SUGAMOTO Kazuhiro

写真a

Affiliation

Engineering educational research section Department of Applied Chemistry Program

Title

Associate Professor

External Link

Degree 【 display / non-display

  • 博士(工学) ( 1999.3   大阪大学 )

Research Areas 【 display / non-display

  • Nanotechnology/Materials / Green sustainable chemistry and environmental chemistry

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

  • Nanotechnology/Materials / Synthetic organic chemistry

  • Life Science / Bioorganic chemistry

 

Papers 【 display / non-display

  • Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes.

    Sugamoto K, Tanaka YL, Saito A, Goto Y, Nakayama T, Okabayashi T, Kunitake H, Morishita K

    Biochemical and biophysical research communications   615   56 - 62   2022.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Biochemical and Biophysical Research Communications  

    With the current worldwide pandemic of COVID-19, there is an urgent need to develop effective treatment and prevention methods against SARS-CoV-2 infection. We have previously reported that the proanthocyanidin (PAC) fraction in blueberry (BB) leaves has strong antiviral activity against hepatitis C virus (HCV) and human T-lymphocytic leukemia virus type 1 (HTLV-1). In this study, we used Kunisato 35 Gou (K35) derived from the rabbit eye blueberry (Vaccinium virgatum Aiton), which has a high PAC content in the leaves and stems. The mean of polymerization (mDP) of PAC in K35 was the highest of 7.88 in Fraction 8 (Fr8) from the stems and 12.28 of Fraction 7 (Fr7) in the leaves. The composition of BB-PAC in K35 is that most are B-type bonds with a small number of A-type bonds and cinchonain I as extension units. A strong antiviral effect was observed in Fr7, with a high polymerized PAC content in both the leaves and stems. Furthermore, when we examined the difference in the action of BB-PAC before and after SARS-CoV-2 infection, we found a stronger inhibitory effect in the pre-infection period. Moreover, BB-PAC Fr7 inhibited the activity of angiotensin II converting enzyme (ACE2), although no effect was observed in a neutralization test of pseudotyped SARS-CoV-2. The viral chymotrypsin-like cysteine protease (3CLpro) of SARS-CoV-2 was also inhibited by BB-PAC Fr7 in leaves and stems. These results indicate that BB-PAC has at least two different inhibitory effects, and that it is effective in suppressing SARS-CoV-2 infection regardless of the time of infection.

    DOI: 10.1016/j.bbrc.2022.04.072

    Scopus

    PubMed

  • Two new angular-type pyranocoumarins from the aerial parts of Angelica furcijuga and their synthesis from isoepoxypteryxin Reviewed

    Sugamoto K., Sakashita T., Matsumoto T., Hirozawa N.

    Phytochemistry Letters   48   1 - 4   2022.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Phytochemistry Letters  

    Two new angular-type pyranocoumarins, namely hyuganin G (1) and hyuganin H (2), were isolated from an ethyl acetate extract of the aerial parts of Angelica furcijuga, together with three known angular-type pyranocoumarins, isoepoxypteryxin (3), isopteryxin (4), and hyuganin E (5). Assignment of the 1H and 13C NMR data of 1 and 2 were achieved via analysis of the DEPT, HMQC, and HMBC spectra. The absolute configurations of 1 and 2 were determined by semi-synthesis from 3.

    DOI: 10.1016/j.phytol.2022.01.004

    Scopus

  • Synthesis of chalcones bearing 2-hydroperoxy-3-methyl-3-butenyl or 2-hydroxy-3-methyl-3-butenyl group from prenylated chalcones Reviewed

    Sugamoto K., Yoshifuji T., Soejima S., Honda Y.

    Synthetic Communications   50 ( 10 )   1523 - 1527   2020.5

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Synthetic Communications  

    © 2020, © 2020 Taylor & Francis Group, LLC. Chalcones bearing 2-hydroperoxy-3-methyl-3-butenyl or 2-hydroxy-3-methyl-3-butenyl groups, such as xanthoangelol E (1a), xanthoangelol D (2a), psorachalcone A (2 b), xanthohumol D (2c), and related derivatives were first synthesized by using the ene reaction of prenylated chalcones with singlet oxygen.

    DOI: 10.1080/00397911.2020.1745242

    Scopus

  • Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei 「(共著)」 Reviewed

    Kazuhiro Sugamoto, Yoh-ichi Matsushita, Kana Matsui, Chiaki Kurogi, Takanao Matsui

    Tetrahedron   67   5346 - 5359   2011.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Synthesis of 4-hydroxyderricin and related derivatives「(共著)」 Reviewed

    Kazuhiro Sugamoto, Chiaki Kurogi, Yoh-ichi Matsushita, Takanao Matsui

    Tetrahedron Letters   49   6639 - 6641   2008.10

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books 【 display / non-display

  • Sustainable Degradation of Lignocellulosic Biomass - Techniques, Applications and Commercialization

    Masahide Yasuda, Keisuke Takeo, Tomoko Matsumoto, Tsutomu Shiragami, Kazuhiro Sugamoto, Yoh-ichi Matsushita, Yasuyuki Ishii( Role: Joint author)

    InTech  2013.5 

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    Language:English Book type:Scholarly book

MISC 【 display / non-display

  • New Aerobic Oxidations for Organic Synthesis Directed Toward Preservation of the Enviroment

    Y. Matsushita, K. Sugamoto, T. Matsui

    Chemical Industry   51 ( 6 )   37 - 45   2000.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

Presentations 【 display / non-display

  • Selective extraction and extraction equilibrium of Sc(III) from an acidic medium with Deep Eutectic Solvent (DES) composed of isostearic acid and TOPO

    Ushizaki Sora, Kanemaru Shintaro, Sugamoto Kazuhiro, Baba Yoshinari

    化学工学会第87年会 

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    Event date: 2022.3.16 - 2022.3.18

    Language:Japanese   Presentation type:Poster presentation  

  • Selective separation and extraction equilibria of scandium(III) and yttrium(III) with N-lauroylsarcosine

    Matsumoto Marina, Kanemaru Shintaro, Baba Yoshinari, Sugamoto Kazuhiro

    化学工学会第87年会 

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    Event date: 2022.3.16 - 2022.3.18

    Language:Japanese   Presentation type:Poster presentation  

  • Evaluation of blueberry leaf / stem functionality by DI-EI-MS metabolomics

    2022.3.17 

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    Event date: 2022.3.15 - 2022.3.18

    Presentation type:Oral presentation (general)  

  • イソステアリン酸とTOPOによる深共晶溶媒の創出とスカンジウムの抽出平衡

    牛﨑 そら, 金丸 慎太郎, 馬場 由成, 菅本 和寛

    一般社団法人資源・素材学会 2022年度 春季大会 

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    Event date: 2022.3.7 - 2022.3.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 新規抽出剤であるN-ラウロイルサルコシンによるイットリウム(III)とスカンジウム(III)の高選択的分離と抽出平衡

    松本 茉李南, 金丸 慎太郎, 馬場 由成, 菅本 和寛

    一般社団法人資源・素材学会 2022年度 春季大会 

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    Event date: 2022.3.7 - 2022.3.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 工学部賞

    2022.5   宮崎大学工学部  

    菅本 和寛

  • 宮崎日日新聞賞(科学賞)

    2021.10   宮崎日日新聞   ブルーベリー茎葉抽出成分の新型コロナウイルス不活化効果

    宮崎大学「ブルーベリー茎葉抽出成分の新型コロナウイルス不活化効果」研究チーム

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    Award type:Award from publisher, newspaper, foundation, etc. 

  • 科学技術シンポジウム in 宮崎 2007 優秀賞

    2007.2   みやざき産業クラスター推進協議会  

    菅本和寛

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • Poster Presentation Award for Japanese Chemistry 2004 in OITA

    2004.10  

    Kazuhiro Sugamoto

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • フィタン酸の異性体別機能性評価~畜産物摂取によるヒトの健康増進を目指して~

    2019.04 - 2022.03

    科学研究費補助金  基盤研究(C)

    菅本 和寛

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    Authorship:Coinvestigator(s) 

    フィタン酸の異性体別機能性評価~畜産物摂取によるヒトの健康増進を目指して~ 1

  • 芳香環酸素添加酵素の機能改変とコンビナトリアルケミストリーへの利用

    2006.04 - 2008.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

    芳香環酸素添加酵素の機能改変とコンビナトリアルケミストリーへの利用を検討する。

  • アルキルヒドロペルオキシドの新規合成法の開発

    2004.04 - 2005.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

    有用な合成法の少ないアルキルヒドロペルオキシドの新規合成法を開発することを目的とした。
    アラルカンの酸素酸化によるヒドロペルオキシドの触媒となるN-ヒドロキシフタルイミド誘導体の効率的合成法を確立した。従来のN-ヒドロキシフタルイミド誘導体の合成法は長時間の加熱が必要であり,また収率も低い場合が多かった。我々はマイクロ波加熱条件の無溶媒反応で多くのN-ヒドロキシフタルイミド誘導体が高い収率で合成可能なことを見出した。
    また,N-ヒドロキシフタルイミドとアゾ系ラジカル開始剤を組み合わせた共触媒により,アラルカンのアリール位およびa,b-不飽和カルボニル化合物のアリル位が酸素酸化を受け,不安定なヒドロペルオキシシドが生成物として得られる事を見出した。

  • 魚肉貯蔵・加工時における有毒アルデヒド、4-ヒドロキシヘキセナールの生成と抑制

    2001.04 - 2002.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

    脂質過酸化により生じる4-ヒドロキシヘキセナール(HHE)は強い肝臓毒性および変異原性を持ち、食品衛生上問題となる。また、HHEは反応性に富み、タンパク質の変性や栄養の低下を引き起こす。そこでHHEを生じない安全で栄養価の低下しない魚肉および加工食品を供給するための貯蔵・加工条件を明らかにした。