰, 千代反田 顕, 中目 和彦, 明利 聡瑠, 福島 剛, 佐藤 勇一郎, 山口 秀樹, 池ノ上 実, 宗像 駿, 樋口 和宏, 武野 慎祐, 七島 篤志

  Endocrinology Diabetes and Metabolism Case Reports   2025 ( 2 )   2025年5月

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  記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Bioscientifica  

  Summary
  Spindle epithelial tumor with thymic-like elements (SETTLE) is an extremely rare tumor that occurs primarily in the thyroid gland. Histologically, SETTLE is characterized by the presence of spindle-shaped epithelial cells and glandular structures. However, it is known that diagnosis via fine-needle aspiration cytology can be challenging. SETTLE predominantly occurs in younger individuals and has a less favorable prognosis compared to differentiated thyroid carcinoma. Therefore, ensuring accurate diagnosis and appropriate treatment is crucial. We encountered a case of spindle epithelial tumor with thymus-like differentiation in a 10-year-old patient for whom the preoperative diagnosis was successfully established through fine-needle aspiration cytology, which facilitated appropriate surgical resection. Comprehensive histopathological examination and immunohistochemical analysis are essential to ensure appropriate management and surveillance of SETTLE.
  
  Learning points
  A rare thyroid tumor, spindle epithelial tumor with thymic-like elements (SETTLE), was diagnosed preoperatively and treated surgically.
  
  SETTLE presents with characteristic histological features that must be recognized for accurate diagnosis. In addition, diagnosis through cytology is often challenging.
  
  The primary treatment for SETTLE is surgical intervention as radiotherapy and pharmacological treatments are generally not expected to be highly effective.
  
  Radical resection is the only effective treatment, making the selection of the surgical procedure according to the stage of the disease essential.

  CiNii Research

• ガラクトース高値を認め、蛋白質加水分解MCT乳を 使用したシトリン欠損症 査読あり

  明利 聡瑠

  特殊ミルク情報   ( 60 )   49 - 52   2025年2月

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  担当区分：筆頭著者   記述言語：日本語   掲載種別：症例報告  

科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】

科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】

• 新生児スクリーニングを契機に発見される家系内ファブリー病症例のコホート研究

  研究課題/領域番号：25K13371  2025年04月 - 2028年03月

  独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

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  担当区分：研究分担者