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Affiliation |
Faculty of Agriculture Department of Marine Biological and Environmental Science |
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Title |
Professor |
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External Link |
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HAYASHI Masahiro
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Degree 【 display / non-display 】
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Doctor(Agriculture) ( 1994.12 Osaka Prefecture University )
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Bachelor(Education) ( 1986.3 Kyoto University of Education )
Research Areas 【 display / non-display 】
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Life Science / Applied microbiology
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Life Science / Aquatic life science
Papers 【 display / non-display 】
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PUFA synthase-independent DHA synthesis pathway in Parietichytrium sp. and its modification to produce EPA and n-3DPA Reviewed
Yohei Ishibashi, Hatsumi Goda, Rie Hamaguchi, Keishi Sakaguchi, Takayoshi Sekiguchi, Yuko Ishiwata, Yuji Okita, Seiya Mochinaga , Shingo Ikeuchi , Takahiro Mizobuchi , Yoshitake Takao, Kazuki Mori, Kosuke Tashiro, Nozomu Okino, Daiske Honda, Masahiro Hayashi, Makoto Ito
Communications Biology 2021.10
Language：English Publishing type：Research paper (scientific journal)
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Fukuda M., Kinkawa M., Hayashi M.
Bioscience, Biotechnology and Biochemistry 88 ( 2 ) 206 - 211 2024.2
Publishing type：Research paper (scientific journal) Publisher：Bioscience, Biotechnology and Biochemistry
Paramylon, a starch-like carbohydrate accumulated in Euglena gracilis cells, could be a potential source as a raw material for chemical products; its high-yield production would thus be highly desired. Although the molecular weight and polymerization degree of paramylon are important properties for its use as a raw material for chemical products, the available information about paramylon molecular weight remains insufficient. Therefore, in this study, we investigated a high-density E. gracilis culture approach and how culture conditions affect paramylon molecular weight. The nitrogen source, cultivation temperature, and nutrient feeding were optimized for maximum biomass and paramylon productivity. The maximum dry cell weight and paramylon content yields reached 108.9 g/L and 87.2%, respectively. Paramylon molecular weight was in the range of 220 000–320 000 Da. Our gel permeation chromatography analysis showed that the cells with a higher paramylon content tended to contain paramylon of a higher molecular weight.
DOI： 10.1093/bbb/zbad152
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Mizuki Fukuda, Manato Kinkawa and Masahiro Hayashi
Bioscience, Biotechnology and Biochemistry 88 ( 2 ) 206 - 211 2023.11
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Bioscience, Biotechnology and Biochemistry
Comparative metabolic profiling analysis was performed to investigate light- and aeration-dependent regulation of central metabolism in Euglena gracilis. The metabolic profiles of E. gracilis were significantly altered in response to changes in aeration conditions. While many glycolytic intermediates and amino acids accumulated in aerobically grown E. gracilis, a significant reduction in these metabolites was observed for cells under anaerobic conditions, which resulted in elevated production of wax ester.
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The Utilization of Heterotrophic Cultivation for Large Scale Production of Microalgae Invited Reviewed
HAYASHI Masahiro, MATSUDA Ayako
20 ( 6 ) 37 - 42 2023.9
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Oil Chemists' Society
In various industries, practical utilizations of many microalgae are investigated recently. Many problems are recognized for a practical realization of microalgal industry, such as, a choice of cultivation method, autotroph or heterotroph, an effect of sunlight cycle on algal growth, a balance between cell density and efficacy of photosynthesis, an effects of carbon concentration on the growth, a shape and function of culture tank, practical use of extraction residue, molecular breeding and sterilization of the strains.Euglena has unique properties for the cultivation among various microalgae. Euglena can grow autotrophically, heterotrophically, or photoheterotrophically. Although each cultivation method has some merit and demerit, the authors focused on the heterotrophy cultivation, Euglena is industrially cultivated in large scale tanks in the dark.
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The Utilization of Heterotrophic Cultivation for Large Scale Production of<i> Euglena gracilis</i> Invited Reviewed
HAYASHI Masahiro, MATSUDA Ayako, TOKAI Shouta, UKEGAWA Yuino, UDAKA Takaki
Oleoscience 23 ( 2 ) 65 - 72 2023.2
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Oil Chemists' Society
In various industries, practical utilizations of many microalgae are investigated recently. Many problems are recognized for a practical realization of microalgal industry, such as, a choice of cultivation method, autotroph or heterotroph, an effect of sunlight cycle on algal growth, a balance between cell density and efficacy of photosynthesis, an effects of carbon concentration on the growth, a shape and function of culture tank, practical use of extraction residue, molecular breeding and sterilization of the strains.Euglena has unique properties for the cultivation among various microalgae. Euglena can grow autotrophically, heterotrophically, or photoheterotrophically. Although each cultivation method has some merit and demerit, the authors focused on the heterotrophy cultivation, Euglena is industrially cultivated in large scale tanks in the dark.
Books 【 display / non-display 】
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バイオマス材料の開発と応用
林 雅弘（ Role： Sole author , ユーグレナの産業利用ー特にパラミロンとそれを原料とするバイオプラスチックの開発）
株式会社 技術情報協会 2023.3
Language：Japanese Book type：Scholarly book
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カーボンニュートラル燃料最新動向
林 雅弘 松田綾子（ Role： Joint author , 藻類によるバイオ製造製造）
株式会社 情報機構 2022.7
Language：Japanese Book type：Scholarly book
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藻類培養技術
林 雅弘（ Role： Joint author , 藻類の濃縮と乾燥技術（ユーグレナの工業化を例に））
株式会社 情報機構 2021.10
Language：Japanese Book type：Scholarly book
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フードテックの最新動向
親泊政二三 林 雅弘（ Role： Joint author , 海産微生物ラビリンチュラの食品への利用）
シーエムシー出版 2021.7
Language：Japanese Book type：Scholarly book
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脂質・脂肪酸関連物質の使いこなしかたー素材開発・機能創生・応用技術ー
林 雅弘・松田綾子（ Role： Joint author）
株式会社テクノシステム 2020.9
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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微細藻類の大量培養における従属栄養培養の利用 Invited
林 雅弘 松田綾子
研究開発リーダー 20 ( 5 ) 37 - 42 2023.10
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本化学工学会
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Abe E., Ikeda K., Nutahara E., Hayashi M., Yamashita A., Taguchi R., Doi K., Honda D., Okino N., Ito M.
PLoS ONE 13 ( 8 ) 2018.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：PLoS ONE
© 2018 Abe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The titles and legends for Figs 2 and 3 are swapped. Please see the correct Figs 2 and 3 here. (Figure Presented).
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微細藻類プラスチックの開発 Invited Reviewed
林 雅弘、芝上 基成
化学工学 80 ( 5 ) 2 - 4 2016.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本化学工学会
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微細藻類プラスチックの開発
林 雅弘、芝上 基成
化学工学 80 ( 5 ) 2 - 4 2016.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：日本化学工学会
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油糧海洋微生物ラビリンチュラの産業利用
林 雅弘、松田綾子、松田高宜、泉 可也
酵素工学ニュース ( 74 ) 6 - 9 2015.10
Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher：酵素工学研究会
Presentations 【 display / non-display 】
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Optimization of temperature, pH, and thiamine concentration conditions for wax ester production by heterotrophically cultured Euglena gracilis International conference
Kinkawa, Manato , Hayashi, Masahiro
APMBC2023 (シーガイアコンベンションセンター) 2023.10.4 マリンバイオテクノロジー学会
Event date： 2023.10.2 - 2023.10.6
Language：English Presentation type：Poster presentation
Venue：シーガイアコンベンションセンター
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Heterotrophic high-density cultivation of Euglena gracilis to produce paramylon International conference
Fukuda Mizuki , Hayashi, Masahiro
APMBC2023 (シーガイアコンベンションセンター) 2023.10.4 マリンバイオテクノロジー学会
Event date： 2023.10.2 - 2023.10.6
Language：English Presentation type：Poster presentation
Venue：シーガイアコンベンションセンター
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Heterotrophic high-density cultivation of Euglena gracilis to produce paramylon and its utilization as a raw material for some chemicals. Invited International conference
Masahiro Hayashi, Mizuki Fukuda and Manato Kinkawa
3rd Annual International Congress on Euglenoids (シーガイアコンベンションセンター) 2023.7.18 マリンバイオテクノロジー学会
Event date： 2023.7.17 - 2023.7.18
Language：English Presentation type：Oral presentation (keynote)
Venue：シーガイアコンベンションセンター
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Euglena gracilisにおけるバイオマスの高収率生産法の開発および貯蔵多糖類パラミロンの分子量分析に関する考察
福田 美月、林 雅弘
マリンバイオテクノロジー学会大会 (シーガイアコンベンションセンター) 2023.5.27 マリンバイオテクノロジー学会
Event date： 2023.5.27 - 2023.5.28
Language：Japanese Presentation type：Poster presentation
Venue：シーガイアコンベンションセンター
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Euglena gracilisの従属栄養的流加培養による高収量なワックスエステル生産
金川真人、林 雅弘
マリンバイオテクノロジー学会大会 (シーガイアコンベンションセンター) 2023.5.27 マリンバイオテクノロジー学会
Event date： 2023.5.27 - 2023.5.28
Language：Japanese Presentation type：Poster presentation
Venue：シーガイアコンベンションセンター
Awards 【 display / non-display 】
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AgriFood SBIRピッチ2023 ビジネス構想優秀賞
2023.3 ⽣物系特定産業技術研究⽀援センター
林 雅弘
Award type：Award from Japanese society, conference, symposium, etc.
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日本農芸化学会2016年度大会トピックス賞
2016.4 日本農芸化学会
合田初美，持永聖也，濱口理恵，坂口圭史，伊東信，関口俊，石渡夕子，沖田裕司，本多大輔，林 雅弘
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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情動制御作用を有するプラズマローゲンのデザインと脳内輸送経路および標的細胞の 解明
Grant number：20K07918 2020.04 - 2023.03
独立行政法人日本学術振興会 科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
Available Technology 【 display / non-display 】
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海洋微生物ラビリンチュラの産業利用
ユーグレナ（ミドリムシ）の産業利用
海洋マイクロプラスチック問題に関する要素技術の開発Related fields where technical consultation is available：新奇微生物の探索、育種、高密度培養や産業利用全般
Message： 新奇海洋微生物の探索のためなら、潜水作業もやります。
（本人及びスタッフ、院生は潜水士免許を取得）