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Affiliation |
Faculty of Agriculture Region of Veterinary Science |
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Title |
Assistant Professor |
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Related SDGs |
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FUKE Naoyuki
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Degree 【 display / non-display 】
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Ph.D（Veterinary Medicine） ( 2020.4 University of Miyazaki )
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Veterinary Medicine ( 2016.3 University of Miyazaki )
Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Papers 【 display / non-display 】
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KAWAGUCHI Nijiho, FUKE Naoyuki, NUEANGPHUET Phawut, PORNTHUMMAWAT Apisit, NIAZI Ahmad Massoud, IZZATI Uda Zahli, HIRAI Takuya, YAMAGUCHI Ryoji
Journal of Veterinary Medical Science 86 ( 1 ) 49 - 53 2024.1
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
After an Egyptian fruit bat (<i>Rousettus aegyptiacus</i>) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.
DOI： 10.1292/jvms.23-0152
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Detection of bovine respiratory disease complex-related pathogens in nasopharynx-associated lymphoid tissue. Reviewed International journal
Asmaa A Hegazy, Mutsumi Nakai, Naoyuki Fuke, Amaal E Hussein, Hiroaki Kondo, Takuya Hirai
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 37 ( 2 ) 10406387251318415 - 297 2025.2
Language：English Publishing type：Research paper (scientific journal)
Bovine respiratory disease complex (BRDC) is a multi-etiologic disease that significantly impacts the cattle industry. Nasopharynx-associated lymphoid tissue (NALT) is the nasal mucosal immune system that protects against various pathogens; however, reports on its pathology are limited. We compared the pathologic impact of BRDC-related viruses on the NALT and lungs of 10 pneumonic and 3 negative control Japanese black (JB) calves. Three bovine viral diarrhea virus (BVDV) persistently infected Holstein calves were examined as positive control; all 3 calves had BVDV in situ hybridization (ISH)-positive signals in NALT follicular macrophages and lymphocytes, suggesting viral replication in these cells. NALT and lungs of pneumonic JB calves had weak-positive BVDV results in PCR and negative results in ISH, indicating late-stage transient BVDV infection. The finding of BVDV in unvaccinated pneumonic JB calves confirmed the involvement of a BVDV field strain. PCR detection of bovine coronavirus (BCoV) and bovine respiratory syncytial virus (BRSV) in NALT along with ISH BCoV-positive signals in NALT epithelial cells confirms infection by those viruses. Pneumonic JB calves had nasopharyngitis and pneumonia, with the same bacteria present in nasopharyngeal swabs and lungs, indicating that, in these animals, the bacteria proliferating in the nasopharynx probably migrated to the lungs via inhalation. BVDV transient infection in the NALT may induce local immunosuppression; BCoV and BRSV infections are thought to damage epithelial cells, facilitating bacterial infection of the NALT and lungs. Our results confirm that bovine NALT is a location for viral replication and may be associated with BRDC development in cattle.
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Malignant myoepithelioma of the sublingual salivary gland in a Japanese Black cow Reviewed
FUKE Naoyuki, KAWAGUCHI Njiho, HEGAZY Asmaa A, AHMED Amaal Ezzat, SATO Reiichiro, HIRAI Takuya, YAMAGUCHI Ryoji
Journal of Veterinary Medical Science 87 ( 6 ) 594 - 599 2025
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
A six years and four months old Japanese Black cow presented with a solid mass in the left and middle mandible. Treatment involved the administration of antibiotics and the mass was surgically removed. Recurrence of the mass was observed, and the cow exhibited hypersalivation and anorexia before dying naturally. A necropsy revealed a solid subcutaneous mass infiltrating the oral cavity and the left mandibular bone, with hemorrhage and necrosis. Histopathological examination revealed clear, plasmocytic, spindle-shaped, or polygonal neoplastic cells. The neoplastic cells were immunoreactive with cytokeratin, cytokeratin 5, vimentin, smooth muscle actin, and p63. Considering these findings, the mass was diagnosed as malignant myoepithelioma. This is the first report of malignant myoepithelioma arising from the salivary glands in a cow.
DOI： 10.1292/jvms.24-0435
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Histopathology of nasopharyngeal and palatine tonsils in Japanese black calves naturally infected with <i>Mycoplasma bovis</i> Reviewed
AHMED Amaal Ezzat, NAKAI Mutsumi, KAKIYA Miho, FUKE Naoyuki, HEGAZY Asmaa A, KONDO Hiroaki, HIRAI Takuya
Journal of Veterinary Medical Science advpub ( 0 ) 2025
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
DOI： 10.1292/jvms.25-0188
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HEGAZY Asmaa A., FUKE Naoyuki, NAKAI Mutsumi, KAKIYA Miho, KONDO Hiroaki, HIRAI Takuya
Journal of Veterinary Medical Science 87 ( 7 ) 735 - 740 2025
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
A 4-month-old Japanese black calf exhibited anorexia and respiratory distress. Necropsy revealed a spongiform appearance of the rumen wall and histologically diagnosed as emphysematous rumenitis. The ruminal mucosa exhibited characteristic lesions of chemical rumenitis, so ruminal acidosis is suspected. Gram-positive bacilli were discernible on the degenerated ruminal mucosal surface and reacted with <i>Clostridium</i> species antibodies. Anaerobic cultures yielded <i>Clostridium perfringens</i> (<i>C. perfringens</i>), identified by multiplex polymerase chain reaction (PCR) as <i>C. perfringens</i> type A. The lumen and submucosa of the rumen showed a large ciliated trophozoite confirmed by PCR as <i>Balantidium coli</i> (<i>B. coli</i>). These findings suggest that ruminal acidosis leads to dysbiosis and allows <i>C. perfringens</i> type A to grow, causing emphysematous rumenitis and facilitating secondary <i>B. coli</i> infection.
DOI： 10.1292/jvms.24-0403
Books 【 display / non-display 】
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牛枝肉の”シミ”発生率に影響する生体、飼育管理、およびと畜処理要因の検証
遠矢宏美、福家直幸、萩平敦朗（ Role： Joint author）
畜産技術 2024.10
Language：Japanese Book type：Report
Presentations 【 display / non-display 】
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爪床と口唇に発生した悪性上皮系腫瘍から型の異なるパピローマウイルスが検出された猫の１例
安部陽、福家直幸、島袋泰治、田邊美加、平井卓哉、齊藤暁
令和6年度獣医学術九州地区学会 日本小動物獣医学会 2024.11.1
Event date： 2024.11.1
Language：Japanese Presentation type：Oral presentation (general)
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重症熱性血小板減少症候群を発症した猫の病理学的解析およびin situ hybridizaiton法の確立
高田蓮栞、福家直幸、岡林環樹、目堅博久、平井卓哉
令和6年度獣医学術九州地区学会 日本獣医公衆衛生学会 2024.11.1
Event date： 2024.11.1
Language：Japanese Presentation type：Oral presentation (general)
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重症熱性血小板減少症候群から回復した妊娠猫とその胎児の事例
福家直幸、金子泰之、高田蓮栞、岡林環樹、平井卓哉
令和6年度獣医学術九州地区学会 日本獣医公衆衛生学会 2024.11.1
Event date： 2024.11.1
Language：Japanese Presentation type：Oral presentation (general)
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宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
第11回日本獣医病理学専門家協会学術集会 2024.3.29
Event date： 2024.3.28 - 2024.3.29
Language：Japanese Presentation type：Poster presentation
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猫の脾臓
福家直幸
第65回獣医病理学研修会 2025.3.27
Event date： 2025.3.27 - 2025.3.28
Language：English Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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優秀ポスター賞
2024.3 日本獣医病理学専門家協会 宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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九州地区獣医師会連合会長賞
2024.9 九州地区獣医師会連合会 豚呼吸器複合病における扁桃と鼻咽頭関連リンパ組織病変の比較検討
齋藤江連、垣屋美穂、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2024.3 日本獣医病理学専門家協会 PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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九州地区獣医師会連合会長賞
2023.9 九州地区獣医師会連合会 Mycoplasma hyopneumoniaeおよび豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭病変の解析
齋藤江連、山下鉄平、上久保正一、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.