KANEKO Masatoki

写真a

Affiliation

Faculty of Medicine School of Nursing Parenting generation and child health nursing course

Title

Professor

External Link

Degree 【 display / non-display

  • Medical Doctor ( 2004.2   Miyazaki Medical College )

  • Medical Doctor ( 1987.3   Miyazaki Medical College )

Research Areas 【 display / non-display

  • Life Science / Embryonic medicine and pediatrics

  • Life Science / Obstetrics and gynecology

 

Papers 【 display / non-display

  • The estimation of a cytomegalovirus immunoglobulin G avidity using the mathematical model Invited Reviewed

    Masatoki Kaneko

    Journal of Basic and Clinical Pharmacy   13 ( 127 )   127   2022.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.37532/0976-0113.13(1).127

  • Low maternal immunoglobulin g avidity and single parity as adverse implications of human cytomegalovirus vertical transmission in pregnant women with immunoglobulin m positivity Reviewed

    Kaneko M., Muraoka J., Kusumoto K., Minematsu T.

    Viruses   13 ( 5 )   2021.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Viruses  

    Human cytomegalovirus (CMV) is the leading cause of neurological sequelae in infants. Understanding the risk factors of primary CMV infection is crucial in establishing preventive strategies. Thus, we conducted a retrospective cohort study to identify risk factors of vertical transmission among pregnant women with immunoglobulin (Ig) M positivity. The study included 456 pregnant women with IgM positivity. Information on age, parity, occupation, clinical signs, IgM levels, and IgG avidity index (AI) was collected. The women were divided into infected and non-infected groups. The two groups showed significant differences in IgM level, IgG AI, number of women with low IgG AI, clinical signs, and number of pregnant women with single parity. In the multiple logistic regression analysis, pregnant women with single parity and low IgG AI were independent predictors. Among 40 women who tested negative for IgG antibody in their previous pregnancy, 20 showed low IgG AI in their current pregnancy. Among the 20 women, 4 had vertical transmission. These results provide better understanding of the risk factors of vertical transmission in pregnant women with IgM positivity.

    DOI: 10.3390/v13050866

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  • A multiple regression model for predicting a high cytomegalovirus immunoglobulin G avidity level in pregnant women with IgM positivity Reviewed

    Kaneko M., Ohhashi M., Fujii Y., Minematsu T., Kusumoto K.

    International Journal of Infectious Diseases   100   1 - 6   2020.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:International Journal of Infectious Diseases  

    Objective: To establish a model to predict high cytomegalovirus (CMV) immunoglobulin (Ig)G avidity index (AI) using clinical information, to contribute to the mental health of CMV-IgM positive pregnant women. Methods: We studied 371 women with IgM positivity at ≤14 w of gestation. Information on the age, parity, occupation, clinical signs, IgM and G values, and IgG AI was collected. The IgG AI cut-off value for diagnosing congenital infection was calculated based on a receiver operating characteristic curve analysis. Between-group differences were assessed using the Mann–Whitney U-test or χ2 analysis. The factors predicting a high IgG AI were determined using multiple logistic regression. Results: The women were divided into high or low IgG AI groups based on an IgG AI cut-off value of 31.75. There were significant differences in the IgG and IgM levels, age, clinical signs, and the number of women with one parity between the two groups. In a multiple logistic regression analysis, IgM and the number of women with one parity were independent predictors. This result helped us establish a mathematical model that correctly classified the IgG AI level for 84.6% of women. Conclusion: We established a highly effective model for predicting a high IgG AI immediately after demonstrating IgM positivity.

    DOI: 10.1016/j.ijid.2020.08.034

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  • Intrapartum fetal heart rate monitoring in cases of cytomegalovirus infection Reviewed

    金子 政時,鮫島 浩,池田 智明,池ノ上 克,峰松 俊夫

    Am. J. Obstet. Gynecol.   191   1257 - 1262   2014.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Cell-mediated and humoral immune responses to human cytomegalovirus in pregnant women with vertically transmitted infection following primary infection: A case report Reviewed

    Yamada N., Kaneko M., Yang L., Matsuzawa S., Minematsu T., Kodama Y.

    Journal of Infection and Chemotherapy   29   1071 - 1074   2023.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Infection and Chemotherapy  

    Human cytomegalovirus (HCMV) is the major cause of neurological sequelae in infants. Immune control of primary HCMV infection appears to depend on the interaction between humoral and cell-mediated immune responses. We report the case of an HCMV-transmitter mother observed with dissociation between humoral and cell-mediated immune responses. The patient had immunoglobulin (Ig) G and M positivity at 11 weeks of gestation and showed fetal hyperechoic bowel and minimal ascites at 21 weeks of gestation. At 25 weeks of gestation, the polymerase chain reaction result for HCMV using amniotic fluid was positive. The numbers of spots in the enzyme-linked immunosorbent spot (ELISPOT) assay at 25, 36, and 39 weeks of gestation were three, five, and six spots/2 × 105 peripheral blood mononuclear cells, respectively. Furthermore, IgG avidity indexes (AIs) at 21, 25, 36, and 39 weeks of gestation were 37.6, 49.7, 72.5, and 74.3, respectively. At 40+1 weeks of gestation, the patient delivered a symptomatic infected newborn with a weight of 2,384 g (−2.6 SD) and a head circumference of 30 cm (−2.6 SD). The neonate had a petechial rash and bilateral hearing loss although did not show liver dysfunction or thrombocytopenia. Cranial magnetic resonance imaging revealed mild ventriculomegaly, left lateral/parietal polymicrogyria, and a punctate white matter lesion. This case showed that IgG AI increased with increasing gestational age, whereas the numbers of spots in the ELISPOT assay had no change. The dissociation between humoral and cell-mediated immune responses may be characteristic of the immune response of a transmitter mother.

    DOI: 10.1016/j.jiac.2023.07.004

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Books 【 display / non-display

  • 胎児超音波診断

    金子政時、前山彩( Role: Contributor ,  感染症 TORCH症候群)

    メジカルビュー社  2023.4  ( ISBN:978-4-7583-2148-8 C3047

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    Language:Japanese Book type:Textbook, survey, introduction

  • 周産期の栄養

    金子政時( Role: Contributor ,  食後の胸焼けがひどくなりました。食事はどうしたらよいですか?)

    東京医学社  2022.11 

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    Book type:Textbook, survey, introduction

  • The science of Pregnancy. New edition

    Masatoki Kaneko( Role: Contributor)

    2022.9  ( ISBN:978-4-524-23437-0

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    Language:Japanese Book type:Scholarly book

  • 宮崎市の人口減少問題に対する現状把握と課題解決に向けた提案

    金子政時( Role: Joint author)

    宮崎大学大学院看護学研究科  2022.3 

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    Language:Japanese Book type:Report

  • Cytomegalovirus Infection, Toxoplasmosis

    Kaneko M.( Role: Sole author)

    Cerebral Palsy: Perspective and Clinical Relation to Perinatal Complications/Events in Japan  2022.1  ( ISBN:9789811922169

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    Language:English Book type:Scholarly book

    Congenital cytomegalovirus (CMV) infection and congenital toxoplasmosis can occur when a pregnant woman is infected with CMV or toxoplasma parasites. Infection of pregnant women with these pathogenic microorganisms often goes unrecognized because of asymptomatic or minimal symptoms, and even if they are infected, clinical symptoms are difficult to diagnose because of nonspecific symptoms.

    DOI: 10.1007/978-981-19-2217-6_8

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MISC 【 display / non-display

  • 新しい卒後臨床研修制度の始まりについて

    池ノ上 克,金子 政時

    Clinical OB-Gyne   8 ( 1 )   8 - 11  

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 「垂直感染の管理と対策 5」サイトメガロウイルス

    池田 智明,金子 政時,池ノ上 克

    臨床婦人科産科   58 ( 1 )   55 - 59  

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 一絨毛膜二羊膜性双胎(MD twin)の娩出時期のタイミング MD-Twin Scoreの有用性に関する前方視的研究

    金子 政時,鮫島 浩,池田 智明,池ノ上 克

    周産期シンポジウム   22   73 - 80  

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 多胎妊娠 -ARTによる多胎妊娠の分娩方法-

    金子 政時,鮫島 浩

    産婦人科の実際   53 ( 12 )   1859 - 1863  

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胎内サイトメガロウイルス感染と胎児心拍数モニタリング

    金子 政時,鮫島 浩,池田 智明,池ノ上 克,峰松 俊夫

    産婦人科の実際   53 ( 13 )   2063 - 2068  

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations 【 display / non-display

  • 胎児心拍陣痛図の記録の質を高めよう Invited

    金子政時

    宮崎県産婦人科病医院従事者研修会第26回ひむかセミナー 

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    Event date: 2023.3.4 - 2023.3.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • 母子感染:COVID-19流行の影響 Invited

    金子政時

    宮崎県産婦人科病医院従事者研修会第25回ひむかセミナー  2022.3.6 

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    Event date: 2022.3.5 - 2022.3.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  • 遅発型B型溶連菌による頭頸部蜂窩織炎を呈した超低出生体重児の1例

    金子 政時

    宮崎県産婦人科医会・宮崎県産科婦人科学会令和2年度冬期定時総会・講演会 

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    Event date: 2021.1.30

    Presentation type:Oral presentation (general)  

  • 妊娠18週で胎児胸水に対して胸腔-羊水腔シャント術を行い救命した一例

    金子 政時

    宮崎県産婦人科医会・宮崎県産科婦人科学会令和2年度冬期定時総会・講演会 

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    Event date: 2021.1.30

    Presentation type:Oral presentation (general)  

  • 脳室内出血を生じた超早産児の呼吸循環動態に関連する因子の検討

    金子 政時

    公益社団法人日本産科婦人科学会第72回学術講演会 

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    Event date: 2020.4.23 - 2020.4.28

    Presentation type:Poster presentation  

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Awards 【 display / non-display

  • Best Researcher Award

    2022.2   International Research Awards on Pediatrics, Perinatology and Child Health  

    Masatoki Kaneko

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    Award type:Award from international society, conference, symposium, etc. 

  • 日本母性衛生学会学術論文奨励賞

    2019.10   日本母性衛生学会  

    黒木真菜、金子政時

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • ALSOブロバイダーコース功労賞

    2022.9   周産期医療支援機構ALSO-Japan  

    金子政時

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • 日本産婦人科新生児血液学会真木賞

    2006.6   日本産婦人科新生児血液学会  

    金子政時

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 日本産科婦人科学会学術奨励賞

    2001.4   日本産科婦人科学会  

    金子政時

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • 低侵襲・効率的な胎内サイトメガロウイルス感染症診断のための新たなアルゴリズム開発

    Grant number:21K09452  2021.04 - 2025.03

    独立行政法人日本学術振興会  科学研究費補助金  産科

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    Authorship:Principal investigator 

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  • 子育て期にある女性の健康支援と体力・運動機能向上プログラムの構築

    Grant number:22K11007  2022.04 - 2025.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 絨毛膜羊膜炎におけるプロカルシトニンの変動と周産期領域における意義の解明

    2013.04 - 2016.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    絨毛膜羊膜炎におけるプロカルシトニンの変動と周産期領域における意義の解明

  • 胎内サイトメガロウイルス感染症のハイリスク群抽出法と児の予後に関する研究

    2007.04 - 2009.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    胎内サイトメガロウイルス感染症の児の予後を含めたハイリスク群抽出法を確立する。

Other external funds procured 【 display / non-display

  • Promotion and technical improvement of Team Medical Care in Perinatal Care

    2020.04 - 2021.03

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    Authorship:Principal investigator 

Other research activities 【 display / non-display

  • 厚生労働省科学研究費補助金 難治性疾患克服研究事業 新生児・小児における特発性血栓症の診断、予防および治療法の確立に関する研究

    2014.04 - 2015.03

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    新生児、小児における特発性血栓症の診断、予防および治療法の確立に関する研究において、ハイリスク母体のスクリーニング法の関する研究を分担した。

  • 厚生労働省科学研究費補助金難治性疾患克服研究事業「小児・新生児期における遺伝性血栓症(プロテインC異常症を含む)の効果的診断と治療予防法の確立に関する研究」平成24年度総括・分担研究報告書

    2013.03

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    厚生科研分担報告書

  • サイトメガロウイルス感染と周産期医療

    2012.08

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    Round-Table Discussionの記事掲載

  • 看護師等の高度な臨床実践能力の評価及び向上に関する研究;分担研究報告書「助産師主体の分娩管理における医師との連携に関する研究」

    2012.04 - 2014.03

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    助産師主体の分娩における医師との連携に必要な要件を、厚生労働科学研究費補助金 地域医療基盤開発推進研究事業の中で多施設共同研究を行った。

  • 栓友病の新生児期からの効果的診断法と治療管理法の確立に関する研究

    2011.04 - 2012.03

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    栓友病新生児のハイリスク群を妊婦の病歴から捉える方法に関して研究を行なった。

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