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Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Pediatrics |
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MORITAKE Hiroshi
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Research Areas 【 display / non-display 】
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Life Science / Embryonic medicine and pediatrics
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Life Science / Hematology and medical oncology
Papers 【 display / non-display 】
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Novel SKIC3 variants in tricho-hepato-enteric syndrome with hemochromatosis Reviewed
Ochiai K., Aoki Y., Yamada N., Aman M., Yamashita A., Yamaguchi M., Nakato D., Takenouchi T., Kosaki K., Kodama Y., Moritake H.
Human Genome Variation 12 ( 1 ) 14 2025.12
Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Human Genome Variation
Tricho-hepato-enteric syndrome (THES), a rare autosomal recessive disorder caused by variants in the SKIC3 or SKIC2 gene, is characterized by intractable diarrhea, woolly hair, growth restriction and liver disease. Here we report a neonatal case of THES with neonatal hemochromatosis, in which the novel compound heterozygous SKIC3 variants NM_014639.4:c.815_816del p.(Gly272AlafsTer9) and NM_014639.4:c.2284G>A p.(Gly762Arg) were identified. Further research is needed to elucidate the mechanisms underlying iron metabolism dysregulation in THES.
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Age-specific mutation profiles and their prognostic implications in pediatric KMT2A-rearranged acute myeloid leukemia. Reviewed
Shoji K, Yoshida K, Iyoda S, Ishikawa M, Tanaka M, Nobe M, Saito N, Shino Y, Nannya Y, Yamato G, Tsujimoto S, Shiba N, Hayashi Y, Shiozawa Y, Shiraishi Y, Chiba K, Okada A, Tanaka H, Miyano S, Koga Y, Goto H, Terui K, Ito E, Kiyokawa N, Tomizawa D, Taga T, Moritake H, Tawa A, Takita J, Nishikori M, Adachi S, Ogawa S, Matsuo H
Haematologica 2025.10
Language：English Publishing type：Research paper (scientific journal)
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Interference of Intravenous Acetaminophen with Continuous Glucose Monitoring System Reviewed
Matsuyama Misayo, Meiri Satoru, Sawada Hirotake, Masuya Ryuta, Nakame Kazuhiko, Moritake Hiroshi
JMA Journal 8 ( 4 ) 1463 - 1467 2025.10
Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Medical Association / The Japanese Associaiton of Medical Sciences
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盛武 浩
Frontiers in Hematology 4 1668408 2025.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers Media SA
Background: Epigenetic dysregulation plays a central role in pediatric acute myeloid leukemia (AML), yet its clinical relevance remains underexplored. This study primarily aimed to elucidate the clinical effect of H3K27me3 and H3K4me3 status on pediatric acute myeloid leukemia. We evaluated the prognostic impact of H3K27me3 and H3K4me3 histone trimethylation, along with associated gene expression profiles, in pediatric AML. Methods: We retrospectively analyzed 74 children with newly diagnosed non-FAB M3 and non-Down syndrome AML in a prolonged cohort in Japan. Bone marrow immunohistochemistry assessed H3K27me3 and H3K4me3 expression levels. RNA sequencing was successfully performed on sorted leukemic blasts in six representative cases, owing to limited sample availability. Chemoresistance and epigenetic modulation were evaluated in AML cell lines treated with GSK-J4, a histone demethylase inhibitor. Results: High H3K27me3 expression at diagnosis was significantly associated with superior overall and event-free survival over three years (OS HR 8.0; EFS HR 5.0; both p < 0.01). H3K4me3 levels at diagnosis showed no prognostic impact. Among 14 KMT2A-rearranged cases, all six patients with high H3K27me3 achieved a long-term first remission (median follow-up: 10 years), whereas those with low expression had higher relapse rates. Transcriptomic analysis revealed upregulation of HOXA9, and HOXA-cluster genes and downregulation of ABCB1, in low H3K27me3 samples. In vitro, GSK-J4 increased H3K27me3 and suppressed HOXA9 expression in KG-1 cells, enhancing sensitivity to cytarabine. Conclusion: Low H3K27me3 expression defines a poor-risk group in pediatric AML, potentially via HOXA9-driven dysregulation. H3K27me3 may serve as a prognostic biomarker and potential therapeutic target.
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Yamamoto N, Maeda K, Kimoto Y, Moritake H
BMJ case reports 18 ( 8 ) 2025.8
Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：BMJ Case Reports
Rasmussen encephalitis (RE) is a progressive disease characterised by unilateral brain atrophy, drug-resistant epilepsy, epilepsia partialis continua, hemiparesis and cognitive decline. Early initiation of immunomodulatory therapy is crucial to slow disease progression. However, early formal diagnosis is challenging as it typically requires hemispheric atrophy or brain biopsy. This case reports on a preschool-aged boy with RE who began immunotherapy before demonstrating clear hemispheric atrophy. Follow-up MRI did not indicate global hemispheric atrophy; however, FreeSurfer-based volumetric analysis revealed a decreased left:right hemispheric volume ratio, suggesting early left hemispheric atrophy. Subsequently, intensive immunotherapy was administered. Over 3 years of treatment, the patient exhibited gradual hemispheric atrophy on MRI, along with mild motor and cognitive impairments. Serial FreeSurfer-based volumetric analysis may contribute to detecting subtle hemispheric volume changes in RE, facilitating prompt diagnosis and early initiation of immunotherapy - potentially limiting disease progression.
Books 【 display / non-display 】
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今日の治療指針
盛武 浩（ Role： Joint author , 小児の白血病）
医学書院 2021 （ ISBN:978-4-260-04283-3 ）
Responsible for pages：1494-1495 Language：Japanese Book type：Textbook, survey, introduction
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血液専門医テキスト 改訂第3版
盛武 浩（ Role： Joint author , 小児の急性骨髄性白血病）
南江堂 2019
Responsible for pages：456-460 Language：Japanese Book type：Textbook, survey, introduction
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鉄欠乏性貧血. 小児疾患診療のための病態生理3 改訂第5版.
盛武 浩（ Role： Sole author）
東京医学社 2016
Language：Japanese Book type：Textbook, survey, introduction
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白血球と分画
盛武 浩（ Role： Sole author）
今日の小児診断指針 2004.7
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia Reviewed
Iyoda S., Yoshida K., Shoji K., Ito N., Tanaka M., Nannya Y., Yamato G., Tsujimoto S., Shiba N., Hayashi Y., Shiozawa Y., Shiraishi Y., Chiba K., Okada A., Tanaka H., Miyano S., Koga Y., Goto H., Moritake H., Terui K., Ito E., Kiyokawa N., Tomizawa D., Taga T., Tawa A., Takita J., Nishikori M., Adachi S., Ogawa S., Matsuo H.
Leukemia 38 ( 7 ) 1609 - 1612 2024
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Leukemia
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Reduced-intensity therapy for relapsed Philadelphia chromosome-positive leukemia Reviewed
Nagasawa S., Yamada A., Nakagawa M., Kinoshita M., Koga Y., Ohga S., Moritake H.
Pediatric Blood and Cancer 71 ( 2 ) e30802 2023
Authorship：Corresponding author Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Pediatric Blood and Cancer
DOI： 10.1002/pbc.30802
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Nagasawa S., Yamada A., Kinoshita M., Kamimura S., Moritake H.
Pediatrics International 64 ( 1 ) e14970 2022.1
Authorship：Corresponding author Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Pediatrics International
DOI： 10.1111/ped.14970
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Kinoshita M., Yamada A., Saito Y., Kamimura S., Moritake H.
Pediatrics International 64 ( 1 ) e14975 2022.1
Authorship：Corresponding author Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Pediatrics International
DOI： 10.1111/ped.14975
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Taga T., Tanaka S., Hasegawa D., Terui K., Toki T., Iwamoto S., Hiramatsu H., Miyamura T., Hashii Y., Moritake H., Nakayama H., Takahashi H., Shimada A., Taki T., Ito E., Hama A., Ito M., Koh K., Hasegawa D., Saito A.M., Adachi S., Tomizawa D.
Leukemia 35 ( 12 ) 3622 - 3624 2021.12
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：Leukemia
Following the publication of this article, the authors noted an error in the data reported.
Presentations 【 display / non-display 】
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COVID-19 ワクチン接種後に発症した心膜心筋炎
二見 加菜、髙村 一成、山下 尚人、原田 雅子、澤 大介、盛武 浩
第91回日本小児科学会宮崎地方会, 宮崎
Event date： 2022.3.20
Presentation type：Oral presentation (general)
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発症早期に免疫修飾治療を開始したラスムッセン脳炎
山本 夏穂、 下田 貴史、 森 こずえ、 前田 謙一、 木許 恭宏、 池田 俊郎、 盛武 浩
第91回日本小児科学会宮崎地方会, 宮崎
Event date： 2022.3.20
Presentation type：Oral presentation (general)
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集団健診を契機に診断された頻拍誘発性心筋症２例
興梠 智子、髙村 一成、山下 尚人、原田 雅子、盛武 浩
第91回日本小児科学会宮崎地方会, 宮崎
Event date： 2022.3.20
Presentation type：Oral presentation (general)
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Clonal architecture and its prognostic significance in KMT2A-rearranged acute myeloid leukemia
Matsuo H, Yoshida K, Nannya Y, Kamikubo Y, Saito S, Koga Y, Moritake H, Terui K, Kawaguchi K, Okamoto Y,Nakayama H, Kanno M, Hino M, Akane Y, Inoue A, Shimada A, Goto H, Ueno H, Takita J, Yamato G, Shiba N, Hayashi Y, Shiraishi Y, Miyano S, Kiyokawa N, Tomizawa D, Taga T, Tawa A, Ogawa S, Adachi S
Event date： 2021.9.23 - 2021.9.25
Presentation type：Oral presentation (general)
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不明熱を呈し, リンパ節生検により診断に至ったTAFRO症候群の１例
小川 智香, 山元 綾子, 西村 豊樹, 盛武 浩
第90回日本小児科学会宮崎地方会, 宮崎
Event date： 2021.9.12
Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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日本白血病研究基金 一般研究賞（クレディセゾン賞）
2014.11 公益信託 日本白血病研究基金助成事業
盛武 浩
Award type：Award from publisher, newspaper, foundation, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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PDXマウスモデルを用いた再発難治小児急性骨髄性白血病の病態解明と新規治療法開発
Grant number：23K07337 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
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Mfsd2遺伝子KOマウスを用いた、脳内ＤＨＡによるエネルギー代謝調節機構の解明
Grant number：16K09971 2018.04
科学研究費補助金 基盤研究(C)
KOマウスの脳の組織学的評価と、摂食行動およびエネルギー代謝特性、代謝関連遺伝子発現を評価する。
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網羅的遺伝子解析をとおして同定した家族性白血病原因遺伝子の機能解析
Grant number：16K10032 2016.04 - 2019.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
網羅的遺伝子解析をとおして同定した家族性白血病原因遺伝子と想定される2つの遺伝子変異の機能解析を行う
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家族性急性リンパ性白血病の原因遺伝子の探索
Grant number：25461600 2013.04 - 2016.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
家族性急性リンパ性白血病の原因遺伝子の探索
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Mfsd2遺伝子ノックアウトマウスにおけるエネルギー代謝特性の解明
Grant number：25461556 2013.04 - 2015.03
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
我々が作成したMfsd2遺伝子ノックアウトマウスにおけるエネルギー代謝特性を解析する