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Affiliation |
Faculty of Medicine School of Medicine Department of Social Medicine, Data Management |
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Title |
Associate Professor |
NAKAI Michikazu
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Research Areas 【 display / non-display 】
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Informatics / Statistical science / BioStatistics
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Life Science / Hygiene and public health (non-laboratory)
Papers 【 display / non-display 】
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The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B
Watanabe K., Nishio S.Y., Usami S.I., Kumai T., Katada A., Ogasawara N., Shintani T., Morita S.Y., Takeichi N., Goto S.I., Nanba A., Sasaki A., Kobayashi Y., Honkura Y., Adachi M., Takai S., Oda K., Sato T., Yamada T., Shiina K., Ito T., Shinkawa C., Amano A., Kikuchi D., Ogawa H., Wada T., Hirose Y., Noguchi E., Moriyama N., Ohtsuka K., Shirai K., Sadayasu R., Shimada M., Suzumura H., Tono T., Motegi M., Mitoh I., Tada H., Nagai K., Sakata H., Ishikawa K., Yoshida N., Mizutari K., Suzuki Y., Ikezono T., Matsuda H., Noguchi Y., Takeda H., Kobayashi M., Sakurai Y., Hirabayashi G., Tajima S., Nishiyama N., Shirai K., Kawaguchi S., Iwasaki S., Takahashi M., Furutate S., Oka S.I., Yoshihashi H., Futagawa H., Ohishi N., Hosoya M., Kawashima Y., Ito T., Maruyama A., Kumakawa K., Matsunobu T., Sakuma N., Takahashi K., Kashio A., Monobe H., Miyoshi Y., Yabuki K., Seto Y., Sano H., Araki N., Arai Y., Okami M., Wasano K., Hatakeyama H., Isono Y., Ohira S., Komori M., Izumi S., Fujisaka M., Watanabe A., Okamoto M., Ito Y., Takahashi M., Miyagawa M., Takumi Y., Yoshimura H., Shinagawa J., Moteki H., Tsukamoto K., Ichinose A., Obara N., Kuza B., Takada N.
Scientific Reports 14 ( 1 ) 2024.12
Publishing type：Research paper (scientific journal) Publisher：Scientific Reports
The MYO7A gene is known to be responsible for both syndromic hearing loss (Usher syndrome type1B:USH1B) and non-syndromic hearing loss including autosomal dominant and autosomal recessive inheritance (DFNA11, DFNB2). However, the prevalence and detailed clinical features of MYO7A-associated hearing loss across a large population remain unclear. In this study, we conducted next-generation sequencing analysis for a large cohort of 10,042 Japanese hearing loss patients. As a result, 137 patients were identified with MYO7A-associated hearing loss so that the prevalence among Japanese hearing loss patients was 1.36%. We identified 70 disease-causing candidate variants in this study, with 36 of them being novel variants. All variants identified in autosomal dominant cases were missense or in-frame deletion variants. Among the autosomal recessive cases, all patients had at least one missense variant. On the other hand, in patients with Usher syndrome, almost half of the patients carried biallelic null variants (nonsense, splicing, and frameshift variants). Most of the autosomal dominant cases showed late-onset progressive hearing loss. On the other hand, cases with autosomal recessive inheritance or Usher syndrome showed congenital or early-onset hearing loss. The visual symptoms in the Usher syndrome cases developed between age 5–15, and the condition was diagnosed at about 6–15 years of age.
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Fujino M., Aikawa H., Nakao K., Takagi K., Otsuka F., Kataoka Y., Asaumi Y., Sumita Y., Nakai M., Kanaoka K., Miyamoto Y., Nicholls S.J., Noguchi T.
International Journal of Cardiology 411 132329 2024.9
Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Cardiology
Background: Left ventricular (LV) thrombus is not common but poses significant risks of embolic stroke or systemic embolism. However, the distinction in embolic risk between nonischemic cardiomyopathy (NICM) and ischemic cardiomyopathy (ICM) remains unclear. Methods and results: In total, 2738 LV thrombus patients from the JROAD-DPC (Japanese Registry of All Cardiac and Vascular Diseases Diagnosis Procedure Combination) database were included. Among these patients, 1037 patients were analyzed, with 826 (79.7%) having ICM and 211 with NICM (20.3%). Within the NICM group, the distribution was as follows: dilated cardiomyopathy (DCM; 41.2%), takotsubo cardiomyopathy (27.0%), hypertrophic cardiomyopathy (18.0%), and other causes (13.8%). The primary outcome was a composite of embolic stroke or systemic embolism (SSE) during hospitalization. The ICM and NICM groups showed no significant difference in the primary outcome (5.8% vs. 7.6%, p = 0.34). Among NICM, SSE occurred in 12.6% of patients with DCM, 7.0% with takotsubo cardiomyopathy, and 2.6% with hypertrophic cardiomyopathy. Multivariate logistic regression analysis for SSE revealed an odds ratio of 1.4 (95% confidence interval [CI], 0.7–2.7, p = 0.37) for NICM compared to ICM. However, DCM exhibited a higher adjusted odds ratio for SSE compared to ICM (2.6, 95% CI 1.2–6.0, p = 0.022). Conclusions: This nationwide shows comparable rates of embolic events between ICM and NICM in LV thrombus patients, with DCM posing a greater risk of SSE than ICM. The findings emphasize the importance of assessing the specific cause of heart disease in NICM, within LV thrombus management strategies.
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Translated and culturally adapted internet-delivered cognitive therapy for social anxiety disorder in Japanese clinical settings: study protocol for a randomised controlled trial.
Yoshinaga N, Thew GR, Hayashi Y, Tanoue H, Nakai M, Clark DM
Trials 25 ( 1 ) 492 2024.7
Language：English Publishing type：Research paper (scientific journal)
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Kimura Mitsukuni, Matoba Tetsuya, Nakano Yasuhiro, Katsuki Shunsuke, Sakamoto Kazuo, Nishihara Masaaki, Nagata Takuya, Tahara Yoshio, Nagao Ken, Okura Hiroyuki, Ikeda Takanori, Nakai Michikazu, Tsutsui Hiroyuki
Circulation Reports 6 ( 6 ) 191 - 200 2024.6
Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society
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Koyanagi M., Hatano T., Nakai M., Ogura T., Minematsu K., Kobayashi S., Toyoda K.
Journal of the Neurological Sciences 460 123000 2024.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of the Neurological Sciences
Introduction: Clinical trials have historically underrepresented patients with posterior circulation ischemic stroke (PCIS). This study aimed to comprehensively assess the clinical characteristics and outcomes of PCIS patients compared to those with anterior circulation ischemic stroke (ACIS). Methods: A retrospective analysis was conducted using data from the Japan Stroke Data Bank, encompassing 20 years across 130 stroke centers. The study focused on patients diagnosed with PCIS or ACIS. Results: Among 37,069 patients reviewed, 7425 had PCIS, whereas 29,644 had ACIS. PCIS patients were younger and had a lower female representation than ACIS patients. Notably, PCIS patients had more favorable outcomes: 71% achieved a modified Rankin Scale of 0–2 or showed no deterioration at discharge (17 days at the median after admission), compared to 60% for ACIS patients (p < 0.001). Factors associated with an unfavorable outcome in the PCIS subgroup were older age, female sex (assigned at birth), history of hypertension, and higher National Institute of Health Stroke Scale (NIHSS) scores at admission. In both sexes, older age and higher NIHSS scores were negatively associated with favorable outcomes. Conclusions: PCIS patients demonstrated a more favorable prognosis than ACIS patients. Factors like older age, female sex, and higher NIHSS scores at admission were identified as independent predictors of unfavorable outcomes in PCIS patients. Older age and higher NIHSS scores at admission were common independent negative factors for a favorable outcome regardless of sex.
MISC 【 display / non-display 】
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心臓サルコイドーシス患者の免疫抑制療法開始後における心筋トロポニン値経時的評価の予後的意義
數井 翔, 竹中 秀, 永井 利幸, 加藤 喜哉, 小森山 弘和, 小林 雄太, 高橋 昌寛, 神谷 究, 佐藤 琢真, 多田 篤司, 安井 悠太郎, 中井 陸運, 佐藤 隆博, 辻野 一三, 今野 哲, 安斉 俊久
日本サルコイドーシス/肉芽腫性疾患学会雑誌 43 ( サプリメント号 ) 64 - 64 2023.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本サルコイドーシス
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心臓サルコイドーシス患者におけるガドリニウム遅延造影心臓MRIとFDG-PETを用いた複合的画像評価の予後的意義
數井 翔, 竹中 秀, 永井 利幸, 常田 慧徳, 加藤 喜哉, 小森山 弘和, 小林 雄太, 高橋 昌寛, 神谷 究, 天満 太郎, 佐藤 琢真, 多田 篤司, 安井 悠太郎, 中井 陸運, 佐藤 隆博, 辻野 一三, 工藤 與亮, 今野 哲, 安斉 俊久
日本サルコイドーシス/肉芽腫性疾患学会雑誌 43 ( サプリメント号 ) 65 - 65 2023.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：日本サルコイドーシス
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糖尿病患者における虚血性脳卒中の機序,病巣と予後 日本脳卒中データバンク
江頭 柊平, 三輪 佳織, 和田 晋一, 吉村 壮平, 中井 陸運, 笹原 祐介, 高下 純平, 石上 晃子, 岩永 善高, 宮本 恵宏, 小林 祥泰, 峰松 一夫, 豊田 一則, 古賀 政利
臨床神経学 63 ( Suppl. ) S309 - S309 2023.9
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本神経学会
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成人先天性心疾患患者の栄養評価(CONUTスコア)の意義
大内 秀雄, 森 有希, 黒嵜 健一, 白石 公, 中井 陸運
日本心臓病学会学術集会抄録 71回 O - 3 2023.9
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本心臓病学会
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JROAD-DPCを用いた循環器疾患患者における前立腺疾患(肥大症・癌)の有病率に関する疫学的検討
兼田 浩平, 田中 敦史, 中井 陸運, 住田 陽子, 野出 孝一
日本抗加齢医学会総会プログラム・抄録集 23回 261 - 261 2023.6
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：(一社)日本抗加齢医学会
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23K27522 2024.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Principal investigator
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Risks and benefits associated with stroke antithrombotic therapy in the new antithrombotics era
Grant number：23H02831 2023.04 - 2027.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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成人先天性心疾患診療体制の患者アウトカムへの影響：DPCデータを用いた検討
Grant number：23K10089 2023.04 - 2027.03
日本学術振興会 科学研究費助成事業 基盤研究(C)
落合 亮太, 石津 智子, 中井 陸運, 仁田 学
Authorship：Coinvestigator(s)
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先天性心疾患を主体とする小児期発症の心血管難治性疾患の救命率の向上と生涯にわたる QOL 改善のための総合的研究
Grant number：21FC1014 2023.04 - 2024.03
厚生労働省 科学研究費補助金 難治性疾患政策研究事業
Authorship：Coinvestigator(s)
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心血管病発症における血管壁ずり応力の意義の解明～新規内皮機能検査法を用いて
Grant number：22K07463 2022.04 - 2025.03
日本学術振興会 科学研究費助成事業 基盤研究(C) 基盤研究(C)
大畑 洋子, 細田 公則, 冨田 努, 中井 陸運, 吉村 壮平, 斎藤 こずえ, 槇野 久士
Authorship：Coinvestigator(s)