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Affiliation |
Faculty of Medicine School of Medicine Department of Social Medicine, Data Management |
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Professor |
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Related SDGs |
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NAKAI Michikazu
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Research Areas 【 display / non-display 】
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Life Science / Hygiene and public health (non-laboratory)
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Informatics / Statistical science / BioStatistics
Papers 【 display / non-display 】
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Peak aortic jet velocity as a predictor of short- and long-term outcomes following percutaneous coronary intervention. Reviewed International journal
Takamasa Iwai, Kensuke Takagi, Takeshi Kitai, Yasuhide Asaumi, Yoko Sumita, Yoshitaka Iwanaga, Michikazu Nakai, Teruo Noguchi, Yoshihiro Miyamoto, Kotaro Nochioka, Masaharu Nakayama, Naoyuki Akashi, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Masanobu Ishii, Taishi Nakamura, Kenichi Tsujita, Yuri Matoba, Hisahiko Sato, Hideo Fujita, Ryozo Nagai
International journal of cardiology. Heart & vasculature 64 101929 - 101929 2026.6
Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: Coronary artery disease (CAD) and aortic valve stenosis (AS) often coexist, with AS exacerbating myocardial ischemia and affecting prognosis. AIMS: To investigate the prognostic impact of AS stratified by peak aortic jet velocity (AV-Vel) in patients undergoing PCI. METHODS AND RESULTS: We conducted retrospective multicenter observational study involving patients who underwent percutaneous coronary intervention (PCI) between April 2013 and March 2019. The patients were divided into non-AS group and AS group. The AS group was further categorized: 2.6 ≤ AV-Vel < 3.0 m/s, mild AS; 3.0 ≤ AV-Vel < 4.0 m/s, moderate AS; and AV-Vel ≥ 4.0 m/s, severe AS. The primary outcome was all-cause mortality, and the secondary outcome was major adverse cardiovascular events (MACE), defined as a composite of all-cause mortality, myocardial infarction, or stroke. Multivariable Cox proportional hazards analysis was performed over 5-year observation period, with landmark analyses conducted at 30 days after PCI and from day 31 after PCI to 5 years. In total, 9,690 patients were analyzed (AS group, n = 361). Over a median follow-up of 2.57 (IQR: 0.89-4.24) years, AS group exhibited higher rates of mortality (HR: 3.06; 95% CI: 2.41-3.90; p < 0.001) and MACE (HR: 2.45; 95%CI: 1.97-3.04; p < 0.001) compared with non-AS group. Subgroup analysis revealed that patients with moderate and severe AS had worse short-term mortality and MACE within 30 days after PCI than the non-AS group, while patients with mild to severe AS showed significantly worse long-term outcomes than the non-AS group. CONCLUSIONS: AV-Vel is independently associated with both short- and long-term outcomes in patients undergoing PCI.
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Takashi Suzuki, Ryohei Nejima, Tomoyuki Inoue, Yuichi Kaji, Takaaki Hattori, Saichi Hoshi, Daisuke Todokoro, Hiroshi Eguchi, Michikazu Nakai, Yoshitsugu Inoue
Japanese journal of ophthalmology 2026.5
Language：English Publishing type：Research paper (scientific journal)
PURPOSE: To compare physician-assessed and patient-reported outcomes quantified with the Japanese Ocular Surface Disease Index (J-OSDI) following the treatment of bacterial blepharitis and to evaluate the utility of the J-OSDI. STUDY DESIGN: Multicenter prospective observational study. METHODS: Physicians assessed symptoms and findings, calculating clinical total scores at baseline (T0), 7 (T1) and 14 (T2) days post-treatment with 1% azithromycin ophthalmic solution, and 1 month after discontinuation (T3). Patients self-reported symptoms using the J-OSDI at these times. The J-OSDI score trends and differences in temporal changes between the J-OSDI and clinical total scores were analyzed by use of a linear mixed-effects model. RESULTS: Forty-six eyes (46 patients; mean age, 71.8 years) were studied. The J-OSDI scores decreased significantly post-treatment for all the patients, with similar trends for both anterior and posterior blepharitis. For all the patients, the slope difference between the J-OSDI and clinical total scores was not significant in the T0-T1 period (P = .219), meaning that the J-OSDI scores reflected the clinical results, whereas it was significant in the T1-T2 (P = .004) and T2-T3 (P <.001) periods. The within-subject correlation between the 2 scores was 0.525 (95% CI 0.401-0.631). For anterior blepharitis, the slope differences were significant across all the periods, but for posterior blepharitis, no significant differences were observed in the T0-T1 or T1-T2 (P = .205, 0.06, respectively) periods, although significant differences were noted in the T2-T3 period (P = .018). CONCLUSION: The J-OSDI trajectory often diverges from physician-rated changes. Whilst the J-OSDI does not assess treatment response in anterior blepharitis, it may be partially reflective of improvement in posterior blepharitis.
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Reduced Left Atrial Reservoir Strain is Associated with Histopathologically Confirmed ANP-Amyloid Deposition. Reviewed International journal
Shun Nishino, Yujiro Asada, Chiharu Nishino, Michikazu Nakai, Atsuko Yokota, Masanori Nishimura, Mitsuhiro Yano, Kinta Hatakeyama, Yoshisato Shibata
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2026.5
Language：English Publishing type：Research paper (scientific journal)
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Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) Reflects Global Pathophysiology and Predicts All-Cause Morbidity and Mortality in Patients With Fontan Circulation Reviewed
Ohuchi Hideo, Mori Aki, Morimoto Yoshihito, Kato Yoshiaki, Fujimoto Kazuto, Iwasa Toru, Shiraishi Isao, Kurosaki Kenichi, Nakai Michikazu
Circulation Journal advpub ( 0 ) 2026.4
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society
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Etiology-specific predictors for short-term functional outcomes of OHCA: A Japanese Nationwide registry study. Reviewed International journal
Satoru Hanada, Michikazu Nakai, Shohei Koyama, Hironao Iwakiri, Koichi Kaikita, Naohiro Yonemoto, Tetsuya Matoba, Yoshio Tahara
The American journal of emergency medicine 106 90 - 95 2026.4
Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) functional outcomes vary widely by etiology, but cerebrovascular-origin OHCA remains poorly characterized. This study aimed to identify etiology-specific predictors of favorable functional outcomes after OHCA using a nationwide Japanese registry. METHODS: We analyzed 392,770 adult OHCA cases (311,632 cardiac-origin and 81,138 cerebrovascular-origin) recorded between 2005 and 2023 using data from the All-Japan Utstein Registry, a prospective nationwide population-based registry. Favorable outcome was defined as CPC 1-2 and OPC 1-2 at 30 days. Demographic, clinical, and time variables were evaluated using multivariable logistic regression. Missing time data were treated as an "unknown" category. A sensitivity analysis using Firth's penalized likelihood regression was performed on subgroups with recorded time data. RESULTS: Favorable outcomes were observed in 9.7% of cardiac-origin and 2.5% of cerebrovascular-origin OHCA. In cardiac-origin OHCA, early defibrillation (<5 min) was a strong predictor. Cerebrovascular OHCA showed a negligible association with age (OR 1.00, 95% CI 0.99-1.00), and defibrillation at 5-10 min was paradoxically associated with better outcomes. Time to ROSC >15 min was consistently associated with poor outcomes in both groups. Crucially, the sensitivity analysis demonstrated that the paradoxical associations were no longer statistically significant after applying Firth's correction. CONCLUSIONS: Determinants of favorable outcomes may differ fundamentally. The findings suggest that prognosis after cerebrovascular-origin OHCA may be largely influenced by the initial severity of cerebral injury, rather than by the timing of prehospital resuscitation efforts. However, given the limitation of registry-based research, prospective studies are warranted to confirm these observations.
MISC 【 display / non-display 】
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川崎病既往成人の重症心血管後遺症入院例の検討 JROAD-DPC研究
三谷 義英, 中井 陸運, 津田 悦子
日本成人先天性心疾患学会雑誌 15 ( 1 ) 131 - 131 2026.1
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本成人先天性心疾患学会
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宮崎泌尿器癌データベース(MUCD)を用いた宮崎県医療圏別腎がん診断時の臨床的特徴と治療選択の地域差
木村 翔一, 中井 陸運, 寺田 直樹, 澤田 篤郎, 賀本 敏行
西日本泌尿器科学会総会抄録集 77回 215 - 215 2025.11
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)西日本泌尿器科学会
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川崎病に対する急性期から遠隔期・成人期に至る医療の国際的展開 成人期川崎病の重症心血管後遺症の日本の疫学 JROAD-DPC研究
三谷 義英, 中井 陸運, 津田 悦子
日本小児循環器学会総会・学術集会抄録集 61回 III - 5 2025.7
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(NPO)日本小児循環器学会
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抗血栓薬未使用の成人患者における血液血栓形成能の臨床的決定因子 健診でのT-TAS 01研究(Clinical Determinants of Blood Thrombogenicity in Antithrombotic Drug-naive Adults: A Total Thrombus-Formation Analysis System (T-TAS 01) Study at Health Checkup)
工藤 丈明, 松浦 祐之介, 中井 陸運, 小山 彰平, 岩切 弘直, 海北 幸一, 柴田 剛徳
日本循環器学会学術集会抄録集 89回 PJ51 - 3 2025.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本循環器学会
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No-Hidden AF Project: All-Miyazak Alignment of University Hospital, Medical Association and Local Government for Monitoring Subclinical Atrial Fibrillation(タイトル和訳中)
渡邉 望, 海北 幸一, 古川 貢之, 井手口 武史, 松浦 祐之介, 中井 陸運, 山下 篤, 渡邊 玲子, 名越 敏郎
日本循環器学会学術集会抄録集 89回 OJ28 - 2 2025.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本循環器学会
Grant-in-Aid for Scientific Research 【 display / non-display 】
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先天性心疾患を主体とする小児期発症の心血管難治性疾患の救命 率の向上、円滑な移行医療、成人期以降の予後改善を目指した総合的研究
Grant number：24FC0201 2024.04 - 2027.03
厚生労働省 厚生科研 難治性疾患政策研究事業
Authorship：Coinvestigator(s)
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Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23K27522 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Principal investigator
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ビッグデータ・機械学習を用いたアブレーション治療の有効性・安全性予測モデルの作成
Grant number：23K24623 2024.04 - 2025.03
日本学術振興会 科学研究費基金 基盤研究(B)
草野 研吾, 山根 禎一, 清水 渉, 中井 陸運, 岩永 善高
Authorship：Principal investigator
2017年に始まった本邦で行われている不整脈に対するカテーテルアブレーション全例登録事業（J-AB）は27万件を超える前向き登録事業が継続中でアブレーションレジストリとしては世界最大である。このビッグデータを用い、再発率が高く、また世界的にも合併症が増加している心房細動アブレーションについて、患者背景・使用デバイス・アブレーション部位・使用薬剤などの因子と急性期合併症発生や急性期・退院時・1年後の手技成功に関して、機械学習を用いたアブレーションの安全性・有効性に関する予測モデルを作成し、外部検証を行う。この予測モデルによって、治療成績の向上が期待できるのみならず、現在、ガイドラインでも解決されていない高齢者、心不全患者、無症状患者へのアブレーションの妥当性が明らかとなり、治療適応の大きなジレンマに対応できることが期待される。また、J-ABレジストリデータの解析結果を他国のデータベースと比較することで、本邦のカテーテルアブレーション治療の診療実態をより客観的に評価することが可能と考えられるが、同様の報告は存在しない。本研究の目的は、J-ABレジストリデータと他国データベースを用いて、本邦におけるカテーテルアブレーションの合併症発生率とそのリスク要因を明らかにし、本邦でのアブレーション治療の安全性向上に役立てるためのエビデンスを創出することである。
本研究の特徴として、①解析内容については、JAB登録（通年調査）から取得可能な項目を使用しており、実現可能性が高い（Feasible）、②本邦におけるリスク因子を明らかにするとともに、他国と比較した成績を明らかにすることで、特にリスクが高い患者においてリスク低減させる方法が明らかになれば、今後の治療方法を改善することができる（Modifiable）、③中央解析のみである。以上の点で、倫理的に問題がない（Ethical）。 -
Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23H02831 2023.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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成人先天性心疾患診療体制の患者アウトカムへの影響：DPCデータを用いた検討
Grant number：23K10089 2023.04 - 2027.03
日本学術振興会 科学研究費基金 基盤研究(C)
落合 亮太, 石津 智子, 中井 陸運, 仁田 学
Authorship：Coinvestigator(s)