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Affiliation |
Faculty of Medicine School of Medicine Department of Clinical Neuroscience, Neurosurgery |
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Professor |
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Related SDGs |
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OKITA Yoshiko
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Papers 【 display / non-display 】
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Accurate classification of ependymomas and medulloblastomas using Raman spectroscopy and pilot transcriptomic profiling. Reviewed International journal
Yuki Kawamoto, Yoshiko Okita, Kenta Temma, Toshiki Kubo, Yasuaki Kumamoto, Yasuhiro Fujii, Keisuke Nishimoto, Reina Utsugi, Chisato Yokota, Ryuichi Hirayama, Noriyuki Kijima, Khoo Hui Ming, Naoki Tani, Satoru Oshino, Naoki Kagawa, Daisuke Motooka, Katsumasa Fujita, Haruhiko Kishima
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 352 127532 - 127532 2026.1
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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A Rare Case of a Solid Variant Aneurysmal Bone Cyst of the Medial Sphenoid Bone: Clinical Features, Diagnostic Points, and Treatment Reviewed
YAMASHITA Shinji, MATSUMOTO Fumitaka, OKUYAMA Hironobu, OGASAWARA Natsuki, TAMURA Mitsuru, KAWANO Tomoki, YOKOGAMI Kiyotaka, KIWAKI Takumi, FUKUSHIMA Tsuyoshi, SATO Yuichiro, TOMONAGA Takumi, OKITA Yoshiko
NMC Case Report Journal 12 ( 0 ) 369 - 375 2025.12
Language：English Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本脳神経外科学会
A 5-year-old boy presented to our hospital with ptosis and an abnormal ocular position. Magnetic resonance imaging showed a well-defined mass measuring 20 mm in diameter in the medial sphenoid bone extending to the orbit and compressing the external ocular muscle. The patient underwent total surgical excision and was subsequently diagnosed with a solid variant of aneurysmal bone cyst via molecular integrated diagnosis. Solid variant of aneurysmal bone cyst is an extremely rare subtype of aneurysmal bone cyst, accounting for 0.2% of all primary bone tumors. It is characterized by the absence of a solid cystic component, which is difficult to diagnose via conventional hematoxylin and eosin staining. Molecular analyses revealed that this subtype is also characterized by the rearrangement of <i>USP6</i> and the absence of the H3F3A mutation. This report discusses the clinical features of this extremely rare neoplastic lesion, the importance of an integrated diagnosis, and treatment options.
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Radiomics Analysis of Non-Enhancing Lesions After Bevacizumab Administration in Recurrent Glioblastoma. Reviewed International journal
Takahiro Sanada, Takeshi Shimizu, Yoshiko Okita, Hideyuki Arita, Hirotaka Sato, Masato Saito, Nobuyuki Mitsui, Satoru Hiroshima, Kayako Isohashi, Mishie Tanino, Yonehiro Kanemura, Haruhiko Kishima, Manabu Kinoshita
Bioengineering (Basel, Switzerland) 13 ( 1 ) 2025.12
Language：English Publishing type：Research paper (scientific journal)
This study explored radiomic features that help identify non-contrast-enhancing tumors (nCET) by analyzing regions where contrast-enhancing tumors (CET) transformed into nCET after Bevacizumab (BEV) treatment. The BEV cohort included 24 recurrent GBM (rGBM) patients treated with BEV, showing reduced contrast-enhancement on gadolinium-enhanced T1-weighted imaging (T1Gd) imaging. The 11C-methionine positron emission tomography (Met-PET) cohort consisted of 24 newly diagnosed GBM (nGBM) patients with available Met-PET data. VOIs were created from T2WI, FLAIR, T1Gd, and Met-PET to analyze nCET and T2/FLAIR lesions. After significant radiomic features were identified, a prediction model for nCET was developed in the BEV cohort and subsequently evaluated in the Met-PET cohort. A total of 37 and 46 significant radiomic features were found in the BEV and Met-PET cohorts, respectively. The key feature, T2WI_whole_GLCMcorrelation_1, was selected for predictive modeling. The model demonstrated high accuracy (AUC = 0.93, p < 0.0001) in the BEV cohort, with sensitivity and specificity of 0.91, while the Met-PET cohort showed moderate accuracy (AUC = 0.74, p = 0.0053). Image reconstruction using these features also effectively visualized nCET in nGBM. These findings suggest that radiomic features in CET regions transforming to nCET after BEV treatment harbors valuable information for identifying nCET in GBM.
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Arita H., Ikawa T., Kanayama N., Morimoto M., Umehara T., Yoshizawa H., Kodama Y., Okita Y., Kinoshita M., Konishi K.
Acta Neurochirurgica 167 ( 1 ) 163 2025.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Acta Neurochirurgica
Background: Recent advances in cancer treatment have prolonged survival after the onset of brain metastasis (BM), increasing the incidence of local progression (LP) following radiotherapy. However, no standard approach exists for managing LP. We aimed to evaluate the outcomes of salvage surgery in a clinical setting. Methods: The clinical data were retrospectively collected from the medical records of 49 patients who underwent their first salvage surgery for LP of BM at a single institution between April 2014 and March 2024. Overall survival (OS) and LP-free survival (LPFS) were evaluated using the Kaplan–Meier method. Results: Most patients (47/49, 96%) had a history of stereotactic radiosurgery (n = 34) and/or stereotactic radiotherapy (n = 14). The histopathological examination of surgical specimens confirmed tumor recurrence in 33 patients and radiation necrosis (RN) in 16 patients. The interval from prior radiotherapy to salvage surgery was longer in patients with RN than in those with recurrence (median: 42.3 vs. 9.3 months, respectively). OS was longer in the RN group compared with the recurrent group (median: 68.5 months and 21.8 months, respectively). In the recurrent group, shorter OS was associated with preoperative poor KPS (< 70), the presence of active extracranial lesions, and RPA classes 2–3. The extent of resection, postoperative chemotherapy, and local irradiation had no significant effect on OS. After salvage surgery, further LP was observed in 20 patients (61%), with a median LPFS of 7.0 months in the recurrent group. No significant association was found between LPFS and the extent of tumor removal, postoperative chemotherapy, and RT. Conclusions: This study highlights a relatively prolonged survival period following salvage surgery for local progression of BM after irradiation. Salvage surgery is a treatment option in patients with good extracranial control and performance status. The high recurrence rate following salvage treatment underscores the need for developing additional treatment approaches.
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Dysembryoplastic neuroepithelial tumor in an atypical location without epilepsy: a case report Reviewed
Masato Hidaka, Shinji Yamashita, Tsuyoshi Fukushima, Natsuki Ogasawara, Mitsuru Tamura, Tomoki Kawano, Fumitaka Matsumoto, Hironobu Okuyama, Nei Fukasawa, Junko Hirato, Yuichiro Sato, Yoshiko Okita
Acta Scientific Neurology 8 ( 5 ) 89 - 94 2025.4
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
Grant-in-Aid for Scientific Research 【 display / non-display 】
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膠芽腫に対する新規治療法の探索を可能とするデジタルツインの基盤技術開発
Grant number：25K22913 2025.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 挑戦的研究（萌芽）
Authorship：Coinvestigator(s)
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膠芽腫におけるシングルセルラマン分光法の確立による腫瘍細胞特性の解明
Grant number：24K12261 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator