SHINOHARA Akio

写真a

Affiliation

Frontier Science Research Center Living thing of experiment support section resource field

Title

Associate Professor

External Link

Degree 【 display / non-display

  • 博士(環境科学) ( 2008.6   北海道大学 )

  • 修士(地球環境科学) ( 2001.3   北海道大学 )

  • 学士(理学) ( 1998.3   北海道大学 )

Research Areas 【 display / non-display

  • Life Science / Evolutionary biology

  • Life Science / Biodiversity and systematics

  • Life Science / Laboratory animal science

 

Papers 【 display / non-display

  • Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world’s smallest mammalian divers Reviewed International coauthorship

    He K., Eastman T.G., Czolacz H., Li S., Shinohara A., Kawada S.I., Springer M.S., Berenbrink M., Campbell K.L.

    eLife   10   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:eLife  

    The speciose mammalian order Eulipotyphla (moles, shrews, hedgehogs, solenodons) combines an unusual diversity of semi-aquatic, semi-fossorial, and fossorial forms that arose from terrestrial forbearers. However, our understanding of the ecomorphological pathways leading to these lifestyles has been confounded by a fragmentary fossil record, unresolved phylogenetic relationships, and potential morphological convergence, calling for novel approaches. The net surface charge of the oxygen-storing muscle protein myoglobin (ZMb ), which can be readily determined from its primary structure, provides an objective target to address this question due to mechanistic linkages with myoglobin concentration. Here, we generate a comprehensive 71 species molecular phylogeny that resolves previously intractable intra-family relationships and then ancestrally reconstruct ZMb evolution to identify ancient lifestyle transitions based on protein sequence alone. Our phylogenetically informed analyses confidently resolve fossorial habits having evolved twice in talpid moles and reveal five independent secondary aquatic transitions in the order housing the world’s smallest endothermic divers.

    DOI: 10.7554/eLife.66797

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  • Volatile fatty acids and microflora composition in the digestive tract of the East European vole (Microtus levis) Reviewed

    Ikemoto-Kobayashi, M., Shinohara, A., Jogahara, T., Oda, S. & Mekada, K

    Naturalistae   26   7 - 13   2022.2

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    Language:English   Publishing type:Research paper (bulletin of university, research institution)  

    Other Link: http://www1.ous.ac.jp/garden/naturalistae26.html

  • Influence of Quaternary environmental changes on mole populations inferred from mitochondrial sequences and evolutionary rate estimation Reviewed

    Nakamoto A., Harada M., Mitsuhashi R., Tsuchiya K., Kryukov A.P., Shinohara A., Suzuki H.

    Zoological Letters   7 ( 1 )   2   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Zoological Letters  

    Quaternary environmental changes fundamentally influenced the genetic diversity of temperate-zone terrestrial animals, including those in the Japanese Archipelago. The genetic diversity of present-day populations is taxon- and region-specific, but its determinants are poorly understood. Here, we analyzed cytochrome b gene (Cytb) sequences (1140 bp) of mitochondrial DNA (mtDNA) to elucidate the factors determining the genetic variation in three species of large moles: Mogera imaizumii and Mogera wogura, which occur in central and southern mainland Japan (Honshu, Shikoku, and Kyushu), and Mogera robusta, which occurs on the nearby Asian continent. Network construction with the Cytb sequences revealed 10 star-shaped clusters with apparent geographic affinity. Mismatch distribution analysis showed that modes of pairwise nucleotide differences (τ values) were grouped into five classes in terms of the level, implying the occurrence of five stages for rapid expansion. It is conceivable that severe cold periods and subsequent warm periods during the late Quaternary were responsible for the population expansion events. The first and third oldest events included island-derived haplotypes, indicative of the involvement of land bridge formation between remote islands, hence suggesting an association of the ends of the penultimate (PGM, ca. 130,000 years ago) and last (LGM, ca. 15,000 years ago) glacial maxima, respectively. Since the third event was followed by the fourth, it is plausible that the termination of the Younger Dryas and subsequent abrupt warming ca. 11,500 years ago facilitated the fourth expansion event. The second event most likely corresponded to early marine isotope stage (MIS) 3 (ca. 53,000 years ago) when the glaciation and subsequent warming period were predicted to have influenced biodiversity. Utilization of the critical times of 130,000, 53,000, 15,000, and 11,500 years ago as calibration points yielded evolutionary rates of 0.03, 0.045, 0.10 and 0.10 substitutions/site/million years, respectively, showing a time-dependent manner whose pattern was similar to that seen in small rodents reported in our previous studies. The age of the fifth expansion event was calculated to be 5800 years ago with a rate of 0.10 substitutions/site/million years ago during the mid-Holocene, suggestive of the influence of humans or other unspecified reasons, such as the Jomon marine transgression.

    DOI: 10.1186/s40851-021-00169-9

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  • New Dental Anomalies in the Greater Japanese Shrew Mole Urotrichus talpoides (Eulipotyphla: Talpidae) Reviewed

    Shinya Okabe, Akio Shinohara, Masaharu Motokawa

    Mammal Study   46 ( 4 )   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Mammalogical Society of Japan  

    DOI: 10.3106/ms2020-0095

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  • Comparison of Ovarian Morphology and Follicular Disturbances between Two Inbred Strains of Cotton Rats (Sigmodon hispidus) Reviewed

    Md Rashedul Islam, Osamu Ichii, Teppei Nakamura, Takao Irie, Akio Shinohara, Md Abdul Masum, Yuki Otani, Takashi Namba, Tsolmon Chuluunbaatar, Yaser Hosny Ali Elewa, Yasuhiro Kon

    Animals   11 ( 6 )   1768 - 1768   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Most mammalian ovarian follicles contain only a single oocyte having a single nucleus. However, two or more oocytes and nuclei are observed within one follicle and one oocyte, respectively, in several species, including cotton rat (CR, Sigmodon hispidus). The present study compared ovarian histology, focusing on folliculogenesis, between two inbred CR strains, HIS/Hiph and HIS/Mz. At 4 weeks of age, ovarian sections from both the strains were analyzed histologically. Multi-oocyte follicles (MOFs) and double-nucleated oocytes (DNOs) were observed in all stages of developing follicles in HIS/Hiph, whereas HIS/Mz had MOFs up to secondary stages and lacked DNOs. The estimated total follicles in HIS/Mz were almost half that of HIS/Hiph, but interstitial cells were well developed in HIS/Mz. Furthermore, immunostaining revealed no clear strain differences in the appearance of oocytes positive for Ki67, PCNA, and p63 in MOF or DNOs; no cell death was observed in these oocytes. Ultrastructural analysis revealed more abundant mitochondrial clouds in oocytes of HIS/Hiph than HIS/Mz. Thus, we clarified the strain differences in the CR ovary. These findings indicate that early events during folliculogenesis affect the unique ovarian phenotypes found in CRs, including MOFs or DNOs, and their strain differences.

    DOI: 10.3390/ani11061768

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Books 【 display / non-display

  • 動物学の百科事典

    日本動物学会(編)( Role: Contributor ,  脊椎動物(哺乳類)―恐竜絶滅後の地球を制した覇者)

    丸善出版  2018.9 

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    Responsible for pages:102-103   Language:Japanese Book type:Dictionary, encyclopedia

  • 大・中・小動物実験プロトコール

    宮崎大学動物実験プロトコール編集委員会( Role: Joint author)

    宮日情報文化センター  2016.3 

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    Language:Japanese Book type:Scholarly book

  • 日本の哺乳類学 第1巻 小型哺乳類

    本川雅治、岩佐真宏、大舘智氏、佐藤和彦、船越公威、佐野明、芝田史仁、田村典子、関島恒夫、島田卓哉( Role: Joint author)

    東京大学出版会  2008.5 

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    Language:Japanese Book type:Scholarly book

  • エラブオオコウモリ天然記念物緊急調査報告書

    土屋公幸, 篠原明男, 船越公威, 國崎敏廣( Role: Joint author ,  エラブオオコウモリの遺伝的多様性について)

    鹿児島県上屋久町教育委員会  2003.3 

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    Language:Japanese Book type:Report

  • 生物多様性・遺伝的多様性調査報告書

    篠原明男, 鈴木仁, 土屋公幸, 原田正史(3.哺乳類)

    環境庁自然保護局・生物多様性センター  2000.3 

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    Language:Japanese Book type:Report

MISC 【 display / non-display

  • 脳波測定を活用したデグー(Octodon degus)のセボフルラン及びイソフルラン吸入麻酔特性の検討

    伊海結貴、七條宏樹、名倉悟郎、篠原明男、越本知大

    九州実験動物雑誌   37   43 - 45   2021.10

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:九州実験動物研究会  

  • 希少固有種アマミトゲネズミの実験動物化に向けた飼育ストレス評価の試み

    2緒方穂波、前山賢太、林扶充子、仮屋博敬、川辺敏晃、名倉悟郎、城ヶ原貴通、篠原明男、越本知大

    九州実験動物雑誌   35   59   2019.10

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:九州実験動物研究会  

  • BALB/c系統マウスの休眠発現は成長初期の栄養獲得量により調節される

    加藤悟郎,坂本信介,篠原明男,森田哲夫,越本知大

    九州実験動物雑誌   31   43 - 44   2015.10

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:九州実験動物研究会  

  • 哺乳類分子系統学のこれから 日本哺乳類学会2014年度大会自由集会記録

    篠原明男, 佐藤淳, 米澤隆弘, He Kai, 今井啓雄

    哺乳類科学   55 ( 1 )   98 - 99   2015.6

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:日本哺乳類学会  

  • 実験動物化に向けたアカネズミの繁殖

    酒井悠輔,坂本信介,森田哲夫,篠原明男,越本知大

    九州実験動物雑誌   29   57 - 58   2013.11

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    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)   Publisher:九州実験動物研究会  

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Presentations 【 display / non-display

  • ヨーロッパモリネズミ(Apodemus sylvaticus)の生殖工学技術の改善に向けた検討

    横上由惟、名倉悟郎、篠原明男、越本知大

    第39回九州実験動物研究会総会 

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    Event date: 2021.11.6 - 2021.11.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  • トゲマウス属齧歯類の子宮内膜症モデル化に向けた基礎研究

    天野桃子、柴彩夏、名倉悟郎、篠原明男、中家雅隆、越本知大

    第39回九州実験動物研究会総会 

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    Event date: 2021.11.6 - 2021.11.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  • ヨーロッパモリネズミ(Apodemus sylvaticus)の誘起排卵卵子及び卵胞卵子の蛍光免疫染色による形態的解析

    竹口加那子、Narantsog Choijookhuu、名倉悟郎、篠原明男、菱川善隆、越本知大

    第39回九州実験動物研究会総会 

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    Event date: 2021.11.6 - 2021.11.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  • ハムスターから学んだ腸内細菌叢の進化(自由集会「野生のネズミに学んだ遺伝学」)

    篠原明男

    日本哺乳類学会2021年度大会  

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    Event date: 2021.8.28 - 2021.8.31

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  • Dental anomalies in Talpinae, with new report in Urotrichus talpoides (Eulipotyphla: Talpidae) International conference

    S. Okabe, A. Shinohara, M. Motokawa

    100th Annual Meeting of the American Society of Mammalogists  (Online)  American Society of Mammalogists

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    Event date: 2021.6.14 - 2021.6.18

    Language:English   Presentation type:Poster presentation  

    Venue:Online  

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Awards 【 display / non-display

  • 日本哺乳類学会2017年度大会 優秀ポスター賞(主発表者)

    2017.9   日本哺乳類学会  

    5) 篠原明男、井上比加里、稲留健人、樫村敦、江藤毅、加藤悟郎、坂本信介、越本知大

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 日本哺乳類学会2010年度大会 最優秀ポスター賞(共同発表者)

    2016.9   日本哺乳類学会  

    中本あずさ・原田正史・篠原明男・土屋公幸・鈴木仁

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • Vth International Wildlife Management Congress (IWMC2015) MSJ Poster Award

    2015.7   日本哺乳類学会  

    A Nakamoto, M Harada, A Shinohara, K Tsuchiya, H Suzuki

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  • 第29回日本霊長類学会・日本哺乳類学会2013年度合同大会 優秀ポスター賞(共同発表者)

    2013.9   日本哺乳類学会  

    井上比加里, 酒井悠輔, 坂本信介, 森田哲夫, 越本知大, 篠原明男

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 日本哺乳類学会2010年度大会 優秀ポスター賞(共同発表者)

    2010.9   日本哺乳類学会  

    坂本信介・鈴木惟司・篠原明男・越本知大

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Grant-in-Aid for Scientific Research 【 display / non-display

  • 発酵槽である盲腸をもたない哺乳類(真無盲腸目)の消化管内微生物叢の多様性と進化

    2015.04 - 2019.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    近年になってヒトの消化管内微生物叢には3種類の典型的なパターンが存在することが明らかとなったが、ヒト以外の哺乳類においては殆ど研究が進んでいない。とりわけ野生の小型哺乳類は食性や生息環境の多様性が高いことから、多様な微生物叢のパターンが存在することが予想できる。本研究では、微生物発酵槽となる前胃も盲腸も持たない真無盲腸目から、地下生活への適応度が異なる種の消化管内微生物叢の多様性を明らかにすることによって、食性と生息環境が消化管内微生物叢に与える影響を明らかにする。さらに、他の分類群の結果と比較することによって微生物発酵槽を持たない哺乳類の消化管内微生物叢の多様性と進化を明らかにする

  • 小型哺乳類における食性と腸内細菌叢の共進化に関する研究

    2010.04 - 2014.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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  • 地下生活への適応度合いによる視物質遺伝子の適応進化に関する研究

    2007.04 - 2010.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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  • 第三紀後期のユーラシア産小型哺乳類の断続的放散と環境適応に関する分子系統解析

    2007.04 - 2009.03

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

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  • 食虫類モグラ科における地下適応の歴史は協調進化か?

    2003.04 - 2005.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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Other external funds procured 【 display / non-display

  • Research platform for East Asian vertebrate species diversity and formation of specimen network

    2011.04 - 2014.03

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    Grant type:Competitive

Other research activities 【 display / non-display

  • 中国海南省における小型哺乳類調査

    2012.02 - 2014.03

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    中国海南省海南島において、小型哺乳類の生息調査を行った。

  • 書評「新図説 動物の起源と進化(長谷川政美著)」

    2011.12

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    2) 篠原明男「新図説 動物の起源と進化 〜書きかえられた系統樹(長谷川政美著)」哺乳類科学51:393-394(2011年12月)

  • 中国四川省における小型哺乳類調査

    2010.08

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    中国四川省において、小型哺乳類の生息調査を行った。

  • 中国雲南省における小型哺乳類調査

    2010.01

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    中国雲南省において、小型哺乳類の生息調査を行った。

  • インド国における小型哺乳類調査

    2009.12

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    インド国ミゾラム州において、小型哺乳類の生息調査を行った。

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