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Affiliation |
Faculty of Medicine School of Medicine Department of Medicine of Sensory and Motor Organs, Orthopedic Surgery |
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Professor |
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Laboratory Address |
〒889-1692 宮崎県宮崎市清武町木原5200 |
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Laboratory Phone number |
+81-985-85-0986 |
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Laboratory Fax number |
+81-985-85-2931 |
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Contact information |
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Homepage |
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External Link |
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Related SDGs |
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KAMEI Naosuke
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Degree 【 display / non-display 】
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PhD ( 2006.3 Hiroshima University )
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MD ( 1997.3 Hiroshima University )
Research Interests 【 display / non-display 】
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Regenerative medicine
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Spine surgery
Education 【 display / non-display 】
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Hiroshima University
2002.4 - 2006.3
Country：Japan
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Hiroshima University
1991.4 - 1997.3
Country：Japan
Campus Career 【 display / non-display 】
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University of Miyazaki Faculty of Medicine School of Medicine Department of Medicine of Sensory and Motor Organs, Orthopedic Surgery Professor
2024.10 - Now
External Career 【 display / non-display 】
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Hiroshima University Associate Professor
2020.4 - 2024.9
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Hiroshima University Associate Professor
2019.4 - 2020.3
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Hiroshima University Lecturer
2015.4 - 2019.3
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Hiroshima University Assistant Professor
2009.4 - 2015.3
Professional Memberships 【 display / non-display 】
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2025.1
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西日本整形・災害外科学会
2024.10
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2019.3
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2008.3
Papers 【 display / non-display 】
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Evaluation of Epiconus and Conus Medullaris Disorders due to Thoracolumbar Vertebral Fracture using Motor Evoked Potentials Reviewed International coauthorship International journal
Kamei N, Nakamae T, Maruyama T, Nakao K, Farid F, Fukui H, Adachi N
Spine 49 ( 23 ) E387 - E393 2024.12
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
Study Design.
A retrospective case-control study.
Objective.
To characterize the motor evoked potential (MEP) when the epiconus or conus medullaris is compressed by a fracture of the T12 or L1 vertebra.
Summary of Background Data.
Although the characteristics of compressive cervical and thoracic myelopathy with transcranial magnetic stimulation MEP have been reported, the MEP parameters in compressive disorders of the epiconus and conus medullaris have not yet been characterized.
Methods.
Twenty patients with T12 or L1 vertebral fractures who had lower extremity symptoms due to compression of the epiconus or conus medullaris were included. These patients were compared with 28 healthy controls and 32 patients with cervical spondylotic radiculopathy (CSR) without spinal cord compression. MEPs of abductor hallucis muscles were recorded using transcranial magnetic stimulation and electrical stimulation of the tibial nerve. MEP latency, central motor conduction time (CMCT), and peripheral conduction time (PCT) were evaluated.
Results.
MEP latency, CMCT, and PCT were significantly longer in patients with fractures than in healthy controls and patients with CSR. MEP latency was most accurate for differentiating patients with fracture from healthy controls (cutoff value, 40.0 ms, sensitivity, 95.0%; specificity, 100%), and CMCT was most accurate for comparing patients with fracture and CSR (cutoff value, 15.5 ms, sensitivity, 80.0%; specificity, 93.8%). In the distinction between patients with fracture and CSR, 16 of the 20 patients with fracture exceeded the cutoff values for any of the parameters, and 12 of them exceeded the cutoff values for all parameters. There was no significant correlation between the linear distance from the most inferior end of the spinal cord to the site of compression and any of the MEP parameters.
Conclusion.
Both CMCT and PCT are often prolonged in compressive lesions of the epiconus and conus medullaris, and MEP latency and CMCT are useful in the diagnosis. -
Differentiating Neurodegenerative Disease From Compressive Cervical Myelopathy Using Motor-Evoked Potentials Reviewed International coauthorship International journal
Kamei N., Nakamae T., Maruyama T., Nakao K., Farid F., Adachi N.
Spine 49 ( 10 ) 726 - 732 2024.5
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Differentiation of compressive cervical myelopathy and compressive thoracic myelopathy by central motor conduction time ratio Reviewed International journal
Kamei N., Nakamae T., Nakanishi K., Maruyama T., Nakao K., Farid F., Adachi N.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY 41 ( 4 ) 351 - 356 2024.5
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
Purpose:Thoracic myelopathy is a rare condition whose diagnosis is often missed or delayed. This study aimed to differentiate between cervical and thoracic myelopathy using motor-evoked potential testing.Methods:The authors included 835 patients with compressive cervical myelopathy and 94 patients with compressive thoracic myelopathy. Myelopathy using motor-evoked potentials were recorded from the bilateral abductor digiti minimi and abductor hallucis muscles through transcranial magnetic stimulation. The peripheral conduction time was measured through electrical stimulation of the ulnar and tibial nerves; moreover, the central motor conduction time (CMCT) was calculated by subtracting the peripheral conduction time from the myelopathy using motor-evoked potential latency.Results:The most accurate differentiation between compressive cervical myelopathy and compressive thoracic myelopathy was achieved by the CMCT ratios (CMCT-ADM:CMCT-AH; cutoff value of 0.490, sensitivity of 83.0%, and specificity of 80.5%). After excluding patients with compressive cervical myelopathy who had spinal cord compression at C6-7, the cutoff value was 0.490, with a sensitivity of 83.0% and specificity of 87.3%.Conclusions:Determining the CMCT ratio (cutoff value of 0.490) through motor-evoked potential testing could facilitate differentiation between compressive cervical myelopathy and compressive thoracic myelopathy.
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Comparison of the electrophysiological characteristics of tight filum terminale and tethered cord syndrome Reviewed International journal
Kamei, Naosuke, Nakamae, Toshio, Nakanishi, Kazuyoshi, Morisako, Taiki, Harada, Takahiro, Maruyama, Toshiaki, Adachi, Nobuo
ACTA NEUROCHIRURGICA 164 ( 8 ) 2235 - 2242 2022.8
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER WIEN
Purpose This study aims to characterize tight filum terminale (TFT) in motor evoked potential (MEP) testing by comparing TFT patients with both tethered cord syndrome (TCS) patients and healthy subjects. Methods Fifty TFT patients, 18 TCS patients, and 35 healthy volunteers participated in this study. We recorded MEPs following transcranial magnetic stimulation from the bilateral abductor hallucis muscles as well as compound muscle action potentials and F-waves evoked by electrical stimulation of the tibial nerve from the bilateral abductor pollicis brevis muscles. The peripheral conduction time (PCT) was calculated from the latency of the compound action potential and F-wave. Furthermore, the central motor conduction time (CMCT) was calculated by subtracting PCT from MEP latency. Results TFT and TCS patients had a significantly longer MEP latency than healthy subjects. PCT in TFT patients was significantly longer than those in TCS patients or healthy subjects. Using the cutoff values for PCT, we were able to diagnose patients with TFT patients with a sensitivity of 72.0% and a specificity of 91.4%. Conclusion Prolonged PCT in the MEP test may be a useful indicator for TFT and suggests that MEP may be used as an adjunct diagnostic tool for TFT.
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Evaluation of intervertebral disc degeneration using T2 signal ratio on magnetic resonance imaging Reviewed International journal
Kamei, Naosuke, Nakamae, Toshio, Nakanishi, Kazuyoshi, Tamura, Takayuki, Tsuchikawa, Yuji, Morisako, Taiki, Harada, Takahiro, Maruyama, Toshiaki, Adachi, Nobuo
EUROPEAN JOURNAL OF RADIOLOGY 152 110358 - 110358 2022.7
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD
Purpose: Intervertebral disc degeneration is assessed clinically by magnetic resonance imaging (MRI). Although some quantitative evaluation methods for MRI under special imaging conditions have been reported, they are widely and generally difficult to use. The aim of this study is to determine if intervertebral disc degeneration can be assessed using the ratio of MRI T2 values of the disc to the spinal cord T2 values. Methods: Signal ratio was calculated using the T2 signal intensity of the disc and the spinal cord on MRI under common conditions for a new assessment of disc degeneration. T2-weighted images of 100 patients undergoing MRI twice within a year under different imaging conditions, 1.5 T or less and 3.0 T, were used for the assessment. The T2 signal intensity was measured at the center of the discs at L2-3, L3-4, L4-5, L5-S1 and the spinal cord at T12 level. Signal ratio was calculated using these T2 signal intensity values. The ratio of the difference between the first and second values to the mean of the first and second values was calculated to confirm the equivalence of MRI assessments of disc degeneration in the same patient under different imaging conditions. Results: The equivalence of values between the first MRI and the second MRI in the signal ratio was significantly higher than that in the T2 signal intensity. In addition, the signal ratio was negatively correlated with age and were significantly associated with Pfirrmann grade. Conclusions: By using the signal ratio, disc degeneration can be evaluated by MRI even under different imaging conditions.
Books 【 display / non-display 】
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関節・軟骨の再生医療
亀井直輔，越智光夫，安達伸生（ Role： Joint author , 自家培養軟骨移植による軟骨再生と磁気ターゲティングによる治療）
シーエムシー出版 2019.12
Responsible for pages：106-114 Language：Japanese Book type：Scholarly book
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再生医療用語ハンドブック
亀井直輔，越智光夫（ Role： Joint author , 冒頭概説 軟骨）
メディカルトリビューン 2015.3
Language：Japanese Book type：Dictionary, encyclopedia
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先進医療NAVIGATORⅡ
亀井直輔，越智光夫（ Role： Joint author , 整形外科と再生医療 -骨・軟骨-）
日本医学出版 2014.3
Language：Japanese Book type：Scholarly book
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Neuroprotection and Regeneration of the Spinal Cord
Naosuke Kamei（ Role： Joint author , Vascular regeneration therapies for spinal cord injury）
Springer 2014.3
Language：English Book type：Scholarly book
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幹細胞研究と再生医療
亀井直輔，越智光夫（ Role： Joint author , 骨・軟骨の再生）
南山堂 2013.12
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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整形トピックス 細胞磁気ターゲティングの医師主導治験 Invited
亀井 直輔
整形外科 74 ( 9 ) 990 - 990 2023.8
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：南江堂
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【頸椎疾患・症候群対応マニュアル】Arnold-Chiari奇形の病態と治療 Invited
亀井直輔
Monthly Book Orthopaedics 35 ( 7 ) 51 - 57 2022.7
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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特集 間葉系幹細胞治療の現状と課題 骨髄間葉系幹細胞を用いた軟骨再生医療 Invited
亀井 直輔, 越智 光夫, 安達 伸生
整形･災害外科 61 ( 11 ) 1361 - 1366 2018.10
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：金原出版
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【先端医療の現状と腎疾患への応用】先人から学ぶ(患者に届いた先端医療) 関節軟骨の再生 Invited
亀井直輔，越智光夫
腎と透析 85 ( 1 ) 19 - 22 2018.7
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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【超高齢社会における骨・関節疾患】軟骨再生の現状 Invited
亀井直輔，安達伸生
臨床と研究 94 ( 10 ) 1259 - 1262 2017.10
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Industrial property rights 【 display / non-display 】
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半月板再生用材料
安達伸生，亀井直輔，石川正和，中佐智幸，川端慎吾，山中翼
Applicant：国立大学法人広島大学，三洋化成工業株式会社
Application no：特願2020-550335 Date applied：2019.9.25
Announcement no：WO2020/071208 Date announced：2020.4.9
Patent/Registration no：第7429929号 Date registered：2024.2.1
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Meniscus Regeneration Material
Application no：PCT/JP2019/037589 Date applied：2019.9.25
Announcement no：WO2020/071208 Date announced：2020.9.25
Publication no：WO2020/071208
Patent/Registration no：ZL201980065130.4 Date registered：2020.10.25
Country of applicant：Foreign country Country of acquisition：Foreign country
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磁場誘導装置
亀井直輔，越智光夫，田中義和，平見尚隆
Applicant：国立大学法人広島大学
Application no： 特願2018-168725 Date applied：2018.9.10
Announcement no：特開2020-39557 Date announced：2020.3.19
Publication no：特開2020-39557
Patent/Registration no：第7174207号 Date registered：2022.11.9
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磁場誘導装置
亀井直輔，越智光夫，田中義和，平見尚隆
Applicant：国立大学法人広島大学
Application no： 特願2017-152023 Date applied：2017.8.4
Announcement no：特開2019-30393 Date announced：2019.2.28
Publication no：特開2019-30393
Patent/Registration no：第6942340号 Date registered：2021.9.10
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脊髄損傷の予後予測を補助する方法
亀井直輔，越智光夫，蜂須賀晋
Applicant：国立大学法人広島大学
Application no：特願2014-019146 Date applied：2014.2.4
Announcement no：特開2015-144586 Date announced：2015.8.13
Publication no：特開2015-144586
Patent/Registration no：第6445237号 Date registered：2015.8.13
Awards 【 display / non-display 】
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文部科学大臣表彰 科学技術賞 研究部門
2020.4 文部科学省 磁性化細胞と磁場を用いた低侵襲再生医療研究
越智光夫，安達伸生，亀井直輔
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Best Presenter Award, 4th Annual Meeting of JASA
2015.8 Japan Association of Spine Surgeons with Ambition Serum microRNA as a predictor of prognosis in acute spinal cord injury
Naosuke Kamei
Award type：Award from Japanese society, conference, symposium, etc.
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New Investigator Recognition Award, 2011 Annual Meeting of ORS (USA)
2011.1 Orthopaedic Research Society Endothelial progenitor cells promote regeneration of injured spinal cord through Notch signaling
Naosuke Kamei
Award type：Award from international society, conference, symposium, etc. Country：United States
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第35回日本脊椎脊髄病学会学術集会 最優秀ポスター賞
2006.4 日本脊椎脊髄病学会 神経幹細胞移植による脊髄再生機序
亀井直輔
Award type：Award from Japanese society, conference, symposium, etc.
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第19回日本整形外科学会基礎学術集会 優秀ポスター賞
2004.10 日本整形外科学会 器官共存培養法を用いた神経幹細胞による中枢神経再生の評価
亀井直輔
Award type：Award from Japanese society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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中枢神経髄鞘形成におけるマイクロRNAクラスターの機能的役割の解明
Grant number：24K12353 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
亀井直輔，味八木茂，中前稔生
Authorship：Principal investigator Grant type：Competitive
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Grant number：17K10931 2017 - 2019
MEXT KAKENHI Grant-in-Aid for Scientific Research (C)
Naosuke Kamei, Shigeru Miyaki, Nobuo Adachi, Masakazu Ishikawa
Authorship：Principal investigator Grant type：Competitive
The purpose of this study was to investigate the relationship between endoplasmic reticulum (ER) stress mediated by old astrocyte specifically induced substance (OASIS) and astrogliosis in spinal cord injury (SCI). We used siRNA of OASIS and mice deficient for OASIS in SCI models. In a mouse model of spinal cord contusion injury, a significant increase in OASIS mRNA on day 7 and an increase in protein on days 7 and 14 was observed in injured spinal cords. Furthermore, siRNA injection inhibited astrogliosis and hindlimb motor function recovery. On the other hand, functional recovery was better in the OASIS-deficient mice than in the wild-type mice after SCI. OASIS deletion did not inhibit astrocyte migration but reduced the excessive accumulation of N-cadherin-expressing reactive astrocytes that formed the glial scar around the injury site. In addition, OASIS deletion increased the number of serotonin-positive axons in spinal cord regions caudal to the injury site.
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Grant number：25293324 2013 - 2015
MEXT KAKENHI Grant-in-Aid for Scientific Research (B)
KAMEI NAOSUKE, OCHI MITSUO, MIYAKI SHIGERU, NAKASA TOMOYUKI, ISHIKAWA MASAKAZU
Authorship：Principal investigator Grant type：Competitive
The administration of miR-210 to the mouse spinal cord injury model promoted angiogenesis and astrogliosis, and improved functional recovery after spinal cord injury compared with the non-injected controls. Additionally, the administration of miR-145 to the same model improved functional recovery and inhibited the expression of semaphorin 3A.
An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells. The administration of miR-210 to the rat calcaneal tendon injury model promoted the repair of a calcaneal tendon at early phase follow injury. -
脊髄損傷に対する神経・血管特異的マイクロRNAを用いた新たな治療アプローチの開発
Grant number：23791646 2011 - 2012
文部科学省 科学研究費助成事業 若手研究(B)
亀井直輔
Authorship：Principal investigator Grant type：Competitive
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Grant number：21791399 2009 - 2010
文部科学省 科学研究費助成事業 若手研究(B)
亀井直輔
Authorship：Principal investigator Grant type：Competitive
Committee Memberships 【 display / non-display 】
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西日本整形・災害外科学会 評議員・理事
2024.10
Committee type：学協会
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日本整形外科学会 脊椎脊髄病委員会 委員
2021.6
Committee type：学協会
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日本脊椎脊髄病学会 評議員
2020.4
Committee type：学協会
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日本軟骨代謝学会 評議員
2019.3
Committee type：学協会
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日本再生医療学会 代議員
2018.11
Committee type：学協会