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医学部 医学科 臨床神経科学講座脳神経外科学分野 |
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論文 【 表示 ／ 非表示 】
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Tamura M, Yamashita S, Kawano T, Komaki S, Tsukino T, Kojima K, Maeda K, Kimoto Y, Kadota Y, Azuma M, Okita Y
NMC Case Report Journal 13 ( 0 ) 69 - 75 2026年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本脳神経外科学会
Abusive head trauma in infants and young children can have a significant impact on neurological outcomes and, in severe cases, may be life-threatening. We report 3 cases of abusive head trauma that presented with acute subdural hematomas on computed tomography scans, accompanied by extensive low-density areas and parenchymal brain swelling. All patients exhibited impaired consciousness due to brain injury and underwent craniotomy for hematoma evacuation as well as extensive decompressive craniectomy. Despite the severity of the initial presentation, hemiparesis was mild and gradually improved over several months. Postoperative magnetic resonance imaging revealed widespread parenchymal injury but preservation of the corticospinal tract, including the precentral gyrus. In the acute phase, diffusion-weighted imaging showed no irreversible infarction in the motor cortex, and arterial spin labeling demonstrated increased perfusion in peri-motor regions of the affected hemisphere. These findings suggest that preserved corticospinal pathways and compensatory hyperperfusion may correlate with favorable motor recovery even in the presence of extensive parenchymal damage. These cases highlight the radiological features and short-term neurological outcomes of abusive head trauma, demonstrating preserved motor function despite extensive parenchymal damage.
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Okuyama H., Yokogami K., Yamashita S., Okita Y.
Human Pathology Reports 43 2026年3月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Human Pathology Reports
Currarino syndrome is a rare congenital disorder characterized by a triad of presacral mass, sacral agenesis, and anorectal malformation. We report a case of Currarino syndrome with heterozygous in-frame deletion in homeobox of MNX1 gene. Currarino syndrome is an autosomal-dominant inheritance, and many cases of MNX1 mutations have been reported, but there are no reports of symptomatic with heterozygous in-frame deletions in sporadic cases. We downloaded the MNX1 data from open database ClinVar-NCBI. After adding seven literature reports not included in the database with present case, we re-analyzed the mutation type, location and symptoms. Among 81 cases with gene mutations upstream of homeobox, structural changes in homeobox were observed in 39 of 41 symptomatic cases (95.1%), while in only 1 of 40 asymptomatic cases (2.5%). This finding indicates that structural changes in the homeobox of the MNX1 gene are significantly involved in whether Currarino syndrome becomes symptomatic.
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Accurate classification of ependymomas and medulloblastomas using Raman spectroscopy and pilot transcriptomic profiling. 査読あり 国際誌
Kawamoto Y, Okita Y, Temma K, Kubo T, Kumamoto Y, Fujii Y, Nishimoto K, Utsugi R, Yokota C, Hirayama R, Kijima N, Ming KH, Tani N, Oshino S, Kagawa N, Motooka D, Fujita K, Kishima H
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 352 127532 - 127532 2026年1月
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
Raman spectroscopy enabled accurate discrimination of posterior fossa ependymomas and medulloblastomas in both frozen and formalin-fixed, paraffin-embedded (FFPE) specimens in this retrospective study. We acquired Raman spectra (532 nm excitation) from frozen and FFPE tissues to evaluate a principal component analysis-support vector machine classifier by using fivefold cross-validation. We also performed a pilot spatial transcriptomics analysis on three FFPE sections by using the 10× Genomics Xenium In Situ v2 FFPE workflow. In total, 34 specimens (21 frozen and 13 FFPE) were analyzed, and the classification models achieved >90% accuracy in distinguishing ependymomas from medulloblastomas under spectrum-level fivefold cross-validation, suggesting discriminative biochemical differences, whereas patient-level performance requires further validation in larger cohorts. Ependymomas had higher lipid-associated Raman bands (1084, 1128, and 1654 cm-1), whereas medulloblastomas exhibited higher deoxyhemoglobin-related Raman bands (1356, 1548, and 1604 cm-1). Compared with normal controls, tumor tissues had increased carotenoid-related Raman bands and reduced lipid-associated Raman bands. The observed spectral differences are consistent with differences in lipid-associated composition and the heme/oxygenation-related tissue context, and pilot transcriptomic profiling provided qualitative biological context related to lipid metabolism and angiogenesis. These findings support Raman spectroscopy as a label-free spectroscopic technique that may complement conventional diagnostics and aid surgical and therapeutic decision-making. Larger, prospective studies are warranted to further evaluate the clinical generalizability and intraoperative translation of our results.
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A Rare Case of a Solid Variant Aneurysmal Bone Cyst of the Medial Sphenoid Bone: Clinical Features, Diagnostic Points, and Treatment 査読あり
YAMASHITA Shinji, MATSUMOTO Fumitaka, OKUYAMA Hironobu, OGASAWARA Natsuki, TAMURA Mitsuru, KAWANO Tomoki, YOKOGAMI Kiyotaka, KIWAKI Takumi, FUKUSHIMA Tsuyoshi, SATO Yuichiro, TOMONAGA Takumi, OKITA Yoshiko
NMC Case Report Journal 12 ( 0 ) 369 - 375 2025年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本脳神経外科学会
A 5-year-old boy presented to our hospital with ptosis and an abnormal ocular position. Magnetic resonance imaging showed a well-defined mass measuring 20 mm in diameter in the medial sphenoid bone extending to the orbit and compressing the external ocular muscle. The patient underwent total surgical excision and was subsequently diagnosed with a solid variant of aneurysmal bone cyst via molecular integrated diagnosis. Solid variant of aneurysmal bone cyst is an extremely rare subtype of aneurysmal bone cyst, accounting for 0.2% of all primary bone tumors. It is characterized by the absence of a solid cystic component, which is difficult to diagnose via conventional hematoxylin and eosin staining. Molecular analyses revealed that this subtype is also characterized by the rearrangement of <i>USP6</i> and the absence of the H3F3A mutation. This report discusses the clinical features of this extremely rare neoplastic lesion, the importance of an integrated diagnosis, and treatment options.
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Kawano T, Matsumoto F, Yamashita S, Oguri N, Akizuki K, Tomonaga T, Akiyama Y, Kadota Y, Oda Y, Azuma M, Yamashita A, Okita Y
NMC Case Report Journal 12 ( 0 ) 525 - 530 2025年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本脳神経外科学会
A 72-year-old woman with a history of breast cancer presented with left oculomotor nerve palsy. Magnetic resonance imaging revealed a progressive mass lesion in the cavernous sinus. Initially, Tolosa-Hunt syndrome and metastatic brain tumor from breast cancer were suspected; however, radiological differentiation proved challenging. Pathological examination confirmed the diagnosis of primary intracranial Ewing sarcoma. The tumor exhibited progressive growth, and Gamma Knife radiosurgery was performed. After treatment, tumor shrinkage and symptomatic improvement were observed. Ewing sarcoma typically occurs in children and young adults; however, the safety and efficacy of chemotherapy in older populations remain largely unstudied. In this older patient, the rare location of the tumor within the cavernous sinus posed challenges to surgical resection. Chemotherapy was administered at a reduced dose of 50%, with limited side effects. After 7 cycles of chemotherapy, tumor showed further shrinkage, and no recurrence was observed. This case demonstrates that, even in rare tumors with unestablished chemotherapy protocols for older patients, satisfactory outcomes can be achieved with accurate pathological diagnosis and a multidisciplinary treatment approach.
講演・口頭発表等 【 表示 ／ 非表示 】
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悪性脳腫瘍の診断と集学的治療
沖田 典子
神戸オンコロジーセミナー 2025年12月11日
開催年月日： 2025年12月11日
記述言語：日本語 会議種別：公開講演，セミナー，チュートリアル，講習，講義等
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悪性脳腫瘍診療と私なりのリーダーシップ ― 女性が管理職になるということ
沖田 典子
愛知脳神経外科カンファレンス2025 2025年8月7日
開催年月日： 2025年12月6日
記述言語：日本語 会議種別：公開講演，セミナー，チュートリアル，講習，講義等
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悪性脳腫瘍の診断と集学的治療
沖田 典子
第14回Mt.Tsukuba 2025年11月7日
開催年月日： 2025年11月7日
記述言語：日本語 会議種別：公開講演，セミナー，チュートリアル，講習，講義等
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KINEVO 900Sが可能にする術者の体格に左右されない脳腫瘍手術
沖田 典子
日本脳神経外科第84回学術集会 2025年10月29日
開催年月日： 2025年10月29日 - 2025年11月1日
記述言語：日本語 会議種別：公開講演，セミナー，チュートリアル，講習，講義等
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少人数医局における脳腫瘍手術の安全管理ー合併症対策の実際と工夫
沖田 典子
日本脳神経外科第84回学術集会 2025年10月30日
開催年月日： 2025年10月29日 - 2025年11月1日
記述言語：日本語 会議種別：公開講演，セミナー，チュートリアル，講習，講義等
科研費（文科省・学振・厚労省）獲得実績 【 表示 ／ 非表示 】
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膠芽腫に対する新規治療法の探索を可能とするデジタルツインの基盤技術開発
研究課題/領域番号：25K22913 2025年04月 - 2027年03月
独立行政法人日本学術振興会 科学研究費基金 挑戦的研究（萌芽）
担当区分：研究分担者
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膠芽腫におけるシングルセルラマン分光法の確立による腫瘍細胞特性の解明
研究課題/領域番号：24K12261 2024年04月 - 2027年03月
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
担当区分：研究代表者
寄附金・講座・研究部門 【 表示 ／ 非表示 】
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臨床神経科学講座脳神経外科学分野研究奨学金
2025年01月
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臨床神経科学講座脳神経外科学分野研究奨学金
2024年11月
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臨床神経科学講座脳神経外科学分野研究奨学金（潤和ﾘﾊﾋﾞﾘﾃｰｼｮﾝ振興財団）
2024年09月
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臨床神経科学講座脳神経外科学分野研究奨学金
2024年06月
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臨床神経科学講座脳神経外科学分野研究奨学金（潤和ﾘﾊﾋﾞﾘﾃｰｼｮﾝ振興財団）
2024年05月