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Affiliation |
Faculty of Medicine School of Medicine Department of Clinical Neuroscience, Psychiatry |
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Professor |
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Related SDGs |
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HIRANO YOJI
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Research Interests 【 display / non-display 】
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Cognitive Neuroscience
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Psychiatry
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EEG・MEG
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Neuroimaging
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Schizophrenia
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Gamma Oscillation
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Translational Research
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Neurofeedback
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Neuroscience
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Neurophysiology
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Neural Oscillation
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Mood Disorders
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Metacognitive Training
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Neuromodulation
Research Areas 【 display / non-display 】
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Life Science / Psychiatry / Psychiatry, Neuropsychiatry, Psychophysiology
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Life Science / Neuroscience-general / Neuroscience, Neurophysiology, Cognitive Neuroscience, Neuroimaging, EEG/MEG
Education 【 display / non-display 】
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Kyushu University Graduate School of Medical Sciences Department of Neuropsychiatry
2004.4 - 2008.3
Country：Japan
Notes：PhD
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Miyazaki Medical College Faculty of Medicine
1994.4 - 2000.3
Country：Japan
External Career 【 display / non-display 】
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Kyushu University Department of Neuropsychiatry Lecturer
2021.6 - 2022.11
Country：Japan
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The University of Tokyo Institute of Industrial Science Research Fellow
2020.7
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Harvard Medical School Psychiatry Research Associate
2016.8 - 2020.7
Country：United States
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Kyushu University Neuropsychiatry Assistant Professor
2014.4 - 2021.5
Country：Japan
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Harvard Medical School Psychiatry Lecturer
2014.3 - 2016.7
Country：United States
Professional Memberships 【 display / non-display 】
Papers 【 display / non-display 】
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Characteristics of psychiatric patients with nightmares after suvorexant administration: A retrospective study. Reviewed
Kazuya Yasuda, Yoji Hirano, Ryuichiro Takeda, Ryuji Ikeda, Yasushi Ishida
Neuropsychopharmacology Reports 45 ( 1 ) e12506 2025.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1002/npr2.12506
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Gamma and Theta/Alpha-Band Oscillations in the Electroencephalogram Distinguish the Content of Inner Speech. Reviewed International coauthorship
Thomas Whitford, Kevin Spencer, Marianthe Godwin, Yoji Hirano, Lawrence Kin-hei Chung, Wadim Vodovozov, Oren Griffiths, Anthony Harris, Mike Le Pelley and Bradley Jack
eNeuro 12 ( 2 ) 2025.2
Language：English Publishing type：Research paper (scientific journal)
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Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography. Reviewed
Mai Hatano, Waki Nakajima, Hideaki Tani, Hiroyuki Uchida, Tomoyuki Miyazaki, Tetsu Arisawa, Yuuki Takada, Sakiko Tsugawa, Akane Sano, Kotaro Nakano, Tsuyoshi Eiro, Hiroki Abe, Akira Suda, Takeshi Asami, Akitoyo Hishimoto, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Shunya Kurokawa, Yohei Ohtani, Kie Takahashi, Yuhei Kikuchi, Taisuke Yatomi, Shiori Honda, Masahiro Jinzaki, Yoji Hirano, Ryo Mitoma, Shunsuke Tamura, Shingo Baba, Osamu Togao, Hirotaka Kosaka, Hidehiko Okazawa, Yuichi Kimura, Masaru Mimura & Takuya Takahashi
Molecular Psychiatry 2024.10
Language：English Publishing type：Research paper (scientific journal)
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Oxytocin-induced increases in cytokines and clinical effect on the core social features of autism: Analyses of RCT datasets. Reviewed
Wakuda T, Benner S, Uemura Y, Nishimura T, Kojima M, Kuroda M, Matsumoto K, Kanai C, Inada N, Harada T, Kameno Y, Munesue T, Inoue J, Umemura K, Yamauchi A, Ogawa N, Kushima I, Suyama S, Saito T, Hamada J, Kano Y, Honda N, Kikuchi S, Seto M, Tomita H, Miyoshi N, Matsumoto M, Kawaguchi Y, Kanai K, Ikeda M, Nakamura I, Isomura S, Hirano Y, Onitsuka T, Ozaki N, Kosaka H, Okada T, Kuwabara H, Yamasue H
Brain, Behavior, and Immunity 118 398 - 407 2024.5
Language：English Publishing type：Research paper (scientific journal)
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Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons. Reviewed International coauthorship
Tatsuya Osaki, Tomoya Duenki, Siu Yu A. Chow, Yasuhiro Ikegami, Romain Beaubois, Timothée Levi, Nao Nakagawa-Tamagawa, Yoji Hirano & Yoshiho Ikeuchi
Nature Communications 15 ( 1 ) 2945 2024.4
Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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Characterization and Features of Neural Oscillations in Mental Disorders International journal
Yoji Hirano*, Murat İlhan Atagün（ Role： Joint author , Handbook of the Biology and Pathology of Mental Disorders）
Springer Nature 2024.8
Language：English Book type：Scholarly book
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Methods for Measuring Neural Oscillations in Mental Disorders International journal
Murat İlhan Atagün, Shunsuke Tamura, Yoji Hirano*（ Role： Joint author , Handbook of the Biology and Pathology of Mental Disorders）
Springer Nature 2024.8
Language：English Book type：Scholarly book
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The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR)
（ Role： Contributor , Somatic Symptom and Related Disorders）
Igaku Shoin Ltd 2023.6 （ ISBN:9784260052184 ）
Language：Japanese Book type：Scholarly book
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Guideline for Pharmacological Therapy of Schizophrenia 2022 (for patients and supporters)
（ Role： Joint author）
Working Group for Guideline for Pharmacological Therapy of Schizophrenia 2022 2023.2
Language：Japanese Book type：Scholarly book
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100 Keywords for Reading Papers in the Field of Psychiatry!
（ Role： Joint editor , Neurophysiology）
Shinkoh Igaku Shuppan Co., Ltd 2023.1 （ ISBN:9784880028866 ）
Total pages：245p Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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統合失調症患者に対するメタ認知トレーニング
平野羊嗣
精神科臨床Legato 9 ( 3 ) 2023
Authorship：Lead author, Corresponding author Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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台湾精神医学の発展と日本のかかわり 台大醫院精神部五十年紀要・日治時代精神病學史より Reviewed International coauthorship
平野 羊嗣, 王 百慧, 謝 明憲, 黄 宗正, 黒木 俊秀, 神庭 重信
精神神経学雑誌 121 ( 5 ) 356 - 365 2019.5
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(公社)日本精神神経学会
国立台湾大学医学部精神科が1996年に出版した「台大醫院精神部五十年紀要」に掲載された日治時代精神病學史について翻訳を行い,他の資料より情報を追加したうえで,若干の解説を加えた.国立台湾大学(臺灣大學)は,7番目の帝国大学として,1928年に台北帝国大学(臺北帝國大學)として設立され,終戦後に現在の国立台湾大学に改名された.台北帝国大学時代,3人の高名な精神科医(中村讓,竹内八和太,中脩三)が台湾の精神医学の創成期に活躍し,その礎を築いた.台湾の精神医学は終戦とともに台湾初の精神科教授である林宗義に継承され,今日まで発展を遂げている.紀要には,日治時代の台湾における当時の授業の様子と,同国の精神医療の事始めの状況が克明に記録されている.これまで,日治時代の台湾の精神医学・医療の状況は,風祭や橋本らが報告しているが,本資料は現代の台湾の精神医学者による精神医学史という点で意義深く思われる.(著者抄録)
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Metacognitive Training for Schizophrenia Invited
Yoji Hirano
9 ( 3 ) 37 - 41 2023.12
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【聴覚とその異常-up to date】病態と治療 統合失調症における幻聴と聴覚皮質の活動について 幻聴の発生機序と幻聴緩和治療の可能性 Invited
光藤 崇子, 平野 羊嗣, 鬼塚 俊明
Clinical Neuroscience 41 ( 6 ) 841 - 846 2023.6
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(株)中外医学社
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Abnormal neural oscillations in schizophrenia Invited Reviewed
Ryo Mitoma, Yoji Hirano
Japanese Journal of Biological Psychiatry 34 ( 1 ) 30 - 37 2023.3
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Japanese Society of Biological Psychiatry
In schizophrenia and other psychiatric disorders, the proximity of various neural indexes to the disease mechanisms has been investigated in order to elucidate the pathophysiology and to establish effective treatments. Neural oscillations, rhythmic cortical activity that is based on the balance in excitatory and inhibitory neurons, are considered to be particularly promising candidates for neurophysiological biomarkers among these indices. Abnormal findings of neural oscillations, including impaired smooth shift between spontaneous and task‐related activity, are consistently observed in schizophrenia. In addition, the upcoming large‐scale EEG data will reinforce these findings and may facilitate further translational research.
Presentations 【 display / non-display 】
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Brain Network Alterations as Potential Therapeutic Targets in Psychosis Invited International coauthorship International conference
Yoji Hirano
22rd WPA World Congress of Psychiatry (Chair & Symposiast) (Bangkok) 2022.8.5
Event date： 2022.8.3 - 2022.8.6
Language：English Presentation type：Symposium, workshop panel (public)
Venue：Bangkok Country：Thailand
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Spontaneous and Evoked Neural Oscillation Abnormalities in Schizophrenia Invited International coauthorship International conference
Yoji Hirano
The 8th European Conference on Schizophrenia Research (ECSR) (Co-Chair & Symposiast) (Berlin) 2021.9.25
Event date： 2021.9.23 - 2021.9.25
Language：English Presentation type：Symposium, workshop panel (nominated)
Venue：Berlin Country：Germany
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Visualization of Mental Phenomena: Elucidation and Treatment of Schizophrenia Based on Gamma Oscillation Invited
Yoji Hirano
43th JSBP & 51th JSNP (Presentation of the 7th JSBP Young Researchers Development Program's Outstanding Incentive Award) (Kyoto) 2021.7.15
Event date： 2021.7.14 - 2021.7.16
Language：Japanese Presentation type：Oral presentation (invited, special)
Venue：Kyoto Country：Japan
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Spontaneous and Evoked Auditory Gamma Abnormalities in First- Episode Schizophrenia: A Longitudinal Study International coauthorship International conference
Yoji Hirano, Kevin M. Spencer
58th Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP) (Orlando, FL, USA) 2019.12.8
Event date： 2019.12.8 - 2019.12.11
Language：English Presentation type：Oral presentation (general)
Venue：Orlando, FL, USA Country：United States
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Spontaneous Gamma Activity in Schizophrenia Invited International coauthorship International conference
Yoji Hirano
6th Congress of Asian College of Neuropsychopharmacology (AsCNP) (Fukuoka) 2019.10.12
Event date： 2019.10.11 - 2019.10.13
Language：English Presentation type：Symposium, workshop panel (nominated)
Venue：Fukuoka Country：Japan
Works 【 display / non-display 】
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Psychiatry and Clinical Neurosciences Art Brut Series
Yoji Hirano, Kenji Hosaka
2018.1
Work type：Artistic work
File： pcn.12579.pdf
Awards 【 display / non-display 】
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The Grand Prize Young Investigator Program Award
2020.8 [ Japanese Society of Biological Psychiatry ]
Yoji Hirano
Award type：International academic award (Japan or overseas)
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60th Young Researcher's Award
2020.4 [UBE INDUSTRIES FOUNDATION]
Yoji hirano
Award type：International academic award (Japan or overseas)
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SIRS Research Fund Award
2019.9 [ Schizophrenia International Research Society ]
Yoji Hirano
Award type：International academic award (Japan or overseas)
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Outstanding Research Award
2019.7 [ Asia Pacific Society for Biology and Medical Sciences ]
Yoji Hirano
Award type：International academic award (Japan or overseas)
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SIRS Travel Award
2018.4 [ Schizophrenia International Research Society ]
Yoji Hirano
Award type：International academic award (Japan or overseas)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Elucidation of human neuro-pathological mechanism for subtypes of psychiatric disorders by the co-production of mathematical science and clinical psychiatry
Grant number：JP24wm0625302 2024.04 - 2029.03
Japan Agency for Medical Research and Development (AMED) Brain/MINDS 2.0 Priority Research Project
Shinsuke Koike, Hirano Yoji, Ikegame Tempei, Shinichiro Nakajima, Tsutomu Takahashi, Yutaka Nakachi, Shingo Iwami
Authorship：Coinvestigator(s)
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Translational research on schizophrenia based on neural oscillation: Towards the understanding of the pathophysiology and the development of new treatments
Grant number：21H02851 2021.04 - 2025.03
Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research（B）PI Grant-in-Aid for Scientific Research（B）
Yoji Hirano
Authorship：Principal investigator
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Toward reconstructing psychiatric disorders based on brain structure and function: International joint research project International coauthorship
Grant number：20KK0193 2020.10 - 2025.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)) Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Yoji Hirano
Authorship：Principal investigator
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Machine learning using neuroimaging dataset around the onset of schizophrenia and the proposal for the optimal MRI protocol: An Asian multicenter study
Grant number：19H03579 2019.04 - 2022.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research（B） Grant-in-Aid for Scientific Research（B）
Koike Shunsuke, Yoji Hirano
Authorship：Coinvestigator(s)
The objectives of this study are to coordinate the Asian Consortium on MRI in Psychosis (ACMP) to establish a large-scale brain imaging analysis scheme for first-episode schizophrenia and ultra-high risk for psychosis (Early clinical staging of schizophrenia, ECS) (Study 1, Koike), to elucidate the pathophysiology of ECS using large-scale multimodality brain structural imaging (Study 2, Sasabayashi), to elucidate the pathophysiology of ECS using MRI and EEG MMN/GBO (Study 3, Hirano), and to apply to machine learning for prognosis prediction of ECS (Study 4, Koike). Study 1) was delayed significantly due to the spread of COVID-19 infection. Studies 2) - 4) were able to proceed as originally planned, partially exceeding the plan, and many academic achievements were obtained.
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Detecting the neural oscillation deficits during abnormal emotional regulation in schizophrenia patients
Grant number：18K07604 2018.04 - 2021.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research（C） Grant-in-Aid for Scientific Research (C)
Yoji hirano
Authorship：Principal investigator
This study aimed to elucidate the pathophysiology involved in emotion dysregulation, which is also a cause of social dysfunction in patients with schizophrenia. Specifically, we used electroencephalography (EEG) to measure changes in frontal neural activity indices during emotion regulation in healthy subjects and patients with schizophrenia. The results showed that compared to normal subjects, schizophrenia showed abnormal neural activity in the gamma-band of the frontal cortex during emotion regulation. Based on this finding, we also performed a discrimination task using different frequency stimuli and found that discrimination ability improved and EEG synchronization changed after training. Some of the results were presented at domestic and international conferences and 33 papers were accepted by international journals. We have also applied for a patent for innovative real-time time-frequency analysis, which is indispensable for clinical applications.
Other external funds procured 【 display / non-display 】
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Multimodal research in schizophrenia using AMPA-PET and MEG International coauthorship
2023.11 - 2025.03
SENSHIN Medical Research Foundation Research grant of psychopharmacological field
Yoji Hirano
Authorship：Principal investigator
Committee Memberships 【 display / non-display 】
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World Psychiatric Association Affective Disorders Section [Co-Chair]
2023.12
Committee type：学協会
https://www.wpanet.org/affective-disorders
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Japanese Society of Biological Psychiatry Future Planning Committee [Vice-Chair]
2023.11
Committee type：学協会
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Psychiatry and Clinical Neurosciences [Associate Editor]
2019.3
Committee type：学協会
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WHO ICD-11 SCI-11 [SCI-11 Core Member]
2018.4
Committee type：学協会
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Psychiatry and Clinical Neurosciences Reports [Associate Editor]
2021.10
Committee type：学協会
Social Activities 【 display / non-display 】
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Background of Suicide and Depression
Role(s)： Lecturer
Miyazaki Medical Association Miyazaki Medical Association, Suicide Prevention and Depression Workshop 2023.12.11
Audience： Teachers, General, Scientific, Civic organization, Governmental agency
Type：Lecture
Media Coverage 【 display / non-display 】
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Cortical representation of speech temporal information through high gamma-band activity Internet
University of Miyazaki 2023.5.12
Author：Myself
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Abnormalities in Brain Networks Associated with Social Dysfunction in Schizophrenia Revealed Internet
University of Miyazaki University of Miyazaki News Release 2023.11.24
Author：Other
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Increased Spontaneous Gamma Activity in Schizophrenia Newspaper, magazine
https://www.zaikei.co.jp/article/20150116/231069.html Zaikei Newspaper https://www.zaikei.co.jp/article/20150116/231069.html 2015.1.16
Author：Other
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Increased Spontaneous Gamma Activity in Schizophrenia Internet
https://news.mynavi.jp/article/20150116-a259/ My Navi News 2015.1.16
Author：Other
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Kyushu University Finds that Spontaneous Brain Activity, Which Governs Perception, Is Elevated by Sound Stimulation in Schizophrenia Newspaper, magazine
Zaikei Newspaper 2015.1.15
Author：Other