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Affiliation |
Faculty of Medicine School of Medicine Department of Social Medicine, Data Management |
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Professor |
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Related SDGs |
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NAKAI Michikazu
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Research Areas 【 display / non-display 】
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Life Science / Hygiene and public health (non-laboratory)
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Informatics / Statistical science / BioStatistics
Papers 【 display / non-display 】
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Yamaguchi F, Kuroki M, Yoshinaga N, Nakai M, Arimura Y
Contemporary clinical trials communications 50 101613 2026.4
Language：English Publishing type：Research paper (scientific journal) Publisher：Contemporary Clinical Trials Communications
Background Shikuwasa ( Citrus depressa Hayata) essential oil, rich in limonene and γ-terpinene, produces calming effects, but its psychological and physiological relaxation effects in humans remain unclear. This study examined the short-term relaxation effects of inhaling Shikuwasa essential oil compared to odor-free air among young adult females. Methods In this two-arm, parallel-group, open-label, randomized controlled superiority trial, healthy females aged 18–39 were randomly assigned to either the Shikuwasa essential oil group (n = 20) or the odor-free air group (n = 20). The primary outcome was subjective tense-arousal, measured using the Japanese version of the University of Wales Institute of Science and Technology Mood Adjective Checklist (JUMACL). Secondary outcomes included miosis rate, peripheral skin temperature, and cerebral blood flow. Due to measurement constraints, the experiment was divided into three 2-min inhalation phases. Results No significant between-group differences were observed in tense-arousal, miosis rate, or cerebral blood flow. Additional analyses of covariance, performed for each outcome variable using the Visual Analog Scale score and its interaction with the group as covariates, revealed a trend toward an interaction effect for the JUMACL tense-arousal subscale score, although the overall effects were not statistically significant. Conclusions Short-term inhalation of Shikuwasa essential oil did not significantly reduce tense-arousal or affect physiological indices in healthy, normal-to-low stress young adult females. However, aroma preference may influence psychological and neural responses. Future studies should consider pre-assessed aroma preference, longer inhalation durations, single-phase protocols, extended rest periods, and participants’ baseline mood. Trial registration This study was prospectively registered with the UMIN-CTR, UMIN000053914.
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Prognostic Value of Serum Lipoprotein(a) Levels in Japanese Patients With ST-Segment Elevation Myocardial Infarction. Reviewed
Nishiyama K, Nishihira K, Nakai M, Baba K, Takamatsu M, Honda Y, Yamamoto K, Nishino S, Kadooka K, Kudo T, Ogata K, Kimura T, Kuriyama N, Shibata Y
Circulation journal : official journal of the Japanese Circulation Society 2026.3
Language：English Publishing type：Research paper (scientific journal)
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Fujimoto K, Kikuchi M, Nakai M, Konta T, Iseki K, Tsuruya K, Yamagata K, Narita I, Moriyama T, Shibagaki Y, Kasahara M, Kondo M, Asahi K, Watanabe T, Kaikita K, Fujimoto S
Clinical and experimental nephrology 30 ( 3 ) 434 - 445 2026.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Clinical and Experimental Nephrology
Background: Cardiovascular-kidney-metabolic (CKM) syndrome, integrating cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic dysfunction, is a construct proposed by the American heart association. Although associations with CVD are well recognized, evidence linking CKM stage to renal outcomes remains limited. Methods: We analyzed health checkup data of 266,256 Japanese aged 40–74 years. Participants were classified into CKM stages 0–4a. Outcomes included all-cause mortality, cardiovascular death, and a composite renal outcome (end-stage kidney disease [eGFR < 15 mL/min/1.73 m<sup>2</sup>], ≥ 40% eGFR decline, or doubling of serum creatinine). Multivariable Cox proportional hazards models were used to estimate hazard ratios (HRs), with CKM stage 0 as the reference. Results: CKM stage 2 was the most prevalent stage (65.0%). Stage 4a showed the strongest association with all-cause and cardiovascular mortality (HRs 1.79, 3.16; 95% CIs 1.41–2.28, 1.92–5.20, respectively). In contrast, stage 3 conferred the highest risk of renal outcomes (HR 15.29, 95% CI 10.13–23.08). The number and type of metabolic risk factors correlated with outcomes, furthermore, severe CKD and prior CVD were stronger drivers of adverse outcomes than metabolic dysfunction. Conclusion: CKM staging stratifies risk in the general population. No significant increase in risk was observed until CKM stage 2, and these findings underscore the progressive, cumulative nature of CKM syndrome. Metabolic dysfunction plays a crucial role in progression, stage 3 marks a pivotal inflection point for renal deterioration, and stage 4a identifies individuals at the greatest mortality risk. Early interventions targeting metabolic dysfunction may help prevent progression to advanced CKM stages and improve long-term outcomes.
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Ischemic and Bleeding Events After Early Initiation of Direct Oral Anticoagulants for Acute Intracranial Hemorrhage With Non-Valvular Atrial Fibrillation ― A Multicenter Prospective Registry ― Reviewed
Koga Masatoshi, Toyoda Kazunori, Iguchi Yasuyuki, Itabashi Ryo, Kataoka Hiroharu, Nakai Michikazu, Tanaka Kanta, Miwa Kaori, Kondo Rei, Todaka Tatemi, Kimura Naoto, Yoshimura Kunikazu, Yamashiro Shigeo, Ogishima Takahiro, Terasawa Yuka, Komoribayashi Nobukazu, Sakai Nobuyuki, Hatano Taketo, Arakawa Shuji, Sonoda Kazutaka, Hagii Joji, Hirano Teruyuki, Miyashita Fumio, Ohnishi Hiroyuki, Kimura Kazumi, Ueda Toshihiro, Maezono-Kandori Keiko, Yazawa Yukako, Kinosada Masanori, Izumo Tsuyoshi, Noshiro Shouhei, Nagasawa Hikaru, Wada Kuniyasu, Yamagami Hiroshi, Kamiyama Kenji, Takagi Yasushi, Ito Yasuhiro, Sugio Kumiko, Takita Atsushi, Kimura Tetsuya, Unverdorben Martin, Ihara Masafumi, Fujimoto Shigeru, Shoamanesh Ashkan, on behalf of the SAFE-ICH Registry Group
Circulation Journal advpub ( 0 ) 2026.2
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society
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Efficacy and safety of intravenous anticoagulation for noncardioembolic stroke: an analysis of data from the Japan Stroke Data Bank. Reviewed
Itabashi R, Yoshimura S, Koga M, Nakai M, Wada S, Miyamoto Y, Matsumoto K, Yagita Y, Inaba M, Katayama M, Yazawa Y, Hatano T, Yoshida Y, Kamiyama K, Ogasawara K, Toyoda K, Minematsu K
International journal of stroke : official journal of the International Stroke Society 17474930261427471 2026.2
Language：English Publishing type：Research paper (scientific journal)
MISC 【 display / non-display 】
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Clinical Determinants of Blood Thrombogenicity in Antithrombotic Drug-naive Adults: A Total Thrombus-Formation Analysis System (T-TAS 01) Study at Health Checkup(タイトル和訳中)
工藤 丈明, 松浦 祐之介, 中井 陸運, 小山 彰平, 岩切 弘直, 海北 幸一, 柴田 剛徳
日本循環器学会学術集会抄録集 89回 PJ51 - 3 2025.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本循環器学会
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No-Hidden AF Project: All-Miyazak Alignment of University Hospital, Medical Association and Local Government for Monitoring Subclinical Atrial Fibrillation(タイトル和訳中)
渡邉 望, 海北 幸一, 古川 貢之, 井手口 武史, 松浦 祐之介, 中井 陸運, 山下 篤, 渡邊 玲子, 名越 敏郎
日本循環器学会学術集会抄録集 89回 OJ28 - 2 2025.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本循環器学会
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荻野均, 吉野秀朗, 下川智樹, 圷宏一, 高橋寿由樹, 薄井宙男, 國原孝, 渡邉和宏, 中井陸運, 山本剛, 高山守正
ICUとCCU 48 ( 別冊 ) S11 - S11 2024.12
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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The efficacy and safety of intravenous anticoagulants for non-cardioembolic stroke: the Japan Stroke Data Bank
Ryo Itabashi, Sohei Yoshimura, Masatoshi Koga, Michikazu Nakai, Yoshihiro Miyamoto, Kenichi Matsumoto, Yoshiki Yagita, Makoto Inaba, Masateru Katayama, Yukako Yazawa, Takeo Hatano, Yasuhisa Yoshida, Naomichi Wada, Kenji Kamiyama, Kuniaki Ogasawara, Kazunori Toyoda, Kazuo Minematsu
CEREBROVASCULAR DISEASES 53 62 - 62 2024.9
Language：English Publishing type：Research paper, summary (international conference)
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フォンタン患者遠隔期の管理・治療のControversy 体静脈肺静脈副側血行路は塞栓すべきか?
大内 秀雄, 森 有希, 藤本 一途, 黒嵜 健一, 中井 陸運
日本小児循環器学会総会・学術集会抄録集 60回 II - 5 2024.7
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(NPO)日本小児循環器学会
Grant-in-Aid for Scientific Research 【 display / non-display 】
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先天性心疾患を主体とする小児期発症の心血管難治性疾患の救命 率の向上、円滑な移行医療、成人期以降の予後改善を目指した総合的研究
Grant number：24FC0201 2024.04 - 2027.03
厚生労働省 厚生科研 難治性疾患政策研究事業
Authorship：Coinvestigator(s)
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Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23K27522 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Principal investigator
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ビッグデータ・機械学習を用いたアブレーション治療の有効性・安全性予測モデルの作成
Grant number：23K24623 2024.04 - 2025.03
日本学術振興会 科学研究費基金 基盤研究(B)
草野 研吾, 山根 禎一, 清水 渉, 中井 陸運, 岩永 善高
Authorship：Principal investigator
2017年に始まった本邦で行われている不整脈に対するカテーテルアブレーション全例登録事業（J-AB）は27万件を超える前向き登録事業が継続中でアブレーションレジストリとしては世界最大である。このビッグデータを用い、再発率が高く、また世界的にも合併症が増加している心房細動アブレーションについて、患者背景・使用デバイス・アブレーション部位・使用薬剤などの因子と急性期合併症発生や急性期・退院時・1年後の手技成功に関して、機械学習を用いたアブレーションの安全性・有効性に関する予測モデルを作成し、外部検証を行う。この予測モデルによって、治療成績の向上が期待できるのみならず、現在、ガイドラインでも解決されていない高齢者、心不全患者、無症状患者へのアブレーションの妥当性が明らかとなり、治療適応の大きなジレンマに対応できることが期待される。また、J-ABレジストリデータの解析結果を他国のデータベースと比較することで、本邦のカテーテルアブレーション治療の診療実態をより客観的に評価することが可能と考えられるが、同様の報告は存在しない。本研究の目的は、J-ABレジストリデータと他国データベースを用いて、本邦におけるカテーテルアブレーションの合併症発生率とそのリスク要因を明らかにし、本邦でのアブレーション治療の安全性向上に役立てるためのエビデンスを創出することである。
本研究の特徴として、①解析内容については、JAB登録（通年調査）から取得可能な項目を使用しており、実現可能性が高い（Feasible）、②本邦におけるリスク因子を明らかにするとともに、他国と比較した成績を明らかにすることで、特にリスクが高い患者においてリスク低減させる方法が明らかになれば、今後の治療方法を改善することができる（Modifiable）、③中央解析のみである。以上の点で、倫理的に問題がない（Ethical）。 -
Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23H02831 2023.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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成人先天性心疾患診療体制の患者アウトカムへの影響：DPCデータを用いた検討
Grant number：23K10089 2023.04 - 2027.03
日本学術振興会 科学研究費基金 基盤研究(C)
落合 亮太, 石津 智子, 中井 陸運, 仁田 学
Authorship：Coinvestigator(s)