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Affiliation |
Faculty of Medicine School of Medicine Department of Social Medicine, Data Management |
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Professor |
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Related SDGs |
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NAKAI Michikazu
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Research Areas 【 display / non-display 】
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Informatics / Statistical science / BioStatistics
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Life Science / Hygiene and public health (non-laboratory)
Papers 【 display / non-display 】
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Contemporary Use of Oral Inotropes in the Outpatient Treatment of Heart Failure: Analysis of a Japanese Nationwide Database. International journal
Michikazu Nakai, Yoshitaka Iwanaga, Koshiro Kanaoka, Yoko Sumita, Yuichi Nishioka, Tomoya Myojin, Katsuki Okada, Tatsuya Noda, Tomoaki Imamura, Yoshihiro Miyamoto
Journal of clinical pharmacology 2025.3
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SETDB1-Mediated Chromatin Regulation in Intestinal Epithelial Cells During Intestinal Ischemia-Reperfusion Injury
Higuchi Kazuhiro, Ikenoue Makoto, Ishizuka Takumi, Kai Kengo, Takahashi Nobuyasu, Kubota Toshiki, Shirouzu Shinichiro, Lkham-Erdene Baljinnyam, Aung Kham Mo, Nakai Michikazu, Sawaguchi Akira, Nanashima Atsushi, Hishikawa Yoshitaka
ACTA HISTOCHEMICA ET CYTOCHEMICA 58 ( 1 ) 9 - 18 2025.2
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY
DOI： 10.1267/ahc.24-00061
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Low-Gradient Severe Aortic Stenosis: Insights From the CURRENT AS Registry-2
Taniguchi T., Morimoto T., Takeji Y., Shirai S., Ando K., Tabata H., Yamamoto K., Murai R., Osakada K., Sakamoto H., Tada T., Murata K., Obayashi Y., Amano M., Kitai T., Izumi C., Toyofuku M., Kanamori N., Miyake M., Nakayama H., Izuhara M., Nagao K., Nakatsuma K., Furukawa Y., Inoko M., Kimura M., Ishii M., Usami S., Nakazeki F., Shirotani M., Inuzuka Y., Ono K., Minatoya K., Kimura T., Saito N., Kato T., Watanabe H., Shiomi H., Toyota T., Minamino-Muta E., Takeji Y., Yoneda T., Kaneko N., Yamamoto K., Kitano K., Ishii K., Inada T., Tamura T., Miki S., Yokomatsu T., Kato M., Kadota K., Ikeguchi S., Aoyama T., Onodera T., Takeuchi Y., Matsuda M., Sato Y., Akao M., Mabuchi H., Kaitani K., Okabayashi M., Yamazaki K., Ohno N., Arai Y., Koyama T., Fujita T., Fukushima S., Iwakura A., Uehara K., Suenaga E.
JACC: Cardiovascular Interventions 18 ( 4 ) 471 - 487 2025.2
Publishing type：Research paper (scientific journal) Publisher：JACC: Cardiovascular Interventions
Background: Low-gradient (LG) aortic stenosis (AS) has not been fully characterized compared with high-gradient (HG) AS in terms of cardiac damage, frailty, aortic valve calcification, and clinical outcomes. Objectives: The aim of this study was to compare the clinical characteristics and outcomes between each hemodynamic type of LG AS and HG AS. Methods: The current study included 3,363 patients in the CURRENT AS (Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis) Registry-2 after excluding patients without indexed stroke volume or left ventricular ejection fraction (LVEF) data. Patients were divided into 4 groups (LG AS with reduced LVEF: n = 285; paradoxical low flow, low gradient [LFLG]: n = 220; normal flow, low gradient [NFLG]: n = 872; HG: n = 1,986). Results: Compared with HG AS, LG AS with reduced LVEF more often had cardiovascular comorbidities, advanced cardiac damage, and frailty with less severe valve calcification and paradoxical LFLG AS more often had atrial fibrillation, advanced cardiac damage, and frailty with less severe valve calcification, while NFLG AS had comparable cardiac damage and frailty with less severe valve calcification. Cumulative 3-year incidence of death or heart failure hospitalization was higher in LG AS with reduced LVEF and paradoxical LFLG than in HG AS. After adjusting for confounders, LG AS with reduced LVEF and paradoxical LFLG compared with HG AS were independently associated with higher risk for death or heart failure hospitalization (HR: 1.82; 95% CI: 1.49-2.23; P < 0.001; and HR: 1.43; 95% CI: 1.13-1.82; P = 0.003, respectively) but NFLG AS was not (HR: 1.03; 95% CI: 0.88-1.21; P = 0.68). Conclusions: Clinical outcomes were significantly worse in LG AS with reduced LVEF and paradoxical LFLG AS and comparable in NFLG AS compared with HG AS.
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Detection of bovine respiratory disease complex-related pathogens in nasopharynx-associated lymphoid tissue.
Hegazy AA, Nakai M, Fuke N, Hussein AE, Kondo H, Hirai T
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 10406387251318415 2025.2
Language：English Publishing type：Research paper (scientific journal)
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Stepwise cardiovascular risk stratification in patients with type 2 diabetes based on coronary CT assessment. International journal
Shinichi Wada, Yoshitaka Iwanaga, Michikazu Nakai, Teruo Noguchi, Yoshihiro Miyamoto
Journal of diabetes and its complications 39 ( 1 ) 108908 - 108908 2025.1
Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: We aimed to examine the stepwise risk stratification for predicting major adverse cardiovascular events (MACE) in patients with DM and suspected coronary artery disease (CAD). METHOD: 1187 patients with suspected CAD enrolled in a prospective cohort study were examined. The patients were evaluated step-by-step with coronary artery calcification (CAC), coronary artery stenosis (CAS), and FFRCT analysis. Hazard ratio (HR) and 95 % confidence interval (CI) for incidence MACE were calculated by Cox Proportional Hazards model for adjustment of Framingham risk score. RESULTS: During a median follow-up of 4.0 years, MACE frequently occurred in DM patients than non-DM (15.9 % vs. 5.7 %). A lower CAC threshold with >0 or > 50 Agatston score was significantly associated with increased MACE in DM (HR [95 % CI], 3.62 [1.12-11.67] or 4.72 [2.11-10.55], respectively), but not in non-DM. DM patients with >50 CAC, CAS, and ≤ 0.71 FFRCT value showed the HR (95 % CI) for MACE was 9.84 (4.26-22.69) as compared with those with ≤50 CAC, whereas non-DM patients showed that it was 2.56 (1.02-6.43). CONCLUSION: Step-by-step assessment using CAC, CAS, and FFRCT on top of clinical risk factors was useful for more accurate cardiovascular risk stratification in patients with DM.
MISC 【 display / non-display 】
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妊婦の体位変換・子宮左方移動による母体循環の変動 2D/3D心エコー図による観察
田中 美与, 山村 善政, 東 真理恵, 伊藤 芽生, 尾方 美幸, 榎本 尚助, 中井 陸運, 桂木 真司, 渡邉 望
超音波医学 51 ( Suppl. ) S629 - S629 2024.4
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(公社)日本超音波医学会
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妊婦の体位変換・子宮左方移動による母体循環の変動 2D/3D心エコー図による観察
田中 美与, 山村 善政, 東 真理恵, 伊藤 芽生, 尾方 美幸, 榎本 尚助, 中井 陸運, 桂木 真司, 渡邉 望
超音波医学 51 ( Suppl. ) S629 - S629 2024.4
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(公社)日本超音波医学会
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Guideline-directed Medical Therapy for Elderly Patients with Acute Myocardial Infarction Who Undergo Percutaneous Coronary Intervention(タイトル和訳中)
西平 賢作, 中井 陸運, 栗山 根廣, 海北 幸一, 柴田 剛徳
日本循環器学会学術集会抄録集 88回 PJ087 - 2 2024.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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日本人における至適抗血栓療法を考える(Novel Risk Stratification Schemes for Ischemic Stroke and Major Bleeding in Japanese Non-valvular Atrial Fibrillation Patients: The J-RISK AF Study)
富田 泰史, 奥村 謙, 赤尾 昌治, 中井 陸運, 小谷 英太郎, 鈴木 信也, 林 研至, 澤野 充明, 合屋 雅彦, 山下 武志, 福田 恵一, 津田 豊暢, 磯部 光章, 豊田 一則, 宮本 恵宏, 岡村 智教, 笹原 祐介
日本循環器学会学術集会抄録集 88回 SY08 - 3 2024.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Hepatorenal images have powerful prognostic value of all-cause mortality in patients with Fontan circulation
大内秀雄, 森有希, 加藤愛章, 伊藤裕貴, 藤本一途, 岩朝透, 坂口平馬, 黒嵜健一, 中井陸運
日本成人先天性心疾患学会雑誌(Web) 13 ( 1 ) 74 - 74 2024.1
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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先天性心疾患を主体とする小児期発症の心血管難治性疾患の救命 率の向上、円滑な移行医療、成人期以降の予後改善を目指した総合的研究
Grant number：24FC0201 2024.04 - 2027.03
厚生労働省 厚生科研 難治性疾患政策研究事業
Authorship：Coinvestigator(s)
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Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23K27522 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Principal investigator
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ビッグデータ・機械学習を用いたアブレーション治療の有効性・安全性予測モデルの作成
Grant number：23K24623 2024.04 - 2025.03
日本学術振興会 科学研究費基金 基盤研究(B)
草野 研吾, 山根 禎一, 清水 渉, 中井 陸運, 岩永 善高
Authorship：Principal investigator
2017年に始まった本邦で行われている不整脈に対するカテーテルアブレーション全例登録事業（J-AB）は27万件を超える前向き登録事業が継続中でアブレーションレジストリとしては世界最大である。このビッグデータを用い、再発率が高く、また世界的にも合併症が増加している心房細動アブレーションについて、患者背景・使用デバイス・アブレーション部位・使用薬剤などの因子と急性期合併症発生や急性期・退院時・1年後の手技成功に関して、機械学習を用いたアブレーションの安全性・有効性に関する予測モデルを作成し、外部検証を行う。この予測モデルによって、治療成績の向上が期待できるのみならず、現在、ガイドラインでも解決されていない高齢者、心不全患者、無症状患者へのアブレーションの妥当性が明らかとなり、治療適応の大きなジレンマに対応できることが期待される。また、J-ABレジストリデータの解析結果を他国のデータベースと比較することで、本邦のカテーテルアブレーション治療の診療実態をより客観的に評価することが可能と考えられるが、同様の報告は存在しない。本研究の目的は、J-ABレジストリデータと他国データベースを用いて、本邦におけるカテーテルアブレーションの合併症発生率とそのリスク要因を明らかにし、本邦でのアブレーション治療の安全性向上に役立てるためのエビデンスを創出することである。
本研究の特徴として、①解析内容については、JAB登録（通年調査）から取得可能な項目を使用しており、実現可能性が高い（Feasible）、②本邦におけるリスク因子を明らかにするとともに、他国と比較した成績を明らかにすることで、特にリスクが高い患者においてリスク低減させる方法が明らかになれば、今後の治療方法を改善することができる（Modifiable）、③中央解析のみである。以上の点で、倫理的に問題がない（Ethical）。 -
Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23H02831 2023.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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成人先天性心疾患診療体制の患者アウトカムへの影響：DPCデータを用いた検討
Grant number：23K10089 2023.04 - 2027.03
日本学術振興会 科学研究費基金 基盤研究(C)
落合 亮太, 石津 智子, 中井 陸運, 仁田 学
Authorship：Coinvestigator(s)