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所属 |
医学部 医学科 社会医学講座データマネジメント分野 |
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職名 |
准教授 |
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Usuki K., Kameda T., Kawano N., Ito T., Hashimoto Y., Shide K., Kawano H., Sekine M., Toyama T., Iizuka H., Sato S., Takeuchi M., Ishizaki J., Maeda K., Nakai M., Yamashita K., Kubuki Y., Shimoda K.
International Journal of Hematology 2024年3月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：International Journal of Hematology
Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or insertions of 8p11.2 were detected. Among the 10 patients with 8p11.2 translocations, three patients were diagnosed with MLN-FGFR1 abnormalities, which were confirmed by FISH analysis. Peripheral blood eosinophilia was observed in all three patients, and all progressed to AML or T-lymphoblastic lymphoma/leukemia. The prevalence of 8p11.2 translocations in clinical practice and the proportion of MLN-FGFR1 abnormalities in patients with 8p11.2 translocations in Japan were consistent with those in previous reports from Western countries.
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Two-Year Clinical Outcome of MitraClip Transcatheter Edge-to-Edge Repair From the J-MITRA Registry Data.
Imamura T, Nakai M, Iwanaga Y, Sumita Y, Tao M, Ohno Y, Hayashida K, Morino Y, Seo Y, Saiki Y, Anzai T, Toda K, Matsumiya G, Yamamoto K, Hirata K, Kinugawa K, J-MITRA Investigators
Circulation journal : official journal of the Japanese Circulation Society advpub ( 0 ) 539 - 548 2024年3月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本循環器学会
<b><i>Background:</i></b> The introduction of transcatheter edge-to-edge repair for moderate-to-severe or severe mitral regurgitation (MR) utilizing the MitraClip system became reimbursed and clinically accessible in Japan in April 2018. This study presents the 2-year clinical outcomes of all consecutively treated patients who underwent MitraClip implantation in Japan and were prospectively enrolled in the Japanese Circulation Society-oriented J-MITRA registry.<b><i>Methods and Results:</i></b> Analysis encompassed 2,739 consecutive patients enrolled in the J-MITRA registry with informed consent (mean age: 78.3±9.6 years, 1,550 males, STS risk score 11.7±8.9), comprising 1,999 cases of functional MR, 644 of degenerative MR and 96 in a mixed group (DMR and FMR). The acute procedure success rate was 88.9%. After MitraClip implantation, >80% exhibited an MR grade ≤2+ and the trend was sustained over the 2 years. Within this observation period, the mortality rate was 19.3% and the rate of heart failure readmissions was 20.6%. The primary composite endpoint, inclusive of cardiovascular death and heart failure readmission, was significantly higher in patients with functional MR than in with degenerative MR (32.0% vs. 17.5%, P<0.001).<b><i>Conclusions:</i></b> The 2-year clinical outcomes after MitraClip implantation were deduced from comprehensive data within an all-Japan registry.
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Nishihira K, Nakai M, Kuriyama N, Kadooka K, Honda Y, Emori H, Yamamoto K, Nishino S, Kudo T, Ogata K, Kimura T, Kaikita K, Shibata Y
Circulation journal : official journal of the Japanese Circulation Society advpub ( 0 ) 2024年1月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本循環器学会
<b><i>Background:</i></b> The efficacy of guideline-directed medical therapy (GDMT) in the elderly remains unclear. This study evaluated the impact of GDMT (aspirin or a P2Y<sub>12</sub>inhibitor, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, β-blocker, and statin) at discharge on long-term mortality in elderly patients with acute myocardial infarction (AMI) who had undergone percutaneous coronary intervention (PCI).<b><i>Methods and Results:</i></b> Of 2,547 consecutive patients with AMI undergoing PCI in 2009–2020, we retrospectively analyzed 573 patients aged ≥80 years. The median follow-up period was 1,140 days. GDMT was prescribed to 192 (33.5%) patients at discharge. Compared with patients without GDMT, those with GDMT were younger and had higher rates of ST-segment elevation myocardial infarction and left anterior descending artery culprit lesion, higher peak creatine phosphokinase concentration, and lower left ventricular ejection fraction (LVEF). After adjusting for confounders, GDMT was independently associated with a lower cardiovascular death rate (hazard ratio [HR] 0.35; 95% confidence interval [CI] 0.16–0.81), but not with all-cause mortality (HR 0.77; 95% CI 0.50–1.18). In the subgroup analysis, the favorable impact of GDMT on cardiovascular death was significant in patients aged 80–89 years, with LVEF <50%, or with an estimated glomerular filtration rate ≥30 mL/min/1.73 m<sup>2</sup>.<b><i>Conclusions:</i></b> GDMT in patients with AMI aged ≥80 years undergoing PCI was associated with a lower cardiovascular death rate but not all-cause mortality.
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Yamaguchi T, Nakai M, Kodama T, Kuwabara M, Yonemoto N, Ikeda T, Tahara Y, behalf of Japanese Circulation Society Resuscitation Science Study JCS-ReSS Group
Resuscitation 195 110116 - 110116 2024年1月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Resuscitation
Background: The impact of a national initiative to provide cardiopulmonary resuscitation (CPR) education to the public on the rates of citizen-initiated CPR and survival following out-of-hospital cardiac arrest (OHCA) remains uncertain. Methods: We examined 358,025 cases of citizen-witnessed OHCA with presumed cardiac origin, recorded in the Japanese nationwide registry from 2005 to 2020. We assessed the relationship between the number of individuals certified in CPR courses, citizen interventions, and neurologically favorable survival at one month. Results: The cumulative number of certified citizens has linearly increased from 9,930,327 in 2005 to 34,938,322 in 2020 (incidence rate ratio for annual number = 1.03, p < 0.001), encompassing 32.3% of the Japanese population aged 15 and above. Similarly, the prevalence of citizen-initiated CPR has consistently increased from 40.6% in 2005 to 56.8% in 2020 (P for trend < 0.001). Greater citizen CPR engagement was significantly associated with better outcome in initial shockable rhythm patients [chest compression only: odds ratio (OR) 1.24; 95% confidence interval (CI) 1.02–1.51; P = 0.029; chest compression with rescue breathing: OR 1.33; 95% CI 1.08–1.62; P = 0.006; defibrillation with chest compression: OR 2.27; 95% CI 1.83–2.83; P < 0.001; defibrillation with chest compression and rescue breathing: OR 2.15; 95% CI 1.70–2.73; P < 0.001 vs. no citizen CPR]. Conclusions: The incidence of citizen-initiated CPR across Japan has consistently and proportionately increased with the rising number of individuals certified in CPR courses. Greater citizen CPR involvement has been linked to neurologically favorable survival, particularly in cases with an initial shockable rhythm.
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Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome 国際誌
Komaki S., Matsuura Y., Tanaka H., Moribayashi K., Yamamura Y., Kurogi K., Ideguchi T., Yamamoto N., Nakai M., Tsuruda T., Kaikita K.
Open Heart 11 ( 1 ) 2024年1月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Open Heart
Objective The primary care for acute coronary syndrome (ACS) includes the administration of nitroglycerin (GTN). This study aimed to investigate the association between the use of GTN before percutaneous coronary intervention (PCI) for ACS and clinical outcomes. Methods Nine-hundred and forty-seven patients who underwent PCI for ACS were examined and classified into two groups: those who were treated with GTN before PCI (GTN group) and those who were not (non-GTN group). The incidence of major adverse cardiovascular events (MACE), which consist of all-cause mortality, non-fatal myocardial infarction, stroke and rehospitalisation for heart failure at 1 year, was compared between the two groups. Results This study identified 289 patients with ACS who used GTN preceding PCI. Pre-PCI systolic blood pressure was significantly lower in the GTN group than in the non-GTN group (median (IQR); 132.0 (110.0-143.5) mm Hg vs 134.0 (112.0-157.0) mm Hg, respectively, p=0.03). Multivariate Cox regression analysis indicated that GTN use preceding PCI showed an independent association with the incidence of MACE (HR 1.57; 95% CI 1.09-2.28; p=0.016). Overall, the incidence of MACE 1 year after PCI for ACS was significantly higher in the GTN group than in the non-GTN group (log-rank test, p=0.024); however, this trend was consistently found in elderly patients aged ≥75 years (p=0.002) but not in non-elderly patients aged <75 years (p=0.773). Conclusions GTN use preceding PCI for ACS is associated with lower blood pressure and adverse clinical outcomes in elderly patients.
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心臓サルコイドーシス患者の免疫抑制療法開始後における心筋トロポニン値経時的評価の予後的意義
數井 翔, 竹中 秀, 永井 利幸, 加藤 喜哉, 小森山 弘和, 小林 雄太, 高橋 昌寛, 神谷 究, 佐藤 琢真, 多田 篤司, 安井 悠太郎, 中井 陸運, 佐藤 隆博, 辻野 一三, 今野 哲, 安斉 俊久
日本サルコイドーシス/肉芽腫性疾患学会雑誌 43 ( サプリメント号 ) 64 - 64 2023年10月
記述言語：日本語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：日本サルコイドーシス
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心臓サルコイドーシス患者におけるガドリニウム遅延造影心臓MRIとFDG-PETを用いた複合的画像評価の予後的意義
數井 翔, 竹中 秀, 永井 利幸, 常田 慧徳, 加藤 喜哉, 小森山 弘和, 小林 雄太, 高橋 昌寛, 神谷 究, 天満 太郎, 佐藤 琢真, 多田 篤司, 安井 悠太郎, 中井 陸運, 佐藤 隆博, 辻野 一三, 工藤 與亮, 今野 哲, 安斉 俊久
日本サルコイドーシス/肉芽腫性疾患学会雑誌 43 ( サプリメント号 ) 65 - 65 2023年10月
記述言語：日本語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：日本サルコイドーシス
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糖尿病患者における虚血性脳卒中の機序,病巣と予後 日本脳卒中データバンク
江頭 柊平, 三輪 佳織, 和田 晋一, 吉村 壮平, 中井 陸運, 笹原 祐介, 高下 純平, 石上 晃子, 岩永 善高, 宮本 恵宏, 小林 祥泰, 峰松 一夫, 豊田 一則, 古賀 政利
臨床神経学 63 ( Suppl. ) S309 - S309 2023年9月
記述言語：日本語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：(一社)日本神経学会
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成人先天性心疾患患者の栄養評価(CONUTスコア)の意義
大内 秀雄, 森 有希, 黒嵜 健一, 白石 公, 中井 陸運
日本心臓病学会学術集会抄録 71回 O - 3 2023年9月
記述言語：日本語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：(一社)日本心臓病学会
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JROAD-DPCを用いた循環器疾患患者における前立腺疾患(肥大症・癌)の有病率に関する疫学的検討
兼田 浩平, 田中 敦史, 中井 陸運, 住田 陽子, 野出 孝一
日本抗加齢医学会総会プログラム・抄録集 23回 261 - 261 2023年6月
記述言語：日本語 掲載種別：速報，短報，研究ノート等（学術雑誌） 出版者・発行元：(一社)日本抗加齢医学会
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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抗血栓薬新時代の脳卒中診療リスクベネフィット：複数大規模データベースを用いた解析
研究課題/領域番号：23H02831 2023年04月 - 2027年03月
日本学術振興会 科学研究費助成事業 基盤研究(B)
豊田 一則, 宮本 恵宏, 古賀 政利, 中井 陸運, 吉村 壮平, 三輪 佳織, 田中 寛大
担当区分：研究分担者
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成人先天性心疾患診療体制の患者アウトカムへの影響：DPCデータを用いた検討
研究課題/領域番号：23K10089 2023年04月 - 2027年03月
日本学術振興会 科学研究費助成事業 基盤研究(C)
落合 亮太, 石津 智子, 中井 陸運, 仁田 学
担当区分：研究分担者
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先天性心疾患を主体とする小児期発症の心血管難治性疾患の救命率の向上と生涯にわたる QOL 改善のための総合的研究
研究課題/領域番号：21FC1014 2023年04月 - 2024年03月
厚生労働省 科学研究費補助金 難治性疾患政策研究事業
担当区分：研究分担者
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心血管病発症における血管壁ずり応力の意義の解明～新規内皮機能検査法を用いて
研究課題/領域番号：22K07463 2022年04月 - 2025年03月
日本学術振興会 科学研究費助成事業 基盤研究(C) 基盤研究(C)
大畑 洋子, 細田 公則, 冨田 努, 中井 陸運, 吉村 壮平, 斎藤 こずえ, 槇野 久士
担当区分：研究分担者
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ビッグデータ・機械学習を用いたアブレーション治療の有効性・安全性予測モデルの作成
研究課題/領域番号：22H03365 2022年04月 - 2025年03月
日本学術振興会 科学研究費助成事業 基盤研究(B) 基盤研究(B)
草野 研吾, 山根 禎一, 清水 渉, 中井 陸運, 岩永 善高
担当区分：研究分担者