FUKE Naoyuki

写真a

Affiliation

Faculty of Agriculture Department of Veterinary Science

Title

Assistant Professor

Degree 【 display / non-display

  • Ph.D(Veterinary Medicine) ( 2020.4   University of Miyazaki )

  • Veterinary Medicine ( 2016.3   University of Miyazaki )

 

Papers 【 display / non-display

  • Hepatocellular carcinoma with lung metastasis showing hemochromatosis in an Egyptian fruit bat (<i>Rousettus aegyptiacus</i>)

    KAWAGUCHI Nijiho, FUKE Naoyuki, NUEANGPHUET Phawut, PORNTHUMMAWAT Apisit, NIAZI Ahmad Massoud, IZZATI Uda Zahli, HIRAI Takuya, YAMAGUCHI Ryoji

    Journal of Veterinary Medical Science   86 ( 1 )   49 - 53   2024

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPANESE SOCIETY OF VETERINARY SCIENCE  

    After an Egyptian fruit bat (<i>Rousettus aegyptiacus</i>) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.

    DOI: 10.1292/jvms.23-0152

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    CiNii Research

  • Surgical management of a dermoid cyst with mandibular gland tissue in a Japanese Black calf

    SATO Reiichiro, SONODA Misaki, MATSUO Ringo, TAKADA Ren, KANDA Isamu, SATOH Hiroyuki, FUKE Naoyuki, YAMADA Kazutaka, HIRAI Takuya

    Journal of Veterinary Medical Science   85 ( 10 )   1110 - 1115   2023

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPANESE SOCIETY OF VETERINARY SCIENCE  

    A 131-day-old male Japanese Black calf presented with a swollen right cheek from birth. Imaging examination revealed a cyst under the right buccal area and debris-containing fluid inside the cyst, and puncture aspiration revealed a mildly cloudy fluid containing hair and tissue fragments. Histological examination of the excised cyst revealed stratified squamous epithelium with skin appendages in the cyst wall, which was diagnosed as a dermoid cyst. In addition, some submandibular gland tissue was found within the cyst wall. After removal of the cyst, there was swelling in the same area, which resolved with steroid administration. Surgical treatment of buccal dermoid cysts should be performed with caution to avoid damage to adjacent salivary gland tissue.

    DOI: 10.1292/jvms.23-0248

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    CiNii Research

  • Detection of Swine Influenza A and Porcine Reproductive and Respiratory Syndrome Viruses in Nasopharynx-Associated Lymphoid Tissue

    Niazi A.M., ZiHeng Z., Fuke N., Toyama K., Habibi W.A., Kawaguchi N., Yamaguchi R., Hirai T.

    Journal of Comparative Pathology   197   23 - 34   2022.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Comparative Pathology  

    Porcine respiratory disease complex, which is caused by a combination of pathogens, including swine influenza A virus (SIV) and porcine reproductive respiratory syndrome virus (PRRSV), results in significant economic losses in pig production systems. Nasopharynx-associated lymphoid tissue (NALT) plays an important role in the uptake of pathogens and defence of the nasal mucosa in rodents and humans. We characterized NALT M cells in pigs and detected SIV antigen and PRRSV nucleic acid in NALT using histopathological, immunohistochemical and in-situ hybridization analyses. All SIV- and PRRSV-positive cases examined had suppurative nasopharyngitis and pneumonia. M cells were detected by immunohistochemistry and the distribution of M cells showed an increase in the middle section of NALT. SIV antigen was detected in M cells and PRRSV nucleic acid was demonstrated in the cytoplasm of macrophages in NALT. We believe that SIV and PRRSV infection in the upper respiratory tract induces local immunosuppression and these results confirm that swine NALT is a location for virus replication and may be strongly associated with the development of pneumonia in pigs.

    DOI: 10.1016/j.jcpa.2022.06.006

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  • Natural Mycoplasma bovis infection associated with epithelioid granulomatous caseonecrotic bronchiolitis at a progressed disease stage in calves

    Suwanruengsri M., Uemura R., Izzati U.Z., Kanda T., Fuke N., Yasuda M., Hirai T., Yamaguchi R.

    Thai Journal of Veterinary Medicine   52 ( 1 )   33 - 44   2022.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Thai Journal of Veterinary Medicine  

    Mycoplasma bovis (M. bovis) is a pathogen that especially effects the respiratory system of cattle. We focused on the histopathological changes in the lungs caused by M. bovis because the lesions in the bronchi or bronchioles and alveoli are quite different in natural infections. Thirty-five lung samples from 2-to 12-month-old Japanese Black calves with respiratory symptoms were collected and examined for bacteria presence and pathological changes using immunohistochemistry (IHC). Using the loop-mediated isothermal amplification method, 18 of the 35 samples were found to be positive for M. bovis, which was isolated and identified. In 7 of the samples, only M. bovis was detected, whereas in the other 11, other bacteria coexisted with M. bovis. Anti-M. bovis, anti-MAC387, anti-Iba1, anti-CD3, anti-CD20, anti-AE1/AE3 cytokeratin and anti-IL8 were used for antigen detection. Histopathological studies and diagnoses of the lungs were examined in two parts; bronchiolar lesions and alveolar lesions. The bronchiolar findings were divided into three groups: granulomatous, caseonecrotic and suppurative bronchiolitis. The alveolar lesions found were quite mild, except in three cases. IHC staining revealed strong evidence of M. bovis in degenerated neutrophils, which was confirmed by electron microscopy. The main inflammatory cell response to M. bovis infections was degenerate neutrophils, which caused the destruction of the bronchial epithelium and possibly induced epithelioid granulomatous inflammation, resulting in severe chronic respiratory diseases in cattle.

    DOI: 10.14456/tjvm.2022.4

    Scopus

  • Role of Mel1/Prdm16 in bone differentiation and morphology.

    Kaneda-Nakashima K, Igawa K, Suwanruengsri M, Naoyuki F, Ichikawa T, Funamoto T, Kurogi S, Sekimoto T, Yamashita Y, Chosa E, Yamaguchi R, Morishita K

    Experimental cell research   410 ( 2 )   112969   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.yexcr.2021.112969

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