|
Affiliation |
Faculty of Medicine School of Medicine Department of Medicine of Sensory and Motor Organs, Otorhinolaryngology-Head and Neck Surgery |
|
Title |
Assistant Professor |
|
Related SDGs |
|
SARUWATARI Emi
|
|
|
Papers 【 display / non-display 】
-
A case of suspected ectopic thyroid cancer originating from the lateral thyroid primordium Reviewed
SARUWATARI Emi, OKUDA Takumi, IDE Shinsuke, KOGA Hiroyuki, TAKAHASHI Kuniyuki
jibi to rinsho 69 ( 3 ) 238 - 242 2023.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：JIBI TO RINSHO KAI
Ectopic thyroid gland is an embryological abnormality in which thyroid tissue is present outside the appropriate location of the thyroid gland, often occurring in the midline of the neck. We report a case of suspected ectopic thyroid cancer originating from the lateral thyroid primordium and arising in the lateral neck. The patient was a man in his 60s who was aware of a right neck tumor that had been gradually enlarging for half a year. At the first visit to our hospital, he had a cystic mass in his right neck. Fine-needle aspiration cytology raised the suspicion of metastasis of adenocarcinoma of unknown primary. However, we subsequently performed lumpectomy and diagnosed papillary thyroid carcinoma. This mass was cystic; however, although it was huge for lymph node metastasis, it was single a single mass of unknown origin because no lymph node structure was seen. Since the patient was at high risk of postoperative recurrence, we judged that internal radioactive iodine therapy was appropriate and performed total thyroidectomy and D1 dissection. Postoperative pathological examination revealed papillary carcinoma in both lobes and no lymph node metastasis. Postoperatively, he received radioactive iodine therapy and is currently under observation.
-
NOJIRI Nao, OKUDA Takumi, TSUMAGARI Shogo, SARUWATARI Emi, IDE Shinsuke, TONO Tetsuya
jibi to rinsho 69 ( 2 ) 124 - 128 2023.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：JIBI TO RINSHO KAI
We herein report a case of inflammation of a pendulous tonsil that was initially suspected of being malignant. A teenage girl had been experiencing discomfort when swallowing for several years and visited a local doctor because of sudden dysphagia and hemoptysis. The pharyngeal cavity was narrowed by a dark-red mass about 3cm in diameter with a base near the right inferior tonsillar pole, and the patient was referred to our department the next day under suspicion of a hemangioma of the oropharynx. At the initial visit, the mass was erythematous and swollen with white moss. Blood tests showed a mild inflammatory reaction, but the coagulation function was normal. Contrast-enhanced magnetic resonance imaging suggested malignant lymphoma or a malignant solid tumor as possible differential diagnoses. One week later, the inflammation of the mass had subsided, and the appearance resembled the right palatine tonsil. A biopsy showed inflammation of the tonsil tissue. Three weeks after the initial visit, tonsillectomy was performed. A histopathologic examination revealed that the mass was hyperplasia of the tonsil and was not malignant.
-
Cancer multi-gene panel testing for a patient with a rare type of head and neck cancer Reviewed
OKUDA Takumi, SARUWATARI Emi, KUBUKI Kan, GA Naoki, IDE Shinsuke, TONO Tetsuya
jibi to rinsho 68 ( 4 ) 299 - 307 2022.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：JIBI TO RINSHO KAI
We experienced a case in which cancer multi-gene panel testing was performed for a patient with a rare type of head and neck cancer. Namely, salivary duct carcinoma of the parotid gland. In this case, we first detected an overexpression of androgen receptor. CAB therapy was successful. However, the patient's condition subsequently worsened and therefore an extracted cancer tissue specimen was submitted for multi-gene panel testing. An immune checkpoint inhibitor was recommended and administered based on the genetic abnormalities of the neoplastic cells. However, due to the development of an irAE, continuation of the drug became difficult and the outcome was unsatisfactory. The enforcement rate of treatment based on this test is currently low (10%). In addition, we recognized the limitations of enforcement through medical services covered by health insurance. Thus, in order to increase the utilization of this test in order for its usage to spread, governmental approval of this test at the early therapeutic stage is necessary, and the expansion of the indications for the administration of this drug in combination with both insured and non-insured treatments in the current Japanese medical environment is desirable. On the other hand, negative conversion of androgen receptor expression was seen in cancer tissue specimens from this patient whose condition worsened. Therefore, when planning treatment strategies, we must take the intra-tumor heterogeneity which is thought to be an intractable factor into careful consideration.