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Affiliation |
Faculty of Agriculture Region of Veterinary Science |
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Title |
Assistant Professor |
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Related SDGs |
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FUKE Naoyuki
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Degree 【 display / non-display 】
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Ph.D（Veterinary Medicine） ( 2020.4 University of Miyazaki )
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Veterinary Medicine ( 2016.3 University of Miyazaki )
Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Papers 【 display / non-display 】
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Distribution of domestic cat hepatitis B virus in cholangiocarcinoma and non-neoplastic liver tissue Reviewed
DOSAKA Haruka, KATO Nanami X, TAGA Kei, YAMAMOTO Soshin, KONDO Kaito, RINGO Rissar Siringo, KANEKO Yasuyuki, HIRAI Takuya, SAITO Akatsuki, FUKE Naoyuki
Journal of Veterinary Medical Science 88 ( 3 ) 458 - 462 2026.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
DOI： 10.1292/jvms.25-0372
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Hinata ABE, Nanami X KATO, Mika TANABE, Taichi SHIMABUKURO, Saki HASHIMOTO, Takuya HIRAI, Naoyuki FUKE, Akatsuki SAITO
Journal of Veterinary Medical Science 2026.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1292/jvms.25-0517
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Detection of bovine respiratory disease complex-related pathogens in nasopharynx-associated lymphoid tissue. Reviewed International journal
Asmaa A Hegazy, Mutsumi Nakai, Naoyuki Fuke, Amaal E Hussein, Hiroaki Kondo, Takuya Hirai
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 37 ( 2 ) 10406387251318415 - 297 2025.2
Language：English Publishing type：Research paper (scientific journal)
Bovine respiratory disease complex (BRDC) is a multi-etiologic disease that significantly impacts the cattle industry. Nasopharynx-associated lymphoid tissue (NALT) is the nasal mucosal immune system that protects against various pathogens; however, reports on its pathology are limited. We compared the pathologic impact of BRDC-related viruses on the NALT and lungs of 10 pneumonic and 3 negative control Japanese black (JB) calves. Three bovine viral diarrhea virus (BVDV) persistently infected Holstein calves were examined as positive control; all 3 calves had BVDV in situ hybridization (ISH)-positive signals in NALT follicular macrophages and lymphocytes, suggesting viral replication in these cells. NALT and lungs of pneumonic JB calves had weak-positive BVDV results in PCR and negative results in ISH, indicating late-stage transient BVDV infection. The finding of BVDV in unvaccinated pneumonic JB calves confirmed the involvement of a BVDV field strain. PCR detection of bovine coronavirus (BCoV) and bovine respiratory syncytial virus (BRSV) in NALT along with ISH BCoV-positive signals in NALT epithelial cells confirms infection by those viruses. Pneumonic JB calves had nasopharyngitis and pneumonia, with the same bacteria present in nasopharyngeal swabs and lungs, indicating that, in these animals, the bacteria proliferating in the nasopharynx probably migrated to the lungs via inhalation. BVDV transient infection in the NALT may induce local immunosuppression; BCoV and BRSV infections are thought to damage epithelial cells, facilitating bacterial infection of the NALT and lungs. Our results confirm that bovine NALT is a location for viral replication and may be associated with BRDC development in cattle.
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Malignant myoepithelioma of the sublingual salivary gland in a Japanese Black cow Reviewed
FUKE Naoyuki, KAWAGUCHI Njiho, HEGAZY Asmaa A, AHMED Amaal Ezzat, SATO Reiichiro, HIRAI Takuya, YAMAGUCHI Ryoji
Journal of Veterinary Medical Science 87 ( 6 ) 594 - 599 2025
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
A six years and four months old Japanese Black cow presented with a solid mass in the left and middle mandible. Treatment involved the administration of antibiotics and the mass was surgically removed. Recurrence of the mass was observed, and the cow exhibited hypersalivation and anorexia before dying naturally. A necropsy revealed a solid subcutaneous mass infiltrating the oral cavity and the left mandibular bone, with hemorrhage and necrosis. Histopathological examination revealed clear, plasmocytic, spindle-shaped, or polygonal neoplastic cells. The neoplastic cells were immunoreactive with cytokeratin, cytokeratin 5, vimentin, smooth muscle actin, and p63. Considering these findings, the mass was diagnosed as malignant myoepithelioma. This is the first report of malignant myoepithelioma arising from the salivary glands in a cow.
DOI： 10.1292/jvms.24-0435
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AHMED Amaal Ezzat, NAKAI Mutsumi, KAKIYA Miho, FUKE Naoyuki, HEGAZY Asmaa A, KONDO Hiroaki, HIRAI Takuya
Journal of Veterinary Medical Science advpub ( 0 ) 924 - 933 2025
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
<i>Mycoplasma bovis</i> (<i>M. bovis)</i> is an important bacterium in the bovine respiratory disease complex (BRDC), which causes significant economic losses. The nasopharyngeal and palatine tonsils are mucosal-associated lymphoid tissue components that are the initial barrier to respiratory pathogens. In the present study, we investigated 5 pneumonic Japanese black and 3 control calves (2 Japanese black and 1 Holstein). The localization of <i>M. bovis</i> in the nasopharyngeal, palatine tonsils, and lungs was examined using nested and multiplex polymerase chain reaction (PCR), histopathology, and <i>in situ</i> hybridization (ISH) techniques. Nested PCR revealed that all examined tissues from all pneumonic calves were positive for <i>M. bovis</i> infection, but not the control. Histopathology revealed suppurative nasopharyngeal tonsillitis and palatine tonsillar cryptitis in all cases. Surprisingly, prominent histologic changes were observed in the palatine tonsils but not in the nasopharyngeal tonsils. Necrotizing suppurative bronchopneumonia was observed in 4 pneumonic calves. In ISH analysis, positive hybridization signals adherent to and/or within the surface epithelium of nasopharyngeal tonsils and crypt epithelium of nasopharyngeal and palatine tonsils were observed. Additionally, these signals were seen in the palatine tonsillar cryptic detritus. In the lungs, ISH signals were observed in necrotic areas, the bronchial epithelium, and pulmonary inflammatory exudate. These findings suggest that the nasopharyngeal and palatine tonsils are the primary sites of <i>M. bovis</i> infection. Also, <i>M. bovis</i> can colonize the detritus in the crypts of the palatine tonsils of the pneumonic animals.
DOI： 10.1292/jvms.25-0188
Books 【 display / non-display 】
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牛枝肉の”シミ”発生率に影響する生体、飼育管理、およびと畜処理要因の検証
遠矢宏美、福家直幸、萩平敦朗（ Role： Joint author）
畜産技術 2024.10
Language：Japanese Book type：Report
Presentations 【 display / non-display 】
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ネコにおけるSFTSの病理学的特徴-宮崎県の野外感例を中心に- Invited
福家直幸
第168回日本獣医学会学術集会病理分科会 2025.9.4
Event date： 2025.9.3 - 2025.9.5
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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猫B型肝炎ウイルス（DCHBV）感染猫10例の肝病変に関する病理組織学的検討
銅坂悠、加藤七海、足立行庸、金子泰之、平井卓哉、齊藤暁、福家直幸
第13回日本獣医病理学専門家協会学術集会 2026.3.26
Event date： 2026.3.25 - 2026.3.27
Language：Japanese Presentation type：Poster presentation
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Histopathological analysis of 11 cats infected with severe fever with thrombocytopenia syndrome virus at the Miyazaki prefecture
Muhammad Haroon Khan, Naoyuki Fuke, Ren Takada, Yasuyuki Kaneko, Hirohisa Mekata, Tamaki Okabayashi, Takuya Hirai
第13回日本獣医病理学専門家協会学術集会 2026.3.26
Event date： 2026.3.25 - 2026.3.27
Language：English Presentation type：Poster presentation
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Severe Fever with Thrombocytopenia Syndrome: An Emerging Tick-borne Threat in Asia Invited
Naoyuki Fuke
International Veterinary Conference 2025 2025.11.25
Event date： 2025.11.24 - 2025.11.25
Language：English Presentation type：Oral presentation (invited, special)
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猫ヘパドナウイルス感染を伴う猫の胆管癌
銅坂 悠、加藤 七海、近藤 海斗、多賀 佳 、山本 宗伸、 Rissar Siringo Ringo、金子 泰之、平井 卓哉、齊藤 暁、福家 直幸
令和7年度獣医学術九州地区学会 日本小動物獣医学会 2025.10.26
Event date： 2025.10.26
Language：Japanese Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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フレッシャー・アワード
2025.10 九州地区獣医師会連合会 猫ヘパドナウイルス感染を伴う猫の胆管癌
銅坂悠、加藤七海、近藤海斗、多賀佳、山本宗伸、Rissar Siringo Ringo、金子泰之、平井卓哉、齊藤暁、福家直幸
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2024.3 日本獣医病理学専門家協会 宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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奨励賞
2025.10 九州地区獣医師会連合会 肉用雄子牛の免疫学的去勢法の検討
西岡快人、三樹孝太郎、福家直幸、大澤健司、北原豪
Award type：Award from Japanese society, conference, symposium, etc.
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九州地区獣医師会連合会長賞
2024.9 九州地区獣医師会連合会 豚呼吸器複合病における扁桃と鼻咽頭関連リンパ組織病変の比較検討
齋藤江連、垣屋美穂、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2024.3 日本獣医病理学専門家協会 PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.