KODAMA Yuki

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Obstetrics and Gynecology

Title

Professor

External Link

Degree 【 display / non-display

  • 医学博士 ( 2009.7   宮崎医科大学 )

  • 医学士 ( 1991.3   宮崎医科大学 )

 

Papers 【 display / non-display

  • Low-dose aspirin therapy improves decidual arteriopathy in pregnant women with a history of preeclampsia.

    Tomimori-Gi K, Katsuragi S, Kodama Y, Yamada N, Sameshima H, Maekawa K, Yamashita A, Gi T, Sato Y

    Virchows Archiv : an international journal of pathology   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00428-022-03388-3

    PubMed

  • Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous Blood

    Kaneko M., Muraoka J., Yamada N., Kodama Y.

    Clinical and Experimental Obstetrics and Gynecology   49 ( 7 )   2022.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Clinical and Experimental Obstetrics and Gynecology  

    Background: Procalcitonin can effectively differentiate between bacterial sepsis and a systemic inflammatory response syndrome of noninfectious origins in the adult. However, the usefulness of procalcitonin in perinatal field is not determined. Thus, the purpose of this study was to determine whether procalcitonin levels in the umbilical blood reflect the severity of chorioamnionitis and to assess their correlation with perinatal outcomes. Methods: A retrospective study was conducted in 145 pregnant women with singleton pregnancies and their neonates at a tertiary center between September 2010 and March 2013. Procalcitonin levels in the umbilical blood were measured by an immunoluminometric assay. The severity of chorioamnionitis was classified by the histological stage and grade for maternal and fetal inflammatory responses. Procalcitonin levels were evaluated according to the severity of chorioamnionitis; and the association with neonatal sepsis, intraventricular hemorrhage (IVH), neonatal death within 28 days of life, and periventricular leukomalacia was investigated. Results: In total, 28 women (19%) had chorioamnionitis, of which 21 (75%) delivered at less than 34 weeks of gestation. Fetal response in those with chorioamnionitis was correlated with maternal response. Procalcitonin levels in the group with fetal stage 2 and 3 or grade 2 responses were significantly higher than those infants with any other stage or grade. The frequency of neonatal sepsis, IVH stage III or IV, and neonatal death significantly increased (p < 0.01), when a Procalcitonin level of ≥2 ng/mL was obtained. Conclusions: Procalcitonin levels in the umbilical blood reflect the severity of chorioamnionitis and are associated with neonatal outcomes such as neonatal sepsis, neonatal death, and severe IVH. When PCT level in umbilical venous blood show the high value of ≥2 ng/mL, it might be required that antibiotics therapy is initiated immediately after birth.

    DOI: 10.31083/j.ceog4907160

    Scopus

  • Myeloid cell thrombus and fetal vascular malperfusion in placentas with transient abnormal myelopoiesis

    Tomimori K., Kodama Y., Tanaka H., Yamashita A., Gi T., Asada Y., Doi K., Katsuragi S., Sato Y.

    Virchows Archiv   480 ( 6 )   1181 - 1187   2022.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Virchows Archiv  

    Transient abnormal myelopoiesis (TAM), also known as transient myeloproliferative disorder or transient leukemia, is a self-regressing neoplasia that afflicts infants with trisomy 21. A recent review article documented “myeloid cell thrombus (MCT)” and “fetal vascular malperfusion (FVM)” in placentas with TAM, although the characteristic TAM placental findings have not been clarified. Here, we compared the clinical and pathological placental findings between trisomy 21 patients with or without TAM. In 13 cases of trisomy 21, we identified six placentas with TAM and seven placentas without TAM. The six placentas with TAM included two stillborn cases. Microscopically, MCT was noted in all the cases, and a high incidence of FVM (50%) was observed in TAM cases. Immunohistochemically, MCT was found to be a platelet-rich thrombus. The placentas were grouped according to the presence or absence of TAM and subsequently compared. Clinically, the incidences of abnormal fetal heart rate pattern and fetal or neonatal death were significantly higher in TAM cases. Pathologically, placenta in TAM cases weighted more than those in cases without TAM, and the incidence of MCT was significantly higher in placentas with TAM. Moreover, the incidence of FVM was higher in placentas with TAM, but this difference was not statistically significant. We propose that MCT is a diagnostic feature of placentas with TAM and may be associated with poor fetal outcomes.

    DOI: 10.1007/s00428-022-03289-5

    Scopus

    PubMed

  • C4d deposition and CD39 downregulation in the placental infection by SARS-CoV-2. Reviewed

    Shimao Y, Yamauchi A, Ohtsuka T, Terao K, Kodama Y, Yamada N, Asada Y, Sato Y

    Pathology international   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pin.13214

    PubMed

  • Association between fetal vascular malperfusion and gestational diabetes Reviewed

    Goto T., Sato Y., Kodama Y., Tomimori K., Sameshima H., Aman M., Maekawa K., Yamashita A., Asada Y.

    Journal of Obstetrics and Gynaecology Research   48 ( 1 )   80 - 86   2022.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Obstetrics and Gynaecology Research  

    Aim: Diabetes mellitus (DM) is a major complication in pregnancy. Placental lesions with DM remain unclear and controversial. Recently, the terms of placental pathological findings, such as maternal and fetal vascular malperfusions (MVM and FVM, respectively) were introduced by the Amsterdam Placental Workshop Group Consensus Statement (APWGCS). FVM cases were classified as the partial obstruction type (global FVM) and the complete obstruction type (segmental FVM). The aim of this study was to clarify the pathological characteristics of the placenta with pregestational DM/gestational DM; GDM according to APWGCS. Methods: We studied the placentas of 182 DM women (27 pregestational DM and 155 GDM) and control placentas of 460 women without DM during 2011–2018. We excluded cases of intrauterine fetal death or multiple pregnancies. We reviewed microscopical findings including, MVM, FVM, chorioamnionitis with the slides according to the APWGCS. Results: Microscopically, the incidence of FVM was significantly higher in GDM patients than control (17% vs. 10%, p = 0.0138), but not significant in pregestational DM (11%, p = 0.7410). Segmental FVM (complete obstruction) was significantly more observed in GDM than control group (5% vs. 0.4%, p = 0.0013). Segmental FVM in GDM showed high incidence of light-for-dates infant (three of seven cases, 43%, p = 0.0288). In addition, several segmental FVM findings (villous stromal-vascular karyorrhexis and stem vessel occlusion) were frequently noted in 2 or 3 points positive of 75 g oral glucose tolerance test than 1 point positive GDM. Conclusion: Our placental findings suggest disorder of carbohydrate metabolism might affect the fetal vascular damage, especially complete fetal vascular obstruction.

    DOI: 10.1111/jog.15046

    Scopus

    PubMed

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Books 【 display / non-display

  • 標準産科婦人科学 第5版

    児玉由紀( Role: Contributor ,  第27章 新生児)

    医学書院  2021.3 

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    Responsible for pages:619-654   Language:Japanese Book type:Textbook, survey, introduction

  • 第27章 新生児

    児玉由紀( Role: Joint author)

    医学書院  2021.3 

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    Book type:Scholarly book

  • 新生児のアセスメント 注意すべき周産期情報

    谷口朋子,児玉由紀( Role: Joint author)

    MCメディカ出版  2020.12 

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    Responsible for pages:36-44   Language:Japanese Book type:Scholarly book

  • 産婦人科専門医のための必修知識2020年版

    児玉由紀( Role: Contributor ,  新生児検査)

    公益社団法人 日本産科婦人科学会  2020.11 

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    Responsible for pages:B35-38   Language:Japanese Book type:Scholarly book

  • B. 周産期 7)新生児検査

    児玉由紀( Role: Joint author)

    杏林社  2020.11 

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    Book type:Scholarly book

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MISC 【 display / non-display

  • 事例でシミュレーション 周産期の緊急対応 3-06 羊水混濁

    児玉 由紀,池田 智明,土井 早苗

    ペリネイタルケア   ( 新春増刊 )   116 - 121  

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 弛緩出血の処置と対応

    児玉 由紀,鮫島 浩

    臨床婦人科産科   59 ( 6 )   881 - 885  

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 当科の管理指針

    児玉 由紀,鮫島 浩

    臨床婦人科産科   59 ( 12 )   1590 - 1593  

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 切迫早産の管理 Invited

    松澤聡史、児玉由紀

    周産期医学   51 ( 8 )   1109 - 1112   2021.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:東京医学社  

  • 退院後1ヶ月健診まで(2週間健診も含む)の母体・新生児への対応 Invited

    村岡純輔,児玉由紀

    周産期医学   50 ( 12 )   2042 - 2044   2020.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Presentations 【 display / non-display

  • 「働き方改革と地域救急医療の両立」産婦人科医の立場より

    児玉由紀

    日本救急医学会九州地方会  (WEB)  日本救急医学会九州地方会

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    Event date: 2021.6.25

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:WEB  

  • 宮崎県の周産期医療〜30年間の歩みとこれからの展望〜 Invited

    児玉由紀

    宮崎市郡医師会しののめ医学会特別講演  (宮崎市郡医師会)  宮崎市郡医師会しののめ医学会

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    Event date: 2021.5.28

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:宮崎市郡医師会  

  • 宮崎県における有料拡大新生児スクリーニングの実施報告

    児玉 由紀

    日本小児科学会宮崎地方会89回例会 

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    Event date: 2021.2.14

    Presentation type:Oral presentation (general)  

  • 妊娠18週で胎児胸水に対して胸腔-羊水腔シャント術を行い救命した一例

    児玉 由紀

    宮崎県産婦人科医会・宮崎県産科婦人科学会令和2年度冬期定時総会・講演会 

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    Event date: 2021.1.30

    Presentation type:Oral presentation (general)  

  • 遅発型B型溶連菌による頭頸部蜂窩織炎を呈した超低出生体重児の1例

    児玉 由紀

    宮崎県産婦人科医会・宮崎県産科婦人科学会令和2年度冬期定時総会・講演会 

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    Event date: 2021.1.30

    Presentation type:Oral presentation (general)  

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Other research activities 【 display / non-display

  • センター便り

    2020.01

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    宮崎県の産科医療とpopulation-based研究 -周産期予後改善の取り組み-(講演内容掲載)

  • 国際協力

    2019.09

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    JICA研修生への講義

  • Fetal & Neonatal Medicine

    2018.08

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    胎児、新生児、乳児の突然死を巡る最新情報(座談会)

  • 座談会「胎児、新生児、乳児の突然死を考える」

    2018.05

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    座談会での研究発表
    「Terminal bradycardiaに関連した胎内死亡および脳障害」

  • 国際学会Report 第63回Society for Reproductive Investigation(SRI)

    2016.08

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