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Engineering educational research section Applied Chemistry Program |
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OSHIMA Tatsuya
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Degree 【 display / non-display 】
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Doctor (Engineering) ( 2001.9 Kyushu University )
Research Areas 【 display / non-display 】
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Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Chemical reaction and process system engineering
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Nanotechnology/Materials / Nanomaterials
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Nanotechnology/Materials / Functional solid state chemistry
Papers 【 display / non-display 】
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Hirano S., Oshima T., Inada A., Tsuruda T.
ACS Applied Bio Materials 9 ( 7 ) 3564 - 3572 2026.3
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：ACS Applied Bio Materials
Amyloid protein aggregates pose a significant challenge due to their extreme insolubility and association with neurodegenerative diseases. To identify effective solvents for dissolving amyloid-forming proteins, a screening of deep eutectic solvents (DESs), including natural DESs (NADES), and related solvents was conducted. Aggregated lysozyme (LA) was reproducibly prepared under acidic and thermal conditions as a model of poorly soluble protein aggregates. Spectroscopic analyses using Thioflavin T fluorescence and circular dichroism (CD), along with morphological observations under polarized light and SEM, confirmed the formation of β-sheet-rich amyloid-like structures. The citric acid−glycerol DES showed the highest solubility for LA, outperforming other DESs and DMSO. Its performance was further enhanced by the addition of ∼5% water. This result also suggests a strong contribution of multivalent organic acids, such as citric and malic acid, to protein solubilization. CD analysis indicated that lysozyme recovered a native-like secondary structure, suggesting partial structural recovery after dissolution in this DES. These findings highlight the potential of DESs as effective media for dissolving protein aggregates and suggest their possible utility in protein refolding and related biotechnological applications, including potential future biomedical applications.
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Two-step selective extraction of Ga(III) and in(III) from hydrochloric acid media using different ketones Reviewed International coauthorship
Stankovic N., Oshima T.
Separation and Purification Technology 386 2025.12
Authorship：Corresponding author Publishing type：Research paper (scientific journal) Publisher：Separation and Purification Technology
Indium and gallium are critical metals with increasing demand in advanced electronics and photovoltaics but a limited primary supply. This work presents a two-step solvent extraction process using neutral ketones for their selective recovery from hydrochloric acid leachates. Gallium (Ga(III)) was first separated using 2-nonanone, achieving >99 % extraction at 5 mol·L<sup>−1</sup> HCl with <1 % indium (In(III)) co-extraction. In(III) was then recovered using MIBK, reaching 85 % in a single stage and up to 99.7 % after three stages. Stripping tests showed that dilute hydrochloric acid (0.01 mol·L<sup>−1</sup>) enabled >92 % In(III) recovery, while deionized water achieved >99 % across all O/A ratios. Ga(III) was quantitatively stripped at moderate HCl concentrations (0.5–1.0 mol·L<sup>−1</sup>) and reached approximately 89 % recovery with water at O/A = 2:1. The use of water eliminates acid neutralization steps, reduces chemical consumption, and produces low-ionic-strength solutions that are ideal for downstream recovery operations. Process reproducibility was confirmed by low standard deviation and RSD values (<3 %) under all tested conditions. The integrated two-step flowsheet thus provides a cost-effective, environmentally friendly alternative to traditional systems based on organophosphorus extractants or ionic liquids. Its closed-loop design enables solvent regeneration and aqueous phase recycling, offering a scalable and sustainable approach for Ga(III) and indium recovery from secondary resources and electronic waste.
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Oshima T., Iwakiri Y., Yokota H., Inada A.
ACS Sustainable Chemistry and Engineering 13 ( 24 ) 9110 - 9118 2025.6
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：ACS Sustainable Chemistry and Engineering
Selective recovery of gold from waste electrical and electronic equipment has attracted increasing attention. Au(III), which is present as tetrachloroauric acid (HAuCl<inf>4</inf>) in hydrochloric acid media, can be extracted by using various organic solvents, such as ketones and ethers. However, the decisive factors of the solvent for predicting Au(III) extractability have not been confirmed. In the present study, the relationship between the extraction percentage of Au(III) and the properties of the solvent was investigated for 79 types of solvents. Based on the relationships between the Hansen solubility parameters of the solvent and the extraction percentage of Au(III) in 5.0 M HCl with a threshold of 80%, the extractability was classified with 93.7% accuracy. To predict the Au(III) extractability, a machine learning model was constructed using the relationship between the molecular descriptors of the solvents obtained from RDKit as explanatory variables and the extraction percentage of Au(III) as the objective variable. By selection of the descriptors that showed a strong correlation with the Au(III) extraction percentage, the squared correlation coefficient (R<sup>2</sup>) of the test data for the nonlinear support vector regression model using 35 descriptors was 0.943. Machine learning was performed again with the addition of surface charge density descriptors obtained from the solvent structure using the conductor-like screening model for real solvents. The R<sup>2</sup> value of the test data for the nonlinear support vector regression model using 28 descriptors, including the hydrogen bond acceptor descriptor as an additional descriptor, was 0.899, which was slightly lower than that of the model with 35 descriptors. Experimental validation using six additional solvents confirmed the model’s accuracy, with predicted values closely matching the measured extraction percentages.
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Development of a Pillar[6]arene Carboxylic Acid Derivative for the Extraction of a Cationic Protein Reviewed
Y. Ikushima, T. Oshima
Biomacromolecules 26 ( 3 ) 1571 - 1579 2025.2
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted from kumquats by complexation with casein Reviewed
T. Oshima, K. Takahashi, A. Inada, M. Yamasaki, Y. Yamasaki, N. Eto
Food Chemistry 360 12982 2021.10
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
Books 【 display / non-display 】
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脱炭素と環境浄化に向けた吸着剤・吸着技術の開発動向 第23章 ポリビニルアミン架橋樹脂による貴金属およびヒ素・セレンの吸着特性
大榮薫, 大島達也（ Role： Joint author）
シーエムシー出版 2023.2
Language：Japanese Book type：Scholarly book
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Ion Exchange and Solvent Extraction Volume 21: Supramolecular Aspects of Solvent Extraction
B. A. Moyer, K. Gloe, P. A. Tasker, K. Ohto, T. Oshima, H. Watarai, M. Nilsson（ Role： Joint author）
CRC Press 2013.10
Language：English Book type：Scholarly book
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九州支部若手ケミカルエンジニア連絡会編：「若手研究者の大きな可能性を秘めた研究開発」 pp.66-70 金属アフィニティー吸着による食品バイオマスからの有価ペプチド回収の可能性
大島達也，大栄薫，馬場由成（ Role： Joint author）
化学工学会九州支部若手ケミカルエンジニア連絡会 2009.7
Language：Japanese Book type：Report
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化学工学シンポジウムシリーズ80 機能性微粒子の高機能化・新展開・用途開発 pp.113-119 バクテリアセルロースを担体とするイオン交換体の吸着特性
大島達也, 大栄薫, 馬場由成（ Role： Joint author）
化学工学会 2008.7
Language：Japanese Book type：Report
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化学工学シンポジウムシリーズ80 機能性微粒子の高機能化・新展開・用途開発 pp.177-185 O/W/Oエマルションを利用した超多孔性キトサン誘導体微粒子の調製と貴金属イオン回収技術への応用
馬場由成, 金井祐基, 大島達也（ Role： Joint author）
化学工学会 2008.7
Language：Japanese Book type：Report
MISC 【 display / non-display 】
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Nano vesicles derived from edible plants~A new player that contributes to the function of foods Reviewed
M. Yamasaki, Y. Yamasaki, T. Oshima
Bioscience, Biotechnology, and Biochemistry 89 ( 2 ) 179 - 186 2024.12
Authorship：Last author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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高効率・低環境負荷な金属リサイクルに寄与する液液抽出溶媒の要件 Invited
大島 達也
ケミカルタイムス 273 16 - 21 2024.7
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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ペプチドで「溶かす」：薬・栄養を体に届ける（特集 ペプチド科学の最近の進展） Invited Reviewed
ペプチドで「溶かす」：薬・栄養を体に届ける（特集 ペプチド科学の最近の進展）
化学工学 88 ( 2 ) 69 - 72 2024.2
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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A Comprehensive Research of Extraction Solvents That Satisfy both Au(III) Extractability and Requirements of Properties for Industrial Operation Invited Reviewed
OSHIMA Tatsuya
Resources Processing 70 ( 1 ) 18 - 24 2023.10
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：The Resources Processing Society of Japan
DOI： 10.4144/rpsj.70.18
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食品中のナノ粒子に関する機能性研究 Invited
山﨑 正夫, 山﨑 有美, 大島 達也
化学と生物 61 78 - 84 2023.2
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Presentations 【 display / non-display 】
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長鎖アルコール類による塩酸系でのAu(III)抽出特性
大島 達也、長谷川 雄大、大榮 薫、 稲田 飛鳥
化学工学会第91年会
Event date： 2026.3.17 - 2026.3.19
Language：Japanese Presentation type：Oral presentation (general)
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2'-Octoxyacetophenone as an extracting solvent for Ga(III) in acidic chloride media International coauthorship
Stankovic Nicolas、大島 達也、大榮 薫、稲田 飛鳥、長谷川 雄大
化学工学会第91年会
Event date： 2026.3.17 - 2026.3.19
Language：Japanese Presentation type：Oral presentation (general)
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Comparative Study of Metal-Ion Adsorption and Gold Reduction by Crosslinked and non-crosslinked Sericin International conference
Event date： 2026.1.31
Presentation type：Oral presentation (general)
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Application of Natural Deep Eutectic Solvents for Enhancing Solubility of Poorly Water-Soluble Drugs International conference
2025.12.5
Event date： 2025.12.5
Language：English Presentation type：Oral presentation (general)
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Supramolecular Gelation Driven by Cu(II)-Binding Tetrapeptides International conference
2025.12.5
Event date： 2025.12.5
Language：English Presentation type：Oral presentation (general)
Awards 【 display / non-display 】
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2020年度「貴金属に関わる研究助成金」シルバー賞
2021.3 一般財団法人 田中貴金属記念財団 金の抽出分離プロセスに最適なイオン溶媒和抽出剤の発見と探求
大島達也
Award type：Award from publisher, newspaper, foundation, etc. Country：Japan
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日本溶媒抽出学会 平成30年度 奨励賞
2018.11 日本溶媒抽出学会 抽出剤・希釈剤の開発を基盤とした新規溶媒抽出システムに関する研究
大島達也
Award type：International academic award (Japan or overseas) Country：Japan
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2017年度「貴金属に関わる研究助成金」奨励賞
2018.3 一般財団法人 田中貴金属記念財団 塩酸系からAu(III)を選択的・高容量に抽出する新規エーテル化合物の開発
大島達也
Award type：Award from publisher, newspaper, foundation, etc. Country：Japan
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the Journal of Chemical Engineering of Japan, Outstanding Paper Award of 2016
2017.3 化学工学会 Water Solubility of Complexes between a Peptide Mixture and Poorly Water-Soluble Ionic and Nonionic Drugs
A. Inada, M. Wang, T. Oshima, Y. Baba
Award type：Honored in official journal of a scientific society, scientific journal Country：Japan
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化学工学会論文審査貢献賞
2017.3 化学工学会
大島達也
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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希少金属への優れた分離回収能力と低環境負荷性を両立した新規抽出溶媒の機械学習探索
Grant number：23K26449 2024.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship：Principal investigator
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『特異な』相互作用を示す抽出試薬を用いた都市鉱山からの有価金属逐次回収システム
Grant number：23K26697 2024.04 - 2026.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(B)
Authorship：Coinvestigator(s)
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希少金属への優れた分離回収能力と低環境負荷性を両立した新規抽出溶媒の機械学習探索
Grant number：23H01756 2023.04 - 2027.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
Authorship：Principal investigator
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『特異な』相互作用を示す抽出試薬を用いた都市鉱山からの有価金属逐次回収システム
Grant number：23H02004 2023.04 - 2026.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(B)
Authorship：Coinvestigator(s)
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アミンへの分子認識試薬を利用したCO2の固体化とアミン吸収液の非加熱再生
Grant number：22K18926 2022.04 - 2025.03
独立行政法人日本学術振興会 科学研究費基金 挑戦的研究(萌芽)
Authorship：Principal investigator
Available Technology 【 display / non-display 】
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水に溶けにくい機能性物質の水溶性・経口吸収性の改善技術
タンパク質、ペプチド等の分離技術・分離材料の開発
抗がん剤等のドラッグデリバリーシステム開発Related fields where technical consultation is available：・機能性物質の製剤技術・吸収性改善
・タンパク質、ペプチド等の分離技術（吸着・抽出等）ならびに分離材料・分離技術
・ドラッグデリバリーシステム開発Message：共同研究の希望テーマ：機能性物質の製剤技術・吸収性改善、生体分子分離技術
上記技術の共同開発と応用、への技術相談などあれば ご連絡ください。