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Affiliation |
Faculty of Medicine School of Medicine Department of Social Medicine, Data Management |
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Title |
Associate Professor |
NAKAI Michikazu
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Research Areas 【 display / non-display 】
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Informatics / Statistical science / BioStatistics
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Life Science / Hygiene and public health (non-laboratory)
Papers 【 display / non-display 】
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Kensuke Usuki, Takuro Kameda, Noriaki Kawano, Tomoki Ito, Yoshinori Hashimoto, Kotaro Shide, Hiroshi Kawano, Masaaki Sekine, Takanori Toyama, Hiromitsu Iizuka, Seiichi Sato, Masanori Takeuchi, Junzo Ishizaki, Kouichi Maeda, Michikazu Nakai, Kiyoshi Yamashita, Yoko Kubuki, Kazuya Shimoda
International journal of hematology 2024.3
Language：English Publishing type：Research paper (scientific journal)
Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or insertions of 8p11.2 were detected. Among the 10 patients with 8p11.2 translocations, three patients were diagnosed with MLN-FGFR1 abnormalities, which were confirmed by FISH analysis. Peripheral blood eosinophilia was observed in all three patients, and all progressed to AML or T-lymphoblastic lymphoma/leukemia. The prevalence of 8p11.2 translocations in clinical practice and the proportion of MLN-FGFR1 abnormalities in patients with 8p11.2 translocations in Japan were consistent with those in previous reports from Western countries.
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Two-Year Clinical Outcome of MitraClip Transcatheter Edge-to-Edge Repair From the J-MITRA Registry Data
Imamura Teruhiko, Nakai Michikazu, Iwanaga Yoshitaka, Sumita Yoko, Tao Misato, Ohno Yohei, Hayashida Kentaro, Morino Yoshihiro, Seo Yoshihiro, Saiki Yoshikatsu, Anzai Toshihisa, Toda Koichi, Matsumiya Goro, Yamamoto Kazuhiro, Hirata Kenichi, Kinugawa Koichiro, on behalf of J-MITRA Investigators
Circulation Journal advpub ( 0 ) 539 - 548 2024.3
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society
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Nishihira Kensaku, Nakai Michikazu, Kuriyama Nehiro, Kadooka Kosuke, Honda Yasuhiro, Emori Hiroki, Yamamoto Keisuke, Nishino Shun, Kudo Takeaki, Ogata Kenji, Kimura Toshiyuki, Kaikita Koichi, Shibata Yoshisato
Circulation Journal advpub ( 0 ) 2024.1
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society
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Tetsuo Yamaguchi, Michikazu Nakai, Takahide Kodama, Masanari Kuwabara, Naohiro Yonemoto, Takanori Ikeda, Yoshio Tahara
Resuscitation 195 110116 - 110116 2024.1
Language：English Publishing type：Research paper (scientific journal)
BACKGROUND: The impact of a national initiative to provide cardiopulmonary resuscitation (CPR) education to the public on the rates of citizen-initiated CPR and survival following out-of-hospital cardiac arrest (OHCA) remains uncertain. METHODS: We examined 358,025 cases of citizen-witnessed OHCA with presumed cardiac origin, recorded in the Japanese nationwide registry from 2005 to 2020. We assessed the relationship between the number of individuals certified in CPR courses, citizen interventions, and neurologically favorable survival at one month. RESULTS: The cumulative number of certified citizens has linearly increased from 9,930,327 in 2005 to 34,938,322 in 2020 (incidence rate ratio for annual number = 1.03, p < 0.001), encompassing 32.3% of the Japanese population aged 15 and above. Similarly, the prevalence of citizen-initiated CPR has consistently increased from 40.6% in 2005 to 56.8% in 2020 (P for trend < 0.001). Greater citizen CPR engagement was significantly associated with better outcome in initial shockable rhythm patients [chest compression only: odds ratio (OR) 1.24; 95% confidence interval (CI) 1.02-1.51; P = 0.029; chest compression with rescue breathing: OR 1.33; 95% CI 1.08-1.62; P = 0.006; defibrillation with chest compression: OR 2.27; 95% CI 1.83-2.83; P < 0.001; defibrillation with chest compression and rescue breathing: OR 2.15; 95% CI 1.70-2.73; P < 0.001 vs. no citizen CPR]. CONCLUSIONS: The incidence of citizen-initiated CPR across Japan has consistently and proportionately increased with the rising number of individuals certified in CPR courses. Greater citizen CPR involvement has been linked to neurologically favorable survival, particularly in cases with an initial shockable rhythm.
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Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome. International journal
Soichi Komaki, Yunosuke Matsuura, Hiroki Tanaka, Kohei Moribayashi, Yoshimasa Yamamura, Kazumasa Kurogi, Takeshi Ideguchi, Nobuyasu Yamamoto, Michikazu Nakai, Toshihiro Tsuruda, Koichi Kaikita
Open heart 11 ( 1 ) 2024.1
Language：English Publishing type：Research paper (scientific journal)
OBJECTIVE: The primary care for acute coronary syndrome (ACS) includes the administration of nitroglycerin (GTN). This study aimed to investigate the association between the use of GTN before percutaneous coronary intervention (PCI) for ACS and clinical outcomes. METHODS: Nine-hundred and forty-seven patients who underwent PCI for ACS were examined and classified into two groups: those who were treated with GTN before PCI (GTN group) and those who were not (non-GTN group). The incidence of major adverse cardiovascular events (MACE), which consist of all-cause mortality, non-fatal myocardial infarction, stroke and rehospitalisation for heart failure at 1 year, was compared between the two groups. RESULTS: This study identified 289 patients with ACS who used GTN preceding PCI. Pre-PCI systolic blood pressure was significantly lower in the GTN group than in the non-GTN group (median (IQR); 132.0 (110.0-143.5) mm Hg vs 134.0 (112.0-157.0) mm Hg, respectively, p=0.03). Multivariate Cox regression analysis indicated that GTN use preceding PCI showed an independent association with the incidence of MACE (HR 1.57; 95% CI 1.09-2.28; p=0.016). Overall, the incidence of MACE 1 year after PCI for ACS was significantly higher in the GTN group than in the non-GTN group (log-rank test, p=0.024); however, this trend was consistently found in elderly patients aged ≥75 years (p=0.002) but not in non-elderly patients aged <75 years (p=0.773). CONCLUSIONS: GTN use preceding PCI for ACS is associated with lower blood pressure and adverse clinical outcomes in elderly patients.
MISC 【 display / non-display 】
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心臓サルコイドーシス患者の免疫抑制療法開始後における心筋トロポニン値経時的評価の予後的意義
數井 翔, 竹中 秀, 永井 利幸, 加藤 喜哉, 小森山 弘和, 小林 雄太, 高橋 昌寛, 神谷 究, 佐藤 琢真, 多田 篤司, 安井 悠太郎, 中井 陸運, 佐藤 隆博, 辻野 一三, 今野 哲, 安斉 俊久
日本サルコイドーシス/肉芽腫性疾患学会雑誌 43 ( サプリメント号 ) 64 - 64 2023.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本サルコイドーシス
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心臓サルコイドーシス患者におけるガドリニウム遅延造影心臓MRIとFDG-PETを用いた複合的画像評価の予後的意義
數井 翔, 竹中 秀, 永井 利幸, 常田 慧徳, 加藤 喜哉, 小森山 弘和, 小林 雄太, 高橋 昌寛, 神谷 究, 天満 太郎, 佐藤 琢真, 多田 篤司, 安井 悠太郎, 中井 陸運, 佐藤 隆博, 辻野 一三, 工藤 與亮, 今野 哲, 安斉 俊久
日本サルコイドーシス/肉芽腫性疾患学会雑誌 43 ( サプリメント号 ) 65 - 65 2023.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本サルコイドーシス
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糖尿病患者における虚血性脳卒中の機序,病巣と予後 日本脳卒中データバンク
江頭 柊平, 三輪 佳織, 和田 晋一, 吉村 壮平, 中井 陸運, 笹原 祐介, 高下 純平, 石上 晃子, 岩永 善高, 宮本 恵宏, 小林 祥泰, 峰松 一夫, 豊田 一則, 古賀 政利
臨床神経学 63 ( Suppl. ) S309 - S309 2023.9
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本神経学会
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成人先天性心疾患患者の栄養評価(CONUTスコア)の意義
大内 秀雄, 森 有希, 黒嵜 健一, 白石 公, 中井 陸運
日本心臓病学会学術集会抄録 71回 O - 3 2023.9
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本心臓病学会
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JROAD-DPCを用いた循環器疾患患者における前立腺疾患(肥大症・癌)の有病率に関する疫学的検討
兼田 浩平, 田中 敦史, 中井 陸運, 住田 陽子, 野出 孝一
日本抗加齢医学会総会プログラム・抄録集 23回 261 - 261 2023.6
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本抗加齢医学会
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23H02831 2023.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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成人先天性心疾患診療体制の患者アウトカムへの影響：DPCデータを用いた検討
Grant number：23K10089 2023.04 - 2027.03
日本学術振興会 科学研究費助成事業 基盤研究(C)
落合 亮太, 石津 智子, 中井 陸運, 仁田 学
Authorship：Coinvestigator(s)
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先天性心疾患を主体とする小児期発症の心血管難治性疾患の救命率の向上と生涯にわたる QOL 改善のための総合的研究
Grant number：21FC1014 2023.04 - 2024.03
厚生労働省 科学研究費補助金 難治性疾患政策研究事業
Authorship：Coinvestigator(s)
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心血管病発症における血管壁ずり応力の意義の解明～新規内皮機能検査法を用いて
Grant number：22K07463 2022.04 - 2025.03
日本学術振興会 科学研究費助成事業 基盤研究(C) 基盤研究(C)
大畑 洋子, 細田 公則, 冨田 努, 中井 陸運, 吉村 壮平, 斎藤 こずえ, 槇野 久士
Authorship：Coinvestigator(s)
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ビッグデータ・機械学習を用いたアブレーション治療の有効性・安全性予測モデルの作成
Grant number：22H03365 2022.04 - 2025.03
日本学術振興会 科学研究費助成事業 基盤研究(B) 基盤研究(B)
草野 研吾, 山根 禎一, 清水 渉, 中井 陸運, 岩永 善高
Authorship：Coinvestigator(s)