Date Yukari

写真a

Affiliation

Frontier Science Research Center Life science field of inquiry physiology activator function analysis field

Title

Professor

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Degree 【 display / non-display

  • 博士(医学) ( 1995.3   宮崎医科大学 )

  • 医学士 ( 1987.3   大分医科大学 )

Research Areas 【 display / non-display

  • Life Science / Metabolism and endocrinology  / Metabolism

  • Life Science / Metabolism and endocrinology  / Endocrinology

 

Papers 【 display / non-display

  • Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus.

    Jang Y, Heo JY, Lee MJ, Zhu J, Seo C, Go DH, Yoon SK, Yukari D, Oike Y, Sohn JW, Shong M, Kweon GR

    International journal of molecular sciences   22 ( 7 )   2021.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms22073443

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  • Palmitic acid induces guanylin gene expression through the toll-like receptor 4/nuclear factor-κB pathway in rat macrophages

    Akieda-Asai S., Ma H., Date Y.

    American Journal of Physiology - Cell Physiology   317 ( 6 )   C1239 - C1246   2019

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:American Journal of Physiology - Cell Physiology  

    Recently, we showed that double-transgenic rats overexpressing guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), specifically in macrophages demonstrate an antiobesity phenotype and low-expression levels of proinflammatory cytokines in the mesenteric fat even when fed a high-fat diet. Here, we examined the levels and mechanism of Gn and GC-C transcription following saturated fatty acid and lipopolysaccharide (LPS), an activator of Toll-like receptor 4 (TLR4), exposure by using the NR8383 macrophage cell line. In addition, the levels of guanylin and cGMP were increased by addition of either palmitic acid or LPS. Next, we investigated the interaction of the gene transcription and nuclear factor-κB (NF-κB) by using an NF-κB inhibitor and chromatin immunoprecipitation assay. We showed that palmitic acid induced Gn gene expression via TLR4 and NF-κB. Moreover, we demonstrated that NF-κB binding to the Gn promoter was responsible for the induction of gene transcription by palmitic acid or LPS. Our results indicate that saturated fatty acids such as palmitic acid activate Gn gene expression via the NF-κB pathway, raising the possibility that the activated Gn-GC-C system may contribute to the inhibition of high-fat diet-induced proinflammatory cytokines in macrophages.

    DOI: 10.1152/ajpcell.00081.2019

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  • Influence of food texture on energy metabolism and adiposity in male rats.

    Han W, Utoyoma M, Akieda-Asai S, Hidaka A, Yamada C, Hasegawa K, Nunoi H, Date Y

    Exp Physiol   103 ( 10 )   1347 - 1356   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Interleukin-15 derived from Guanylin–GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.

    Akieda-Asai S, Ida T, Miyazato M, Kangawa K, Date Y

    Peptides   99   14 - 19   2018.1

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  • Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue.

    Yasuda M, Kawabata J, Akieda-Asai S, Nasu T, Date Y

    J Vet Sci   18 ( 3 )   341 - 348   2017.9

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Books 【 display / non-display

  • Brain and Orexin

    Date Y( Role: Joint author)

    Kyouritsu Syuppann  2005.9 

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    Language:Japanese Book type:Scholarly book

  • Gastro-Entero-Pancreatic Action of Ghrelin

    Date Y 他( Role: Joint author)

    Springer  2003.4 

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    Language:English Book type:Scholarly book

MISC 【 display / non-display

  • Common clinicopathological features in late-onset hereditary transthyretin amyloidosis (Ala97Gly, Val94Gly and Val30Met)

    Koike H., Nakamura T., Nishi R., Ikeda S., Kawagashira Y., Iijima M., Yasuda T., Mukai E., Date Y., Shiomi K., Nakazato M., Katsuno M., Sobue G.

    Amyloid   26 ( sup1 )   24 - 25   2019.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:Amyloid  

    DOI: 10.1080/13506129.2019.1582495

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  • グレリン関連物質

    伊達紫

    ホルモンと臨床   54 ( 12 )   116 - 120   2006.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:医学の世界社  

  • PYY3-36

    伊達 紫

    内分泌・糖尿病科   23 ( 3 )   309 - 312   2006.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:科学評論社  

  • 摂食行動の分子メカニズム

    伊達 紫

    実験医学   24 ( 15 )   2434 - 2439   2006.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:羊土社  

  • 消化管由来摂食調節因子(グレリンとCCKを中心に)

    伊達 紫

    内分泌・糖尿病科   22 ( 5 )   499 - 504   2006.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:科学評論社  

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Presentations 【 display / non-display

  • グアニリン・グアニル酸シクラーゼC発現マクロファージ由来のIL-15による脂肪蓄積抑制機構 International conference

    秋枝さやか, 伊達紫

    第40回日本肥満学会 

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    Event date: 2019.11.2

    Language:Japanese  

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  • Influence of food texture on energy metabolism and adiposity in male rats. International conference

    Han W, Utoyama M, Akieda-Asai S, Date Y

    Influence of food texture on energy metabolism and adiposity in male rats. 

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    Event date: 2018.8.18

    Language:Japanese  

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  • グアニリンおよびグアニル酸シクラーゼC高発現マクロファージ由来のIL-15は脂肪細胞の脂肪酸合成を抑制する International conference

    秋枝さやか, 井田隆徳, 宮里幹也, 伊達紫

    第91回日本内分泌学会 

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    Event date: 2018.4.28

    Language:Japanese  

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  • 農と食の未来を切り拓け!ホルモン研究-「食物の性状が糖代謝や脂質代謝に及ぼす影響」 International conference

    秋枝さやか, 伊達紫

    ConBio2017 

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    Event date: 2017.12.6

    Language:Japanese  

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  • Sex differences in high-fat diet-induced obesity in rats International conference

    Sex differences in high-fat diet-induced obesity in rats 

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    Event date: 2017.5.29

    Language:Japanese  

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Awards 【 display / non-display

  • 日本肥満学会学術奨励賞

    2007.10   日本肥満学会  

    伊達 紫

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 日本内分泌学会研究奨励賞

    2006.5   日本内分泌学会  

    伊達 紫

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 川上賞

    2004.10   日本神経内分泌学会  

    伊達 紫

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • トランスサイレチン変異による心アミロイドーシスの遺伝子解析と臨床像の特徴

    2001.4   日本内科学会  

    伊達 紫

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • 軟らかい食物摂取により引き起こされる日本人型糖尿病の病態解析

    2016.04 - 2019.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 軟らかい食物が小太り糖尿病をまねく機序とその分子機構の解明

    2013.04 - 2016.03

    科学研究費補助金  挑戦的萌芽研究

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    Authorship:Principal investigator 

    軟らかい食物が小太り糖尿病をまねく機序とその分子機構の解明

  • 脂肪滴蓄積制御におけるグアニリン/GC-C発現マクロファージの役割

    2013.04 - 2015.03

    科学研究費補助金  新学術領域研究(研究領域提案型)(公募研究)

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    Authorship:Principal investigator 

    脂肪滴蓄積制御におけるグアニリン/GC-C発現マクロファージの役割

  • 肥満制御に機能する腸間膜生理活性ペプチドの役割

    2011.04 - 2013.03

    科学研究費補助金  新学術領域研究

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    Authorship:Principal investigator 

    肥満制御に機能する腸間膜生理活性ペプチドの役割

  • 高脂肪食耐性ラットのエネルギー代謝特性と肥満制御に関わる新たな分子基盤の解明

    2010.04 - 2013.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    高脂肪食耐性ラットのエネルギー代謝特性と肥満制御に関わる新たな分子基盤の解明

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