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Affiliation |
Organization for Promotion of Research and Industry-Academic Regional Collaboration Division for Research Facility Support |
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Title |
Associate Professor |
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External Link |
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SAKAI Kentaro
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Degree 【 display / non-display 】
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Doctor (Engineering) ( 2001.3 University of Miyazaki )
Research Areas 【 display / non-display 】
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Nanotechnology/Materials / Inorganic materials and properties
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Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Electric and electronic materials
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Environmental Science/Agriculture Science / Agricultural environmental engineering and agricultural information engineering
Papers 【 display / non-display 】
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Dopant-induced photodegradation of organic water pollutants using cobalt oxide nanostructures of low cytotoxicity Reviewed International coauthorship
Ranjitha R., Dileep Kumar V.G., Navada M.K., Shetty S.M., Jayanna B.K., Bhatt A.S., Santosh M.S., Madhyastha H., Sakai K., Ravikumar C.R.
Journal of Environmental Chemical Engineering 11 ( 2 ) 2023.4
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Environmental Chemical Engineering
Metal oxides are the simplest and most approachable solutions for attaining multifunctional properties applicable to modern-day technology. With growing concern over environmental conservation, an evaluation of the cytotoxicity of the metal oxides becomes necessary. The present work focuses on the photocatalytic and cytocompatibility behavior of Co3O4 nanomaterial. It has been observed that the addition of Li to the Co3O4 nanostructure generates a positive impact on the photodegradation of cationic dyes under UV light. The photocatalyst with 1 wt% Li-doped Co3O4 was found to be the most competent among the synthesized samples. Further, the sample has been employed for photocatalytic removal of the hazardous pollutant, pyrocatechol (PyC), in the presence of visible light. A photocatalytic efficiency of 84.5% (after 9 h) and high stability (86% after 5 cycles) is observed. A noteworthy revelation is the lower toxicity observed for Li-doped samples when compared to the pristine Co3O4. The (3-(4,5-dimethylthiazolyl-2)− 2,5-diphenyltetrazolium bromide) (MTT) assay carried out on mouse skin fibroblast cell lines reveals cytotoxicity inhibition by the doped nanostructures for up to 10 μg mL−1 concentration and excellent cell proliferation up to 24 h. The superior catalytic behavior and non-toxic nature of the Li-doped Co3O4 nanostructures provide ample opportunity for their integration into water remediation and effluent treatment systems.
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Fine Particle Adsorption Capacity of Volcanic Soil from Southern Kyushu, Japan Reviewed
Naoaki Misawa, Kentaro Yasui, Kentaro Sakai, Taichi Kobayashi, Hideki Nagahama, Tomohiro Haraguchi, Satomi Sasaki, Vetchapitak Torrung, Taradon Luangtongkum, Takako Taniguchi, Kentaro Yamada, Makoto Minamimagari, Toshihiro Usami, Hiroyuki Kinoshita
Nanomaterials 13 ( 3 ) 568-1 - 568-19 2023.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Nanomaterials
“Akahoya” is a volcanic soil classified as a special soil deposited in Kyushu, Japan. Many of its properties are not yet clearly understood. We found that Akahoya had the potential to adsorb bacteria in cattle feces, which prompted us to investigate its material properties and perform experiments to comprehensively evaluate its adsorption performance for various fine particles such as acidic and basic dyes, NOx/SOx gas, and phosphoric acid ions, in addition to bacteria. Akahoya had a very high specific surface area owing to the large number of nanometer-sized pores in its structure; it exhibited a high adsorption capacity for both NO2 and SO2. Regarding the zeta potential of Akahoya, the point of zero charge was approximately pH 7.0. The surface potential had a significant effect on the adsorption of acidic and basic dyes. Akahoya had a very high cation exchange capacity when the sample surface was negatively charged and a high anion exchange capacity when the sample surface was positively charged. Akahoya also exhibited a relatively high adsorption capacity for phosphoric acid because of its high level of Al2O3, and the immersion liquid had a very high Al ion concentration. Finally, filtration tests were performed on Escherichia coli suspension using a column filled with Akahoya or another volcanic soil sample. The results confirmed that the Escherichia coli adhered on the Akahoya sample. The results of the Escherichia coli release test, after the filtration test, suggested that this adhesion to Akahoya could be phosphorus-mediated.
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Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing. Reviewed International coauthorship
Sharma S, Madhyastha H, Kirwale SS, Sakai K, Katakia YT, Majumder S, Roy A
Carbohydrate polymers 298 120126 2022.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Carbohydrate Polymers
None of the currently available wound dressings exhibit combined antibacterial and anti-inflammatory activity. Using polyelectrolyte complexation (PEC) between a cationic polysaccharide chitosan (CH) and an anionic glycosaminoglycan chondroitin sulfate (CS), we have developed a unique in-situ forming scaffold (CH-CS PEC), which develops at the wound site itself to influence the function of the wound bed cells. The current study demonstrated that CH-CS PEC could induce bacterial cell death through membrane pore formation and increased ROS production. Moreover, possibly due to its unique material properties including medium-soft viscoelasticity, porosity, and surface composition, CH-CS PEC could modulate macrophage function, increasing their phagocytic ability with low TNF-α and high IL-10 production. Faster wound closure and decreased CFU count was observed in an in-vivo infected wound model, with reduced NF-κB and increased VE-cadherin expression, indicating reduced inflammation and enhanced angiogenesis. In summary, this study exhibited that CH-CS PEC has substantial antibacterial and immunomodulatory properties.
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Dural Changes Induced by an Ultrasonic Bone Curette in an Excised Porcine Spinal Cord Reviewed
Rizou Ota, Eri Iwaki, Kentaro Sakai, Tomohiro Haraguchi, Yasuyuki Kaneko, Satoshi Sekiguchi, Ryoji Yamaguchi and Kiyokazu Naganobu
Veterinary Science 9 ( 11 ) 601-1 - 601-11 2022.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Veterinary Sciences
In spinal surgery, ultrasonic bone curettes are considered unlikely to cause mechanical injury to the dura; however, there is little evidence to support this claim. We investigated the effect of direct contact with an ultrasonic bone curette on the dura and the protective effect of covering the dura with a cotton pattie using an excised porcine spinal cord. The ultrasonic bone curette was pressed against the porcine spinal cord with constant force and activated for 1 s, with or without covering the dura with a cotton pattie. The dural surface and cross-section were observed using electron and light microscopy. When the ultrasonic bone curette was applied directly against the dura, most specimens showed non-perforating dural injuries. However, none of the specimens showed dural perforation. Histological changes were also observed. The use of a cotton pattie reduced the occurrence of these changes, although it did not prevent them when ultrasonic vibration was applied with a large force. We considered ultrasonic bone curettes to have a low risk of dural perforation and, thus, to be a safe surgical device as long as they did not accidentally make strong contact with the dura.
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Designer exosomes: Smart nano-communication tools for translational medicine Reviewed International coauthorship
Harishkumar M., Radha M., Yuichi N., Muthukalianan G.K., Kaoru O., Shiomori K., Sakai K., Nozomi W.
Bioengineering 8 ( 11 ) 2021.11
Language：English Publishing type：Research paper (scientific journal) Publisher：Bioengineering
Exosomes are the master transporters of genes, RNAs, microRNAs, proteins, and lipids. They have applications in major diseases, including cancer, cardiovascular diseases, neurological disorders, and diabetes mellitus. Delivery of the exosomes to recipient cells is governed by the functional heterogenicity of the tissues. Engineered exosomes are promising tools in tissue regeneration. In addition to their role as intracellular communication cargos, exosomes are increasingly primed as standard biomarkers in the progression of diseases, thereby solving the diagnostic dilemma. Futuris-tic empowerment of exosomes with OMICS strategy can undoubtedly be a bio-tool in translational medicine. This review discusses the advent transformation of exosomes in regenerative medicine and limitations that are caveats to broader applications in clinical use.
MISC 【 display / non-display 】
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非発光遷移検出によるポリジへキシルシランの光分解性評価
福山敦彦, 境健太郎, 碇 哲雄, 古川昌司
超音波TECHNO 11-12 2009.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：日本工業出版
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圧電素子光熱分光法による微結晶シリコン薄膜の光吸収スペクトル
碇哲雄, 境健太郎, 福山敦彦
超音波TECHNO 9-10 75 - 81 2004.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：日本工業出版
Presentations 【 display / non-display 】
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紫外線励起蛍光カラー画像による農産物の品質評価 〜宮崎県産露地へべすの貯蔵過程における状態変化〜
境健太郎, 日吉健二, 槐島芳徳, 松本朋子, 小林太一, 辻本祐加子, ⻄本素三
日本生物環境工学会2023年豊橋大会 2023.9.13
Event date： 2023.9.12 - 2023.9.15
Language：Japanese Presentation type：Poster presentation
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紫外線励起蛍光分光画像による農産物の品質評価 -へべすの貯蔵過程における状態変化-
小林太一, 日吉健二, 槐島芳徳, 松本朋子, 境健太郎, ⻄本素三, 辻本祐加子
日本生物環境工学会2023年豊橋大会 2023.9.13
Event date： 2023.9.12 - 2023.9.15
Language：Japanese Presentation type：Poster presentation
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植物計測情報によるセル苗CA貯蔵環境制御の可能性 ―深度情報によるトマトセル苗の草丈計測技術の構築−
槐島芳徳, 日吉健二, 松本朋子, 境健太郎, 小林太一, ⻄本素三, 辻本祐加子
日本生物環境工学会2023年豊橋大会 2023.9.13
Event date： 2023.9.12 - 2023.9.15
Language：Japanese Presentation type：Poster presentation
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画像処理による牛の個体識別についてー牛顔検出と個体識別アルゴリズムの構築ー
槐島芳徳, 境健太郎, 小林太一, 山本直之
農業環境工学関連学会2023年合同大会 2023.9.5
Event date： 2023.9.4 - 2023.9.8
Language：Japanese Presentation type：Poster presentation
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FT-IR/ATR法による日向夏みかんのアラビノガラクタン評価に関する研究
小林太一, 山口昌俊, 宮武宗利, 西園祥子, 境健太郎
農業環境工学関連学会2023年合同大会 2023.9.7
Event date： 2023.9.4 - 2023.9.8
Language：Japanese Presentation type：Poster presentation
Industrial property rights 【 display / non-display 】
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三方向成分速度検出機構
盆子原 康博、境 健太郎、中野 敦、寺薗 信一
Applicant：宮崎大学、株式会社アコー
Application no：2023-024877 Date applied：2023.2.21
Announcement no：2023-129306 Date announced：2023.9.14
Country of applicant：Domestic
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判定装置
小林 太一、境 健太郎、日吉 健二、松本 朋子、 槐島 芳德、西本 素、佐藤 喜一郎、仲野 政賢、並川 敬、前田 祥太郎、川合 蕉吾、柳 友理
Applicant：宮崎大学、ダイキン工業株式会社
Application no：22791742.4 Date applied：2022.4.19
Announcement no：EP4303569A1 Date announced：2024.1.4
Country of applicant：Foreign country
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判定装置
小林 太一、境 健太郎、日吉 健二、松本 朋子、槐島 芳徳、西本 素三、佐藤 喜一郎、仲野 政賢、並川 敬、前田 祥太郎、川合 蕉吾、中川 威、柳 友理
Applicant：宮崎大学、ダイキン工業株式会社
Application no：2022-068891 Date applied：2022.4.19
Announcement no：2022-165940 Date announced：2022.11.1
Patent/Registration no：7317324 Date registered：2023.7.21
Country of applicant：Domestic
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判定装置
小林 太一、境 健太郎、日吉 健二、松本 朋子、 槐島 芳德、西本 素、佐藤 喜一郎、仲野 政賢、並川 敬、前田 祥太郎、川合 蕉吾、柳 友理
Applicant：宮崎大学、ダイキン工業株式会社
Application no：202280029094.8 Date applied：2022.4.19
Announcement no：CN117178184A Date announced：2023.12.5
Country of applicant：Foreign country
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ニッケル皮膜の生成方法及びその装置
今井正人、吉野賢二、境健太郎、中野敦
Applicant：宮崎大学
Application no：特願2019-131921 Date applied：2019.7.17
Announcement no：2021-017604 Date announced：2021.2.15
Country of applicant：Domestic
Grant-in-Aid for Scientific Research 【 display / non-display 】
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農薬を光で見よう
2017.04 - 2020.03
科学研究費補助金 基盤研究(C)
境健太郎、小林太一
Available Technology 【 display / non-display 】
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半導体を中心とした機能性材料の物性評価
農産物の光を使った非破壊検査技術の開発
大型分析装置を用いたさまざまな材料の各種分析Home Page： 研究・産学地域連携推進機構研究基盤支援部門HP
Related fields where technical consultation is available：・半導体をはじめとした工業用材料の物性評価に関すること
・様々な材料（農産物等も含む）の機器分析装置を用いた各種分析に関することMessage：・共同研究の希望テーマ:様々な材料の大型分析装置を用いた各種分析
・県内に設置してほしい分析装置があれば、ぜひ教えてください。
・大型分析装置を用いて材料分析したいというニーズがあれば、ぜひご連絡ください。