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Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Obstetrics and Gynecology |
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Professor |
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External Link |
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KODAMA Yuki
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Degree 【 display / non-display 】
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医学博士 ( 2009.7 宮崎医科大学 )
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医学士 ( 1991.3 宮崎医科大学 )
Education 【 display / non-display 】
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Miyazaki Medical College Faculty of Medicine
- 1991.3
Country：Japan
Campus Career 【 display / non-display 】
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University of Miyazaki Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Obstetrics and Gynecology Professor
2017.03 - Now
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University of Miyazaki Faculty of Medicine College Hospital Lecturer
2010.07 - 2012.07
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University of Miyazaki Faculty of Medicine School of Medicine Genital development medicine course obstetrics and gynecology study field Assistant Professor
2007.04 - 2010.06
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University of Miyazaki Faculty of Medicine School of Medicine Genital development medicine course obstetrics and gynecology study field Research Assistant
2004.02 - 2007.03
External Career 【 display / non-display 】
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県立延岡病院 産婦人科医長
2001.4 - 2004.1
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カリフォルニア大学 ポストドクターフェロー
1996.6 - 1997.8
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医療法人えびの共立病院 医師
1995.2 - 1996.5
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鹿児島市立病院 臨床研修医
1992.6 - 1993.6
Professional Memberships 【 display / non-display 】
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日本産科婦人科学会
1991.6
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日本周産期・新生児医学会
1995
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日本母体胎児医学会
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新生児医療連絡会
2016.12
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その他
2011.5
Papers 【 display / non-display 】
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Fetal heart rate patterns complicated by chorioamnionitis and subsequent cerebral palsy in Japan Reviewed
Yamaguchi-Goto T., Ohashi M., Kodama Y., Sameshima H.
Journal of Obstetrics and Gynaecology Research 49 ( 2 ) 625 - 634 2023.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
Aim: This retrospective study was performed to investigate whether certain fetal heart rate patterns were associated with subsequent cerebral palsy (CP) in infants with chorioamnionitis at or near term. Methods: We used cases registered by the Japan Obstetric Compensation System for CP, which is a nationwide population-based database. Among them, 133 infants with chorioamnionitis who were born at ≥34 weeks of gestation were enrolled. All infants underwent magnetic resonance imaging (MRI), and all fetal heart rate charts had been interpreted according to the National Institute of Child Health and Human Development criteria, focusing on antepartum and immediately before delivery. Results: The incidence of CP after chorioamnionitis at ≥34 weeks of gestation was 0.3 per 10 000 in Japan. Between the clinical (24%) and subclinical groups (76%), the incidence of abnormal fetal heart rate patterns did not differ. According to the MRI classification, 88% of the infants with CP showed hypoxic–ischemic encephalopathy. Half of the infants with CP experienced terminal bradycardia, leading to severe acidosis and exclusively to hypoxic–ischemic encephalopathy. In another half, who did not experience bradycardia, 80% had moderate acidosis (pH 7.00–7.20) resulting in hypoxic–ischemic encephalopathy, and the remaining 20% showed non-acidosis resulting in brain damage other than hypoxic–ischemic encephalopathy. The fetal heart rate patterns before the terminal bradycardia showed that the incidence rates of late deceleration or decreased variability were high (>60%). Conclusion: Fifty percent of pregnant women with chorioamnionitis-related CP had terminal bradycardia that exclusively resulted in hypoxic–ischemic encephalopathy.
DOI： 10.1111/jog.15508
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Muraoka J., Kaneko M., Doi K., Kodama Y., Sameshima H.
Microbiology Research 13 ( 3 ) 598 - 608 2022.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Microbiology Research
The use of prenatal antibiotics should be carefully considered, owing to their potential adverse effects on neonatal outcomes. This study aimed to identify the contributing factors to early-onset neonatal infection and to determine the influence of antepartum antibiotics on women and neonates. This study included 127 pregnant women without obvious intra-amniotic infection on admission, who delivered under 34 weeks of gestation. Information on maternal and neonatal characteristics was obtained from their medical charts. Vaginal swabs were taken from all women on admission. In total, 29 (22.8%) neonates developed early-onset infection. Multivariate analysis revealed that antepartum antibiotics were the most strongly associated factor for early-onset neonatal infection (odds ratio, 11.2; 95% confidence interval, 4.08–31.02). The frequency of early-onset neonatal infection was significantly higher in women who received antibiotic therapy than in those who did not; no significant difference in prolonging their gestation or neonatal morbidities was observed. The prevalence of women who hosted vaginal microorganisms on admission was similar to that in women whose infants subsequently developed early-onset neonatal infection compared with that of women whose infants did not. Among infants of the 40 women who received antepartum antibiotic therapy, 21 developed early-onset infection. Of the women who delivered these 21 infants, 62% (13/21) showed reduced lactobacilli and 43% (9/21) had resistant bacterial strains in their vaginal microbiota at the time of delivery. The use of antepartum antibiotics is the most strongly associated factor in early-onset neonatal infection; it does not prolong gestation and would change the vaginal environment.
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Yamada N, Kaneko M, Yang L, Matsuzawa S, Minematsu T, Kodama Y
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2023.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Human cytomegalovirus (HCMV) is the major cause of neurological sequelae in infants. Immune control of primary HCMV infection appears to depend on the interaction between humoral and cell-mediated immune responses. We report the case of an HCMV-transmitter mother observed with dissociation between humoral and cell-mediated immune responses. The patient had immunoglobulin (Ig) G and M positivity at 11 weeks of gestation and showed fetal hyperechoic bowel and minimal ascites at 21 weeks of gestation. At 25 weeks of gestation, the polymerase chain reaction result for HCMV using amniotic fluid was positive. The numbers of spots in the enzyme-linked immunosorbent spot (ELISPOT) assay at 25, 36, and 39 weeks of gestation were three, five, and six spots/2 × 105 peripheral blood mononuclear cells, respectively. Furthermore, IgG avidity indexes (AIs) at 21, 25, 36, and 39 weeks of gestation were 37.6, 49.7, 72.5, and 74.3, respectively. At 40+1 weeks of gestation, the patient delivered a symptomatic infected newborn with a weight of 2,384 g (−2.6 SD) and a head circumference of 30 cm (−2.6 SD). The neonate had a petechial rash and bilateral hearing loss although did not show liver dysfunction or thrombocytopenia. Cranial magnetic resonance imaging revealed mild ventriculomegaly, left lateral/parietal polymicrogyria, and a punctate white matter lesion. This case showed that IgG AI increased with increasing gestational age, whereas the numbers of spots in the ELISPOT assay had no change. The dissociation between humoral and cell-mediated immune responses may be characteristic of the immune response of a transmitter mother.
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Sakakibara Kouhei, Yamada Naoshi, Kodama Yuki, Obata Shizuka, Tsuzuki Yasue, Muraoka Junsuke, Aoki Yoshinori, Yamashita Rie, Nakame Kazuhiko, Kaneko Masatoki, Katsuragi Shinji, Tsuzuki Ryo, Sato Yuichiro
Journal of Japan Society of Perinatal and Neonatal Medicine 59 ( 1 ) 116 - 121 2023
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Perinatal and Neonatal Medicine
Here we report a case of pulmonary lymphangiectasia that caused exacerbation of respiratory status after an infection. A preterm infant born at 23 weeks of gestation without obvious clinical intrauterine infection showed worsening respiratory status and increased c-reactive protein on day 15 of life. Chest X-ray showed consolidation in right upper lobe and whole left lung. Several broad-spectrum antibiotics were administered unsuccessfully. Finally, <i>Ureaplasma urealyticum</i> was detected in sputum culture, and azithromycin was administered. Although the inflammation improved, tension pneumothorax and pulmonary hypertension developed and he died on day 44 of life. At autopsy, there were few findings of lung inflammation, and congenital lymphangiectasia was diagnosed. It seems that exacerbation was triggered by the infection, although there was no remarkable evidence to support causality. There have been few case reports of pulmonary lymphangiectasia in extremely low birth weight infants. This case was considered to be classified as primary, although the respiratory condition at birth was relatively good. There are no clear diagnostic criteria for this disease and no effective treatments. Clinically, neonatologists should keep in mind pulmonary lymphangiectasia if respiratory failure in newborns does not respond to common treatment approach.
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Tomimori-Gi K, Katsuragi S, Kodama Y, Yamada N, Sameshima H, Maekawa K, Yamashita A, Gi T, Sato Y
Virchows Archiv : an international journal of pathology 481 ( 5 ) 713 - 720 2022.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Virchows Archiv
Preeclampsia, a multisystem pregnancy-specific hypertensive disorder, results in significant maternal and perinatal morbidity and mortality. This condition is associated with placental histopathological abnormalities and particularly affects the decidual spiral arteries. Reportedly, aspirin prevents preeclampsia, specifically early-onset preeclampsia, although findings in decidual arteries in women treated with aspirin therapy remain unclear. We compared the clinical and histopathological placental findings between women with a history of preeclampsia, who did and did not receive low-dose aspirin therapy (LDA and non-LDA groups, respectively). We identified 26 women with a history of preeclampsia; 9 women received LDA (aspirin ≤ 100 mg/day, initiated at < 16 weeks, LDA group), and 17 women did not receive LDA (non-LDA group). The mean gestational age was higher (36.7 weeks vs. 32.3 weeks, P = 0.0221) and the incidence of preeclampsia was lower (11% vs. 59%, P = 0.0362) in the LDA than in the non-LDA group. Histopathologically, the incidence of decidual arteriopathy, particularly that of fibrinoid necrosis and thrombosis, was lower in the LDA than in the non-LDA group (44% vs. 88%, P = 0.0283). Immunohistologically, endothelial marker (CD31 and CD39) expression was stronger in the LDA than in the non-LDA group. Notably, we observed no significant intergroup differences in inflammatory changes (chronic perivasculitis, protease-activated receptor 1 expression, and CD3-positive cells). This study highlights that LDA inhibits hypertension-induced endothelial injury and thrombosis, and thereby protects maternal placental perfusion and prevents preeclampsia.
Books 【 display / non-display 】
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臍帯血バンクについて〜臍帯血治療の現状と展望〜
児玉由紀（ Role： Sole author , 診療メモ）
日州医事 宮崎県医師会 2023.12
Language：Japanese Book type：Scholarly book
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妊娠中に胎児死亡を起こすことがあると聞いたのですが本当ですか？
児玉由紀（ Role： Joint author）
メディカルビュー社 2021.12
Responsible for pages：167-170 Book type：Scholarly book
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糖尿病合併妊娠、妊娠糖尿病女性の胎児心拍数モニタリング判読時の注意点は？
児玉由紀（ Role： Joint author）
メディカルビュー社 2021.12
Responsible for pages：171-173 Book type：Scholarly book
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標準産科婦人科学 第５版
児玉由紀（ Role： Contributor , 第27章 新生児）
医学書院 2021.3
Responsible for pages：619-654 Language：Japanese Book type：Textbook, survey, introduction
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第27章 新生児
児玉由紀（ Role： Joint author）
医学書院 2021.3
Book type：Scholarly book
MISC 【 display / non-display 】
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事例でシミュレーション 周産期の緊急対応 3-06 羊水混濁
児玉 由紀,池田 智明,土井 早苗
ペリネイタルケア ( 新春増刊 ) 116 - 121
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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弛緩出血の処置と対応
児玉 由紀,鮫島 浩
臨床婦人科産科 59 ( 6 ) 881 - 885
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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当科の管理指針
児玉 由紀,鮫島 浩
臨床婦人科産科 59 ( 12 ) 1590 - 1593
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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更年期障害に伴うホットフラッシュ Invited
藤﨑 碧、児玉由紀
美容皮膚医学 BEAUTY 7 ( 2 ) 39 - 45 2024.2
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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切迫早産の管理 Invited
松澤聡史、児玉由紀
周産期医学 51 ( 8 ) 1109 - 1112 2021.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：東京医学社
Presentations 【 display / non-display 】
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Chorioamnionitis with Poor Perinatal Outcome: A 20-year regional population-based study. International conference
Yuki Kodama
The 22nd Congress of Federation of Asia and Oceania Perinatal Societies 2023.10.7
Event date： 2023.10.7 - 2023.10.9
Language：English Presentation type：Oral presentation (general)
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新生児蘇生〜基本と応用〜
児玉由紀
第27回ひむかセミナー 2024.3.3
Event date： 2024.3.2 - 2024.3.3
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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胎児心拍数パターンとアシデミア・脳障害
児玉由紀
日本母体胎児医学会，第1回胎児心拍数陣痛図セミナー 2023.8.19
Event date： 2023.8.19
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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宮崎県の周産期・新生児医療と感染症 Invited
児玉由紀
Pediatric Conference in Miyazaki 2023.6.14
Event date： 2023.6.14
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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どうする？！新生児仮死への対応
児玉由紀
第26回ひむかセミナー 2023.3.5
Event date： 2023.3.4 - 2023.3.5
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
Awards 【 display / non-display 】
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Outstanding Congress Awards
2023.10 Federation of Asia and Oceania Perinatal Societies Chorioamnionitis with Poor Perinatal Outcome: A 20-year regional population-based study
Yuki Kodama
Award type：Award from international society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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周産期予後改善を目指したウレアプラズマ陽性母体および新生児治療に関する臨床的研究
Grant number：22K07847 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
Other research activities 【 display / non-display 】
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国際協力
2022.11
JICA研修生への講義「宮崎県の周産期システム」
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国際協力
2021.02
JICA研修生への講義
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センター便り
2020.01
宮崎県の産科医療とpopulation-based研究 －周産期予後改善の取り組み－（講演内容掲載）
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国際協力
2019.09
JICA研修生への講義
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Fetal & Neonatal Medicine
2018.08
胎児、新生児、乳児の突然死を巡る最新情報（座談会）
Available Technology 【 display / non-display 】
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宮崎県全域をフィールドとした周産期予後に関するpopulation-based 研究
周産期予後改善のための病態解明と治療戦略の開発
多職種連携を強化した周産期・新生児医療の発展Home Page： 宮崎大学医学部産婦人科
Related fields where technical consultation is available：産婦人科、周産期、新生児医療
Message：日本一、世界一、安全にお産できる県を目指しています。
画像処理技術を活用した新生児の体重測定、黄疸や自発運動解析などでの共同研究を希望します。
Committee Memberships 【 display / non-display 】
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日本産科婦人科学会 災害対策・復興委員会
2023.7 - 2025.7
Committee type：学協会
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日本周産期・新生児医学会 学会制度あり方委員会 幹事
2022.7 - 2026.7
Committee type：学協会
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その他 宮崎県災害時小児周産期リエゾン
2020.2
Committee type：自治体
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宮崎市指定管理者候補者選定委員会 宮崎市指定管理者候補者選定委員会
2023.6 - 2024.3
Committee type：自治体
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宮崎市医療安全推進協議会 宮崎市医療安全推進協議会
2023.4 - 2025.3
Committee type：自治体