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Faculty of Agriculture Region of Applied Biochemistry and Biotechnology |
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Papers 【 display / non-display 】
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食品中のナノ粒子に関する機能性研究 Reviewed
山﨑正夫、山﨑有美、大島達也
化学と生物 61 ( 2 ) 78 - 84 2023.2
Authorship:Lead author, Corresponding author Language:Japanese Publishing type:Research paper (scientific journal)
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Broccoli-derived nanovesicles inhibited LPS-induced inflammatory response in mouse macrophage RAW264 cells. Reviewed International coauthorship
Morita S, Machida K, Yamasaki Y, Sato M, Oshikawa H, Oshima T, Ogawa K, Nishiyama K, Tachibana H, Yamasaki M
Bioscience, biotechnology, and biochemistry 90 ( 4 ) 561 - 570 2026.3
Authorship:Last author, Corresponding author Language:English Publishing type:Research paper (scientific journal)
DOI: 10.1093/bbb/zbag009
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Moghtaderi H., Darweesh M., Mohammadi S., Rahman M.M., Yamasaki Y., Yamasaki M., Al Harrasi A., Rahman S.M.
Bioscience Biotechnology and Biochemistry 90 ( 2 ) 243 - 251 2026.2
Language:English Publishing type:Research paper (scientific journal) Publisher:Bioscience Biotechnology and Biochemistry
Blueberry stem extract (BSE), which contains phenolic compounds like proanthocyanidins, reduces liver lipid synthesis, boosts anti-adult T-cell leukemia action, protects retinal cells from blue light damage, and prevents lacrimal hyposecretion. However, the anticancer functions and immunomodulatory effects of BSE are not well understood. To assess the anticancer properties of BSE, MCF-7 and MDA-MB-231 breast cancer (BC) cells were treated with various concentrations of BSE. BSE suppressed the growth of BC cells in a manner dependent on both dose and exposure times. Furthermore, it triggered apoptosis by disrupting mitochondrial membrane potential. BSE also inhibited cell motility in BC cells. Notably, it reduced the expression of PD-1, TIGIT, and LAG-3 immune checkpoint proteins in peripheral blood mononuclear cells, which are critical for antitumor immune response. These findings suggest that BSE has promising anticancer and immunomodulatory properties that warrant further investigation in preclinical models.
DOI: 10.1093/bbb/zbaf182
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Lactiplantibacillus plantarum Strain 06CC2 Attenuates Fat Accumulation and Modulates the Gut Microbiota in a Mouse Model of Early-Stage Diet-Induced Obesity Reviewed International coauthorship
Tatsuya Matsusaki, Chisato Takakura, Kaho Ichitani, Chuluunbat Tsend-Ayush, Hiroaki Kataoka, Tsuyoshi Fukushima, Junko Kurogi , Kazuo Nishiyama, Kenjirou Ogawa, Takuo Shinyama, Tomoki Nakano, Masao Yamasaki
Nutrients 17 ( 3855 ) 2025.12
Authorship:Corresponding author Language:English Publishing type:Research paper (scientific journal)
DOI: 10.3390/nu17243855
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Kanai Yuki, Asakura Mai, Nagayama Shiho, Takahashi Katsuyoshi, Kawahara Satoshi, Yamasaki Masao
Nippon Shokuhin Kagaku Kogaku Kaishi 72 ( 8 ) 267 - 277 2025.8
Language:Japanese Publishing type:Research paper (scientific journal) Publisher:Japanese Society for Food Science and Technology
The term “<i>koku</i>” is often used by consumers as a sensory descriptor for yogurt-related products. The objective of this study was to understand the sensation of “<i>koku</i>” by exploring the sensory attributes of yogurt drinks consumers recognize as forming “<i>koku</i>”. Initially, a QDA test was conducted on eight commercial samples to identify and measure sensory attributes using the vocabulary derived from consumers. Seven samples selected from the QDA results were then used to evaluate the intensity of “<i>koku</i>” using an untrained panel (n=38). Based on the results of “<i>koku</i>” intensity, a cluster analysis of the 38 panelists was conducted, which resulted in three clusters of 28 (72%), 7 (18%) and 3 (8%) panelists. By performing PLS regression analysis on the “<i>koku</i>” intensity of each cluster and the QDA results, we were able to estimate the sensory attributes associated with the perception of “<i>koku</i>” in each cluster. Based on the findings of this study, further refinement of the sensory attributes may serve as an indicator in determining the sensory attributes that should be emphasized in the development of “<i>koku</i>” yogurt drink products.
Books 【 display / non-display 】
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フードケミカルバイオロジー
山崎正夫。藤村由紀、榊原啓之、立花宏文( Role: Edit)
建帛社 2025.7
Book type:Scholarly book
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『食品機能性脂質の基礎と応用』
山崎正夫( Role: Sole author)
シーエムシー出版 2018.6
Language:Japanese Book type:Scholarly book
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Advances in Conjugated Linoleic Acid Research 3
M. Yamasaki, H. Chujo, and K. Yamada. ( Role: Joint author)
AOCS press 2006.11
Language:English Book type:Scholarly book
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「食品成分のはたらき」
山崎正夫、山田耕路( Role: Joint author)
朝倉書店 2004.3
Language:Japanese Book type:Scholarly book
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Advances in Conjugated Linoleic Acid Research 1
M. Sugano, M. Yamasaki, K. Yamada, and Y.-S. Huang( Role: Joint author)
AOCS press 1999.11
Language:English Book type:Scholarly book
MISC 【 display / non-display 】
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食品が私たちの体に語りかけること Invited
山﨑正夫
日本醸造学会誌 2021.4
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:日本醸造学会
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脂質分析の観点から見たin vivoにおける抗アレルギー活性評価法
山崎正夫、西山和夫
生物機能研究法 2013.1
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:生物機能研究所
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がん悪性形質のレドックス制御機能評価法
西山先生、岩瀬将弘、山崎正夫
生物機能研究法 2013.1
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:生物機能研究所
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Yamasaki M., Nagatomo T., Matsuyama T., Ikeho Y., Kato E., Nishiyama K., Sakakibara Y., Suiko M., Nishiyama K.
Journal of Oleo Science 61 ( 9 ) 491 - 496 2012.11
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher:Journal of Oleo Science
The anti-cancer effects of various fatty acids are drawing a lot of attention. To determine whether different fatty acids affect the hypoxic response of liver cancer cells, we examined the effects of various fatty acids on the stabilization of the hypoxia-inducible factor (HIF)-1α protein in the HepG2 human hepatocellular carcinoma (HCC) cell line under condition containing 1% O 2 . Of the fatty acids examined, only 9cis, 11trans (c9, t11)-conjugated linoleic acid (CLA) and 10trans, 12cis (t10, c12)-CLA inhibited hypoxia-induced HIF-1α stabilization. In addition, HIF-1α prolyl hydroxylase or proteasome inhibition abrogated the effects of c9, t11- and t10, c12-CLA. Moreover, c9, t11- and t10, c12-CLA significantly inhibited cell proliferation and induced apoptotic cell death under hypoxia. This is the first study showing that c9, t11- and t10, c12-CLA inhibit the hypoxic response in HCC cells. ©2012 by Japan Oil Chemists' Society.
DOI: 10.5650/jos.61.491
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大豆イソフラボンの抗ATL(成人T細胞性白血病)作用
山崎正夫、西山和夫
バイオサイエンスとインダストリー 68 ( 5 ) 2010.8
Language:Japanese Publishing type:Article, review, commentary, editorial, etc. (scientific journal) Publisher:バイオインダストリー協会
Presentations 【 display / non-display 】
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Lactiplantibacillus plantarum 06CC2 による高脂肪食フルクトース摂取マウスの 脂質代謝改善作用
高倉知里、市谷花帆、松崎竜也、中野智木、竹下正彦、新山拓男、 Tsend-Ayush Chuluunbat、福島剛 、 佐藤勇一郎 、小川健二郎 、西山 和夫 、 山崎 正夫
第79回日本栄養・食糧学会
Event date: 2025.5.23 - 2025.5.25
Presentation type:Oral presentation (general)
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3 色のパプリカ由来ナノ粒子の特性解析と RAW264.7 細胞におけるNO産生抑制作用
山崎有美、時松桃花、中屋敷香波、 鵜戸真尋 、成合美香 、松本朋子 、 大島達也 、田上兼輔 、河野拓人 、 山崎正夫
第79回日本栄養・食糧学会
Event date: 2025.5.23 - 2025.5.25
Presentation type:Oral presentation (general)
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ブロッコリーナノベシクルに存在するRNA の抗炎症作用
町田果乎、森田優花、押川妃乃、 山崎有美 、大島達也 、立花宏文、 小川健二郎、西山和夫、山崎正夫
第79回日本栄養・食糧学会
Event date: 2025.5.23 - 2025.5.25
Presentation type:Oral presentation (general)
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オタネニンジン由来ナノベシクルの抗炎症 作用の評価
池田真唯、位上健太郎、南大喬、 小川健二郎、山崎正夫
第79回日本栄養・食糧学会
Event date: 2025.5.23 - 2025.5.25
Presentation type:Oral presentation (general)
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ブルーベリー葉熱水抽出物のIL-1β産生抑制作用にはLC3 関連ファゴサイトーシスが 関与する
竹原直也、曲宗信、田中夏子、 児玉直輝 、山崎有美 、小川健二郎、 西山和夫、Rahmen Shaikh.M、山崎正夫
第79回日本栄養・食糧学会
Event date: 2025.5.23 - 2025.5.25
Language:Japanese Presentation type:Oral presentation (general)
Awards 【 display / non-display 】
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技術賞
2024.9 日本生物工学会 モンゴル伝統的乳製品由来乳酸菌のスクリーニングと新規機能性発酵食品の開発
竹下 正彦、黒川 昌彦、山﨑 正夫、上村 修司、竹田 志郎
Award type:Award from Japanese society, conference, symposium, etc.
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宮崎銀行ふるさと振興助成事業
2024.3 みやぎん経済研究所
山崎正夫
Award type:Award from publisher, newspaper, foundation, etc.
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日本栄養・食糧学会 奨励賞
2013.5 日本栄養・食糧学会
山崎正夫
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
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日本農芸化学会西日本支部奨励賞
2004.1 日本農芸化学会
山崎正夫
Award type:Award from Japanese society, conference, symposium, etc. Country:Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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脂肪細胞の低酸素ストレス抑制による生活習慣 病予防
Grant number:21H02142 2021.04 - 2024.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
Authorship:Principal investigator
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低酸素ストレス緩和作用とアデニロコハク酸回路を標的とした尿酸代謝改善
Grant number:25K01970 2025.04 - 2028.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship:Principal investigator
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プラント・オパール中の遺伝情報を利用した稲 作史研究手法の構築に向けた学際的研究
Grant number:19H00542 2021.04 - 2024.03
日本学術振興会 科学研究費補助金 基盤研究(A)
Authorship:Coinvestigator(s)
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食機能実行分子とその機能的相互作用の統合的理解
Grant number:20H05683 2020.08 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(S)
Authorship:Coinvestigator(s)
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機能性脂質による高尿酸血症の改善
Grant number:18K05520 2018.04 - 2021.03
科学研究費補助金 基盤研究(C)
Authorship:Principal investigator
Other research activities 【 display / non-display 】
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CLA懇話会事務局
2004.04 - 2010.10
CLA懇話会開催、会計、諸雑務
Available Technology 【 display / non-display 】
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地域食材の健康機能性評価
食品中のナノ粒子の機能性評価
生活習慣病予防に寄与する食品成分に関する研究Home Page: 食品機能化学研究室
Related fields where technical consultation is available:・食品の健康機能性評価
Message:・食品の高付加価値化に向けて、食品の機能性評価をしたいニーズがあればお知らせください。