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Affiliation |
Faculty of Agriculture Department of Veterinary Science |
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Title |
Assistant Professor |
FUKE Naoyuki
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Degree 【 display / non-display 】
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Ph.D（Veterinary Medicine） ( 2020.4 University of Miyazaki )
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Veterinary Medicine ( 2016.3 University of Miyazaki )
Papers 【 display / non-display 】
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KAWAGUCHI Nijiho, FUKE Naoyuki, NUEANGPHUET Phawut, PORNTHUMMAWAT Apisit, NIAZI Ahmad Massoud, IZZATI Uda Zahli, HIRAI Takuya, YAMAGUCHI Ryoji
Journal of Veterinary Medical Science 86 ( 1 ) 49 - 53 2024.1
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
After an Egyptian fruit bat (<i>Rousettus aegyptiacus</i>) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.
DOI： 10.1292/jvms.23-0152
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Investigation of preinguinal approach for removal of urachal abscess in three Japanese black cattle older than 18 months of age Reviewed
SATO Reiichiro, HAYASHI Jun, FUKE Naoyuki, SAITO Eren, HIDAKA Kanako, SAKA Hideki, SATOH Hiroyuki, STEINER Adrian
Journal of Veterinary Medical Science advpub ( 0 ) 2024
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
DOI： 10.1292/jvms.24-0011
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Surgical management of a dermoid cyst with mandibular gland tissue in a Japanese Black calf Reviewed
SATO Reiichiro, SONODA Misaki, MATSUO Ringo, TAKADA Ren, KANDA Isamu, SATOH Hiroyuki, FUKE Naoyuki, YAMADA Kazutaka, HIRAI Takuya
Journal of Veterinary Medical Science 85 ( 10 ) 1110 - 1115 2023
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
A 131-day-old male Japanese Black calf presented with a swollen right cheek from birth. Imaging examination revealed a cyst under the right buccal area and debris-containing fluid inside the cyst, and puncture aspiration revealed a mildly cloudy fluid containing hair and tissue fragments. Histological examination of the excised cyst revealed stratified squamous epithelium with skin appendages in the cyst wall, which was diagnosed as a dermoid cyst. In addition, some submandibular gland tissue was found within the cyst wall. After removal of the cyst, there was swelling in the same area, which resolved with steroid administration. Surgical treatment of buccal dermoid cysts should be performed with caution to avoid damage to adjacent salivary gland tissue.
DOI： 10.1292/jvms.23-0248
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Niazi A.M., ZiHeng Z., Fuke N., Toyama K., Habibi W.A., Kawaguchi N., Yamaguchi R., Hirai T.
Journal of Comparative Pathology 197 23 - 34 2022.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Comparative Pathology
Porcine respiratory disease complex, which is caused by a combination of pathogens, including swine influenza A virus (SIV) and porcine reproductive respiratory syndrome virus (PRRSV), results in significant economic losses in pig production systems. Nasopharynx-associated lymphoid tissue (NALT) plays an important role in the uptake of pathogens and defence of the nasal mucosa in rodents and humans. We characterized NALT M cells in pigs and detected SIV antigen and PRRSV nucleic acid in NALT using histopathological, immunohistochemical and in-situ hybridization analyses. All SIV- and PRRSV-positive cases examined had suppurative nasopharyngitis and pneumonia. M cells were detected by immunohistochemistry and the distribution of M cells showed an increase in the middle section of NALT. SIV antigen was detected in M cells and PRRSV nucleic acid was demonstrated in the cytoplasm of macrophages in NALT. We believe that SIV and PRRSV infection in the upper respiratory tract induces local immunosuppression and these results confirm that swine NALT is a location for virus replication and may be strongly associated with the development of pneumonia in pigs.
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Suwanruengsri M., Uemura R., Izzati U.Z., Kanda T., Fuke N., Yasuda M., Hirai T., Yamaguchi R.
Thai Journal of Veterinary Medicine 52 ( 1 ) 33 - 44 2022.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Thai Journal of Veterinary Medicine
Mycoplasma bovis (M. bovis) is a pathogen that especially effects the respiratory system of cattle. We focused on the histopathological changes in the lungs caused by M. bovis because the lesions in the bronchi or bronchioles and alveoli are quite different in natural infections. Thirty-five lung samples from 2-to 12-month-old Japanese Black calves with respiratory symptoms were collected and examined for bacteria presence and pathological changes using immunohistochemistry (IHC). Using the loop-mediated isothermal amplification method, 18 of the 35 samples were found to be positive for M. bovis, which was isolated and identified. In 7 of the samples, only M. bovis was detected, whereas in the other 11, other bacteria coexisted with M. bovis. Anti-M. bovis, anti-MAC387, anti-Iba1, anti-CD3, anti-CD20, anti-AE1/AE3 cytokeratin and anti-IL8 were used for antigen detection. Histopathological studies and diagnoses of the lungs were examined in two parts; bronchiolar lesions and alveolar lesions. The bronchiolar findings were divided into three groups: granulomatous, caseonecrotic and suppurative bronchiolitis. The alveolar lesions found were quite mild, except in three cases. IHC staining revealed strong evidence of M. bovis in degenerated neutrophils, which was confirmed by electron microscopy. The main inflammatory cell response to M. bovis infections was degenerate neutrophils, which caused the destruction of the bronchial epithelium and possibly induced epithelioid granulomatous inflammation, resulting in severe chronic respiratory diseases in cattle.
DOI： 10.14456/tjvm.2022.4
Presentations 【 display / non-display 】
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牛の精巣
福家直幸
第64回獣医病理学研修会 2024.3.28
Event date： 2024.3.28 - 2024.3.29
Language：English Presentation type：Oral presentation (general)
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PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
第11回日本獣医病理学専門家協会学術集会 2024.3.29
Event date： 2024.3.28 - 2024.3.29
Language：Japanese Presentation type：Poster presentation
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宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
第11回日本獣医病理学専門家協会学術集会 2024.3.29
Event date： 2024.3.28 - 2024.3.29
Language：Japanese Presentation type：Poster presentation
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Mycoplasma hyopneumoniaeおよび豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭病変の解析
齋藤江連、山下鉄平、上久保正一、坂本英午、福家直幸、平井卓哉
令和5年度獣医学術九州地区学会 日本産業動物獣医学会 2023.9.10
Event date： 2023.9.10
Language：Japanese Presentation type：Oral presentation (general)
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御岬馬でみられた心臓病変とその原因に関する病理学的検討
齋藤江連、山下鉄平、中井睦、高田蓮栞、安部陽、垣屋美穂、Asmaa Answer Hegazy, Amaal Ezzat Hussein Ahmed, 小林郁雄、福家直幸、平井卓哉
第166回日本獣医学術集会病理学分科会 2023.9.5
Event date： 2023.9.5 - 2023.9.8
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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優秀ポスター賞
2024.3 日本獣医病理学専門家協会 宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2024.3 日本獣医病理学専門家協会 PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.
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九州地区獣医師会連合会長賞
2023.9 九州地区獣医師会連合会 Mycoplasma hyopneumoniaeおよび豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭病変の解析
齋藤江連、山下鉄平、上久保正一、坂本英午、福家直幸、平井卓哉
Award type：Award from Japanese society, conference, symposium, etc.