中井 陸運 (ナカイ ミチカズ)

NAKAI Michikazu

写真a

所属

医学部 医学科 社会医学講座データマネジメント分野

職名

准教授

研究分野 【 表示 / 非表示

  • 情報通信 / 統計科学  / 医療統計学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

 

論文 【 表示 / 非表示

  • Prevalence of chromosome 8p11.2 translocations and correlation with myeloid and lymphoid neoplasms associated with FGFR1 abnormalities in a consecutive cohort from nine institutions in Japan

    Usuki K., Kameda T., Kawano N., Ito T., Hashimoto Y., Shide K., Kawano H., Sekine M., Toyama T., Iizuka H., Sato S., Takeuchi M., Ishizaki J., Maeda K., Nakai M., Yamashita K., Kubuki Y., Shimoda K.

    International Journal of Hematology   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Hematology  

    Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or insertions of 8p11.2 were detected. Among the 10 patients with 8p11.2 translocations, three patients were diagnosed with MLN-FGFR1 abnormalities, which were confirmed by FISH analysis. Peripheral blood eosinophilia was observed in all three patients, and all progressed to AML or T-lymphoblastic lymphoma/leukemia. The prevalence of 8p11.2 translocations in clinical practice and the proportion of MLN-FGFR1 abnormalities in patients with 8p11.2 translocations in Japan were consistent with those in previous reports from Western countries.

    DOI: 10.1007/s12185-024-03740-0

    Scopus

    PubMed

  • Two-Year Clinical Outcome of MitraClip Transcatheter Edge-to-Edge Repair From the J-MITRA Registry Data.

    Imamura T, Nakai M, Iwanaga Y, Sumita Y, Tao M, Ohno Y, Hayashida K, Morino Y, Seo Y, Saiki Y, Anzai T, Toda K, Matsumiya G, Yamamoto K, Hirata K, Kinugawa K, J-MITRA Investigators

    Circulation journal : official journal of the Japanese Circulation Society   advpub ( 0 )   539 - 548   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人 日本循環器学会  

    <b><i>Background:</i></b> The introduction of transcatheter edge-to-edge repair for moderate-to-severe or severe mitral regurgitation (MR) utilizing the MitraClip system became reimbursed and clinically accessible in Japan in April 2018. This study presents the 2-year clinical outcomes of all consecutively treated patients who underwent MitraClip implantation in Japan and were prospectively enrolled in the Japanese Circulation Society-oriented J-MITRA registry.<b><i>Methods and Results:</i></b> Analysis encompassed 2,739 consecutive patients enrolled in the J-MITRA registry with informed consent (mean age: 78.3±9.6 years, 1,550 males, STS risk score 11.7±8.9), comprising 1,999 cases of functional MR, 644 of degenerative MR and 96 in a mixed group (DMR and FMR). The acute procedure success rate was 88.9%. After MitraClip implantation, >80% exhibited an MR grade ≤2+ and the trend was sustained over the 2 years. Within this observation period, the mortality rate was 19.3% and the rate of heart failure readmissions was 20.6%. The primary composite endpoint, inclusive of cardiovascular death and heart failure readmission, was significantly higher in patients with functional MR than in with degenerative MR (32.0% vs. 17.5%, P<0.001).<b><i>Conclusions:</i></b> The 2-year clinical outcomes after MitraClip implantation were deduced from comprehensive data within an all-Japan registry.

    DOI: 10.1253/circj.cj-23-0924

    PubMed

    CiNii Research

  • Guideline-Directed Medical Therapy for Elderly Patients With Acute Myocardial Infarction Who Undergo Percutaneous Coronary Intervention - Insights From a Retrospective Observational Study.

    Nishihira K, Nakai M, Kuriyama N, Kadooka K, Honda Y, Emori H, Yamamoto K, Nishino S, Kudo T, Ogata K, Kimura T, Kaikita K, Shibata Y

    Circulation journal : official journal of the Japanese Circulation Society   advpub ( 0 )   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人 日本循環器学会  

    <b><i>Background:</i></b> The efficacy of guideline-directed medical therapy (GDMT) in the elderly remains unclear. This study evaluated the impact of GDMT (aspirin or a P2Y<sub>12</sub>inhibitor, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, β-blocker, and statin) at discharge on long-term mortality in elderly patients with acute myocardial infarction (AMI) who had undergone percutaneous coronary intervention (PCI).<b><i>Methods and Results:</i></b> Of 2,547 consecutive patients with AMI undergoing PCI in 2009–2020, we retrospectively analyzed 573 patients aged ≥80 years. The median follow-up period was 1,140 days. GDMT was prescribed to 192 (33.5%) patients at discharge. Compared with patients without GDMT, those with GDMT were younger and had higher rates of ST-segment elevation myocardial infarction and left anterior descending artery culprit lesion, higher peak creatine phosphokinase concentration, and lower left ventricular ejection fraction (LVEF). After adjusting for confounders, GDMT was independently associated with a lower cardiovascular death rate (hazard ratio [HR] 0.35; 95% confidence interval [CI] 0.16–0.81), but not with all-cause mortality (HR 0.77; 95% CI 0.50–1.18). In the subgroup analysis, the favorable impact of GDMT on cardiovascular death was significant in patients aged 80–89 years, with LVEF <50%, or with an estimated glomerular filtration rate ≥30 mL/min/1.73 m<sup>2</sup>.<b><i>Conclusions:</i></b> GDMT in patients with AMI aged ≥80 years undergoing PCI was associated with a lower cardiovascular death rate but not all-cause mortality.

    DOI: 10.1253/circj.cj-23-0837

    PubMed

    CiNii Research

  • Impact of a national initiative to provide civilian cardiopulmonary resuscitation training courses on the rates of bystander intervention by citizens and survival after out-of-hospital cardiac arrest. 国際誌

    Yamaguchi T, Nakai M, Kodama T, Kuwabara M, Yonemoto N, Ikeda T, Tahara Y, behalf of Japanese Circulation Society Resuscitation Science Study JCS-ReSS Group

    Resuscitation   195   110116 - 110116   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Resuscitation  

    Background: The impact of a national initiative to provide cardiopulmonary resuscitation (CPR) education to the public on the rates of citizen-initiated CPR and survival following out-of-hospital cardiac arrest (OHCA) remains uncertain. Methods: We examined 358,025 cases of citizen-witnessed OHCA with presumed cardiac origin, recorded in the Japanese nationwide registry from 2005 to 2020. We assessed the relationship between the number of individuals certified in CPR courses, citizen interventions, and neurologically favorable survival at one month. Results: The cumulative number of certified citizens has linearly increased from 9,930,327 in 2005 to 34,938,322 in 2020 (incidence rate ratio for annual number = 1.03, p < 0.001), encompassing 32.3% of the Japanese population aged 15 and above. Similarly, the prevalence of citizen-initiated CPR has consistently increased from 40.6% in 2005 to 56.8% in 2020 (P for trend < 0.001). Greater citizen CPR engagement was significantly associated with better outcome in initial shockable rhythm patients [chest compression only: odds ratio (OR) 1.24; 95% confidence interval (CI) 1.02–1.51; P = 0.029; chest compression with rescue breathing: OR 1.33; 95% CI 1.08–1.62; P = 0.006; defibrillation with chest compression: OR 2.27; 95% CI 1.83–2.83; P < 0.001; defibrillation with chest compression and rescue breathing: OR 2.15; 95% CI 1.70–2.73; P < 0.001 vs. no citizen CPR]. Conclusions: The incidence of citizen-initiated CPR across Japan has consistently and proportionately increased with the rising number of individuals certified in CPR courses. Greater citizen CPR involvement has been linked to neurologically favorable survival, particularly in cases with an initial shockable rhythm.

    DOI: 10.1016/j.resuscitation.2024.110116

    Scopus

    PubMed

  • Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome 国際誌

    Komaki S., Matsuura Y., Tanaka H., Moribayashi K., Yamamura Y., Kurogi K., Ideguchi T., Yamamoto N., Nakai M., Tsuruda T., Kaikita K.

    Open Heart   11 ( 1 )   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Open Heart  

    Objective The primary care for acute coronary syndrome (ACS) includes the administration of nitroglycerin (GTN). This study aimed to investigate the association between the use of GTN before percutaneous coronary intervention (PCI) for ACS and clinical outcomes. Methods Nine-hundred and forty-seven patients who underwent PCI for ACS were examined and classified into two groups: those who were treated with GTN before PCI (GTN group) and those who were not (non-GTN group). The incidence of major adverse cardiovascular events (MACE), which consist of all-cause mortality, non-fatal myocardial infarction, stroke and rehospitalisation for heart failure at 1 year, was compared between the two groups. Results This study identified 289 patients with ACS who used GTN preceding PCI. Pre-PCI systolic blood pressure was significantly lower in the GTN group than in the non-GTN group (median (IQR); 132.0 (110.0-143.5) mm Hg vs 134.0 (112.0-157.0) mm Hg, respectively, p=0.03). Multivariate Cox regression analysis indicated that GTN use preceding PCI showed an independent association with the incidence of MACE (HR 1.57; 95% CI 1.09-2.28; p=0.016). Overall, the incidence of MACE 1 year after PCI for ACS was significantly higher in the GTN group than in the non-GTN group (log-rank test, p=0.024); however, this trend was consistently found in elderly patients aged ≥75 years (p=0.002) but not in non-elderly patients aged <75 years (p=0.773). Conclusions GTN use preceding PCI for ACS is associated with lower blood pressure and adverse clinical outcomes in elderly patients.

    DOI: 10.1136/openhrt-2023-002494

    Scopus

    PubMed

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MISC 【 表示 / 非表示

  • 心臓サルコイドーシス患者におけるガドリニウム遅延造影心臓MRIとFDG-PETを用いた複合的画像評価の予後的意義

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    日本サルコイドーシス/肉芽腫性疾患学会雑誌   43 ( サプリメント号 )   65 - 65   2023年10月

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    記述言語:日本語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:日本サルコイドーシス  

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  • 糖尿病患者における虚血性脳卒中の機序,病巣と予後 日本脳卒中データバンク

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    臨床神経学   63 ( Suppl. )   S309 - S309   2023年9月

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    記述言語:日本語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:(一社)日本神経学会  

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    大内 秀雄, 森 有希, 黒嵜 健一, 白石 公, 中井 陸運

    日本心臓病学会学術集会抄録   71回   O - 3   2023年9月

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    記述言語:日本語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:(一社)日本心臓病学会  

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    日本抗加齢医学会総会プログラム・抄録集   23回   261 - 261   2023年6月

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    記述言語:日本語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:(一社)日本抗加齢医学会  

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科研費(文科省・学振・厚労省)獲得実績 【 表示 / 非表示

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    研究課題/領域番号:23H02831  2023年04月 - 2027年03月

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    担当区分:研究分担者 

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    落合 亮太, 石津 智子, 中井 陸運, 仁田 学

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    担当区分:研究分担者 

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