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Affiliation |
Faculty of Medicine School of Medicine Department of Medicine of Sensory and Motor Organs, Orthopedic Surgery |
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Professor |
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Laboratory Address |
〒889-1692 宮崎県宮崎市清武町木原5200 |
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Laboratory Phone number |
+81-985-85-0986 |
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Laboratory Fax number |
+81-985-85-2931 |
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Contact information |
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Homepage |
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External Link |
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Related SDGs |
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KAMEI Naosuke
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Degree 【 display / non-display 】
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PhD ( 2006.3 Hiroshima University )
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MD ( 1997.3 Hiroshima University )
Research Interests 【 display / non-display 】
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Regenerative medicine
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Spine surgery
Education 【 display / non-display 】
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Hiroshima University
2002.4 - 2006.3
Country：Japan
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Hiroshima University
1991.4 - 1997.3
Country：Japan
Campus Career 【 display / non-display 】
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University of Miyazaki Faculty of Medicine School of Medicine Department of Medicine of Sensory and Motor Organs, Orthopedic Surgery Professor
2024.10 - Now
External Career 【 display / non-display 】
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Hiroshima University Associate Professor
2020.4 - 2024.9
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Hiroshima University Associate Professor
2019.4 - 2020.3
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Hiroshima University Lecturer
2015.4 - 2019.3
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Hiroshima University Assistant Professor
2009.4 - 2015.3
Professional Memberships 【 display / non-display 】
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2025.1
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西日本整形・災害外科学会
2024.10
Papers 【 display / non-display 】
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Approximately two-thirds of adolescent male soccer players had increased lateral ankle laxity with functional ankle impairments Reviewed International coauthorship International journal
Yokoe T., Kawaguchi T., Kubo A., Kamei N., Teramoto A., Takao M., Pereira H.
Knee Surgery Sports Traumatology Arthroscopy 34 ( 1 ) 320 - 328 2026.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Knee Surgery Sports Traumatology Arthroscopy
Purpose: The primary purpose of this study was to evaluate the prevalence of increased lateral ankle laxity (ILAL) in adolescent male soccer players. The secondary purpose was to investigate functional ankle impairments and muscle strengths related to chronic lateral ankle instability (CLAI). Methods: The anterior talofibular ligament (ATFL) lengths of adolescent male soccer players were measured in the stress and non-stress positions using ultrasonography. The ATFL ratio, the ratio of stress ATFL length to non-stress ATFL length, was calculated as an indicator of lateral ankle laxity. The Cumberland Ankle Instability Tool (CAIT), Ankle Instability Instrument (AII) and static balance tests were used to assess functional ankle impairments related to CLAI. Isometric hip abduction and ankle eversion muscle strengths, and ankle dorsiflexion angle were also evaluated. Results: One hundred twenty ankles from 60 male soccer players (mean age, 16.4 ± 0.7 years; mean duration of playing soccer, 9.8 ± 2.4 years) were included. ILAL was detected in 63.3% (38/60) of soccer players; 28 with ipsilateral ILAL (group I) and 10 with bilateral ILAL (group Bi). Seventeen participants (28.3%; 10 from group I, 3 from group Bi, and 4 from those without ILAL) showed a CAIT score of ≤24, and 5 (8.3%; 4 from group I and 1 from group Bi) showed an AII score of ≥5. The eversion muscle strength of the ankle with ILAL was significantly weaker than the contralateral side in group I (p = 0.006). Conclusion: ILAL was detected in approximately two-thirds of adolescent male soccer players with relatively low CAIT and AII scores. In addition, the eversion muscle strength of the ankle with ILAL was significantly weaker than that of the contralateral side in subjects with ipsilateral ILAL. These findings suggest the possible importance of preventive interventions for soccer players with ILAL. Level of Evidence: Level III.
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Early surgery within 48 h for post-injury hip fractures improved clinical outcomes Reviewed International journal
Kita T., Funamoto T., Mori H., Ikejiri H., Tajima T., Chosa E., Kamei N.
Journal of Orthopaedic Science 31 ( 1 ) 219 - 225 2026.1
Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science
Background: A medical fee incentive based on a 48-h target time for hip fracture surgery has been implemented in Japan since 2022. This study aimed to evaluate the clinical outcomes of early surgery within 48 h after hip fracture. Methods: This study was a retrospective, single-center study. Patients >60 years of age who underwent hip fracture surgery between 2021 and 2022 were eligible. They were divided into 2 groups: 2021 (before implementation of the system) and 2022 (after implementation of the system). The primary outcome was the surgical waiting time after injury. The secondary outcomes were clinical outcomes such as postoperative complication rate, mortality rate at 1 and 6 months after surgery, and length of stay in our institution. To assess the influence of early surgery on these outcomes, an additional analysis was performed in 2 groups: the early group (surgery within 48 h) and the delayed group (surgery beyond 48 h). Results: In total, 365 patients were included in this study. The surgical waiting time was significantly shortened after the implementation of the system (64.5 h in 2021 vs. 42.8 h in 2022, p < 0.001). There were significant differences between the 2021 and 2022 groups in the complication rate (17 % vs. 9 %, p = 0.03) and length of hospital stay (15 days vs. 13 days, p < 0.001). A multivariate analysis between the early and delayed group showed that early surgery was associated with a lower complication rate and shorter length of stay (p < 0.05). Conclusion: Efforts to perform early surgery within 48 h of injury following the new reimbursement scheme have contributed to improved clinical outcomes, including lower complication rates and shorter hospital stay in our institution.
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Unstable Lumbar Vertebral Body Fracture During Total Hip Arthroplasty Using the Anterolateral Spine Approach in Diffuse Idiopathic Skeletal Hyperostosis: A Case Report and Literature Review Reviewed International journal
Ueki S., Shoji T., Kamei N., Kaneta H., Morita H., Kozuma Y., Nakayama N., Adachi N.
Arthroplasty Today 35 101874 2025.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Arthroplasty Today
This case report describes a 72-year-old man with diffuse idiopathic skeletal hyperostosis who sustained a rare unstable lumbar vertebral body fracture during total hip arthroplasty (THA) using the anterolateral supine approach. Despite a successful THA, the patient developed severe postoperative back pain, leading to the diagnosis of a lumbar vertebral fracture. Prompt posterior spinal fusion effectively relieved the pain. This report emphasizes recognizing high-risk patients, such as those with diffuse idiopathic skeletal hyperostosis complicated by obesity or kyphosis, before THA, and underscores the need for careful perioperative management and intraoperative positioning to reduce stress on the lumbar spine.
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Effects of branched-chain amino acid- and vitamin D-containing high-protein food supplementation plus exercise on elderly people with decreased physical functions Reviewed International journal
Nakamura Y, Yokoe T*, Ouchi K, Funamoto T, Kimura H, Hamada K, Arakawa H, Chosa E, Kamei N
BMC Geriatrics 25 ( 1 ) 500 2025.7
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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ChatGPT-4 Responses on Ankle Cartilage Surgery Often Diverge from Expert Consensus: A Comparative Analysis Reviewed International coauthorship International journal
Yokoe T., Roversi G., Sevivas N., Kamei N., Diniz P., Pereira H.
Foot and Ankle Orthopaedics 10 ( 3 ) 24730114251352494 2025.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Foot and Ankle Orthopaedics
Background: There are few studies that have evaluated whether large language models, such as ChatGPT, can provide accurate guidance to clinicians in the field of foot and ankle surgery. This study aimed to assess the accuracy of ChatGPT's responses regarding ankle cartilage repair by comparing them with the consensus statements from foot and ankle experts as a standard reference. Methods: The open artificial intelligence (AI) model ChatGPT-4 was asked to answer a total of 14 questions on debridement, curettage, and bone marrow stimulation for ankle cartilage lesions that were selected at the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. The ChatGPT responses were compared with the consensus statements developed in this international meeting. A Likert scale (scores, 1-5) was used to evaluate the similarity of the answers by ChatGPT to the consensus statements. The 4 scoring categories (Accuracy, Overconclusiveness, Supplementary, and Incompleteness) were also used to evaluate the quality of ChatGPT answers, according to previous studies. Results: The mean Likert scale score regarding the similarity of ChatGPT’s answers to the consensus statements was 3.1 ± 0.8. Regarding the results of 4 scoring categories of the ChatGPT answers, the percentages of answers that were considered “yes” in the Accuracy, Overconclusiveness, Supplementary, and Incompleteness were 71.4% (10/14), 35.7% (5/14), 78.6% (11/14), and 14.3% (2/14), respectively. Conclusion: This study showed that ChatGPT-4 often provides responses that diverge from expert consensus regarding surgical treatment of ankle cartilage lesions. Level of Evidence: Level V, expert opinion.
Books 【 display / non-display 】
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関節・軟骨の再生医療
亀井直輔，越智光夫，安達伸生（ Role： Joint author , 自家培養軟骨移植による軟骨再生と磁気ターゲティングによる治療）
シーエムシー出版 2019.12
Responsible for pages：106-114 Language：Japanese Book type：Scholarly book
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再生医療用語ハンドブック
亀井直輔，越智光夫（ Role： Joint author , 冒頭概説 軟骨）
メディカルトリビューン 2015.3
Language：Japanese Book type：Dictionary, encyclopedia
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先進医療NAVIGATORⅡ
亀井直輔，越智光夫（ Role： Joint author , 整形外科と再生医療 -骨・軟骨-）
日本医学出版 2014.3
Language：Japanese Book type：Scholarly book
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Neuroprotection and Regeneration of the Spinal Cord
Naosuke Kamei（ Role： Joint author , Vascular regeneration therapies for spinal cord injury）
Springer 2014.3
Language：English Book type：Scholarly book
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幹細胞研究と再生医療
亀井直輔，越智光夫（ Role： Joint author , 骨・軟骨の再生）
南山堂 2013.12
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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細胞を用いた再生医療の現状と今後の展望 臨床への展開(Vol.8) 間葉系幹細胞の磁気ターゲティングによる関節軟骨再生治療の開発 Invited
亀井直輔，安達伸生，越智光夫
292 ( 4 ) 326 - 330 2025.1
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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整形トピックス 細胞磁気ターゲティングの医師主導治験 Invited
亀井 直輔
整形外科 74 ( 9 ) 990 - 990 2023.8
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：南江堂
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【頸椎疾患・症候群対応マニュアル】Arnold-Chiari奇形の病態と治療 Invited
亀井直輔
Monthly Book Orthopaedics 35 ( 7 ) 51 - 57 2022.7
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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特集 間葉系幹細胞治療の現状と課題 骨髄間葉系幹細胞を用いた軟骨再生医療 Invited
亀井 直輔, 越智 光夫, 安達 伸生
整形･災害外科 61 ( 11 ) 1361 - 1366 2018.10
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：金原出版
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【先端医療の現状と腎疾患への応用】先人から学ぶ(患者に届いた先端医療) 関節軟骨の再生 Invited
亀井直輔，越智光夫
腎と透析 85 ( 1 ) 19 - 22 2018.7
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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MicroRNAs in spinal cord development, aging, and regeneration Invited International conference
2025.10.8
Event date： 2025.10.8 - 2025.10.11
Language：English Presentation type：Symposium, workshop panel (nominated)
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脊髄・軟骨・骨格筋再生研究と実用化への取り組み Invited
亀井直輔
第58回 脊椎外科懇話会 2025.10.3
Event date： 2025.10.3
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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腰痛関連疾患の診断と疼痛管理 Invited
亀井直輔
第98回日本整形外科学会学術総会
Event date： 2025.5.22 - 2025.5.25
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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骨粗鬆症性椎体骨折の診断と治療 Invited
亀井直輔
第46回青森県脊椎脊髄病研究会 2025.5.17
Event date： 2025.5.17
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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脊椎疾患の画像診断および電気生理学的診断－骨粗鬆症性椎体骨折を含めて－ Invited
亀井直輔
第10回四国脊椎外科研究会 2025.5.10
Event date： 2025.5.10
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
Industrial property rights 【 display / non-display 】
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半月板再生用材料
安達伸生，亀井直輔，石川正和，中佐智幸，川端慎吾，山中翼
Applicant：国立大学法人広島大学，三洋化成工業株式会社
Application no：特願2020-550335 Date applied：2019.9.25
Announcement no：WO2020/071208 Date announced：2020.4.9
Patent/Registration no：第7429929号 Date registered：2024.2.1
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Meniscus Regeneration Material
Application no：PCT/JP2019/037589 Date applied：2019.9.25
Announcement no：WO2020/071208 Date announced：2020.9.25
Publication no：WO2020/071208
Patent/Registration no：ZL201980065130.4 Date registered：2020.10.25
Country of applicant：Foreign country Country of acquisition：Foreign country
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磁場誘導装置
亀井直輔，越智光夫，田中義和，平見尚隆
Applicant：国立大学法人広島大学
Application no： 特願2018-168725 Date applied：2018.9.10
Announcement no：特開2020-39557 Date announced：2020.3.19
Publication no：特開2020-39557
Patent/Registration no：第7174207号 Date registered：2022.11.9
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磁場誘導装置
亀井直輔，越智光夫，田中義和，平見尚隆
Applicant：国立大学法人広島大学
Application no： 特願2017-152023 Date applied：2017.8.4
Announcement no：特開2019-30393 Date announced：2019.2.28
Publication no：特開2019-30393
Patent/Registration no：第6942340号 Date registered：2021.9.10
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脊髄損傷の予後予測を補助する方法
亀井直輔，越智光夫，蜂須賀晋
Applicant：国立大学法人広島大学
Application no：特願2014-019146 Date applied：2014.2.4
Announcement no：特開2015-144586 Date announced：2015.8.13
Publication no：特開2015-144586
Patent/Registration no：第6445237号 Date registered：2015.8.13
Awards 【 display / non-display 】
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文部科学大臣表彰 科学技術賞 研究部門
2020.4 文部科学省 磁性化細胞と磁場を用いた低侵襲再生医療研究
越智光夫，安達伸生，亀井直輔
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Best Presenter Award, 4th Annual Meeting of JASA
2015.8 Japan Association of Spine Surgeons with Ambition Serum microRNA as a predictor of prognosis in acute spinal cord injury
Naosuke Kamei
Award type：Award from Japanese society, conference, symposium, etc.
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New Investigator Recognition Award, 2011 Annual Meeting of ORS (USA)
2011.1 Orthopaedic Research Society Endothelial progenitor cells promote regeneration of injured spinal cord through Notch signaling
Naosuke Kamei
Award type：Award from international society, conference, symposium, etc. Country：United States
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第35回日本脊椎脊髄病学会学術集会 最優秀ポスター賞
2006.4 日本脊椎脊髄病学会 神経幹細胞移植による脊髄再生機序
亀井直輔
Award type：Award from Japanese society, conference, symposium, etc.
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第19回日本整形外科学会基礎学術集会 優秀ポスター賞
2004.10 日本整形外科学会 器官共存培養法を用いた神経幹細胞による中枢神経再生の評価
亀井直輔
Award type：Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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中枢神経髄鞘形成におけるマイクロRNAクラスターの機能的役割の解明
Grant number：24K12353 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
亀井直輔，味八木茂，中前稔生
Authorship：Principal investigator Grant type：Competitive
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Grant number：17K10931 2017 - 2019
MEXT KAKENHI Grant-in-Aid for Scientific Research (C)
Naosuke Kamei, Shigeru Miyaki, Nobuo Adachi, Masakazu Ishikawa
Authorship：Principal investigator Grant type：Competitive
The purpose of this study was to investigate the relationship between endoplasmic reticulum (ER) stress mediated by old astrocyte specifically induced substance (OASIS) and astrogliosis in spinal cord injury (SCI). We used siRNA of OASIS and mice deficient for OASIS in SCI models. In a mouse model of spinal cord contusion injury, a significant increase in OASIS mRNA on day 7 and an increase in protein on days 7 and 14 was observed in injured spinal cords. Furthermore, siRNA injection inhibited astrogliosis and hindlimb motor function recovery. On the other hand, functional recovery was better in the OASIS-deficient mice than in the wild-type mice after SCI. OASIS deletion did not inhibit astrocyte migration but reduced the excessive accumulation of N-cadherin-expressing reactive astrocytes that formed the glial scar around the injury site. In addition, OASIS deletion increased the number of serotonin-positive axons in spinal cord regions caudal to the injury site.
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Grant number：25293324 2013 - 2015
MEXT KAKENHI Grant-in-Aid for Scientific Research (B)
KAMEI NAOSUKE, OCHI MITSUO, MIYAKI SHIGERU, NAKASA TOMOYUKI, ISHIKAWA MASAKAZU
Authorship：Principal investigator Grant type：Competitive
The administration of miR-210 to the mouse spinal cord injury model promoted angiogenesis and astrogliosis, and improved functional recovery after spinal cord injury compared with the non-injected controls. Additionally, the administration of miR-145 to the same model improved functional recovery and inhibited the expression of semaphorin 3A.
An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells. The administration of miR-210 to the rat calcaneal tendon injury model promoted the repair of a calcaneal tendon at early phase follow injury. -
脊髄損傷に対する神経・血管特異的マイクロRNAを用いた新たな治療アプローチの開発
Grant number：23791646 2011 - 2012
文部科学省 科学研究費助成事業 若手研究(B)
亀井直輔
Authorship：Principal investigator Grant type：Competitive
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Grant number：21791399 2009 - 2010
文部科学省 科学研究費助成事業 若手研究(B)
亀井直輔
Authorship：Principal investigator Grant type：Competitive
Committee Memberships 【 display / non-display 】
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日本整形外科学会 代議員
2025.4
Committee type：学協会
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西日本整形・災害外科学会 評議員・理事
2024.10
Committee type：学協会
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日本脊椎脊髄病学会 評議員
2020.4
Committee type：学協会
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日本軟骨代謝学会 評議員
2019.3
Committee type：学協会
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日本再生医療学会 代議員
2018.11
Committee type：学協会