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Affiliation |
Faculty of Agriculture Department of Biochemistry and Applied Biosciences Food function chemical course |
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YAMASAKI Masao
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Papers 【 display / non-display 】
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食品中のナノ粒子に関する機能性研究 Reviewed
山﨑正夫、山﨑有美、大島達也
化学と生物 61 ( 2 ) 78 - 84 2023.2
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Yamasaki Yumi, Kawano Ami, Matsumoto Tomoko, Oshima Tatsuya, Yamasaki Masao
Nippon Shokuhin Kagaku Kogaku Kaishi 71 ( 3 ) 83 - 91 2024.3
Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Food Science and Technology
β-Cryptoxanthin is a type of carotenoid that contributes to the maintenance and improvement of human health. However, it is sensitive to heat during cooking and food processing. Furthermore, like other carotenoids, β-cryptoxanthin is also highly hydrophobic and does not readily solubilize in the gastrointestinal tract. This property results in its low bioaccessibility, and considerable knowledge has been accumulated on improving the bioavailability of β-cryptoxanthin. In this study, we evaluated the effects of different processing methods on the residual amount of β-cryptoxanthin in kumquats. The results showed that preparation of kumquat paste contained more β-cryptoxanthin than its puree. Next, when the paste was mixed with fermented <i>Aspergillus oryzae</i> milk, the β-cryptoxanthin content did not change. A pasteurization study of the kumquat paste mixed with the fermented milk showed that β-cryptoxanthin was more stable at 65 °C than at 85 °C. In addition, to improve the bioaccessibility of β-cryptoxanthin, a mixture of the fermented milk and kumquat-derived β-cryptoxanthin was evaluated using a human intestinal epithelial Caco-2 cell model. The results showed that β-cryptoxanthin in the mixture permeated the membrane 14 times more than β-cryptoxanthin alone.
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<i>Lactiplantibacillus plantarum</i> 06CC2 upregulates intestinal ZO-1 protein and bile acid metabolism in Balb/c mice fed high-fat diet Reviewed
YAMASAKI Masao, MIYAMOTO Yuko, OGAWA Kenjirou, NISHIYAMA Kazuo, TSEND-AYUSH Chuluunbat, LI Yiran, MATSUSAKI Tatsuya, NAKANO Tomoki, TAKESHITA Masahiko, ARIMA Yuo
Bioscience of Microbiota, Food and Health advpub ( 0 ) 2024.1
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：BMFH出版会
The effects of <i>Lactiplantibacillus plantarum </i>06CC2 (LP06CC2), which was isolated from a Mongolian dairy product, on lipid metabolism and intestinal tight junction–related proteins in Balb/c mice fed a high-fat diet (HFD) were evaluated. The mice were fed the HFD for eight weeks, and the plasma and hepatic lipid parameters, as well as the intestinal tight junction–related factors, were evaluated. LP06CC2 slightly reduced the adipose tissue mass. Further, it dose-dependently decreased plasma total cholesterol (TC). The HFD tended to increase the plasma level of endotoxin and suppressed intestinal ZO-1 expression, whereas a low LP06CC2 dose increased ZO-1 expression and tended to reduce the plasma lipopolysaccharide level. Furthermore, a low LP06CC2 dose facilitated a moderate accumulation of Lactobacillales, a significant decrease in <i>Clostridium </i>cluste<i>r </i>IV, and an increase in <i>Clostridium </i>cluster<i></i>XVIII. The results obtained from analyzing the bile acids (BAs) in feces and cecum contents exhibited a decreasing trend for secondary and conjugated BAs in the low LP06CC2–dose group. Moreover, a high LP06CC2 dose caused excess accumulation of Lactobacillales and failed to increase intestinal ZO-1 and occludin expression, while the fecal butyrate level increased dose dependently in the LP06CC2-fed mice. Finally, an appropriate LP06CC2 dose protected the intestinal barrier function from the HFD and modulated BA metabolism.
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Role of Extracellular Vesicles in Absorption and Functional Mechanisms of Quercetin Reviewed
Ishisaka A., Sugimoto R., Marumo H., Doi T., Hamada K., Fujimoto M., Fujiwara N., Yamasaki M., Murakami A.
Molecular Nutrition and Food Research 67 ( 21 ) e2300225 2023.11
Language：English Publishing type：Research paper (scientific journal) Publisher：Molecular Nutrition and Food Research
Scope: Quercetin (QUE), a phytochemical found in various plant foods, has been shown to have a variety of physiological activities in vivo, though biological sites where it has activities and the mechanisms of transport have not been fully elucidated. Methods and results: In the present study, intracellular uptake of QUE into HT-29 human colon adenocarcinoma cells is found to result in spontaneous release of extracellular vesicles (EVs), which are subsequently embedded with QUE. In addition, QUE-embedded EVs are detected in serum of QUE-administered Sprague-Dawley rats. Interestingly, the rate of cellular uptake of QUE-encapsulated EVs (EV-QUE) into RAW264.7 macrophages is markedly higher than that of free QUE. Moreover, EV-QUE suppresses lipopolysaccharide (LPS)-induced nitric oxide at a lower concentration than free QUE. Conclusion: The present findings suggest that QUE may be embedded in EVs in the gastrointestinal tract, then become absorbed and enter the bloodstream to exhibit biological activities.
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Ogawa Kenjirou, Karitani Takara, Otsu Wataru, Nishiyama Kazuo, Kunitake Hisato, Goto Yo, Nomiyama Shota, Hara Hideaki, Yamasaki Masao
BPB Reports 6 ( 3 ) 87 - 97 2023.5
Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：公益社団法人 日本薬学会
<i>Background</i>: Blue light causes retinal photoreceptor damage via oxidative and endoplasmic reticulum (ER) stress. A previous study showed that blueberry stem extract (BStEx) and its active components have cytoprotective effects against blue-light-induced photoreceptor cell damage by suppressing oxidative stress. This study demonstrated the inhibitory effect of BStEx against blue light-induced ER stress in photoreceptor cells. <i>Methods</i>: The photoreceptor cells treated with BStEx or the antioxidant <i>N</i>-Acetyl-L-cysteine (NAC) as a positive control were used and then exposed to blue light. The cytoprotective effects of BStEx and NAC were evaluated using CCK-8. The ER stress-related protein expression changes over time, and its levels were measured after each exposure time to blue light in photoreceptor cells treated with BStEx or NAC. <i>Results</i>: BStEx and NAC showed protective effects against blue-light-induced photoreceptor morphological abnormalities and cell damage. Although blue light triggered ER stress factors such as BiP, PERK, ATF6, eIF2α, ATF4, and CHOP, which in turn stimulated cell cycle arrest factors p53 and p21 and upregulation of apoptosis-inducing factors caspase-3. However, BStEx suppressed the increase in expression of BiP, ATF4, ATF6, CHOP, p53, p21, and caspase-3, but not mitochondrial apoptotic factors Bax and cytochrome c. Furthermore, the antioxidant NAC showed similar suppressive effects on BStEx. <i>Conclusion</i>: Our findings suggest that blue light-induced ER stress is primarily caused by oxidative stress, and BStEx might suppress ER stress via an antioxidant effect. The antioxidant NAC contributes to the cell proliferative capacity and suppression of apoptosis in photoreceptor cells.
Books 【 display / non-display 】
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『食品機能性脂質の基礎と応用』
山崎正夫（ Role： Sole author）
シーエムシー出版 2018.6
Language：Japanese Book type：Scholarly book
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Advances in Conjugated Linoleic Acid Research 3
M. Yamasaki, H. Chujo, and K. Yamada. （ Role： Joint author）
AOCS press 2006.11
Language：English Book type：Scholarly book
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「食品成分のはたらき」
山崎正夫、山田耕路（ Role： Joint author）
朝倉書店 2004.3
Language：Japanese Book type：Scholarly book
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Advances in Conjugated Linoleic Acid Research 1
M. Sugano, M. Yamasaki, K. Yamada, and Y.-S. Huang（ Role： Joint author）
AOCS press 1999.11
Language：English Book type：Scholarly book
MISC 【 display / non-display 】
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食品が私たちの体に語りかけること Invited
山﨑正夫
日本醸造学会誌 2021.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本醸造学会
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脂質分析の観点から見たin vivoにおける抗アレルギー活性評価法
山崎正夫、西山和夫
生物機能研究法 2013.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：生物機能研究所
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がん悪性形質のレドックス制御機能評価法
西山先生、岩瀬将弘、山崎正夫
生物機能研究法 2013.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：生物機能研究所
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Yamasaki M., Nagatomo T., Matsuyama T., Ikeho Y., Kato E., Nishiyama K., Sakakibara Y., Suiko M., Nishiyama K.
Journal of Oleo Science 61 ( 9 ) 491 - 496 2012.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Journal of Oleo Science
The anti-cancer effects of various fatty acids are drawing a lot of attention. To determine whether different fatty acids affect the hypoxic response of liver cancer cells, we examined the effects of various fatty acids on the stabilization of the hypoxia-inducible factor (HIF)-1α protein in the HepG2 human hepatocellular carcinoma (HCC) cell line under condition containing 1% O 2 . Of the fatty acids examined, only 9cis, 11trans (c9, t11)-conjugated linoleic acid (CLA) and 10trans, 12cis (t10, c12)-CLA inhibited hypoxia-induced HIF-1α stabilization. In addition, HIF-1α prolyl hydroxylase or proteasome inhibition abrogated the effects of c9, t11- and t10, c12-CLA. Moreover, c9, t11- and t10, c12-CLA significantly inhibited cell proliferation and induced apoptotic cell death under hypoxia. This is the first study showing that c9, t11- and t10, c12-CLA inhibit the hypoxic response in HCC cells. ©2012 by Japan Oil Chemists' Society.
DOI： 10.5650/jos.61.491
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大豆イソフラボンの抗ATL（成人T細胞性白血病）作用
山崎正夫、西山和夫
バイオサイエンスとインダストリー 68 ( 5 ) 2010.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：バイオインダストリー協会
Presentations 【 display / non-display 】
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食用植物のナノ粒子の機能性評価
山﨑正夫、山﨑有美、大島達也
2024年度日本農芸化学会大会
Event date： 2024.3.23 - 2024.3.27
Presentation type：Symposium, workshop panel (nominated)
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麹菌発酵乳飲料によるきんかん由来β - クリ プトキサンチンの腸管吸収能向上
山崎 有美、河野 愛未、大島 達也、 松本 朋子、山中 章英 、古市 佳代、 山崎 正夫
第77回日本栄養・食糧学会
Event date： 2023.5.12 - 2023.5.14
Presentation type：Poster presentation
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ブロッコリーナノベシクルの抗炎症作用
森田 優花、押川 妃乃、小野 江梨花、 園田 紘子 、池田 正浩、山崎 有美、 大島 達也、立花 宏文、小川 健ニ郎、 西山 和夫、山崎 正夫
第77回日本栄養・食糧学会
Event date： 2023.5.12 - 2023.5.14
Presentation type：Poster presentation
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青色光誘発網膜視細胞障害に対するブルー ベリー葉エキスの網膜保護作用
浦田 果林、菅本 和寛、鈴木 耀介、 國武 久登 、山﨑 正夫、西山 和夫、 後藤 陽、野見山 将太、小川 健二郎
第77回日本栄養・食糧学会
Event date： 2023.5.12 - 2023.5.14
Presentation type：Poster presentation
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ブルーベリー葉抽出エキスによる動脈弛緩 反応を介した降圧作用に関する研究
藤田 裕之、Shen Chenfeng、Cong Xinyu、 山崎 正夫、矢野 善久
第77回日本栄養・食糧学会
Event date： 2023.5.12 - 2023.5.14
Presentation type：Poster presentation
Awards 【 display / non-display 】
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宮崎銀行ふるさと振興助成事業
2024.3 みやぎん経済研究所
山崎正夫
Award type：Award from publisher, newspaper, foundation, etc.
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日本栄養・食糧学会 奨励賞
2013.5 日本栄養・食糧学会
山崎正夫
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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日本農芸化学会西日本支部奨励賞
2004.1 日本農芸化学会
山崎正夫
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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脂肪細胞の低酸素ストレス抑制による生活習慣 病予防
Grant number：21H02142 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
Authorship：Principal investigator
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プラント・オパール中の遺伝情報を利用した稲 作史研究手法の構築に向けた学際的研究
Grant number：19H00542 2021.04 - 2024.03
日本学術振興会 科学研究費補助金 基盤研究（A）
Authorship：Coinvestigator(s)
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食機能実行分子とその機能的相互作用の統合的理解
Grant number：20H05683 2020.08 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(S)
Authorship：Coinvestigator(s)
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機能性脂質による高尿酸血症の改善
Grant number：18K05520 2018.04 - 2021.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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種を超えたエクソソームシグナル伝達による画期的食品機能性発現の可能性
2015.04 - 2018.03
科学研究費補助金 挑戦的萌芽研究
Authorship：Principal investigator
植物性食品中の微粒子の存在同定と、機能性評価
Other research activities 【 display / non-display 】
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CLA懇話会事務局
2004.04 - 2010.10
CLA懇話会開催、会計、諸雑務
Available Technology 【 display / non-display 】
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地域食材の健康機能性評価
食品中のナノ粒子の機能性評価
生活習慣病予防に寄与する食品成分に関する研究Home Page： 食品機能化学研究室
Related fields where technical consultation is available：・食品の健康機能性評価
Message：・食品の高付加価値化に向けて、食品の機能性評価をしたいニーズがあればお知らせください。