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Affiliation |
Faculty of Medicine College Hospital Odontology department dental surgery |
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Title |
Assistant Professor |
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Related SDGs |
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FUKUI Takehito
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Papers 【 display / non-display 】
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BABA Takashi, YAMAMOTO Noriaki, KASHIMA Koji, FUKUI Takehito, KANEUJI Takeshi, YAMASHITA Yoshihiro
Japanese Journal of Oral and Maxillofacial Surgery 70 ( 3 ) 134 - 140 2024.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Oral and Maxillofacial Surgeons
Solitary fibrous tumor（SFT） is a rare tumor in the oral region, and NAB2-STAT6 gene fusions are pathognomonic for SFT. Recently, various NAB2-STAT6 genotypes have been confirmed. This paper describes a case of a histologically rare metastasis of SFT with intermediate malignant potential that occurred in the maxillary gingiva. A 96-year-old woman visited our hospital because of swelling of the upper gingiva. Intra-oral examination revealed a well-defined elastic hard mass measuring 20×15×15 mm in the maxillary tuberosity. After several imaging examinations, a clinical diagnosis of benign tumor in the upper jaw was suggested. The lesion was surgically excised. Histological examination showed randomly arranged short spindle-shaped cells with indistinct, pale eosinophilic cytoplasm within a variably collagenous stroma, nuclear atypia, and five mitoses in ten high power fields. Immunohistochemical examination showed positive for STAT6, CD34, and CD99, and Ki-67 labeling index was 15%. The patient was considered to be at intermediate risk according to the 3-variable model for the prediction of metastatic risk. Genetic analysis showed NAB2 exon6-STAT6 exon 17 fusion gene. The histological diagnosis was SFT indicating intermediate malignant potential, but with intermediate risk of metastasis. No recurrence or metastasis have been observed in the five years following surgery.
DOI： 10.5794/jjoms.70.134
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宮永 宜明, 高木 秀明, 宇都 倫史, 深谷 知宏, 奈須 遵太, 福井 丈仁, 西川 陽太郎, チヨウジヨウフ ナランツオツク, 菱川 善隆, 中村 雄, 東野 哲也, 佐藤 克明
Communications Biology 3 ( 1 ) 742 (2020) 2020.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature
While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear. Here, we show the prerequisite role of conventional dendritic cells in submandibular lymph nodes (ManLNs) in the effectiveness of SLIT for the treatment of allergic disorders in mice. Deficiency of conventional dendritic cells or CD4+Foxp3+ regulatory T (Treg) cells abrogates the protective effect of SLIT against allergic disorders. Furthermore, sublingual antigenic application primarily induces antigen-specific CD4+Foxp3+ Treg cells in draining ManLNs, in which it is severely impaired in the absence of cDCs. In ManLNs, migratory CD11b+ cDCs are superior to other conventional dendritic cell subsets for the generation of antigen-specific CD4+Foxp3+ Treg cells, which is reflected by their dominancy in the tolerogenic features to favor this program. Thus, ManLNs are privileged sites in triggering mucosal tolerance mediating protect effect of SLIT on allergic disorders that requires a tolerogenesis of migratory CD11b+ conventional dendritic cells.