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Affiliation |
Faculty of Medicine School of Medicine Department of Social Medicine, Data Management |
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Title |
Associate Professor |
NAKAI Michikazu
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Research Areas 【 display / non-display 】
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Informatics / Statistical science / BioStatistics
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Life Science / Hygiene and public health (non-laboratory)
Papers 【 display / non-display 】
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The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B
Watanabe K., Nishio S.Y., Usami S.I., Kumai T., Katada A., Ogasawara N., Shintani T., Morita S.Y., Takeichi N., Goto S.I., Nanba A., Sasaki A., Kobayashi Y., Honkura Y., Adachi M., Takai S., Oda K., Sato T., Yamada T., Shiina K., Ito T., Shinkawa C., Amano A., Kikuchi D., Ogawa H., Wada T., Hirose Y., Noguchi E., Moriyama N., Ohtsuka K., Shirai K., Sadayasu R., Shimada M., Suzumura H., Tono T., Motegi M., Mitoh I., Tada H., Nagai K., Sakata H., Ishikawa K., Yoshida N., Mizutari K., Suzuki Y., Ikezono T., Matsuda H., Noguchi Y., Takeda H., Kobayashi M., Sakurai Y., Hirabayashi G., Tajima S., Nishiyama N., Shirai K., Kawaguchi S., Iwasaki S., Takahashi M., Furutate S., Oka S.I., Yoshihashi H., Futagawa H., Ohishi N., Hosoya M., Kawashima Y., Ito T., Maruyama A., Kumakawa K., Matsunobu T., Sakuma N., Takahashi K., Kashio A., Monobe H., Miyoshi Y., Yabuki K., Seto Y., Sano H., Araki N., Arai Y., Okami M., Wasano K., Hatakeyama H., Isono Y., Ohira S., Komori M., Izumi S., Fujisaka M., Watanabe A., Okamoto M., Ito Y., Takahashi M., Miyagawa M., Takumi Y., Yoshimura H., Shinagawa J., Moteki H., Tsukamoto K., Ichinose A., Obara N., Kuza B., Takada N.
Scientific Reports 14 ( 1 ) 2024.12
Publishing type：Research paper (scientific journal) Publisher：Scientific Reports
The MYO7A gene is known to be responsible for both syndromic hearing loss (Usher syndrome type1B:USH1B) and non-syndromic hearing loss including autosomal dominant and autosomal recessive inheritance (DFNA11, DFNB2). However, the prevalence and detailed clinical features of MYO7A-associated hearing loss across a large population remain unclear. In this study, we conducted next-generation sequencing analysis for a large cohort of 10,042 Japanese hearing loss patients. As a result, 137 patients were identified with MYO7A-associated hearing loss so that the prevalence among Japanese hearing loss patients was 1.36%. We identified 70 disease-causing candidate variants in this study, with 36 of them being novel variants. All variants identified in autosomal dominant cases were missense or in-frame deletion variants. Among the autosomal recessive cases, all patients had at least one missense variant. On the other hand, in patients with Usher syndrome, almost half of the patients carried biallelic null variants (nonsense, splicing, and frameshift variants). Most of the autosomal dominant cases showed late-onset progressive hearing loss. On the other hand, cases with autosomal recessive inheritance or Usher syndrome showed congenital or early-onset hearing loss. The visual symptoms in the Usher syndrome cases developed between age 5–15, and the condition was diagnosed at about 6–15 years of age.
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Fumitake Yamaguchi, Naoki Yoshinaga, Miho Kuroki, Rie Nakasone, Hisanori Kenmotsu, Toshio Ueno, Yukihiro Yada, Michikazu Nakai, Yasuji Arimura
Contemporary Clinical Trials Communications 41 101342 - 101342 2024.10
Publishing type：Research paper (scientific journal) Publisher：Elsevier BV
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Comparison of embolic risk in left ventricular thrombus between nonischemic and ischemic cardiomyopathy: A nationwide database analysis. International journal
Masashi Fujino, Hirohiko Aikawa, Kazuhiro Nakao, Kensuke Takagi, Fumiyuki Otsuka, Yu Kataoka, Yasuhide Asaumi, Yoko Sumita, Michikazu Nakai, Koshiro Kanaoka, Yoshihiro Miyamoto, Stephen J Nicholls, Teruo Noguchi
International journal of cardiology 411 132329 - 132329 2024.9
Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: Left ventricular (LV) thrombus is not common but poses significant risks of embolic stroke or systemic embolism. However, the distinction in embolic risk between nonischemic cardiomyopathy (NICM) and ischemic cardiomyopathy (ICM) remains unclear. METHODS AND RESULTS: In total, 2738 LV thrombus patients from the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases Diagnosis Procedure Combination) database were included. Among these patients, 1037 patients were analyzed, with 826 (79.7%) having ICM and 211 with NICM (20.3%). Within the NICM group, the distribution was as follows: dilated cardiomyopathy (DCM; 41.2%), takotsubo cardiomyopathy (27.0%), hypertrophic cardiomyopathy (18.0%), and other causes (13.8%). The primary outcome was a composite of embolic stroke or systemic embolism (SSE) during hospitalization. The ICM and NICM groups showed no significant difference in the primary outcome (5.8% vs. 7.6%, p = 0.34). Among NICM, SSE occurred in 12.6% of patients with DCM, 7.0% with takotsubo cardiomyopathy, and 2.6% with hypertrophic cardiomyopathy. Multivariate logistic regression analysis for SSE revealed an odds ratio of 1.4 (95% confidence interval [CI], 0.7-2.7, p = 0.37) for NICM compared to ICM. However, DCM exhibited a higher adjusted odds ratio for SSE compared to ICM (2.6, 95% CI 1.2-6.0, p = 0.022). CONCLUSIONS: This nationwide shows comparable rates of embolic events between ICM and NICM in LV thrombus patients, with DCM posing a greater risk of SSE than ICM. The findings emphasize the importance of assessing the specific cause of heart disease in NICM, within LV thrombus management strategies.
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Translated and culturally adapted internet-delivered cognitive therapy for social anxiety disorder in Japanese clinical settings: study protocol for a randomised controlled trial. International journal
Naoki Yoshinaga, Graham R Thew, Yuta Hayashi, Hiroki Tanoue, Michikazu Nakai, David M Clark
Trials 25 ( 1 ) 492 - 492 2024.7
Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: Cognitive therapy for social anxiety disorder (CT-SAD) has extensive empirical support and is recommended in several national guidelines. However, ensuring access to evidence-based psychological therapies such as CT-SAD remains a global challenge. An internet-delivered version of this treatment protocol (iCT-SAD) has recently been developed in the UK as a way to overcome this challenge, demonstrating comparable outcomes to face-to-face CT-SAD whilst requiring less therapist time per client. Initial findings also suggest its cross-cultural transferability, but the previous studies in other cultural settings used the English language programme and only included English-fluent participants as a second language. It is not yet known what outcomes can be achieved once the programme has been translated and adapted for a different cultural context. Therefore, this trial aims to evaluate the clinical efficacy of Japanese iCT-SAD when combined with treatment as usual (TAU) in clients with SAD. METHODS: This two-arm, parallel-group, superiority randomised controlled trial will recruit 60 Japanese participants with SAD, randomly assigning them to either Japanese iCT-SAD + TAU or TAU alone at a ratio of 1:1. The primary outcome measure is the self-report Liebowitz Social Anxiety Scale, and secondary.outcomes include other measures of social anxiety symptoms and processes, general mood and functioning, and response to treatment. We will also assess treatment acceptability and gather participant feedback. Assessments will take place at baseline (week 0), mid-treatment (week 8), and post-treatment (week 15), with a further 3-month follow-up (week 27) for the iCT-SAD + TAU arm. The primary analyses will be conducted on an intent-to-treat basis, comparing the primary and secondary outcome measures between groups using linear mixed-effect models, along with additional mediation analysis. DISCUSSION: Investigating the efficacy of translated and culturally adapted iCT-SAD in different cultural contexts is an important step in evaluating the global reach of internet interventions. This trial will provide valuable insights into the effects of iCT-SAD combined with usual care, and how this treatment could be delivered in routine clinical settings in Japan. TRIAL REGISTRATION: International Standard Randomized Controlled Trials (ISRCTN), ISRCTN82859645, registered on January 19, 2024. UMIN Clinical Trials Registry (UMIN-CTR), UMIN000052702, registered on November 6, 2023.
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Naoki Yoshinaga, Yoko Obara, Naohisa Kawano, Kazuki Kondo, Yuta Hayashi, Michikazu Nakai, Ryuichiro Takeda, Hiroki Tanoue
Behavioral Sciences 14 ( 7 ) 604 - 604 2024.7
Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG
The importance of nurses integrating effective psychological techniques into their clinical practice is widely recognized. Nevertheless, further evidence from real-world settings is needed to establish nurse-led cognitive behavioural therapy (CBT) as an effective approach in clinical practice. This study aimed to examine the clinical effectiveness and predictors of individual CBT for mental disorders delivered by nurses in various routine clinical settings. This pragmatic retrospective cohort study collected data from participants who received nurse-led individual CBT at four institutions from different prefectures in Japan between April 2015 and March 2023. During the study period, 280 clients were referred to nurses for CBT, 240 of whom received nurse-led individual CBT of at least one session. The common primary diagnoses among participants were major depressive disorder (33.8%), social phobia (12.9%), and obsessive–compulsive disorder (10.0%). Of these, 23 participants were ongoing cases at the end of the observation period, and 217 who had completed the course of therapy or discontinued/dropped out from the therapy were included in the analysis (173 completed and 44 discontinued/dropped out (i.e., dropout rate = 20.3%)). Based on the clinical significance definition (primary outcome), 62.4% of the participants who completed the therapy were judged to demonstrate positive clinical significance (recovered or improved), with only a few participants (6.9%) demonstrating deterioration. Significant improvements were observed before and after nurse-led individual CBT across all secondary outcomes, including depression and anxiety symptoms, health-related quality of life, and functional disability (all ps ≤ 0.001). Univariate logistic regression revealed that clients with higher baseline severity of depression and anxiety symptoms were less likely to achieve positive clinical significance following nurse-led individual CBT. The real-world evidence gained through this study will encourage frontline nurses and motivate institutional/organizational leaders and policymakers to employ nurse-led individual CBT, especially for depression and anxiety-related disorders.
DOI： 10.3390/bs14070604
MISC 【 display / non-display 】
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Guideline-directed Medical Therapy for Elderly Patients with Acute Myocardial Infarction Who Undergo Percutaneous Coronary Intervention(タイトル和訳中)
西平 賢作, 中井 陸運, 栗山 根廣, 海北 幸一, 柴田 剛徳
日本循環器学会学術集会抄録集 88回 PJ087 - 2 2024.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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日本人における至適抗血栓療法を考える(Novel Risk Stratification Schemes for Ischemic Stroke and Major Bleeding in Japanese Non-valvular Atrial Fibrillation Patients: The J-RISK AF Study)
富田 泰史, 奥村 謙, 赤尾 昌治, 中井 陸運, 小谷 英太郎, 鈴木 信也, 林 研至, 澤野 充明, 合屋 雅彦, 山下 武志, 福田 恵一, 津田 豊暢, 磯部 光章, 豊田 一則, 宮本 恵宏, 岡村 智教, 笹原 祐介
日本循環器学会学術集会抄録集 88回 SY08 - 3 2024.3
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Hepatorenal images have powerful prognostic value of all-cause mortality in patients with Fontan circulation
大内秀雄, 森有希, 加藤愛章, 伊藤裕貴, 藤本一途, 岩朝透, 坂口平馬, 黒嵜健一, 中井陸運
日本成人先天性心疾患学会雑誌(Web) 13 ( 1 ) 74 - 74 2024.1
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Current Status of Infective Endocarditis in Adult Congenital Heart Disease: A Report from the JROAD-DPC Study
町野智子, 大澤匠, 住田陽子, 中井陸運, 川松直人, 石踊巧, 野崎良寛, 村上卓, 石津智子
日本成人先天性心疾患学会雑誌(Web) 13 ( 1 ) 147 - 147 2024.1
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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Rapid Volume Expansion in Fontan Circulation
大内秀雄, 森有希, 加藤愛章, 伊藤裕貴, 藤本一途, 岩朝透, 坂口平馬, 黒嵜健一, 中井陸運
日本成人先天性心疾患学会雑誌(Web) 13 ( 1 ) 160 - 160 2024.1
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23K27522 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Principal investigator
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ビッグデータ・機械学習を用いたアブレーション治療の有効性・安全性予測モデルの作成
Grant number：23K24623 2024.04 - 2025.03
日本学術振興会 科学研究費助成事業 基盤研究(B)
草野 研吾, 山根 禎一, 清水 渉, 中井 陸運, 岩永 善高
Authorship：Principal investigator
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Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23H02831 2023.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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成人先天性心疾患診療体制の患者アウトカムへの影響：DPCデータを用いた検討
Grant number：23K10089 2023.04 - 2027.03
日本学術振興会 科学研究費助成事業 基盤研究(C)
落合 亮太, 石津 智子, 中井 陸運, 仁田 学
Authorship：Coinvestigator(s)
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先天性心疾患を主体とする小児期発症の心血管難治性疾患の救命率の向上と生涯にわたる QOL 改善のための総合的研究
Grant number：21FC1014 2023.04 - 2024.03
厚生労働省 科学研究費補助金 難治性疾患政策研究事業
Authorship：Coinvestigator(s)