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Affiliation |
Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Obstetrics and Gynecology |
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Title |
Professor |
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External Link |
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Related SDGs |
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KODAMA Yuki
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Degree 【 display / non-display 】
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医学博士 ( 2009.7 宮崎医科大学 )
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医学士 ( 1991.3 宮崎医科大学 )
Research Areas 【 display / non-display 】
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Life Science / Embryonic medicine and pediatrics / ウレアプラズマ
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Life Science / Embryonic medicine and pediatrics / 周産期医学
Education 【 display / non-display 】
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Miyazaki Medical College Faculty of Medicine
- 1991.3
Country：Japan
Campus Career 【 display / non-display 】
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University of Miyazaki Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Obstetrics and Gynecology Professor
2017.03 - Now
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University of Miyazaki Faculty of Medicine College Hospital Associate Professor
2012.08 - 2017.02
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University of Miyazaki Faculty of Medicine College Hospital Lecturer
2010.07 - 2012.07
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University of Miyazaki Faculty of Medicine School of Medicine Genital development medicine course obstetrics and gynecology study field Assistant Professor
2007.04 - 2010.06
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University of Miyazaki Faculty of Medicine School of Medicine Genital development medicine course obstetrics and gynecology study field Research Assistant
2004.02 - 2007.03
External Career 【 display / non-display 】
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県立延岡病院 職員（医療系）
2001.4 - 2004.1
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University of California, San Francisco
1998.2 - 1998.8
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University of California, Irvine
1996.6 - 1997.8
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医療法人えびの共立病院 医師
1995.2 - 1996.5
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鹿児島市立病院 臨床研修医
1992.6 - 1993.6
Professional Memberships 【 display / non-display 】
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日本産科婦人科学会
1991.6
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日本周産期・新生児医学会
1995
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日本母体胎児医学会
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新生児医療連絡会
2016.12
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その他
2011.5
Papers 【 display / non-display 】
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Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California Reviewed International coauthorship
Kusuda S., Bennett M.V., Gould J.B., Yara A., Nakasone K., Oshiro T., Kisato Y., Tokuhisa T., Maruyama Y., Yanagibe S., Kodama Y., Goushi M., Iida K., Fukushima N., Iwai M., Inomata K., Ogata T., Kinoshita F., Sumi M., Aoki M., Takayanagi T., Kokubo T., Kawano H., Takahata Y., Kanda H., Unno M., Suga S., Hikino T., Nakashima T., Ochiai M., Kinoshita M., Nakata Y., Kondo Y., Motoki T., Akiyoshi S., Matsuda O., Kuboi T., Koyano K., Saijo T., Yamagami T., Terada T., Tateishi H., Takahashi K., Hasegawa K., Fukunaga S., Tahara M., Sera Y., Hayakawa S., Nishimura Y., Fukuhara R., Sugimoto M., Tokumasu H., Nakano T., Kageyama M., Takemoto K., Kanai R., Hasegawa Y., Miura M., Tamura A., Kumagaya K., Nishikubo T., Ohashi T., Yoshimoto S., Utsunomiya T., Ioroi T., Fujioka K., Yamakawa M., Okutani T., Kataoka D., Morisawa T., Nabetani M., Michinomae Y., Mizumoto H., Hirano S., Kusumoto Y., Okabe H., Yoshii M., Ichiba H., Kim T., Onishi S., Ogihara A., Takatera A., Sumi K., Tokunaga Y., Yoshinare R., Ogawa S., Negi R., Mine K., Minami H., Sumida H., Kai M., Yamakawa T., Adachi S., Nozaki K., Komatsu H., Nishimura A., Hasegawa R., Kinoshita D., Araki R., Shiomi K.
Scientific Reports 15 ( 1 ) 2025.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports
Infants born in Japan are reported to have a low incidence of necrotizing enterocolitis (NEC) among countries, and these differences remained significant after adjusting for common clinical factors. To investigate the impact of ethnic background, we compared the incidence of NEC between infants born in Japan and those born to mothers of Japanese ethnicity in California. Preterm infants born between 2008 and 2019 at 22–29 weeks of gestational age were analyzed retrospectively. Four groups were analyzed: infants born in Japan (JP), infants born in California to mothers born in Japan (JP-J), infants born in California to mothers with Japanese ethnicity but born in the United States or another country (JP-CA), and a comparison group of infants born in California to non-Hispanic White mothers (NHW-CA). Each cohort consisted of 52,049, 115, 226, and 12,275 infants, respectively. Unadjusted NEC incidences were significantly lower in JP compared to the other three cohorts (1.7% JP, 4.5% JP-J, 4.6% JP-CA, and 3.3% NHW-CA, respectively; p < 0.01). After adjusting for confounding factors, odds ratios for NEC in JP vs. JP-J, JP-CA, and NHW-CA were 3.04 (1.18–7.80), 2.89 (1.45–5.75), and 1.96 (1.56–2.47), respectively. This study suggests that differences in NEC incidence in Japan are not explained by ethnicity. Clinical trial regstration number: Registration numbers is UMIN000006961 (https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000008217) for the Neonatal Research Network of Japan. However, the the California Perinatal Quality Care Collaborative (CPQCC) aims only to assess neonatal outcomes for the purpose of quality assessment and improvement. So, no clinical trial number is available. Please refer to the web site https://www.cpqcc.org/.
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Fetal heart rate patterns complicated by chorioamnionitis and subsequent cerebral palsy in Japan Reviewed
Yamaguchi-Goto T., Ohashi M., Kodama Y., Sameshima H.
Journal of Obstetrics and Gynaecology Research 49 ( 2 ) 625 - 634 2023.2
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
Aim: This retrospective study was performed to investigate whether certain fetal heart rate patterns were associated with subsequent cerebral palsy (CP) in infants with chorioamnionitis at or near term. Methods: We used cases registered by the Japan Obstetric Compensation System for CP, which is a nationwide population-based database. Among them, 133 infants with chorioamnionitis who were born at ≥34 weeks of gestation were enrolled. All infants underwent magnetic resonance imaging (MRI), and all fetal heart rate charts had been interpreted according to the National Institute of Child Health and Human Development criteria, focusing on antepartum and immediately before delivery. Results: The incidence of CP after chorioamnionitis at ≥34 weeks of gestation was 0.3 per 10 000 in Japan. Between the clinical (24%) and subclinical groups (76%), the incidence of abnormal fetal heart rate patterns did not differ. According to the MRI classification, 88% of the infants with CP showed hypoxic–ischemic encephalopathy. Half of the infants with CP experienced terminal bradycardia, leading to severe acidosis and exclusively to hypoxic–ischemic encephalopathy. In another half, who did not experience bradycardia, 80% had moderate acidosis (pH 7.00–7.20) resulting in hypoxic–ischemic encephalopathy, and the remaining 20% showed non-acidosis resulting in brain damage other than hypoxic–ischemic encephalopathy. The fetal heart rate patterns before the terminal bradycardia showed that the incidence rates of late deceleration or decreased variability were high (>60%). Conclusion: Fifty percent of pregnant women with chorioamnionitis-related CP had terminal bradycardia that exclusively resulted in hypoxic–ischemic encephalopathy.
DOI： 10.1111/jog.15508
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Muraoka J., Kaneko M., Doi K., Kodama Y., Sameshima H.
Microbiology Research 13 ( 3 ) 598 - 608 2022.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Microbiology Research
The use of prenatal antibiotics should be carefully considered, owing to their potential adverse effects on neonatal outcomes. This study aimed to identify the contributing factors to early-onset neonatal infection and to determine the influence of antepartum antibiotics on women and neonates. This study included 127 pregnant women without obvious intra-amniotic infection on admission, who delivered under 34 weeks of gestation. Information on maternal and neonatal characteristics was obtained from their medical charts. Vaginal swabs were taken from all women on admission. In total, 29 (22.8%) neonates developed early-onset infection. Multivariate analysis revealed that antepartum antibiotics were the most strongly associated factor for early-onset neonatal infection (odds ratio, 11.2; 95% confidence interval, 4.08–31.02). The frequency of early-onset neonatal infection was significantly higher in women who received antibiotic therapy than in those who did not; no significant difference in prolonging their gestation or neonatal morbidities was observed. The prevalence of women who hosted vaginal microorganisms on admission was similar to that in women whose infants subsequently developed early-onset neonatal infection compared with that of women whose infants did not. Among infants of the 40 women who received antepartum antibiotic therapy, 21 developed early-onset infection. Of the women who delivered these 21 infants, 62% (13/21) showed reduced lactobacilli and 43% (9/21) had resistant bacterial strains in their vaginal microbiota at the time of delivery. The use of antepartum antibiotics is the most strongly associated factor in early-onset neonatal infection; it does not prolong gestation and would change the vaginal environment.
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Novel SKIC3 variants in tricho-hepato-enteric syndrome with hemochromatosis. Reviewed
Ochiai K, Aoki Y, Yamada N, Aman M, Yamashita A, Yamaguchi M, Nakato D, Takenouchi T, Kosaki K, Kodama Y, Moritake H
Human genome variation 12 ( 1 ) 14 2025.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Human Genome Variation
Tricho-hepato-enteric syndrome (THES), a rare autosomal recessive disorder caused by variants in the SKIC3 or SKIC2 gene, is characterized by intractable diarrhea, woolly hair, growth restriction and liver disease. Here we report a neonatal case of THES with neonatal hemochromatosis, in which the novel compound heterozygous SKIC3 variants NM_014639.4:c.815_816del p.(Gly272AlafsTer9) and NM_014639.4:c.2284G>A p.(Gly762Arg) were identified. Further research is needed to elucidate the mechanisms underlying iron metabolism dysregulation in THES.
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Trends in the causes of stillbirths over 20 years in Southern Japan Reviewed
Kino Emi, Maki Yohei, Yamada Naoshi, Kodama Yuki, Katsuragi Shinji, Sameshima Hiroshi, Ikenoue Tsuyomu
BMC Pregnancy and Childbirth 25 654 2025.6
Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC
Background
This study aimed to determine the temporal trend in the causes of stillbirths over a period of two decades using a regional perinatal database in order to facilitate the development of perinatal strategies to prevent stillbirths in Japan.
Methods
This was a population-based retrospective study. Cases of perinatal death and neurological damage were reported by perinatal centers and primary birth clinics, followed by their peer review and audit, and final registration in the database. Data for stillbirths, defined as fetal death at ≥ 22 weeks of gestation between January 1, 2001, and December 31, 2020, were extracted from the database. Causes of stillbirths were reclassified according to the ReCoDe system. Temporal trends in the causes of stillbirths per 1,000 births and proportion of the causes were evaluated using the Cochran-Armitage test.
Results
Over the 20 years, in the study region, a total of 205,025 were delivered at ≥ 22 weeks of gestation, and 569 were stillborn (2.8 per 1,000 births). The most common cause of stillbirth was “no relevant condition identified” in 39.5% cases, followed by “abruption” in 12.3%, “lethal congenital anomaly” in 9.5%, and “umbilical cord, other” in 5.8%. The trends in stillbirths caused by “fetal growth restriction,” “abruption,” “asphyxia,” and “no relevant condition identified” significantly decreased. However, no change in trend due to “lethal congenital anomaly” was seen. The stillbirth trend caused by “cord, other” significantly increased. The proportion of stillbirths related to unidentified causes remained unchanged.
Conclusions
Over the 20-year period, the rate of stillbirths caused by abruption, fetal growth restriction, and asphyxia, which can be reduced by early detection and intervention, decreased. The incidence of stillbirths caused by cord constriction increased. Investigations to prevent cord-accident stillbirths would be required to further reduce stillbirths in the study region. Establishment of algorithms that allow the identification of the causes of stillbirths would be crucial to reduce instances of stillbirths due to unidentified causes.
Books 【 display / non-display 】
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早産のすべて 基礎から臨床、DOHaDまで
村岡純輔、児玉由紀（ Role： Joint author , 38. 子宮内感染/炎症の原因検索を目的とした羊水穿刺の意義と実際について教えてください）
株式会社メジカルビュー社 2025.7
Total pages：364 Responsible for pages：185-187 Language：Japanese Book type：Scholarly book
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早産のすべて 基礎から臨床、DOHaDまで
冨森馨予、児玉由紀（ Role： Joint author , 53 子宮収縮抑制剤併用児の実際を教えてください）
株式会社メジカルビュー社 2025.7
Total pages：364 Responsible for pages：229-230 Language：Japanese Book type：Scholarly book
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早産のすべて 基礎から臨床、DOHaDまで
山内綾、児玉由紀（ Role： Joint author , 48 硫酸マグネシウムの神経保護作用について教えてください）
株式会社メジカルビュー社 2025.7
Total pages：364 Responsible for pages：212-215 Language：Japanese Book type：Scholarly book
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早産のすべて 基礎から臨床、DOHaDまで
圓﨑夏美、児玉由紀（ Role： Joint author , 47 硫酸マグネシウムの適応と使い方は？）
株式会社メジカルビュー社 2025.7
Total pages：364 Responsible for pages：201-211 Language：Japanese Book type：Scholarly book
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骨盤位分娩
後藤智子 児玉由紀（ Role： Joint author , III章 ハイリスク児 11. 骨盤位分娩）
金原出版株式会社 2025.7
Language：Japanese Book type：Textbook, survey, introduction
MISC 【 display / non-display 】
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事例でシミュレーション 周産期の緊急対応 3-06 羊水混濁
児玉 由紀,池田 智明,土井 早苗
ペリネイタルケア ( 新春増刊 ) 116 - 121
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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弛緩出血の処置と対応
児玉 由紀,鮫島 浩
臨床婦人科産科 59 ( 6 ) 881 - 885
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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当科の管理指針
児玉 由紀,鮫島 浩
臨床婦人科産科 59 ( 12 ) 1590 - 1593
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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更年期障害に伴うホットフラッシュ Invited
藤﨑 碧、児玉由紀
美容皮膚医学 BEAUTY 7 ( 2 ) 39 - 45 2024.2
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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赤ら顔の治療戦略を考える 赤ら顔を呈す主な皮膚病 更年期障害に伴うホットフラッシュ
児玉由紀
BEAUTY 7 ( 2 ) 291 - 295 2024.2
Authorship：Corresponding author Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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児の予後からみた子宮内感染症 Invited
児玉由紀
第41回日本産婦人科感染症学会 2025.6.1
Event date： 2025.5.31 - 2025.6.1
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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Chorioamnionitis with Poor Perinatal Outcome: A 20-year regional population-based study. International conference
Yuki Kodama
The 22nd Congress of Federation of Asia and Oceania Perinatal Societies 2023.10.7
Event date： 2023.10.7 - 2023.10.9
Language：English Presentation type：Oral presentation (general)
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新生児蘇生法とフィジカルアセスメント
児玉由紀
第28回ひむかセミナー 2025.3.2
Event date： 2025.3.1 - 2025.3.2
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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新生児蘇生〜基本と応用〜
児玉由紀
第27回ひむかセミナー 2024.3.3
Event date： 2024.3.2 - 2024.3.3
Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech
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妊娠糖尿病の診断時期に関する検討
児玉由紀
第39回日本糖尿病・妊娠学会年次学術集会
Event date： 2023.11.17 - 2023.11.18
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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Outstanding Congress Awards
2023.10 Federation of Asia and Oceania Perinatal Societies Chorioamnionitis with Poor Perinatal Outcome: A 20-year regional population-based study
Yuki Kodama
Award type：Award from international society, conference, symposium, etc.
Grant-in-Aid for Scientific Research 【 display / non-display 】
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ウレアプラズマ子宮内感染母体および早産児に対する抗菌薬治療の確立に向けた臨床研究
Grant number：25K1111 2025.04 - 2028.03
ウレアプラズマ子宮内感染母体および早産児に対する抗菌薬治療の確立に向けた臨床研究 基盤研究C
Authorship：Principal investigator Grant type：Competitive
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周産期予後改善を目指したウレアプラズマ陽性母体および新生児治療に関する臨床的研究
Grant number：22K07847 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
Other research activities 【 display / non-display 】
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国際協力
2022.11
JICA研修生への講義「宮崎県の周産期システム」
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国際協力
2021.02
JICA研修生への講義
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センター便り
2020.01
宮崎県の産科医療とpopulation-based研究 －周産期予後改善の取り組み－（講演内容掲載）
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国際協力
2019.09
JICA研修生への講義
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Fetal & Neonatal Medicine
2018.08
胎児、新生児、乳児の突然死を巡る最新情報（座談会）
Available Technology 【 display / non-display 】
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宮崎県全域をフィールドとした周産期予後に関するpopulation-based 研究
周産期予後改善のための病態解明と治療戦略の開発
多職種連携を強化した周産期・新生児医療の発展Home Page： 宮崎大学医学部産婦人科
Related fields where technical consultation is available：産婦人科、周産期、新生児医療
Message：日本一、世界一、安全にお産できる県を目指しています。
画像処理技術を活用した新生児の体重測定、黄疸や自発運動解析などでの共同研究を希望します。
Committee Memberships 【 display / non-display 】
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日本産科婦人科学会 災害対策・復興委員会
2025.6
Committee type：学協会
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日本産科婦人科学会 災害対策・復興委員会
2023.7 - 2025.7
Committee type：学協会
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日本周産期・新生児医学会 学会制度あり方委員会 幹事
2022.7 - 2026.7
Committee type：学協会
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その他 宮崎県災害時小児周産期リエゾン
2020.2
Committee type：自治体
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宮崎県教育委員会 宮崎県立高鍋高等学校の学校評議員
2024.5 - 2025.3
Committee type：自治体