MORITAKE Hiroshi

写真a

Affiliation

Faculty of Medicine School of Medicine Department of Developmental and Urological-Reproductive Medicine, Pediatrics

Title

Professor

External Link

Degree 【 display / non-display

  • 博士(医学) ( 2001.3   宮崎医科大学 )

Research Areas 【 display / non-display

  • Life Science / Embryonic medicine and pediatrics

  • Life Science / Hematology and medical oncology

 

Papers 【 display / non-display

  • Targeting cholesterol biosynthesis for AT/RT: comprehensive expression analysis and validation in newly established AT/RT cell line. Reviewed

    Matsumoto F, Yokogami K, Yamada A, Moritake H, Watanabe T, Yamashita S, Sato Y, Takeshima H

    Human cell   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13577-023-01022-1

    PubMed

  • B-cell deficiency identified by newborn screening Reviewed

    Matsumoto Takayuki, Nishimura Toyoki, Yamamoto Ayako, Sawada Hirotake, Moritake Hiroshi

    JSIAD Journal   3 ( 1 )   16 - 20   2024.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Immunodeficiency and Autoinflammatory Diseases  

     Newborn screening(NBS)is carried out at public expense for approximately 20 diseases in Japan; however, each prefecture independently conducts additional NBS including several more diseases. Miyazaki Prefecture has optionally included inborn errors of immunity(IEIs)and lysosomal storage diseases since April 2020. We herein report a baby who suffered from B-cell deficiency(BCD)that was identified by NBS conducted in Miyazaki Prefecture. The baby had low levels of kappa-deleting recombination excision circles(KRECs)and was referred to our hospital. Several measurements of CD19-positive B cells in the peripheral blood consistently showed values <2%, leading to the diagnosis of BCD. Periodic immunoglobulin replacement successfully led to a healthy outcome without serious infection developing over a period of more than 17 months. This is the first case of BCD identified by NBS and that underwent prophylactic gamma globulin replacement in Japan. Severe combined immunodeficiency disease and BCD are IEIs known to cause severe sequelae, and patients sometimes die without a correct diagnosis being made; therefore, their early diagnosis and early treatment are extremely important. The inclusion of IEIs in NBS has proven to be cost-effective all over the world. In the future, it is expected that IEIs will be covered by NBS public funds in Japan as well.

    DOI: 10.34563/jsiadjournal.3.1_16

    CiNii Research

  • Novel splice site variant of TMEM38B in osteogenesis imperfecta type XIV Reviewed

    Kodama Y., Meiri S., Asada T., Matsuyama M., Makino S., Iwai M., Yamaguchi M., Moritake H.

    Human Genome Variation   10 ( 1 )   25   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Human Genome Variation  

    Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by brittle bones. In this case report, we describe a patient who suffered from OI type XIV with a novel splice site variant in the TMEM38B gene. Further research is needed to better understand the relationship between the phenotype of OI type XIV and this variant.

    DOI: 10.1038/s41439-023-00252-x

    Scopus

    PubMed

  • Outcomes following induction failure in Japanese children with acute lymphoblastic leukemia.

    Imai C, Sato A, Hiwatari M, Shimomura Y, Hori T, Suenobu S, Imamura T, Hara J, Hasegawa D, Takahashi H, Moriya K, Katayama S, Tomizawa D, Moritake H, Taga T, Horibe K, Koh K, Manabe A, Okamoto Y

    International journal of hematology   118 ( 1 )   99 - 106   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:International Journal of Hematology  

    The characteristics and prognosis of Japanese children with acute lymphoblastic leukemia (ALL) who fail to achieve complete remission after remission induction chemotherapy (i.e., experience induction failure) are poorly understood. Therefore, we retrospectively analyzed data of patients enrolled in Japanese clinical trials for newly diagnosed ALL between 1996 and 2009. Among 4956 participants, 89 (1.8%) experienced induction failure. With a 6.0-year median follow-up, the 5-year overall survival rate of the entire cohort was 43.0% ± 5.5%. Survival rates did not differ between patients with B-cell precursor ALL (BCP-ALL) and T-cell ALL (T-ALL). In multivariate analysis, day 15 M3 marrow (bone marrow blast count ≥ 25%) was significantly correlated with poorer survival in the whole or BCP-ALL cohorts. In T-ALL, age < 6 years was significantly associated with poor survival. However, due to the small sample size, this correlation must be further investigated. Most T-ALL and BCR-ABL-positive BCP-ALL patients underwent allogeneic stem cell transplantation (allo-SCT). Survival rates did not differ between BCR-ABL-negative BCP-ALL patients who did and did not undergo allo-SCT, possibly due to the inclusion of lower-risk patients in the latter group. In conclusion, the induction failure rate and survival after diagnosis of induction failure in our study were comparable to previously reported figures.

    DOI: 10.1007/s12185-023-03600-3

    Scopus

    PubMed

  • Pneumocystis pneumonia during everolimus therapy for Kasabach–Merritt phenomenon Reviewed

    Otomi K., Yamada A., Kurogi J., Kamimura S., Moritake H.

    Pediatrics International   65 ( 1 )   e15593   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Pediatrics International  

    DOI: 10.1111/ped.15593

    Scopus

    PubMed

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Books 【 display / non-display

  • 今日の治療指針

    盛武 浩( Role: Joint author ,  小児の白血病)

    医学書院  2021  ( ISBN:978-4-260-04283-3

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    Responsible for pages:1494-1495   Language:Japanese Book type:Textbook, survey, introduction

  • 血液専門医テキスト 改訂第3版

    盛武 浩( Role: Joint author ,  小児の急性骨髄性白血病)

    南江堂   2019 

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    Responsible for pages:456-460   Language:Japanese Book type:Textbook, survey, introduction

  • 鉄欠乏性貧血. 小児疾患診療のための病態生理3 改訂第5版.

    盛武 浩( Role: Sole author)

    東京医学社  2016 

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    Language:Japanese Book type:Textbook, survey, introduction

  • 白血球と分画

    盛武 浩( Role: Sole author)

    今日の小児診断指針  2004.7 

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    Language:Japanese Book type:Scholarly book

MISC 【 display / non-display

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Presentations 【 display / non-display

  • COVID-19 ワクチン接種後に発症した心膜心筋炎

    二見 加菜、髙村 一成、山下 尚人、原田 雅子、澤 大介、盛武 浩

    第91回日本小児科学会宮崎地方会, 宮崎 

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    Event date: 2022.3.20

    Presentation type:Oral presentation (general)  

  • 発症早期に免疫修飾治療を開始したラスムッセン脳炎

    山本 夏穂、 下田 貴史、 森 こずえ、 前田 謙一、 木許 恭宏、 池田 俊郎、 盛武 浩

    第91回日本小児科学会宮崎地方会, 宮崎 

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    Event date: 2022.3.20

    Presentation type:Oral presentation (general)  

  • 集団健診を契機に診断された頻拍誘発性心筋症2例

    興梠 智子、髙村 一成、山下 尚人、原田 雅子、盛武 浩

    第91回日本小児科学会宮崎地方会, 宮崎 

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    Event date: 2022.3.20

    Presentation type:Oral presentation (general)  

  • Clonal architecture and its prognostic significance in KMT2A-rearranged acute myeloid leukemia

    Matsuo H, Yoshida K, Nannya Y, Kamikubo Y, Saito S, Koga Y, Moritake H, Terui K, Kawaguchi K, Okamoto Y,Nakayama H, Kanno M, Hino M, Akane Y, Inoue A, Shimada A, Goto H, Ueno H, Takita J, Yamato G, Shiba N, Hayashi Y, Shiraishi Y, Miyano S, Kiyokawa N, Tomizawa D, Taga T, Tawa A, Ogawa S, Adachi S

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    Event date: 2021.9.23 - 2021.9.25

    Presentation type:Oral presentation (general)  

  • 不明熱を呈し, リンパ節生検により診断に至ったTAFRO症候群の1例

    小川 智香, 山元 綾子, 西村 豊樹, 盛武 浩

    第90回日本小児科学会宮崎地方会, 宮崎 

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    Event date: 2021.9.12

    Presentation type:Oral presentation (general)  

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Awards 【 display / non-display

  • 日本白血病研究基金 一般研究賞(クレディセゾン賞)

    2014.11   公益信託 日本白血病研究基金助成事業  

    盛武 浩

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • PDXマウスモデルを用いた再発難治小児急性骨髄性白血病の病態解明と新規治療法開発

    Grant number:23K07337  2023.04 - 2026.03

    独立行政法人日本学術振興会  科学研究費基金  基盤研究(C)

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    Authorship:Principal investigator 

  • Mfsd2遺伝子KOマウスを用いた、脳内DHAによるエネルギー代謝調節機構の解明

    2018.04

    科学研究費補助金  基盤研究(C)

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    KOマウスの脳の組織学的評価と、摂食行動およびエネルギー代謝特性、代謝関連遺伝子発現を評価する。

  • 網羅的遺伝子解析をとおして同定した家族性白血病原因遺伝子の機能解析

    2016.04 - 2019.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    網羅的遺伝子解析をとおして同定した家族性白血病原因遺伝子と想定される2つの遺伝子変異の機能解析を行う

  • 家族性急性リンパ性白血病の原因遺伝子の探索

    2013.04 - 2016.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    家族性急性リンパ性白血病の原因遺伝子の探索

  • Mfsd2遺伝子ノックアウトマウスにおけるエネルギー代謝特性の解明

    2013.04 - 2015.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

    我々が作成したMfsd2遺伝子ノックアウトマウスにおけるエネルギー代謝特性を解析する

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