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医学部 附属病院 歯科口腔外科・矯正歯科 |
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助教 |
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Pivotal role of CD103 in the development of psoriasiform dermatitis 査読あり
Fukui T., Fukaya T., Uto T., Takagi H., Nasu J., Miyanaga N., Nishikawa Y., Koseki H., Choijookhuu N., Hishikawa Y., Yamashita Y., Sato K.
Scientific Reports 10 ( 1 ) 8371 (2020) 2020年12月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Scientific Reports
The integrin αE known as CD103 binds integrin β7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is mainly expressed by lymphocytes within epithelial tissues of intestine, lung, and skin as well as subsets of mucosal and dermal conventional dendritic cells (cDCs). CD103 has been originally implicated in the attachment of lymphocytes to epithelium in the gut and skin through the interaction with E-cadherin expressed on intestinal epithelial cells, keratinocytes, and Langerhans cells (LCs). However, an impact of CD103 on the cutaneous immune responses and the development of inflammatory skin diseases remains elusive. Here, we report that CD103 regulates the development of psoriasiform dermatitis through the control of the function of cDCs. Deficiency in CD103 exacerbates psoriasiform dermatitis, accompanied by excessive epidermal hyperplasia and infiltration of inflammatory leukocytes. Furthermore, deficiency in CD103 not only accelerates the production of proinflammatory cytokines in psoriatic lesions but also promotes the generation of lymphocytes producing interleukin (IL)-17 in the skin-draining peripheral lymph nodes (PLNs). Under the deficiency in CD103, cDCs localized in PLNs enhance cytokine production following activation. Thus, our findings reveal a pivotal role for CD103 in the control of the function of cDCs to regulate cutaneous inflammation in psoriasiform dermatitis.
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Baba T., Yamaguma Y., Fukui T., Kaneuji T., Kashima K., Yamashita Y.
Journal of Oral and Maxillofacial Surgery Medicine and Pathology 38 ( 1 ) 140 - 145 2026年1月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Oral and Maxillofacial Surgery Medicine and Pathology
Objectives: Anti-resorptive agents (ARA), such as bisphosphonates and denosumab, are first-line treatments for bone metastases from solid tumors and multiple myeloma. Although these agents effectively inhibit bone resorption, relieve pain associated with bone metastases, and inhibit the growth of bone metastases in malignant diseases, the risk of medication-related osteonecrosis of the jaw (MRONJ) remains a significant concern. In this study, we retrospectively examined patients who received high-dose ARA at our hospital after their initial visit to our department, focusing on their oral condition at the time of the initial visit and at the start of high-dose ARA treatment. Methods: Between 2013 and 2023, 91 patients who received high-dose ARA at our hospital after their initial visit to our department with at least 3 months of follow-up were retrospectively investigated from their medical records. We examined various factors that may increase the risk of MRONJ, but we focused on dental conditions at high-dose ARA administration. Results: Univariate Cox regression analysis showed that sex, steroid use, tooth indicated for extraction at initial visit and tooth indicated for extraction at high-dose ARA administration were significantly associated with MRONJ development. Furthermore, multivariate Cox regression analysis showed that steroid use and tooth indicated for extraction at high-dose ARA administration were significantly associated with MRONJ development. (p < 0.05). Conclusion: A pre-treatment dental examination and timely extraction of the indicated tooth prior to high-dose ARA administration may reduce the risk of MRONJ. These findings highlight the importance of early dental intervention in patients receiving high-dose ARA treatment.
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Epithelioid schwannoma in the buccal region: A case report and review of literature 査読あり
Baba T., Baba H., Yamaguma Y., Fukui T., Kaneuji T., Yamashita Y.
Journal of Oral and Maxillofacial Surgery Medicine and Pathology 37 ( 5 ) 1123 - 1130 2025年9月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Oral and Maxillofacial Surgery Medicine and Pathology
Schwannomas are common, benign peripheral nerve sheath tumors that arise from Schwann cells. Several rare morphological variants include ancient, cellular, plexiform, epithelioid, and microcystic/reticular. The epithelioid variant of schwannoma is scarce, with only a few relevant cases reported in the oral and maxillofacial regions. Herein, we report a case of epithelioid schwannoma in the buccal region. A 61-year-old woman was referred to our department from a medical clinic because of a slow-growing nodule in the buccal region, noticed 3 years before presentation. Clinical examination revealed a nodular mass measuring 20 × 20 mm. Computed tomography (CT) and magnetic resonance imaging (MRI) showed an oval lesion with a clear border on the left cheek. The outer margin of the mass exhibited opacities that appeared as multiple microcalcifications. MRI revealed a well-defined mass similar in size to that observed on CT, with low signal intensity on T1-weighted images and mildly high signal intensity on T2-weighted images. The clinical differential diagnosis includes benign tumors such as pleomorphic adenoma. The tumor was surgically excised under general anesthesia. Histopathological examination revealed multilobulated epithelioid cells arranged in nests. The tumor cells showed eosinophilic cytoplasm and uniformly round nuclei. The tumor was diagnosed as an epithelioid schwannoma. Postoperative follow-up was uneventful, and no evidence of recurrence was observed 2 years postoperatively.
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NAB2-STAT6 融合遺伝子の発現を認め中等度の転移リスクが示唆された上顎孤立性線維腫の1例
馬場 貴, 山本 哲彰, 鹿嶋 光司, 福井 丈仁, 金氏 毅, 山下 善弘
日本口腔外科学会雑誌 70 ( 3 ) 134 - 140 2024年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本口腔外科学会
Solitary fibrous tumor（SFT） is a rare tumor in the oral region, and NAB2-STAT6 gene fusions are pathognomonic for SFT. Recently, various NAB2-STAT6 genotypes have been confirmed. This paper describes a case of a histologically rare metastasis of SFT with intermediate malignant potential that occurred in the maxillary gingiva. A 96-year-old woman visited our hospital because of swelling of the upper gingiva. Intra-oral examination revealed a well-defined elastic hard mass measuring 20×15×15 mm in the maxillary tuberosity. After several imaging examinations, a clinical diagnosis of benign tumor in the upper jaw was suggested. The lesion was surgically excised. Histological examination showed randomly arranged short spindle-shaped cells with indistinct, pale eosinophilic cytoplasm within a variably collagenous stroma, nuclear atypia, and five mitoses in ten high power fields. Immunohistochemical examination showed positive for STAT6, CD34, and CD99, and Ki-67 labeling index was 15%. The patient was considered to be at intermediate risk according to the 3-variable model for the prediction of metastatic risk. Genetic analysis showed NAB2 exon6-STAT6 exon 17 fusion gene. The histological diagnosis was SFT indicating intermediate malignant potential, but with intermediate risk of metastasis. No recurrence or metastasis have been observed in the five years following surgery.
DOI： 10.5794/jjoms.70.134
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宮永 宜明, 高木 秀明, 宇都 倫史, 深谷 知宏, 奈須 遵太, 福井 丈仁, 西川 陽太郎, チヨウジヨウフ ナランツオツク, 菱川 善隆, 中村 雄, 東野 哲也, 佐藤 克明
Communications Biology 3 ( 1 ) 742 (2020) 2020年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Springer Nature
While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear. Here, we show the prerequisite role of conventional dendritic cells in submandibular lymph nodes (ManLNs) in the effectiveness of SLIT for the treatment of allergic disorders in mice. Deficiency of conventional dendritic cells or CD4+Foxp3+ regulatory T (Treg) cells abrogates the protective effect of SLIT against allergic disorders. Furthermore, sublingual antigenic application primarily induces antigen-specific CD4+Foxp3+ Treg cells in draining ManLNs, in which it is severely impaired in the absence of cDCs. In ManLNs, migratory CD11b+ cDCs are superior to other conventional dendritic cell subsets for the generation of antigen-specific CD4+Foxp3+ Treg cells, which is reflected by their dominancy in the tolerogenic features to favor this program. Thus, ManLNs are privileged sites in triggering mucosal tolerance mediating protect effect of SLIT on allergic disorders that requires a tolerogenesis of migratory CD11b+ conventional dendritic cells.