Papers - TAKEDA Ryuichiro
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Takeda R., Watanabe Y., Ikeda T., Abe H., Ebihara K., Matsuo H., Nonaka H., Hashiguchi H., Nishimori T., Ishida Y.
Neuroscience Research 64 ( 4 ) 380 - 384 2009.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neuroscience Research
The objective of the present study was to examine whether milnacipran, a serotonin-noradrenaline reuptake inhibitor, has an analgesic effect in rats with neuropathic pain. In addition, the c-Fos expression was investigated in the supraspinal sites of the brain and in the spinal dorsal horn in association with the nociceptive processing in rats with neuropathic pain produced by chronic constriction injury (CCI) in the sciatic nerve. In the CCI-induced neuropathic rats, behavioral testing for determining the change in the withdrawal threshold to mechanical stimulation and immunohistochemical detection of c-Fos were both performed. The anti-allodynic effect derived from milnacipran gradually increased over the observation period, indicating that the delayed-onset analgesia might be elicited by the continuous administration of milnacipran. The increased level of c-Fos expression in the anterior cingulate cortex (ACC) induced by noxious mechanical stimulation was significantly inhibited by the continuous administration of milnacipran, indicating that milnacipran might cause a functional modification in the nociceptive processing in the ACC. © 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society.
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IKEDA Tetsuya, ISHIDA Yasushi, NAONO Rumi, TAKEDA Ryuichiro, ABE Hiroshi, NAKAMURA Tadashi, NISHIMORI Toshikazu
Neuroscience research : the official journal of the Japan Neuroscience Society 63 ( 1 ) 42 - 46 2009.1
Language：Japanese Publishing type：Research paper (scientific journal)
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当院における修正型電気けいれん療法の現状
牧田昌平,船橋英樹,長友慶子,武田龍一郎,松尾寿栄,野中博意,植田勇人,石田康
宮崎県医師会医学会誌 33 14 - 18 2009.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Ikeda T., Ishida Y., Naono R., Takeda R., Abe H., Nakamura T., Nishimori T.
Neuroscience Research 63 ( 1 ) 42 - 46 2009.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neuroscience Research
Antidepressants, especially tricyclic antidepressants (TCAs) are widely used for the treatment of various types of chronic and neuropathic pain. The antinociceptive effects of TCAs are, however, complicated. Therefore, two kinds of newer antidepressants whose functions have been more fully clarified were selected, milnacipran, a serotonin and noradrenaline reuptake inhibitor (SNRI) and paroxetine and fluvoxamine, which are selective serotonin reuptake inhibitors (SSRIs). The antiallodynic effects of intrathecal administration of these newer antidepressants were examined in two rat models of neuropathic pain, chronic constriction injury (CCI) of the sciatic nerve and streptozotocin (STZ)-induced diabetic neuropathy. The antiallodynic effect of these antidepressants was evaluated using the von Frey test. The intrathecal administration of milnacipran had an antiallodynic effect in both CCI and STZ-induced diabetic rats in a dose-dependent manner. On the other hand, the intrathecal administration of either paroxetine or fluvoxamine elicited little antiallodynic effect in CCI rats, while both SSRIs had antiallodynic effects in the STZ-induced diabetic rats in a dose-dependent manner. These results indicate a considerable difference to exist in the development and/or maintenance between these two animal models of neuropathic pain and suggest that each of these three antidepressants may be effective for the treatment of diabetic neuropathic pain. © 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society.
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Differential expression of Fos and Zif268 in the nigrostriatal system after methamphetamine administration in a rat model of Parkinson’s disease.（共著 Reviewed
「Ishida Y」「Kawai K」「Magata Y」「Ebihara K」「Takeda R」「Abe H」「Yoshimoto M」「Hashiguchi H」「Odagiri K」「Matsuo H」and 「Nishimori T」
Synapse ６２ ９２０ - ９２６ 2008.12
Language：English Publishing type：Research paper (scientific journal)
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Ishida Y., Kawai K., Magata Y., Ebihara K., Takeda R., Abe H., Yoshimoto M., Hashiguchi H., Odagiri K., Matsuo H., Nishimori T.
Synapse 62 ( 12 ) 920 - 926 2008.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Synapse
The goal of this study was to examine the topological specificity of methamphetamine-induced activation of the immediate-early gene proteins, Fos and Zif268, in the nigrostriatal system in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease with or without intrastriatal grafts of fetal ventral mesencephalon. Methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI) dominantly in the striatum and the globus pallidus (GP) on the intact side as well as in the substantia nigra pars reticulata (SNr) on the lesioned side in the 6-OHDA rats. Lower levels of methamphetamine-induced FLI in the striatum and GP on the lesioned side were restored by intrastriatal grafts which could completely suppress the methamphetamine-induced rotation. In the striatum, a similar tendency could be observed between Fos and Zif268 immunoreactivity following methamphetamine. However, sparse immunoreactivity of Zif268 could be detected in the GP and SNr on both sides in the 6-OHDA rats. Intrastriatal grafts had little influence on Zif268 expression in these two regions. The differential expression of Fos and Zif268 was observed among the three regions of the nigrostriatal system following methamphetamine in the 6-OHDA rats. This may suggest that Fos and Zif268 therefore possess gene-specific and region-specific functions in the basal ganglia nuclei. © 2008 Wiley-Liss, Inc.
DOI： 10.1002/syn.20558
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Psychological prenatal stress reduced the number of BrdU immunopositive cells in the dorsal hippocampus without affecting the open field behavior of male and female rats at one month of age. （共著） Reviewed
「Odagiri K」「Abe H」「Kawagoe C」「Takeda R」「Ikeda T」「Matsuo H」「Nonaka H」「Ebihara K」「Nishimori T」「Ishizuka Y」「Hashiguchi H」「Ishida Y」
Neuroscience Letters 2008.11
Language：English Publishing type：Research paper (scientific journal)
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Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain.
Ikeda T, Ishida Y, Naono R, Takeda R, Abe H, Nakamura T, Nishimori T.
Neuroscience research 2008.10
Language：English Publishing type：Research paper (scientific journal)
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Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis. Reviewed
Abe H, Hidaka N, Kawagoe C, Odagiri K, Watanabe Y, Ikeda T, Ishizuka Y, Hashiguchi H, Takeda R, Nishimori T, Ishida Y.
Neuroscience Research 59 145 - 151 2007.6
Language：English Publishing type：Research paper (scientific journal)
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執拗な身体的愁訴に対してフルボキサミンが著効した高齢者の４症例 Reviewed
船橋英樹, 武田龍一郎,松尾寿栄,安部博史,尾薗和彦,谷口浩,三山吉夫,石田康
精神科 11 ( 3 ) 260 - 266 2007.3
Language：Japanese Publishing type：Research paper (scientific journal)
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疼痛治療における抗うつ薬の役割
石田 康，武田龍一郎，安部博史，松尾寿栄，池田哲也，西森利數
臨床と研究 84(2)：99-101（2007） 84 ( 2 ) 99 - 101 2007.2
Language：English Publishing type：Research paper (scientific journal)
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器質性感情障害に対するバルプロ酸ナトリウムの使用経験 Reviewed
鶴衛 亜里砂，植田 勇人，武田 龍一郎，山崎 啓之，児玉 裕文，有森 和彦，石田 康
九州神経精神医学 51 122 - 125 2005.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Ishida Y., Kawai K., Magata Y., Abe H., Yoshimoto M., Takeda R., Hashiguchi H., Mukai T., Saji H.
Neuroscience Letters 389 ( 1 ) 30 - 34 2005.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neuroscience Letters
We studied the positron emission tomography (PET) tracer distributions of ligands for dopamine D 1 receptors ([ 11 C]SCH23390) and D 2 receptors ([ 11 C]raclopride) and of the dopamine precursor analog 6-[ 18 F]fluoro-l-3,4-dihydroxyphenylalanine ([ 18 F]FDOPA) in the brain after 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle in rats. The number of methamphetamine-induced rotation was higher at 14 days than at 3 days after the 6-OHDA lesions. The brains of 6-OHDA-treated rats were analyzed by tissue dissection following i.v. bolus of each tracer at 3 days (acute stage) or 3 weeks (chronic stage) postlesion. [ 11 C]Raclopride, but not [ 11 C]SCH23390, showed higher accumulation in the striatum on the lesion side than on the non-lesion (intact) side both at 3 days and 3 weeks postlesion. On the other hand, lower accumulation of [ 18 F]FDOPA was observed in the striatum on the lesion side at 3 days postlesion and in both the striatum and cerebral cortex on the lesion side at 3 weeks postlesion. Our studies demonstrate that an increase in [ 11 C]raclopride and a decrease in [ 18 F]FDOPA uptake in the denervated striatum is evident even at 3 days after the 6-OHDA lesions when the methamphetamine-induced rotational behavior is not established. © 2005 Elsevier Ireland Ltd. All rights reserved.
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TAKEDA Ryuichiro, IKEDA Tetsuya, TSUDA Fumiko, ABE Hiroshi, HASHIGUCHI Hiroyuki, ISHIDA Yasushi, NISHIMORI Toshikazu
Neuroscience research : the official journal of the Japan Neuroscience Society 52 ( 1 ) 31 - 36 2005.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Ishida Y., Kawai K., Magata Y., Takeda R., Hashiguchi H., Abe H., Mukai T., Saji H.
Neurodegenerative Diseases 1 ( 2-3 ) 109 - 112 2004.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Neurodegenerative Diseases
We studied tracer distributions in positron emission tomography of ligands for dopamine D 1 receptors ([ 11 C]SCH23390) and D 2 receptors ([ 11 C]raclopride) and the dopamine precursor analog 6-[ 18 F]fluoro-L-3,4-dihydroxyphenylalanine ([ 18 F]FDOPA), as a measurement of presynaptic dopaminergic function, in the brain after 6-hydroxydopamine lesioning of the medial forebrain bundle in rats. The unilateral lesions were confirmed behaviorally by methamphetamine- induced rotation 2 weeks after lesioning, and the brains were analyzed by tissue dissection following an intravenous bolus of each tracer 3 weeks after lesioning. [ 11 C]Raclopride, but not [ 11 C]SCH23390, showed a higher accumulation in the striatum on the lesion side compared with that on the non-lesioned (intact) side. On the other hand, a lower accumulation of [ 18 F]FDOPA was found in the striatum and cerebral cortex on the lesion side. Our studies demonstrate upregulation of dopamine D 2 receptors in the striatum and a decrease in FDOPA uptake in both the striatum and cerebral cortex ipsilateral to the 6-hydroxydopamine lesions. Therefore, the combination of a D 2 antagonist and FDOPA may provide a potentially useful method for assessing the effects of dopamine depletion in Parkinson's disease. Copyright © 2004 S. Karger AG, Basel.
DOI： 10.1159/000080051
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パーキンソン病モデルラットにおける痛覚過敏 Reviewed
武田龍一郎，石田康，橋口浩志，西森利數
Progress in medicine 22 ( 11 ) 2905 - 2909 2002.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Ishida Y., Hashiguchi H., Takeda R., Ishizuka Y., Mitsuyama Y., Kannan H., Nishimori T., Nakahara D.
Synapse 45 ( 1 ) 46 - 51 2002.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Synapse
Many studies have demonstrated that physical or psychological stress can increase Fos expression in brainstem monoaminergic nuclei. Little is known, however, about the extent to which stress increases the expression of Fos in monoaminergic and nonmonoaminergic neurons in the brainstem. We examined the effects of conditioned-fear (CF) stress following mild footshock (FS) as unconditioned stress on Fos expression in the monoaminergic and GABAergic neurons of the ventral tegmental area (VTA), locus coeruleus (LC), and dorsal raphe nucleus (DR) in rats. The CF stress significantly increased the number of Fos-positive (Fos+) cells in both the LC and DR, whereas it did not increase the number in the VTA. Using a double-labeling technique, we combined Fos immunostaining with that for tyrosine hydroxylase (TH), serotonin (5-HT), or GABA for histochemical identification of the CF stress-induced Fos+ neurons. The percentage of TH/Fos double-labeled cells resulting from CF stress was 63% of the Fos+ cells in the LC, whereas 52% of the Fos+ cells contained 5-HT in the DR. We also found that approximately 60% of the CF stress-induced Fos+ cells were GABAergic neurons in these brain regions. These results indicate that CF stress induces intense Fos expression in the noradrenergic LC and serotonergic DR neurons, but not in the dopaminergic VTA neurons. They also indicate that not only monoaminergic neurons but also GABAergic neurons within the LC and DR are activated by the stress. © 2002 Wiley-Liss, Inc.
DOI： 10.1002/syn.10086
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フェノバルビタールとの相互作用によりフェニトイン中毒を呈したと診断された１症例 Reviewed
武田 龍一郎，植田 勇人，武藤 仁，熊谷 有紀，児玉 裕文，有森 和彦，三山 吉夫
九州精神神経医学雑誌:-; 2001. 47 83 - 90 2001.12
Language：Japanese Publishing type：Research paper (scientific journal)
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精神障害者の身体合併症への対応 Reviewed
武田龍一郎、三山吉夫
精神医学 41 ( 5 ) 547 - 552 1999.5
Language：Japanese Publishing type：Research paper (scientific journal)