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Affiliation |
Faculty of Agriculture Region of Veterinary Science |
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Title |
Assistant Professor |
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Related SDGs |
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FUKE Naoyuki
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Degree 【 display / non-display 】
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Ph.D（Veterinary Medicine） ( 2020.4 University of Miyazaki )
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Veterinary Medicine ( 2016.3 University of Miyazaki )
Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Papers 【 display / non-display 】
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Distribution of domestic cat hepatitis B virus in cholangiocarcinoma and non-neoplastic liver tissue Reviewed
DOSAKA Haruka, KATO Nanami X, TAGA Kei, YAMAMOTO Soshin, KONDO Kaito, RINGO Rissar Siringo, KANEKO Yasuyuki, HIRAI Takuya, SAITO Akatsuki, FUKE Naoyuki
Journal of Veterinary Medical Science 88 ( 3 ) 458 - 462 2026.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
DOI： https://doi.org/10.1292/jvms.25-0372
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Kato NX, Dosaka H, Adachi Y, Kaneko Y, Hirai T, Sekiguchi S, Fuke N(責任著者), Saito A.
Journal of Veterinary Medical Science 2026
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
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Abe H, Kato NX, Tanbe M, Shimabukuro T, Hashimoto S, Hirai T, Fuke N, Saito A.
Journal of Veterinary Medical Science advpub ( 0 ) 2026
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
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Yamashita T., Hegazy A.A., Yamagishi A., Saito E., Kakiya M., Fuke N., Hirai T.
Journal of Comparative Pathology 227 24 - 30 2026.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Comparative Pathology
Porcine circovirus-associated disease (PCVAD) and porcine respiratory disease complex (PRDC) significantly impact the pig industry worldwide. Porcine circovirus type 2 (PCV2) is the primary pathogen associated with PCVAD, whereas PRDC is caused by a combination of pathogens including porcine reproductive and respiratory syndrome virus (PRRSV) and pathogenic bacteria. Despite the availability of a PCV2 vaccine that effectively controls and prevents PCVAD, subclinical PCV2 infection (PCV2-SI) still occurs under field conditions. Various porcine pathogens enter via the nasal cavity, where nasopharynx-associated lymphoid tissue (NALT) plays an important role in nasal mucosal immunity. This study examined the pathogenesis of PRDC in pigs with PCV2-SI and the distribution of PCV2 and PRRSV in NALT using in-situ hybridization (ISH) analyses in PCV2-SI pigs. All six pigs had suppurative nasopharyngitis and suppurative pneumonia. Lymphoid tissue contained no cytoplasmic inclusions or giant cells. ISH showed positive signals for PCV2 in the NALT and lungs of all six pigs and PRRSV in the NALT of three pigs and lungs of five. PCV2-positive macrophages were primarily identified in the follicles of NALT, whereas PRRSV-positive macrophages were found primarily around crypts. This is the first study to suggest that replication of both viruses in NALT may cause suppression of local immunity and activate important risk factors of PRDC in pigs with PCV2-SI.
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AHMED Amaal Ezzat, NAKAI Mutsumi, KAKIYA Miho, FUKE Naoyuki, HEGAZY Asmaa A, KONDO Hiroaki, HIRAI Takuya
Journal of Veterinary Medical Science 87 ( 8 ) 924 - 933 2025.8
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
<i>Mycoplasma bovis</i> (<i>M. bovis)</i> is an important bacterium in the bovine respiratory disease complex (BRDC), which causes significant economic losses. The nasopharyngeal and palatine tonsils are mucosal-associated lymphoid tissue components that are the initial barrier to respiratory pathogens. In the present study, we investigated 5 pneumonic Japanese black and 3 control calves (2 Japanese black and 1 Holstein). The localization of <i>M. bovis</i> in the nasopharyngeal, palatine tonsils, and lungs was examined using nested and multiplex polymerase chain reaction (PCR), histopathology, and <i>in situ</i> hybridization (ISH) techniques. Nested PCR revealed that all examined tissues from all pneumonic calves were positive for <i>M. bovis</i> infection, but not the control. Histopathology revealed suppurative nasopharyngeal tonsillitis and palatine tonsillar cryptitis in all cases. Surprisingly, prominent histologic changes were observed in the palatine tonsils but not in the nasopharyngeal tonsils. Necrotizing suppurative bronchopneumonia was observed in 4 pneumonic calves. In ISH analysis, positive hybridization signals adherent to and/or within the surface epithelium of nasopharyngeal tonsils and crypt epithelium of nasopharyngeal and palatine tonsils were observed. Additionally, these signals were seen in the palatine tonsillar cryptic detritus. In the lungs, ISH signals were observed in necrotic areas, the bronchial epithelium, and pulmonary inflammatory exudate. These findings suggest that the nasopharyngeal and palatine tonsils are the primary sites of <i>M. bovis</i> infection. Also, <i>M. bovis</i> can colonize the detritus in the crypts of the palatine tonsils of the pneumonic animals.
DOI： 10.1292/jvms.25-0188
Books 【 display / non-display 】
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牛枝肉の”シミ”発生率に影響する生体、飼育管理、およびと畜処理要因の検証
遠矢宏美、福家直幸、萩平敦朗（ Role： Joint author）
畜産技術 2024.10
Language：Japanese Book type：Report
Presentations 【 display / non-display 】
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ネコにおけるSFTSの病理学的特徴-宮崎県の野外感例を中心に- Invited
福家直幸
第168回日本獣医学会学術集会病理分科会 2025.9.4
Event date： 2025.9.3 - 2025.9.5
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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猫B型肝炎ウイルス（DCHBV）感染猫10例の肝病変に関する病理組織学的検討
銅坂悠、加藤七海、足立行庸、金子泰之、平井卓哉、齊藤暁、福家直幸
第13回日本獣医病理学専門家協会学術集会 2026.3.26
Event date： 2026.3.25 - 2026.3.27
Language：Japanese Presentation type：Poster presentation
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Histopathological analysis of 11 cats infected with severe fever with thrombocytopenia syndrome virus at the Miyazaki prefecture
Muhammad Haroon Khan, Naoyuki Fuke, Ren Takada, Yasuyuki Kaneko, Hirohisa Mekata, Tamaki Okabayashi, Takuya Hirai
第13回日本獣医病理学専門家協会学術集会 2026.3.26
Event date： 2026.3.25 - 2026.3.27
Language：English Presentation type：Poster presentation
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Severe Fever with Thrombocytopenia Syndrome: An Emerging Tick-borne Threat in Asia Invited International conference
Naoyuki Fuke
International Veterinary Conference 2025 2025.11.25
Event date： 2025.11.24 - 2025.11.25
Language：English Presentation type：Oral presentation (invited, special)
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猫ヘパドナウイルス感染を伴う猫の胆管癌
銅坂 悠、加藤 七海、近藤 海斗、多賀 佳 、山本 宗伸、 Rissar Siringo Ringo、金子 泰之、平井 卓哉、齊藤 暁、福家 直幸
令和7年度獣医学術九州地区学会 日本小動物獣医学会 2025.10.26
Event date： 2025.10.26
Language：Japanese Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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フレッシャー・アワード
2025.10 九州地区獣医師会連合会 猫ヘパドナウイルス感染を伴う猫の胆管癌
銅坂悠、加藤七海、近藤海斗、多賀佳、山本宗伸、Rissar Siringo Ringo、金子泰之、平井卓哉、齊藤暁、福家直幸
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2024.3 日本獣医病理学専門家協会 宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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奨励賞
2025.10 九州地区獣医師会連合会 肉用雄子牛の免疫学的去勢法の検討
西岡快人、三樹孝太郎、福家直幸、大澤健司、北原豪
Award type：Award from Japanese society, conference, symposium, etc.
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九州地区獣医師会連合会長賞
2024.9 九州地区獣医師会連合会 豚呼吸器複合病における扁桃と鼻咽頭関連リンパ組織病変の比較検討
齋藤江連、垣屋美穂、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2024.3 日本獣医病理学専門家協会 PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
Available Technology 【 display / non-display 】
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Home Page： 宮崎大学 獣医病理学研究室
Related fields where technical consultation is available：・食肉衛生検査所や家畜保健衛生所の診断の助言
・SFTSの病理診断
・ウイルス性疾患（猫パピローマ、猫ヘパドナ）の病理診断
・伴侶動物・産業動物・動物園動物の死因解析（不審死などを含む）Message：獣医病理に関連する内容であれば、御相談下さい。
