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Kawaguchi N., Fuke N., Nueangphuet P., Pornthummawat A., Niazi A.M., Izzati U.Z., Hirai T., Yamaguchi R.
Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 86 ( 1 ) 49 - 53 2024年1月
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本獣医学会
After an Egyptian fruit bat (Rousettus aegyptiacus) in a zoo became emaciated and died, a necropsy revealed multiple nodules on the liver and lung surfaces. Microscopy revealed that the liver nodules consisted of neoplastic hepatocytes and showed metastasis in the lung lobes. Most of the neoplastic cells in the liver and lung showed positive labeling for HepPar-1, cytokeratin 19, glypican-3, and Ki-67. Hepatocellular degeneration and necrosis were diffuse in the liver parenchyma. Berlin blue staining revealed large amounts of iron in normal and neoplastic cells. Based on these pieces of evidence, this case was diagnosed as hepatocellular carcinoma with hemochromatosis. This is believed to be the first report of hepatocellular carcinoma in an Egyptian fruit bat that has been immunophenotypically examined in detail by pathological examination.
DOI： 10.1292/jvms.23-0152
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Hegazy AA, Nakai M, Fuke N, Hussein AE, Kondo H, Hirai T
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 37 ( 2 ) 10406387251318415 - 297 2025年2月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Bovine respiratory disease complex (BRDC) is a multi-etiologic disease that significantly impacts the cattle industry. Nasopharynx-associated lymphoid tissue (NALT) is the nasal mucosal immune system that protects against various pathogens; however, reports on its pathology are limited. We compared the pathologic impact of BRDC-related viruses on the NALT and lungs of 10 pneumonic and 3 negative control Japanese black (JB) calves. Three bovine viral diarrhea virus (BVDV) persistently infected Holstein calves were examined as positive control; all 3 calves had BVDV in situ hybridization (ISH)-positive signals in NALT follicular macrophages and lymphocytes, suggesting viral replication in these cells. NALT and lungs of pneumonic JB calves had weak-positive BVDV results in PCR and negative results in ISH, indicating late-stage transient BVDV infection. The finding of BVDV in unvaccinated pneumonic JB calves confirmed the involvement of a BVDV field strain. PCR detection of bovine coronavirus (BCoV) and bovine respiratory syncytial virus (BRSV) in NALT along with ISH BCoV-positive signals in NALT epithelial cells confirms infection by those viruses. Pneumonic JB calves had nasopharyngitis and pneumonia, with the same bacteria present in nasopharyngeal swabs and lungs, indicating that, in these animals, the bacteria proliferating in the nasopharynx probably migrated to the lungs via inhalation. BVDV transient infection in the NALT may induce local immunosuppression; BCoV and BRSV infections are thought to damage epithelial cells, facilitating bacterial infection of the NALT and lungs. Our results confirm that bovine NALT is a location for viral replication and may be associated with BRDC development in cattle.
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Jiarpinitnun P., Iwakiri A., Fuke N., Pongsawat P., Miyanishi C., Sasaki S., Taniguchi T., Matsui Y., Luangtongkum T., Yamada K., Misawa N.
Microorganisms 12 ( 12 ) 2024年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Microorganisms
Spotty liver disease (SLD) affects free-range laying hens, leading to mortality and reduced egg production. Campylobacter species, including Campylobacter hepaticus, have been associated with SLD cases worldwide. However, the cause of SLD-like lesions found in broilers in Japan still remains unclear. The present study aimed to investigate the involvement of Campylobacter spp. in broiler SLD by conducting microbiological, molecular biological, serological, histopathological, and immunohistopathological examinations using specimens of liver, bile, cecum, and serum from SLD-like and non-SLD chickens. C. jejuni was predominantly isolated and detected in approximately 40% of both non-SLD livers and SLD-like livers, with no significant difference between them. However, C. hepaticus was neither isolated nor detected in this study. Gross and histopathology revealed multifocal necrotizing hepatitis, suppurative granulomatous hepatitis, and cholangiohepatitis. Hepatitis stages are classified as no hepatitis, subclinical, acute, and chronic hepatitis. C. jejuni was more frequently present in acute-stage SLD-like livers, and high IgG antibody levels were noted in both subclinical and SLD-like-affected chickens, indicating C. jejuni infection. Immunohistochemical examination also supported these findings. The findings suggest that C. hepaticus was not involved in SLD-like in broilers in Japan, but C. jejuni translocation from the intestines to the liver may be a contributing factor.
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Sato R, Hayashi J, Fuke N, Saito E, Hidaka K, Saka H, Satoh H, Steiner A
Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ advpub ( 0 ) 512 - 517 2024年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本獣医学会
This study investigated the diagnostic and surgical management of urachal abscessation involving the urinary bladder in three cattle aged >18 months. While the abdominal floor or paralumbar fossa are typically considered for accessing the urachus and bladder in calves and heifers, the distance is too great to perform the procedure under direct vision in adult cows. Therefore, a novel preinguinal approach was used for access in cows with urachal abscesses after 18 months. Access was successfully achieved in all the three cows through a preinguinal incision to the urachal abscess at the apex of the bladder. However, in cases wherein the abscess and adhesions are severe, removal may be challenging or may necessitate a combined median or paramedian approach.
DOI： 10.1292/jvms.24-0011
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A case of urachal abscess resection via colpotomy in a cow. 査読あり
Sato R, Sato Y, Fuke N, Uemura R, Steiner A
Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ advpub ( 0 ) 1156 - 1161 2024年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本獣医学会
This study describes a novel surgical method to remove urinary bladder-related urachal abscesses in a cow. Traditional methods, such as the midline or paramedian approach in calves and the preinguinal approach, can be challenging in adult cattle, especially for lesions situated near the pelvic cavity. In this case, a 4-year-old cow had a urachal abscess attached to the bladder apex, making it difficult to approach via abdominal wall incision. Colpotomy and pulling the abscess through a vaginal wall incision allowed for complete exteriorization of the lesion and comfortable accessibility of the abscess and the resection site. This report suggests that colpotomy is an effective new route in adult cattle for accessing urachal abscesses not accessible via traditional surgical approaches.
DOI： 10.1292/jvms.24-0256
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牛枝肉の”シミ”発生率に影響する生体、飼育管理、およびと畜処理要因の検証
遠矢宏美、福家直幸、萩平敦朗（ 担当： 共著）
畜産技術 2024年10月
記述言語：日本語 著書種別：調査報告書
講演・口頭発表等 【 表示 ／ 非表示 】
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爪床と口唇に発生した悪性上皮系腫瘍から型の異なるパピローマウイルスが検出された猫の１例
安部陽、福家直幸、島袋泰治、田邊美加、平井卓哉、齊藤暁
令和6年度獣医学術九州地区学会 日本小動物獣医学会 2024年11月1日
開催年月日： 2024年11月1日
記述言語：日本語 会議種別：口頭発表（一般）
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重症熱性血小板減少症候群を発症した猫の病理学的解析およびin situ hybridizaiton法の確立
高田蓮栞、福家直幸、岡林環樹、目堅博久、平井卓哉
令和6年度獣医学術九州地区学会 日本獣医公衆衛生学会 2024年11月1日
開催年月日： 2024年11月1日
記述言語：日本語 会議種別：口頭発表（一般）
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重症熱性血小板減少症候群から回復した妊娠猫とその胎児の事例
福家直幸、金子泰之、高田蓮栞、岡林環樹、平井卓哉
令和6年度獣医学術九州地区学会 日本獣医公衆衛生学会 2024年11月1日
開催年月日： 2024年11月1日
記述言語：日本語 会議種別：口頭発表（一般）
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宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
第11回日本獣医病理学専門家協会学術集会 2024年3月29日
開催年月日： 2024年3月28日 - 2024年3月29日
記述言語：日本語 会議種別：ポスター発表
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猫の脾臓
福家直幸
第65回獣医病理学研修会 2025年3月27日
開催年月日： 2025年3月27日 - 2025年3月28日
記述言語：英語 会議種別：口頭発表（一般）
受賞 【 表示 ／ 非表示 】
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優秀ポスター賞
2024年3月 日本獣医病理学専門家協会 宮崎県内で重症熱性血小板減少症を発症した自然感染猫８例における病理学的検索
高田蓮栞、福家直幸、岡林環樹、Mazimpaka Eugene、平井卓哉
受賞区分：国内学会・会議・シンポジウム等の賞
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九州地区獣医師会連合会長賞
2024年9月 九州地区獣医師会連合会 豚呼吸器複合病における扁桃と鼻咽頭関連リンパ組織病変の比較検討
齋藤江連、垣屋美穂、坂本英午、福家直幸、平井卓哉
受賞区分：国内学会・会議・シンポジウム等の賞
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優秀ポスター賞
2024年3月 日本獣医病理学専門家協会 PCV2不顕性感染豚の鼻咽頭関連リンパ組織におけるISH法によるPCV2およびPRRSVの検出
齋藤江連、山下鉄平、坂本英午、福家直幸、平井卓哉
受賞区分：国内学会・会議・シンポジウム等の賞
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九州地区獣医師会連合会長賞
2023年9月 九州地区獣医師会連合会 Mycoplasma hyopneumoniaeおよび豚繁殖・呼吸障害症候群ウイルス感染豚における鼻咽頭病変の解析
齋藤江連、山下鉄平、上久保正一、坂本英午、福家直幸、平井卓哉
受賞区分：国内学会・会議・シンポジウム等の賞
その他競争的資金獲得実績 【 表示 ／ 非表示 】
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牛の呼吸器病原体が鼻咽頭関連リンパ組織および扁桃に与える影響と病態解明
研究課題/領域番号：研１６１ 2024年04月 - 2025年03月
民間財団等 公益財団法人伊藤記念財団 令和６年度公益財団法人伊藤記念財団助成
担当区分：研究代表者