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Faculty of Agriculture Veterinary Teaching Hospital |
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Professor |
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NAGANOBU Kiyokazu
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Research Areas 【 display / non-display 】
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Life Science / Veterinary medical science
Papers 【 display / non-display 】
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Shigemoto J., Kaneko Y., Kawazu M., Naganobu K., Torisu S.
Frontiers in Veterinary Science 11 2024.2
Publishing type：Research paper (scientific journal) Publisher：Frontiers in Veterinary Science
Introduction: Laparoscopic surgery is used for canine congenital extrahepatic portosystemic shunts (CEHPSS). However, outcomes of laparoscopic surgery involving simultaneous portal vein angiography and portal pressure measurement to attenuate or completely occlude the shunt vessel in canines remain unclear. This study aimed to evaluate outcomes and complications of laparoscopic portosystemic shunt occlusion (LAPSSO) for CEHPSS. Methods: Between June 2014 and March 2021, data on dogs undergoing cellophane banding (CB) and complete occlusion of laparoscopically treated congenital extrahepatic port shunts were collected from hospital records. Cases in which complete occlusion was laparoscopically performed, or a CB was used for gradual occlusion were included. A total of 36 dogs (14 males; median age 32.5 months [range, 5–99] with median body weight, 4.2 kg [range, 1.5–7.9]) that underwent LAPSSO for CEHPSS were included. All the dogs underwent computed tomographic angiography (CTA), and data on blood and radiological examinations were collected. Shunt vessel morphology was categorized using CTA findings. Portal pressure measurements and portal angiography were performed by accessing mesenteric and splenic veins in 30 and 6 cases, respectively. Results: The most common shunt types were spleno-phrenic shunts 16/36 (44.4%), followed by spleno-azygos 9/36 (25.0%), spleno-caval 4/36 (11.1%), right gastric-caval 6/36 (16.6%), and right gastric-caval with caudal loop shunts 1/36 (2.7%). The median portal pressure after complete occlusion was 11.5 mmHg (range, 4–16); portal pressures in the two dogs undergoing CB attenuation were 22 and 24 mmHg. The median operating time in the dogs with right (n = 25) and left (n = 11) recumbent positioning was 55 min (range, 28–120) and 54 min (range, 28–88), respectively. One dog had pneumothorax due to injury to the diaphragm. Another dog developed postoperative hypernatremia and succumbed 5 h post-procedure. Nevertheless, no other dogs exhibited signs of portal hypertension within 72 h. Blood tests and abdominal ultrasounds performed 1–2 months postoperatively revealed no residual shunts. Discussion: LAPSSO, coupled with portal pressure measurement and portal angiography, was shown as safe and effective approach that facilitated successful occlusion of CEHPSS. Further large-scale prospective studies and analyses of perioperative complications are needed.
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Dural Changes Induced by an Ultrasonic Bone Curette in an Excised Porcine Spinal Cord.
Ota R, Iwaki E, Sakai K, Haraguchi T, Kaneko Y, Sekiguchi S, Yamaguchi R, Naganobu K.
Vet Sci. 2022.10
Publishing type：Research paper (scientific journal)
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Identification of domestic cat hepadnavirus from a cat blood sample in Japan Reviewed
Kazuki Takahashi 1 , Yasuyuki Kaneko 2 , Akiko Shibanai 3 , Shushi Yamamoto 2 , Ayana Katagiri 3 , Tatsuyuki Osuga 4 , Yoshiyuki Inoue 5 , Kohei Kuroda 5 , Mika Tanabe 6 , Tamaki Okabayashi 1 7 , Kiyokazu Naganobu 2 , Isao Minobe 8 , Akatsuki Saito 1 7
J Vet Med Sci . 2022.5
Publishing type：Research paper (scientific journal)
DOI： 10.1292/jvms.22-0010
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A new needle biopsy approach for dolphins with lesions in the pterygoid sinus Reviewed
KeikoYamamoto, ..., KiyokazuNaganobu, ...
Emerging Animal Species 2022.4
Publishing type：Research paper (scientific journal)
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Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology Reviewed
Fujimoto S., Torisu S., Kaneko Y., Mizutani S., Yamamoto S., Naganobu K., Nakamura K.
Journal of Veterinary Internal Medicine 35 ( 4 ) 1780 - 1788 2021.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Veterinary Internal Medicine
Background: In human medicine, congenital maljunction of the common bile duct (CBD) and main pancreatic duct (MPD), or pancreatobiliary maljunction (PBM), is a known cause of cholecystitis. Objective: Pancreatic enzyme activity in the bile (a diagnostic marker for PBM) of healthy cats was measured to determine normal values and evaluate its relationship with biliary morphology. Animals: Fifty-two healthy cats. Methods: Cross-sectional study of the biliary tracts of healthy cats during laparoscopic ovariohysterectomy and measurement of pancreatic enzyme activity in bile. The cats were divided into groups A and B based on the ratio of the diameter of the cystic duct (CD) to the CBD. The normal ratio was 3.4. Pancreatic enzyme activity in bile was compared between the groups. Results: The CBDs were straight in all cases, whereas the CDs were variably tortuous or dilated. Amylase activity in the bile (median, <100 U/L; range, <100-591 U/L) was lower than in serum in all cases, and group B, which had a CD/CBD ratio >3.4, had significantly higher amylase activity (median, 109 U/L; range, <100-591 U/L) in the bile than did group A (median, <100 U/L; range, <100-238 U/L), which had a CD/CBD ratio <3.4 (P =.0009). Conclusions and Clinical Importance: The results suggest that a dilated CD is associated with reflux of pancreatic juice. In the future, it will be necessary to examine the clinical usefulness of these findings by measuring pancreatic enzyme activity in the bile of cats with cholangitis.
DOI： 10.1111/jvim.16196
Books 【 display / non-display 】
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犬と猫とエキゾチック動物の臨床麻酔・疼痛管理学
（一社）日本獣医麻酔外科学会 麻酔・疼痛管理委員会（ Role： Joint author）
学窓社 2023.9
Book type：Scholarly book
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犬と猫とエキゾチック動物の臨床麻酔学
西村 亮平、佐野 忠士、・・・、永延清和、・・・（ Role： Joint author）
学窓社 2021.10
Book type：Scholarly book
Presentations 【 display / non-display 】
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ＷＨＩＴＥＳＴＡＲ（Ｒ）ＩＣＥ使用時の超音波水晶体乳化吸引装置からのヒドロキシルラジカルの発生
永延清和、中島暉
日本酸化ストレス学会学術集会 (横浜市) 日本酸化ストレス学会
Event date： 2010.6.24 - 2010.6.25
Language：Japanese Presentation type：Poster presentation
Venue：横浜市
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血液ガス分析を麻酔管理や日常診療に活かす：宮崎大学農学部附属動物病院の場合 International conference
永延清和
獣医麻酔外科学会 (福岡市) 獣医麻酔外科学会
Event date： 2011.1.29 - 2011.1.30
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
Venue：福岡市
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臍部疾患の関与が疑われた炎症性眼疾患を発症した黒毛和種子牛
佐藤礼一郎1）、永延清和2）、園田美咲1）、松尾琳子1）、岩崎愛吏1）、熊谷りさ1）、 若松和平3）、永延清和2）、辻田裕規4）
九州地区獣医師大会
Event date： 2023.9.10
Presentation type：Oral presentation (general)
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門脈枝結紮による残存肝の代償性肥大後に肝臓中央・左区域を一括切除した犬の肝臓腫瘍2例
山本集士, 鳥巣至道, 金子泰之, 水谷真也, 長谷川雅史, 貝沼大樹, 吉田均, 藤本晋輔, 永延清和
日本獣医麻酔外科学会 2020年度オンライン学術集会 (オンライン) 日本獣医麻酔外科学会
Event date： 2021.1
Language：English Presentation type：Oral presentation (general)
Venue：オンライン
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犬の肝臓腫瘍の予後不良症例に関する回顧的検討
金子泰之ら
九州地区獣医師大会 (北九州市) 北九州市獣医師会
Event date： 2016.10.15 - 2016.10.16
Language：Japanese Presentation type：Oral presentation (general)
Venue：北九州市
Grant-in-Aid for Scientific Research 【 display / non-display 】
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犬で臨床応用可能な角膜実質再生法の確立
2014.04 - 2015.03
科学研究費補助金
Authorship：Principal investigator
犬で臨床応用可能な角膜実質再生法の研究
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犬で臨床応用可能な角膜実質再生法の確立
2012.04
科学研究費補助金
Authorship：Principal investigator
犬で臨床応用可能な角膜実質再生法の確立を研究する
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犬猫におけるグレリンの病態生理学的役割の解明と臨床応用の可能性
2005.04 - 2006.03
科学研究費補助金