SHINOHARA Akio

写真a

Affiliation

Frontier Science Research Center Department of Biological Science Division of Bio-Resources Kiyotake Section

Title

Associate Professor

External Link

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Degree 【 display / non-display

  • 博士(環境科学) ( 2008.6   北海道大学 )

  • 修士(地球環境科学) ( 2001.3   北海道大学 )

  • 学士(理学) ( 1998.3   北海道大学 )

Research Areas 【 display / non-display

  • Life Science / Evolutionary biology

  • Life Science / Biodiversity and systematics

  • Life Science / Laboratory animal science

 

Papers 【 display / non-display

  • Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world’s smallest mammalian divers Reviewed International coauthorship

    He K., Eastman T.G., Czolacz H., Li S., Shinohara A., Kawada S.I., Springer M.S., Berenbrink M., Campbell K.L.

    eLife   10   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:eLife  

    The speciose mammalian order Eulipotyphla (moles, shrews, hedgehogs, solenodons) combines an unusual diversity of semi-aquatic, semi-fossorial, and fossorial forms that arose from terrestrial forbearers. However, our understanding of the ecomorphological pathways leading to these lifestyles has been confounded by a fragmentary fossil record, unresolved phylogenetic relationships, and potential morphological convergence, calling for novel approaches. The net surface charge of the oxygen-storing muscle protein myoglobin (ZMb ), which can be readily determined from its primary structure, provides an objective target to address this question due to mechanistic linkages with myoglobin concentration. Here, we generate a comprehensive 71 species molecular phylogeny that resolves previously intractable intra-family relationships and then ancestrally reconstruct ZMb evolution to identify ancient lifestyle transitions based on protein sequence alone. Our phylogenetically informed analyses confidently resolve fossorial habits having evolved twice in talpid moles and reveal five independent secondary aquatic transitions in the order housing the world’s smallest endothermic divers.

    DOI: 10.7554/eLife.66797

    Scopus

    PubMed

  • Daily Torpor Induced by Food Restriction in the Chinese Hamster, Cricetulus griseus Reviewed

    Mika Masaki, Yuki Suetsugi, Chihiro Koshimoto, Tetsuo Morita, Akio Shinohara

    Mammal Study   50 ( 3 )   2025.4

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.3106/ms2024-0012

  • Spontaneous daily torpor observed in the greater long-tailed hamster (<i>Tsherskia triton</i>) Reviewed

    Masaki Mika, Morita Tetsuo, Koshimoto Chihiro, Shinohara Akio

    Honyurui Kagaku (Mammalian Science)   65 ( 1 )   9 - 17   2025.2

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Mammal Society of Japan  

    To overcome severe environmental conditions such as cold or food shortage, many small mammals utilize hibernation or daily torpor. Hamsters (subfamily Cricetinae) are a well-known group using hibernation and daily torpor. Interestingly, among hamsters, hibernators tend to have relatively larger body sizes. In contrast, species that use daily torpor have a small body size, although some hamsters still remain unknown in torpor characteristics. In this study, we attempted to induce torpor in the greater long-tailed hamster (<i>Tscherskia triton</i>), which has a large body size among hamsters, by exposing them to condition that mimic winter (short photoperiod 8L:16D and low temperature 5°C). We successfully observed a spontaneous decrease in body temperature, and the duration of the torpor bout did not exceed 24 hours. Therefore, it was revealed for the first time that the greater long-tailed hamster is a heterothermic mammal that utilizes spontaneous daily torpor.

    DOI: 10.11238/mammalianscience.65.9

    CiNii Research

  • Oxidative stress on the male reproductive organs of wild mice collected from an area contaminated by radioactive materials in Fukushima Reviewed

    Ishiniwa H., Okano T., Endoh D., Hirayama H., Yoshioka A., Yokohata Y., Shindo J., Koshimoto C., Shinohara A., Sakamoto S.H., Tamaoki M., Onuma M.

    Scientific Reports   14 ( 1 )   29706   2024.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Scientific Reports  

    The Fukushima Daiichi Nuclear Power Plant accident caused the release of large amounts of radioactive material into the environment. Radiation from radionuclides cause DNA lesions, mainly via oxidation, which adversely affect wild organisms by damaging their germ cells. Here, we investigated the effects of radiation on the reproductive organs of Japanese field mice (Apodemus speciosus) by estimating the dose rate of radiation exposure, the accumulation of DNA lesions, and the expression of DNA repair enzymes. In highly contaminated areas, mouse testes received a radiation dose rate > 0.1 mGy/d. According to the International Commission on Radiological Protection, there is a very low probability of effects in the reference rat species at this exposure level. The results of the current study do not definitively conclude that the expression of 8-oxoguanine DNA glycosylase 1 and superoxide dismutase in mouse testes increase with dose rate and lifetime dose. However, 8-hydroxy-2′-deoxyguanosine accumulation increases in a dose rate- and lifetime dose-dependent manner in mouse testes, but is not observed in the sperm of the cauda epididymis. These results suggest that, although DNA lesions occurred in male germ cells of Fukushima mice, most were successfully repaired by DNA repair enzymes at the observed gene expression level.

    DOI: 10.1038/s41598-024-80869-2

    Scopus

    PubMed

  • Optimization of inhaled anesthesia for <i>Octodon degus</i> using electroencephalography

    IKAI Yuki, NAGURA-KATO Goro A., SAKAMOTO Shinsuke H., SHINOHARA Akio, KOSHIMOTO Chihiro

    Experimental Animals   advpub ( 0 )   93 - 103   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association for Laboratory Animal Science  

    Physiological responses to inhaled anesthetics vary among species. Therefore, a precise anesthetic technique is important for each individual species. In this study, we focused on the degu (<i>Octodon degus</i>), a small herbivorous rodent. Degus have recently begun to be used as laboratory models for brain research because of certain human-like characteristics, such as spontaneous development of Alzheimer’s disease. In this study, we evaluated appropriate induction and maintenance anesthesia conditions for isoflurane and sevoflurane in degus by a stimulation test, electroencephalography (EEG), minimum alveolar concentration (MAC), and vital signs. During induction, more rapid time to loss of the righting reflex and deeper anesthesia in degus were observed in isoflurane. The MAC value for degus were 1.75 ± 0.0% in isoflurane and 2.25 ± 0.27% in sevoflurane. Whereas some degus were awake during maintenance anesthesia using both anesthetics at concentrations of ≤2%, no rats were awake when using sevoflurane at a concentration of 2%. The duration of the total flat EEG, a measure of the depth of maintenance anesthesia, was longer for isoflurane than for sevoflurane. Furthermore, higher concentrations of both anesthetics suppressed the respiratory rate in degus. These new findings regarding inhalation anesthesia in degus will contribute to future developments in the fields of laboratory animals and veterinary medicine.

    DOI: 10.1538/expanim.24-0017

    Scopus

    PubMed

    CiNii Research

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Books 【 display / non-display

  • 動物学の百科事典

    日本動物学会(編)( Role: Contributor ,  脊椎動物(哺乳類)―恐竜絶滅後の地球を制した覇者)

    丸善出版  2018.9 

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    Responsible for pages:102-103   Language:Japanese Book type:Dictionary, encyclopedia

  • 大・中・小動物実験プロトコール

    宮崎大学動物実験プロトコール編集委員会( Role: Joint author)

    宮日情報文化センター  2016.3 

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    Language:Japanese Book type:Scholarly book

  • 日本の哺乳類学 第1巻 小型哺乳類

    本川雅治、岩佐真宏、大舘智氏、佐藤和彦、船越公威、佐野明、芝田史仁、田村典子、関島恒夫、島田卓哉( Role: Joint author)

    東京大学出版会  2008.5 

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    Language:Japanese Book type:Scholarly book

  • エラブオオコウモリ天然記念物緊急調査報告書

    土屋公幸, 篠原明男, 船越公威, 國崎敏廣( Role: Joint author ,  エラブオオコウモリの遺伝的多様性について)

    鹿児島県上屋久町教育委員会  2003.3 

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    Language:Japanese Book type:Report

  • 生物多様性・遺伝的多様性調査報告書

    篠原明男, 鈴木仁, 土屋公幸, 原田正史(3.哺乳類)

    環境庁自然保護局・生物多様性センター  2000.3 

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    Language:Japanese Book type:Report

MISC 【 display / non-display

  • Records of The Annual Meeting of The Mammal Society of Japan under COVID-19 pandemic: briefing

    Shinohara Akio

    Honyurui Kagaku (Mammalian Science)   64 ( 1 )   95 - 95   2024.1

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:The Mammal Society of Japan  

    DOI: 10.11238/mammalianscience.64.95

    CiNii Research

  • 宮崎県椎葉村における「もぐら打ち」

    篠原明男

    宮崎の自然と環境   7   4 - 9   2022.12

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

  • ヨーロッパモリネズミ(Apodemus sylvaticus)の誘起排卵卵子及び卵胞卵子の蛍光免疫染色による形態的解析

    竹口加那子、Narantsog Choijookhuu、名倉悟郎、篠原明男、菱川善隆、越本知大

    九州実験動物雑誌   38   31 - 33   2022.10

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:九州実験動物研究会  

  • 脳波測定を活用したデグー(Octodon degus)のセボフルラン及びイソフルラン吸入麻酔特性の検討

    伊海結貴、七條宏樹、名倉悟郎、篠原明男、越本知大

    九州実験動物雑誌   37   43 - 45   2021.10

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:九州実験動物研究会  

  • 希少固有種アマミトゲネズミの実験動物化に向けた飼育ストレス評価の試み

    2緒方穂波、前山賢太、林扶充子、仮屋博敬、川辺敏晃、名倉悟郎、城ヶ原貴通、篠原明男、越本知大

    九州実験動物雑誌   35   59   2019.10

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:九州実験動物研究会  

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Presentations 【 display / non-display

  • 野生動物を対象とした実験に関わる許認可 Invited

    篠原明男

    第51回(令和7年度)国立大学法人動物実験施設協議会総会  2025.5.30 

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    Event date: 2025.5.29 - 2025.5.31

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • LASセミナー3:「知りたい! 実験動物 Part4」歌を奏でるかしこいネズミ「デグー」 Invited

    名倉悟郎、篠原明男、越本知大

    第72回日本実験動物学会総会 

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    Event date: 2025.5.21 - 2025.5.23

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  • てんかん様発作直後のデグーの血中微量元素動態の解明

    吉村琉那、伊海結貴、名倉悟郎、篠原明男、越本知大

    第72回日本実験動物学会総会 

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    Event date: 2025.5.21 - 2025.5.23

    Language:Japanese   Presentation type:Oral presentation (general)  

  • アラビアトゲマウスを用いた卵巣子宮内膜症モデルの作製と病理学的所見

    森竹美紗樹、小川遥菜、名倉悟郎、久保田壽樹、中家雅隆、篠原明男、菱川善隆、浅田祐士郎、越本知大

    第72回日本実験動物学会総会 

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    Event date: 2025.5.21 - 2025.5.23

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 野生哺乳類とバイオリソース Invited

    篠原明男、名倉悟郎、越本知大

    第12回実験動物科学シンポジウム 「動物学研究を支える実験動物科学」   2024.11.1 

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    Event date: 2024.11.1

    Language:Japanese   Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 日本哺乳類学会2017年度大会 優秀ポスター賞(主発表者)

    2017.9   日本哺乳類学会  

    5) 篠原明男、井上比加里、稲留健人、樫村敦、江藤毅、加藤悟郎、坂本信介、越本知大

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 日本哺乳類学会2010年度大会 最優秀ポスター賞(共同発表者)

    2016.9   日本哺乳類学会  

    中本あずさ・原田正史・篠原明男・土屋公幸・鈴木仁

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • Vth International Wildlife Management Congress (IWMC2015) MSJ Poster Award

    2015.7   日本哺乳類学会  

    A Nakamoto, M Harada, A Shinohara, K Tsuchiya, H Suzuki

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  • 第29回日本霊長類学会・日本哺乳類学会2013年度合同大会 優秀ポスター賞(共同発表者)

    2013.9   日本哺乳類学会  

    井上比加里, 酒井悠輔, 坂本信介, 森田哲夫, 越本知大, 篠原明男

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 日本哺乳類学会2010年度大会 優秀ポスター賞(共同発表者)

    2010.9   日本哺乳類学会  

    坂本信介・鈴木惟司・篠原明男・越本知大

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Grant-in-Aid for Scientific Research 【 display / non-display

  • 食糞行動と脳腸相関:キヌゲネズミ科実験動物を用いて動物実験への影響を解明する

    Grant number:25K02198  2025.04 - 2028.03

    日本学術振興会  科学研究費助成事業  基盤研究(B)一般

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    Authorship:Principal investigator 

  • 発酵槽である盲腸をもたない哺乳類(真無盲腸目)の消化管内微生物叢の多様性と進化

    Grant number:15K07191  2015.04 - 2019.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    近年になってヒトの消化管内微生物叢には3種類の典型的なパターンが存在することが明らかとなったが、ヒト以外の哺乳類においては殆ど研究が進んでいない。とりわけ野生の小型哺乳類は食性や生息環境の多様性が高いことから、多様な微生物叢のパターンが存在することが予想できる。本研究では、微生物発酵槽となる前胃も盲腸も持たない真無盲腸目から、地下生活への適応度が異なる種の消化管内微生物叢の多様性を明らかにすることによって、食性と生息環境が消化管内微生物叢に与える影響を明らかにする。さらに、他の分類群の結果と比較することによって微生物発酵槽を持たない哺乳類の消化管内微生物叢の多様性と進化を明らかにする

  • 小型哺乳類における食性と腸内細菌叢の共進化に関する研究

    Grant number:99999999  2010.04 - 2014.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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  • 地下生活への適応度合いによる視物質遺伝子の適応進化に関する研究

    Grant number:19770209  2007.04 - 2010.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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  • 第三紀後期のユーラシア産小型哺乳類の断続的放散と環境適応に関する分子系統解析

    Grant number:19405010  2007.04 - 2009.03

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

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Other external funds procured 【 display / non-display

  • Research platform for East Asian vertebrate species diversity and formation of specimen network

    2011.04 - 2014.03

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    Grant type:Competitive

Other research activities 【 display / non-display

  • 中国海南省における小型哺乳類調査

    2012.02 - 2014.03

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    中国海南省海南島において、小型哺乳類の生息調査を行った。

  • 書評「新図説 動物の起源と進化(長谷川政美著)」

    2011.12

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    2) 篠原明男「新図説 動物の起源と進化 〜書きかえられた系統樹(長谷川政美著)」哺乳類科学51:393-394(2011年12月)

  • 中国四川省における小型哺乳類調査

    2010.08

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    中国四川省において、小型哺乳類の生息調査を行った。

  • 中国雲南省における小型哺乳類調査

    2010.01

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    中国雲南省において、小型哺乳類の生息調査を行った。

  • インド国における小型哺乳類調査

    2009.12

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    インド国ミゾラム州において、小型哺乳類の生息調査を行った。

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