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Faculty of Agriculture Region of Applied Biochemistry and Biotechnology |
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Professor |
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Related SDGs |
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YAMASAKI Masao
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Papers 【 display / non-display 】
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食品中のナノ粒子に関する機能性研究 Reviewed
山﨑正夫、山﨑有美、大島達也
化学と生物 61 ( 2 ) 78 - 84 2023.2
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Nanovesicles derived from edible plants: a new player that contributes to the function of foods
Yamasaki M., Yamasaki Y., Oshima T.
Bioscience, Biotechnology and Biochemistry 89 ( 2 ) 179 - 186 2025.2
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Bioscience, Biotechnology and Biochemistry
Nano-sized vesicles are ubiquitous in vegetables, fruits, and other edible plants. We have successfully prepared nanovesicles (NVs) from over 150 edible plants. These results suggest that the daily intake of NVs from various foods and their roles in food function are promising novel approaches for explaining the health-promoting properties of edible plants. These vesicles contain RNAs, including miRNAs, similar to extracellular NVs, which play pivotal roles in cell-cell communication. Intriguingly, NVs also contain phytochemicals such as polyphenols and carotenoids that are specific to each edible plant. In conclusion, these dietary NVs have the potential to serve as functional packages to deliver RNAs or phytochemicals to target cells across species from plants to humans.
DOI： 10.1093/bbb/zbae198
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Nei S., Matsusaki T., Kawakubo H., Ogawa K., Nishiyama K., Tsend-Ayush C., Nakano T., Takeshita M., Shinyama T., Yamasaki M.
Nutrients 16 ( 17 ) 2024.9
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Nutrients
ATP-binding cassette transporter subfamily G member 2 (ABCG2) is responsible for the excretion of foreign substances, such as uric acid (UA) and indoxyl sulfate (IS), from the body. Given the importance of increased ABCG2 expression in UA excretion, we investigated the enhancement of intestinal ABCG2 expression using Lactiplantibacillus plantarum 06CC2 (LP06CC2). Mice were reared on a potassium oxonate-induced high-purine model at doses of 0.02% or 0.1% LP06CC2 for three weeks. Results showed that LP06CC2 feeding resulted in increased ABCG2 expression in the small intestine. The expression level of large intestinal ABCG2 also showed a tendency to increase, suggesting upregulation of the intestinal excretion transporter ABCG2 by LP06CC2. Overall, LP06CC2 treatment increased fecal UA excretion and showed a trend towards increased fecal excretion of IS, suggesting that LP06CC2 treatment enhanced the expression of intestinal ABCG2, thereby promoting the excretion of UA and other substances from the intestinal tract.
DOI： 10.3390/nu16173042
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Takeguchi Toru, Kai Hisahiro, Takeshita Michika, Miura Maho, Ogawa Kenjirou, Nishiyama Kazuo, Yamasaki Masao
Journal of Oleo Science 73 ( 7 ) 991 - 999 2024.7
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Oil Chemists' Society
In this study, we evaluated the cancer cell killing activity of koji mold-derived extracts using several solvents. The koji mold lipid extract (KML) exhibited potent cytotoxicity against a human leukemia cell line. Fractionation of the KML via silica gel chromatography revealed the presence of active components in fraction (Fr.) 6. Cytotoxic effects of Fr. 6 were inhibited by the ferroptosis inhibitors, ferrostatin-1 and SRS11-92, and the iron chelator, deferoxamine. Interestingly, ferroptosis inhibitors failed to prevent the KML-induced cell death. Fr. 6 decreased the expression of glutathione peroxidase 4 (GPx4) and increased the level of peroxidized plasma membrane lipids. Furthermore, Fr. 6 decreased the intracellular glutathione levels. Overall, our results suggest that Fr. 6 included in KML induces ferroptosis in HL-60 cells.
DOI： 10.5650/jos.ess24043
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Yamasaki Yumi, Kawano Ami, Matsumoto Tomoko, Oshima Tatsuya, Yamasaki Masao
Nippon Shokuhin Kagaku Kogaku Kaishi 71 ( 5 ) 181 - 181 2024.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Food Science and Technology
DOI： 10.3136/nskkk.71.181
Books 【 display / non-display 】
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『食品機能性脂質の基礎と応用』
山崎正夫（ Role： Sole author）
シーエムシー出版 2018.6
Language：Japanese Book type：Scholarly book
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Advances in Conjugated Linoleic Acid Research 3
M. Yamasaki, H. Chujo, and K. Yamada. （ Role： Joint author）
AOCS press 2006.11
Language：English Book type：Scholarly book
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「食品成分のはたらき」
山崎正夫、山田耕路（ Role： Joint author）
朝倉書店 2004.3
Language：Japanese Book type：Scholarly book
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Advances in Conjugated Linoleic Acid Research 1
M. Sugano, M. Yamasaki, K. Yamada, and Y.-S. Huang（ Role： Joint author）
AOCS press 1999.11
Language：English Book type：Scholarly book
MISC 【 display / non-display 】
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食品が私たちの体に語りかけること Invited
山﨑正夫
日本醸造学会誌 2021.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本醸造学会
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脂質分析の観点から見たin vivoにおける抗アレルギー活性評価法
山崎正夫、西山和夫
生物機能研究法 2013.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：生物機能研究所
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がん悪性形質のレドックス制御機能評価法
西山先生、岩瀬将弘、山崎正夫
生物機能研究法 2013.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：生物機能研究所
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Yamasaki M., Nagatomo T., Matsuyama T., Ikeho Y., Kato E., Nishiyama K., Sakakibara Y., Suiko M., Nishiyama K.
Journal of Oleo Science 61 ( 9 ) 491 - 496 2012.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Journal of Oleo Science
The anti-cancer effects of various fatty acids are drawing a lot of attention. To determine whether different fatty acids affect the hypoxic response of liver cancer cells, we examined the effects of various fatty acids on the stabilization of the hypoxia-inducible factor (HIF)-1α protein in the HepG2 human hepatocellular carcinoma (HCC) cell line under condition containing 1% O 2 . Of the fatty acids examined, only 9cis, 11trans (c9, t11)-conjugated linoleic acid (CLA) and 10trans, 12cis (t10, c12)-CLA inhibited hypoxia-induced HIF-1α stabilization. In addition, HIF-1α prolyl hydroxylase or proteasome inhibition abrogated the effects of c9, t11- and t10, c12-CLA. Moreover, c9, t11- and t10, c12-CLA significantly inhibited cell proliferation and induced apoptotic cell death under hypoxia. This is the first study showing that c9, t11- and t10, c12-CLA inhibit the hypoxic response in HCC cells. ©2012 by Japan Oil Chemists' Society.
DOI： 10.5650/jos.61.491
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大豆イソフラボンの抗ATL（成人T細胞性白血病）作用
山崎正夫、西山和夫
バイオサイエンスとインダストリー 68 ( 5 ) 2010.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：バイオインダストリー協会
Presentations 【 display / non-display 】
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Search for components from methanol extract of PUERARIAE RADIX that inhibit the proliferation of adult T-cell leukemia cells
2025.3
Event date： 2025.3.26
Language：Japanese Presentation type：Oral presentation (general)
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動脈弛緩活性を介したブルーベリー葉エキスによる降圧作用の検討
藤田裕之、山崎正夫、福士江里、矢野善久
日本農芸化学会
Event date： 2025.3
Presentation type：Oral presentation (general)
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納豆から単離したエクソソーム様ナノ粒子の抗炎症作用
山田凜、稲田飛鳥、大島達也、山﨑有美、宮内大治、秋野利郎、小川健二郎、西山和夫、山﨑正夫
日本フードファクター学会
Event date： 2024.12
Presentation type：Oral presentation (general)
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低酸素状態における脂肪細胞の細胞内酸素濃度に対する共役リノール酸(CLA)の影響
岡本清貴、七瀬唯、小川健二郎、西山和夫、山﨑正夫
日本フードファクター学会
Event date： 2024.12
Presentation type：Oral presentation (general)
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ブルーベリー葉熱水抽出物 (BLEx) の抗炎症作用とそのメカニズムの探求 International coauthorship
竹原直也、曲宗信、田中夏子、 児玉直輝、山崎有美、小川健二郎、 西山和夫、Shaikh.M. Rahman、山崎正夫
日本栄養・食糧学会
Event date： 2024.5
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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宮崎銀行ふるさと振興助成事業
2024.3 みやぎん経済研究所
山崎正夫
Award type：Award from publisher, newspaper, foundation, etc.
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日本栄養・食糧学会 奨励賞
2013.5 日本栄養・食糧学会
山崎正夫
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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日本農芸化学会西日本支部奨励賞
2004.1 日本農芸化学会
山崎正夫
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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脂肪細胞の低酸素ストレス抑制による生活習慣 病予防
Grant number：21H02142 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
Authorship：Principal investigator
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プラント・オパール中の遺伝情報を利用した稲 作史研究手法の構築に向けた学際的研究
Grant number：19H00542 2021.04 - 2024.03
日本学術振興会 科学研究費補助金 基盤研究(A)
Authorship：Coinvestigator(s)
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食機能実行分子とその機能的相互作用の統合的理解
Grant number：20H05683 2020.08 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(S)
Authorship：Coinvestigator(s)
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機能性脂質による高尿酸血症の改善
Grant number：18K05520 2018.04 - 2021.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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種を超えたエクソソームシグナル伝達による画期的食品機能性発現の可能性
Grant number：15K14736 2015.04 - 2018.03
科学研究費補助金 挑戦的萌芽研究
Authorship：Principal investigator
植物性食品中の微粒子の存在同定と、機能性評価
Other research activities 【 display / non-display 】
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CLA懇話会事務局
2004.04 - 2010.10
CLA懇話会開催、会計、諸雑務
Available Technology 【 display / non-display 】
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地域食材の健康機能性評価
食品中のナノ粒子の機能性評価
生活習慣病予防に寄与する食品成分に関する研究Home Page： 食品機能化学研究室
Related fields where technical consultation is available：・食品の健康機能性評価
Message：・食品の高付加価値化に向けて、食品の機能性評価をしたいニーズがあればお知らせください。